Publication date: Available online 25 June 2020Source: American Journal of OtolaryngologyAuthor(s): Daniel E. Bestourous, Luke J. Pasick, Daniel A. Benito, Philip E. Zapanta
Fri Jun 26, 2020 21:03
Publication date: Available online 24 June 2020Source: American Journal of OtolaryngologyAuthor(s): Alexis Saadoun
Thu Jun 25, 2020 19:03
Publication date: Available online 24 June 2020Source: American Journal of OtolaryngologyAuthor(s): Daniel P. Russo, Tristan Tham, Yonatan Bardash, Dennis Kraus
Thu Jun 25, 2020 19:03
We describe a case of an 81-year-old male presenting with bitemporal visual field defects and blurry vision in the right eye. The patient was found to have a recurrent primary paraganglioma in the sellar and suprasellar region requiring a repeat transsphenoidal endoscopic resection. Immunohistochemical examination confirmed paraganglioma with the classic zellballen appearance which stained positive for chromogranin, synaptophysin, and S-100 in the periphery. Paragangliomas (PGLs) in the sella turcica...
Sat Jun 27, 2020 16:35
AbstractStudies have suggested that communication between taste cells shapes the gustatory signal before transmission to the brain. To further explore the possibility of intragemmal signal modulation, we adopted an optogenetic approach to stimulate sour-sensitive (Type III) taste cells using mice expressing Cre recombinase under a specific Type III cell promoter, Pkd2l1 (Polycystic kidney Disease-2-Like 1), crossed with mice expressing Cre-dependent Channelrhodopsin (ChR2). The application of blue...
Thu Jun 25, 2020 03:00
The cover image is based on the Correspondence: Our Experience* Using virtual reality in audiological training: Our experience in 22 otolaryngology residents by Charles Aussedat et al., https://doi.org/10.1111/coa.13554.
Sun Jun 21, 2020 19:11
Conditions: Nasopharyngeal Carcinoma; Radiotherapy; ChemotherapyInterventions: Radiation: reduced dosage IMRT; Radiation: conventional dosage IMRTSponsors: Sun Yat-sen University; National Cancer Centre, Singapore; Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Zhongshan People's Hospital, Guangdong, China; Yuebei People's Hospital; Wuzhou Red Cross HospitalRecruiting
Fri Jun 26, 2020 16:49
Condition: Nasopharyngeal CarcinomaInterventions: Drug: Toripalimab, Endostar Combined With Radiotherapy and Chemotherapy; Drug: IC＋CCRTSponsors: First Affiliated Hospital of Guangxi Medical University; Shandong Cancer Hospital and Institute; Wuhan Union Hospital, China; The Affiliated Hospital Of Guizhou Medical University; Xiangya Hospital of Central South University; Jiangxi Provincial Cancer Hospital; Zhejiang Cancer Hospital; Fourth Affiliated Hospital of Guangxi Medical...
Thu Jun 25, 2020 16:52
Condition: Nasopharyngeal CarcinomaInterventions: Drug: Durvalumab; Drug: Cisplatin; Drug: GemcitabineSponsor: The University of Hong KongRecruiting
Thu Jun 25, 2020 16:52
Condition: Nasopharyngeal NeoplasmsInterventions: Drug: Toripalimab; Drug: Albumin-bound Paclitaxel; Drug: Cisplatin; Radiation: intensity-modulated radiotherapySponsor: First People's Hospital of FoshanNot yet recruiting
Thu Jun 25, 2020 16:52
Condition: Differentiated Thyroid CancerInterventions: Drug: Recombinant Human Thyroid Stimulating Hormone for Injection(rhTSH); Other: radioactive iodineSponsor: Suzhou Zelgen Biopharmaceuticals Co.,LtdNot yet recruiting
Thu Jun 25, 2020 16:52
Abstract Background Systemic sclerosis is an autoimmune skin disease which is associated with inflammation and resulting skin fibrosis. Myofibroblasts are the key cell type associated with the fibrosis but how they are differentiated is not clear. DKK‐1 is a Wnt antagonist that blocks Wnt‐mediated fibrosis and is reduced in fibrotic conditions. Thus DKK‐1 is a clear negative regulator of fibrosis in systemic sclerosis and its regulation is unknown.The aim of this work is to determine the levels...
