Abstract Defective sperms cause fertilization failure under both in vivo and in vitro conditions. Therefore, providing optimal conditions during semen storage is a prerequisite for maintaining viability. The current study investigated bull semen quality in vitro and in vivo when zinc (Zn) nanoparticles were used as antioxidant during semen processing and cryopreservation. In total, 32 ejaculates were collected from four Holstein bulls. All ejaculates were pooled and diluted with...
03:00
Abstract Rationale We probed serotonin neurons, those denoted by their developmental gene expression as r2Hoxa2-Pet1 (experiment 1) and Drd1a-Pet1 (experiment 2), for differential modulation of cocaine reward and memory as revealed by the expression and development of conditioned place preference (CPP) in transgenic mice. Objectives To query roles in CPP,...
03:00
Mon Jun 01, 2020 15:24
Herein we demonstrate a sustainable, scalable packed bed flow reactor capable of achieving highly regio‐ and stereoselective C–H functionalization reactions using a newly developed Rh 2 ( S ‐2‐Cl‐5‐CF 3 TPCP) 4 catalyst. To optimize the immobilized dirhodium catalyst employed in the flow reactor, we systematically study both (i) the effects of ligand immobilization position, demonstrating the critical factor that the catalyst‐support attachment location can have on the catalyst performance,...
Mon Jun 01, 2020 16:54
Abstract Although hypertrophic scars and keloidsboth generate excessive scar tissue, keloids are characterized by their extensive growth beyond the borders of the original wound, which is not observed in hypertrophic scars. Whether or not hypertrophic scars and keloids are two sides of the same coin or in fact distinct entities, remains a topic of much debate. However, proper comparison between the two ideally occurs within the same study, but this is the exception rather than the rule. For this...
Mon Jun 01, 2020 22:53
Abstract Background Cutaneous squamous cell carcinoma (SCC) causes 1 million cases in the United States annually. There are germline single nucleotide polymorphisms (SNPs) that result in an increased risk of SCC and altered response to therapy. Premise There may be biologically relevant SNPs not detected using traditional GWAS studies. Hypothesis There are clinically and biologically relevant SNPs in high‐risk SCC that may only be appreciated with next‐generation sequencing. How...
Mon Jun 01, 2020 22:25
Abstract About 1–2% of European population are redheaded, meaning they synthesize more pheomelanin than eumelanin, the main melanin pigment in humans. Several mutations could be responsible for this phenotype. It has been suggested that corresponding mutations spread in Europe due to a founder effect shaped either by a relaxation of selection for dark, UV‐protective phenotypes or by sexual selection in favor of rare phenotypes. In our study, we investigated the levels of vitamin D precursor 25(OH)D3...
Mon Jun 01, 2020 15:53
Cancer immune-interception for prevention of recurrence in patients with high-risk familial cancer like Muir–Torre syndrome or Lynch syndrome using immune checkpoint blockade inhibitors is a promising approach. Albeit, as described in a case report by Pollak and colleagues in the April 2020 issue of Cancer Prevention Research, it has the potential to be used as immune-interceptive with alternative dosing regimens for cancers with microsatellite instability. The combination of additional cancer preventive...
Tue Jun 02, 2020 10:05
Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver tissue; therefore, chemoprevention may be a useful strategy to reduce HCC incidence. Several reports suggest that epigallocatechin gallate (EGCG), extracted from green tea, can suppress liver inflammation and fibrosis in animal models, but its role in HCC chemoprevention is not well established. In this study, male Wistar rats were injected with...
Tue Jun 02, 2020 10:05
The aim of this study was to identify the economic screening strategies for esophageal squamous cell carcinoma (ESCC) in high-risk regions. We used a validated ESCC health policy model for comparing different screening strategies for ESCC. Strategies varied in terms of age at initiation and frequency of screening. Model inputs were derived from parameter calibration and published literature. We estimated the effects of each strategy on the incidence of ESCC, costs, quality-adjusted life-year (QALY),...
Tue Jun 02, 2020 10:05
The aim of this study was to compare and externally validate risk scores developed to predict incident colorectal cancer that include common genetic variants (SNPs), with or without established lifestyle/environmental (questionnaire-based/classical/phenotypic) risk factors. We externally validated 23 risk models from a previous systematic review in 443,888 participants ages 37 to 73 from the UK Biobank cohort who had 6-year prospective follow-up, no prior history of colorectal cancer, and data for...
Tue Jun 02, 2020 10:05
In the United States, the five-year survival rate of colorectal cancer for Latinos is lower than it is for White, non-Latinos. Differences in survival are due, in part, to Latinos being diagnosed at a later stage. An ethnic gap in the use of colorectal cancer screening contributes to the difference in survival. We developed, implemented, and evaluated a targeted colorectal cancer screening intervention to increase colorectal cancer screening uptake by sex, ethnicity, and geography. We measured actual...
Tue Jun 02, 2020 10:05
Vitamin D may influence prostate cancer risk, but evidence is inconsistent. We conducted a nested case–control study in the Prostate Cancer Prevention Trial (PCPT). Cases (n = 1,128) and controls (n = 1,205) were frequency matched on age, first-degree relative with prostate cancer, and PCPT treatment arm (finasteride/placebo); African-Americans were oversampled and case/control status was biopsy confirmed. We selected 21 SNPs in vitamin D–related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1,...
Tue Jun 02, 2020 10:05
Sulforaphane (SFN), a potent antioxidant and antiinflammatory agent, has been shown to protect against cancers especially at early stages. However, how SFN affects UVB-mediated epigenome/DNA methylome and transcriptome changes in skin photodamage has not been fully assessed. Herein, we investigated the transcriptomic and DNA methylomic changes during tumor initiation, promotion, and progression and its impact and reversal by SFN using next-generation sequencing (NGS) technology. The results show...
Tue Jun 02, 2020 10:05
Intertidal limpets are important grazers along rocky coastlines worldwide that not only control algae but also influence invertebrates such as common barnacles. For instance, grazing limpets ingest settling barnacle cyprid larvae (hereafter cyprids) and push cyprids and barnacle recruits off the substrate. Such limpet disturbance effects (LDEs) can limit barnacle recruitment, a key demographic variable affecting barnacle population establishment and persistence. In this study, we examined limpet...
Tue Jun 02, 2020 03:00
Divergences between agricultural management can result in different types of biological interactions between plants and microorganisms, which may affect food quality and productivity. Conventional practices are well-established in the agroindustry as very efficient and lucrative; however, the increasing demand for sustainable alternatives has turned attention towards agroecological approaches. Here we intend to explore microbial dynamics according to the agricultural management used, based on the...
Tue Jun 02, 2020 03:00
Background The fall webworm, Hyphantria cunea Drury (Lepidoptera: Erebidae), is a widespread invasive species. It is native to North America, ranging from southern Canada to northern Mexico. During and after the 1940s, this pest was accidentally introduced in many parts of Europe and Asia. It has now spread to more than 30 countries. The larvae feed on leaves of a wide range of tree species, including ones used as street trees in cities, causing an increase in urban management cost....
Tue Jun 02, 2020 03:00
The proportion of the rural population who live within 2 km of an all-season road is an indicator of the United Nations’ Sustainable Development Goals (SDGs) 9.1.1. This paper aims to calculate SDG indicator 9.1.1 in the proximity of five Algerian expressways. Three monitoring methods are proposed for different spatial regions based on the five expressways built by China’s Belt and Road Initiative Project. These methods are based on remote sensing and WorldPop and The High Resolution Settlement Layer...
Tue Jun 02, 2020 03:00
Abstract Background Swallowing disorder or dysphagia is quite common in hospitalized patients. Using Fiberoptic Endoscopic Evaluation of Swallowing (FEES) is one of the clinical standards for evaluating swallowing disorder to prevent serious consequences such as aspiration pneumonia. Objectives This study aimed to determine the prevalence and the associated risk of dysphagia in hospitalized patients by using FEES finding Methods We retrospectively analyzed the FEES records from the...