Sat Jun 27, 2020 12:20
Abstract Ultraviolet A1 (UVA1)‐phototherapy (spectral range 340‐400 nm) is a well‐established treatment option for various skin diseases such as localized scleroderma. Recent improvements ofconventional UVA1‐light sources (metal‐halide or fluorescent lamps) have brought attention to a new Light Emitting Diodes (LED)‐technology with remarkable advantages in handling and clinical routine. This study providesa preclinical histological and molecular evaluation of an LED‐basedUVA1‐prototype with a narrower...
Sat Jun 27, 2020 11:45
Abstract Reactive oxygen species (ROS) have already been demonstrated to impede the migratory ability in non‐melanocytic cell lines by depleting mitochondrial ATP production. Therefore, understanding the mitochondrial metabolic response to migration in the presence of ROS should be a key to understanding repigmentation in vitiligo. This study aimed to investigate the energy mechanism associated with the ROS‐mediated attenuation of melanocyte migration. After melanocytes were pretreated with H2O2,...
Wed Jun 24, 2020 12:06
Abstract Background Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall...
Sat Jun 27, 2020 22:03
Abstract Backgound The objective of this study is to assess a new parameter, the weighted lymph node ratio (WLNR), which incorporates prognostic information regarding the number of metastatic nodes with extracapsular spread and the lymph node yield for pN0 patients to the lymph node ratio. Methods We studied retrospectively 1118 patients with head and neck squamous cell carcinoma (HNSCC) treated with a neck dissection. Results We obtained a classification with four categories based...
Fri Jun 26, 2020 12:10
Abstract Introduction The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) virus has altered the health care environment for the management of head and neck cancers. The purpose of these guidelines is to provide direction during the pandemic for rational Head and Neck Cancer management in order to achieve a medically and ethically appropriate balance of risks and benefits. Methods Creation of consensus document. Results The process yielded...
Thu Jun 25, 2020 17:30
Abstract Background The present study evaluated the 2‐year survival of the Asian population in the CheckMate 141 trial. Methods The CheckMate 141 trial included patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). In the present study, 34 Asian patients (nivolumab group: 23 patients; investigator's choice of therapy [IC] group: 11 patients) were analyzed. Results The median overall survival (OS) was 12.1 and 6.2 months for the nivolumab...
Wed Jun 24, 2020 20:21
Abstract Background Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC). Methods Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY. Results Mean LNY was 28.59 (SD...
Wed Jun 24, 2020 12:12
Abstract Polymorphous adenocarcinoma (PAC) is the second most common malignant salivary gland tumour of minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues and organs. The literature demonstrates a link between KLKs and salivary gland neoplasms. The purpose of this study was to determine levels of KLK mRNA in tissue samples of PAC and to determine if KLK expression is limited to tumour cells. Nineteen...
Fri Jun 26, 2020 03:00
Abstract T-cell lymphomas are infrequently encountered in the head and neck area, with the most common subtype being Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT). ENKTL-NT shows a predilection for midline facial structures presenting with ulcerative destructive lesions, whereas palatal involvement is one of the most prominent signs from the oral cavity. Herein, we describe a case of a 76-year-old Greek man with nasal obstruction and an extensive painful necrotic ulcer with...
Thu Jun 25, 2020 03:00
Related Articles The effect of superior canal dehiscence size and location on audiometric measurements, vestibular-evoked myogenic potentials and video-head impulse testing. Eur Arch Otorhinolaryngol. 2020 Jun 26;: Authors: Castellucci A, Piras G, Del Vecchio V, Crocetta FM, Maiolo V, Ferri GG, Ghidini A, Brandolini C Abstract PURPOSE: To correlate objective measures of audio-vestibular function with superior canal dehiscence (SCD) size and...
Sun Jun 28, 2020 15:21
Related Articles Cricotracheal separation: do not get fooled by what you see. Eur Arch Otorhinolaryngol. 2020 Jun 26;: Authors: Elbadan HE, Donia MM, Mina A Abstract INTRODUCTION: Laryngeal involvement in neck trauma is quite considerable. The presence of a cricotracheal separation type of injury can be easily missed and overlooked, especially if the neck does not show any external signs. Blunt trauma to the neck affects many anatomical structures...
Sun Jun 28, 2020 15:21
Related Articles Safety and effectiveness in explantation and re-implantation of hypoglossal nerve stimulation devices. Eur Arch Otorhinolaryngol. 2020 Jun 26;: Authors: Arens P, Penzel T, Fietze I, Blau A, Weller B, Olze H, Dommerich S Abstract PURPOSE: Since 2001, hypoglossal nerve stimulators have been implanted in patients with obstructive sleep apnea around the world, initially in trial situations but more recently also in regular care...
Sun Jun 28, 2020 15:21
Related Articles Training model for salvage procedures in endoscopic stapes surgery. Eur Arch Otorhinolaryngol. 2020 Jun 26;: Authors: Fernandez IJ, Bonali M, Yacoub A, Ghirelli M, Fermi M, Presutti L, Caversaccio M, Anschuetz L Abstract PURPOSE: The learning curve in endoscopic stapes surgery, is flat and long. There is limited space during training for advanced and salvage procedures, which could be necessary in unexpected intraoperative scenarios....
Sun Jun 28, 2020 15:21
Related Articles The effect of surgical menopause after bilateral oophorectomy on hormonal changes, mucociliary clearance, and quality of life. Eur Arch Otorhinolaryngol. 2020 Jun 26;: Authors: Gumussoy S, Gumussoy M, Hortu I, Ergenoglu AM Abstract PURPOSE: The removal of the ovaries for any reason causes surgical menopause. Hormonal changes that occur progressively over 5-10 years in natural menopause occur acutely in surgical menopause. Signs...
Sun Jun 28, 2020 15:21
Related Articles Benefits in noise from sound processor upgrade in thirty-three cochlear implant users for more than 20 years. Eur Arch Otorhinolaryngol. 2020 Jun 25;: Authors: Mosnier I, Sterkers O, Nguyen Y, Lahlou G Abstract PURPOSE: Some oldest patients rehabilitated with a cochlear implant more than 20 years ago could still be upgraded with new generations of speech processor (SP). The aim of this study was to show the benefit of a recent...
Sat Jun 27, 2020 15:37
Related Articles Fluoroscopy guided electrode-array insertion for cochlear implantation with straight electrode-arrays: a valuable tool in most cases. Eur Arch Otorhinolaryngol. 2020 Jun 25;: Authors: Perazzini C, Puechmaille M, Saroul N, Plainfossé O, Montrieul L, Bécaud J, Gilain L, Chabrot P, Boyer L, Mom T Abstract PURPOSE: To highlight the advantages of real time fluoroscopy guided electrode-array (EA) insertion (FGI) during cochlear implants...
Sat Jun 27, 2020 15:37
Related Articles Auditory performance of post-lingually deafened adult cochlear implant recipients using electrode deactivation based on postoperative cone beam CT images. Eur Arch Otorhinolaryngol. 2020 Jun 25;: Authors: Danieli F, Dermacy T, do Amaral MSA, Reis ACMB, Gnansia D, Hyppolito MA Abstract PURPOSE: The use of image processing techniques to estimate the position of intra-cochlear electrodes has enabled the creation of personalized...
Sat Jun 27, 2020 15:37
Related Articles Sialendoscopy-assisted transoral approach for parotid gland lithiasis. Eur Arch Otorhinolaryngol. 2020 Jun 25;: Authors: Saga-Gutierrez C, Chiesa-Estomba CM, Larruscain E, González-García JÁ, Sistiaga JA, Altuna X Abstract INTRODUCTION: Although lithiasis represents more than 60% of all cases of salivary gland obstruction, only 20% occurs in the Stensen´s duct. Nonetheless, the potential complications related to parotid gland...