Mon Jun 01, 2020 22:27
Abstract In a recent article in the Journal of Oral Rehabilitation, Miyashita and colleagues suggested the usefulness of measuring the amount of laryngeal upward movement and pharyngeal area by the videofluoroscopic swallowing study to determine decreased swallowing muscle function in sarcopenia (1). Although a small number of patients were included making it hard to perform extensive multivariable analyses and to draw firm conclusions, the study suggests a novel, single procedure to diagnose sarcopenic...
Mon Jun 01, 2020 16:11
Abstract Emotions play a key role in our daily life through their control over our thoughts and behaviors. While it is commonly accepted that depressive patients have emotional perception disorders, it is important to know how these disorders affect patients’ sensory perception to develop products to provide them with better support. In this study, we first examined the existence of modifications in the emotional perception of subjects with minor depressive symptoms (MDS, n=80) compared with healthy...
Mon Jun 01, 2020 15:53
Abstract Myelin deposition in the central nervous system has been shown to be responsive to experience, with sensory enrichment increasing myelination and sensory or social deprivation decreasing myelination. This process is referred to as ‘adaptive myelination’ or ‘myelin plasticity’ and signifies an essential component of new learning. However, whether these experience‐driven adaptations are driven by a) underlying changes in the generation of myelinating cells, b) altered interactions between...
Mon Jun 01, 2020 15:49
During the coronavirus disease 2019 (COVID‐19) pandemic, providers and patients must engage in shared decision making regarding the pros and cons of early versus delayed interventions for localized skin cancer. Patients at highest risk of COVID‐19 complications are older; are immunosuppressed; and have diabetes, cancer, or cardiopulmonary disease, with multiple comorbidities associated with worse outcomes. Physicians must weigh the patient's risk of COVID‐19 complications in the event of exposure...
Mon Jun 01, 2020 16:42
Background The objective of this study was to identify a subgroup of patients with head and neck squamous cell carcinoma (HNSCC) who might be suitable for hypofractionated radiotherapy (RT‐hypo) during the COVID‐19 pandemic. Methods HNSCC cases (oropharynx/larynx/hypopharynx) treated with definitive RT‐hypo (60 Gy in 25 fractions over 5 weeks), moderately accelerated radiotherapy (RT‐acc) alone (70 Gy in 35 fractions over 6 weeks), or concurrent chemoradiotherapy (CCRT) during 2005‐2017 were...
Mon Jun 01, 2020 16:17
Abstract One pivotal factor that leads to multidrug resistance (MDR) is the overexpression of ABCG2. Therefore, tremendous effort has been devoted to the search of effective reversal agents to overcome ABCG2‐mediated MDR. CC‐671 is a potent and selective inhibitor of both TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1)) and CDC Like Kinase 2 (CLK2). It represents a new class of cancer therapeutic drugs. In this study, we demonstrate that CC‐671 is an effective ABCG2 reversal agent that enhances...
Mon Jun 01, 2020 15:56
Abstract Regular menstrual‐shedding and repair of the endometrial functionalis is unique to humans and higher‐order primates. The current consensus postulates endometrial glands to have a single‐tubular architecture, where multi‐potential stem cells reside in the blind‐ending glandular‐bases. Utilising fixed samples from patients, we have studied the three‐dimensional micro‐architecture of the human endometrium. We demonstrate that some non‐branching, single, vertical functionalis glands originate...
Mon Jun 01, 2020 22:56
Abstract Advances in tissue clearing and microscopy make it possible to study human diseases in 3‐dimensions (3‐D). High‐grade tumor budding (TB) is known to be associated with poor prognosis in various cancers; however, little is known about the 3‐D architecture of TB. Using tissue clearing, we analyzed the 3‐D structure of TB and E‐cadherin expression in 31 extrahepatic cholangiocarcinomas. A total of 31 thick slabs (up to 5 mm) were harvested from surgically resected tumor tissue, including 27...