Sat Jun 27, 2020 15:37
Related Articles Correction to: Constant severe imbalance following traumatic otoconial loss: a new explanation of residual dizziness. Eur Arch Otorhinolaryngol. 2020 Jun 25;: Authors: Hegemann SCA, Weisstanner C, Ernst A, Basta D, Bockisch CJ Abstract The original article was updated. PMID: 32583184 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 16:06
Related Articles Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients. Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Calvo-Henriquez C, Maldonado-Alvarado B, Chiesa-Estomba C, Rivero-Fernández I, Sanz-Rodriguez M, Villarreal IM, Rodriguez-Iglesias M, Mariño-Sánchez F, Rivero-de-Aguilar A, Lechien JR, Martínez-Capoccioni G, Saussez S, Capasso R, Karkos PD, Schriever V, Martin-Martin C, Alobid I, Santamaría-Gadea...
Fri Jun 26, 2020 16:06
Related Articles Fascio-cutaneous-free flaps as primary reconstruction in salvage total laryngectomy. Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Piazza C, Paderno A, Del Bon F, Grammatica A, Montalto N, Bresciani L, Giannini L, Incandela F, Fontanella W, Nicolai P Abstract INTRODUCTION: Salvage total laryngectomy (STL) is the most common treatment for recurrent laryngeal cancer after (chemo)-radiotherapy [(C)RT]. In this scenario, a higher...
Fri Jun 26, 2020 16:06
Related Articles Endolymphatic hydrops mimicking obstructive Eustachian tube dysfunction: preliminary experience and literature review. Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Bächinger D, Eckhard AH, Röösli C, Veraguth D, Huber A, Dalbert A Abstract PURPOSE: Aural fullness is a common symptom of middle ear diseases, most importantly Eustachian tube dysfunction (ETD). Yet, aural fullness may also be caused by inner ear disorders, such...
Fri Jun 26, 2020 16:06
Related Articles Outcome of surgery for chronic suppurative otitis media with resistant Pseudomonas aeruginosa. Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Cavel O, Ungar OJ, Oron Y, Ben Ami R, Dekel M, Handzel O Abstract OBJECTIVE: To assess the effectiveness of surgical treatment of active chronic suppurative otitis media (CSOM) with ciprofloxacin-resistant Pseudomonas aeruginosa (P. aeruginosa) that failed comprehensive local and systemic...
Fri Jun 26, 2020 16:06
Related Articles Author's reply to "Letter to the editor: Surgical resection of oral cancer: en-bloc versus discontinuous approach". Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Tirelli G, Marcuzzo AV, Giudici F, Tofanelli M PMID: 32583179 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 16:06
Related Articles Response to the Letter to the Editor: "Histological type homogeneity-a cornerstone in analyzing temporal bone malignancies data". Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Correia-Rodrigues P, Ramalho S, Montalvão P, Magalhães M PMID: 32583178 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 16:06
Related Articles Retrospective study on the potential of albumin/globulin ratio as a prognostic biomarker for oral cavity cancer patients. Eur Arch Otorhinolaryngol. 2020 Jun 24;: Authors: Wang YT, Fang KH, Hsu CM, Chang GH, Lai CH, Lee YC, Tsai MS, Huang EI, Tsai YT Abstract PURPOSE: Although the serum albumin/globulin ratio (AGR) is recognized as a valuable prognostic biomarker in various cancers, its clinical value in oral cavity squamous...
Fri Jun 26, 2020 16:06
Related Articles Otolaryngology in the COVID-19 pandemic era: the impact on our clinical practice. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Anagiotos A, Petrikkos G Abstract PURPOSE: To give an overview of the current knowledge about COVID-19 pandemic and its impact on otolaryngology clinical practice. METHODS: Recent findings about SARS-CoV-2 virus and the COVID-19 infection it causes are reviewed. In addition to international...
Thu Jun 25, 2020 16:36
Related Articles Gustatory dysfunctions in COVID-19. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Lechien JR, Hsieh JW, Ayad T, Fakhry N, Hans S, Chiesa-Estomba CM, Saussez S PMID: 