Mon Jun 01, 2020 22:48
Abstract The diurnal nature of restless legs syndrome (RLS) and its response to dopamine hint that hormones are central in RLS pathophysiology. Hypothyroidism has been linked to RLS, but studies are limited. This study's objective is to determine whether RLS is more prevalent in persons with hypothyroidism and whether hypothyroidism is more prevalent in RLS sufferers. Persons with hypothyroidism and controls were recruited through an on‐line registry of potential research participants. RLS was assessed...
Mon Jun 01, 2020 17:39
Abstract Background This study was performed to examine the association between adulthood recreational physical inactivity (PIA) and mortality among patients with cancers of the head and neck. Methods Patients with head and neck cancer at Roswell Park between years 1990 to 1998 were included (N = 305). Multivariable Cox proportional hazard ratios (HR) with corresponding 95% confidence intervals (CI) were used to analyze the association between PIA and risk of dying. Results There...
Mon Jun 01, 2020 12:47
Abstract Background Patients with head and neck cancer who are receiving radiotherapy can develop aspiration pneumonia. Determination of the incidence of aspiration pneumonia and the associated risk factors could facilitate the identification of high‐risk patients. Methods In this retrospective study, we determined the incidence of aspiration pneumonia in 357 patients receiving radiotherapy along with oral care for head and neck cancer. We also performed univariate and multivariable logistic...
Mon Jun 01, 2020 12:19
Abstract Background In light of the COVID‐19 pandemic, there has been a rapid increase in telemedicine visits. Otolaryngology patient satisfaction with these visits has not yet been extensively studied using a validated survey. Methods All patients who had telemedicine visits with three head and neck surgeons, by phone or video‐based platform, between March 25, 2020 and April 24, 2020. Retrospective chart reviews were conducted to determine demographic, disease, and treatment information....
Mon Jun 01, 2020 11:39
Abstract Background Recent historical management of oropharyngeal squamous cell carcinoma typically includes radiotherapy with/without chemotherapy. Novel surgical techniques such as robotic surgery have made primary surgery more frequent; however, postoperative radiotherapy may be recommended. We aimed to assess adherence to guidelines for postoperative therapy following robotic surgery. Methods Using the National Cancer Database, we analyzed the frequency of radiotherapy following robotic...
Mon Jun 01, 2020 11:30
Abstract Background Approximately one quarter of head and neck cancer (HNC) patients smoke cigarettes at the time of diagnosis. Despite HNC guideline recommendations to treat tobacco dependence, the effectiveness of treatment in this population is poorly described. Methods This retrospective cohort review evaluated 117 current smokers with p16‐negative mucosal head and neck squamous cell carcinoma prospectively enrolled in a tobacco treatment program. Seven‐day point prevalence tobacco...
Mon Jun 01, 2020 11:28
Abstract Introduction For the EARs NOSE AND THROAT (ENT) surgeon, there are many challenges that show‐up in the clinical management of a patient affected by a head and neck cancer during COVID‐19 pandemic, especially in the postoperative period. Methods During the acute COVID‐19 emergency phase in Italy, we analyzed the management of a patient affected by a head and neck cancer. We reported several clinical data about the hospitalization period, pointing out the difficulties encountered...
Mon Jun 01, 2020 11:27
Abstract In the setting of the coronavirus disease 2019 pandemic, the concept of the disease curve has become ubiquitous in medicine and across society. Nevertheless, even among medical specialists, there are common misconception about the curve and how it affects population outcomes. This article provides a simple review of the various population dynamics at play. Principles such as the area under the curve and the threshold of capacity are discussed and simply conceptualized. Understanding the...
Mon Jun 01, 2020 11:26
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
No abstract available
Fri May 29, 2020 03:00
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 01, 2020 11:13
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 01, 2020 07:15
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 01, 2020 07:15
Background and Objectives: Identification of the pathogenic mutations underlying hereditary hearing loss (HL) is difficult, since causative mutations in 60 different genes have so far been reported. Methods: A comprehensive clinical and pedigree examination was performed on a multiplex family suffering from HL. Direct sequencing of GJB2 and genetic linkage analysis of 5 other most common recessive nonsyndromic HL (ARNSHL) genes were accomplished. Next-generation sequencing (NGS) was utilized to reveal...
Tue Jun 02, 2020 08:56
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου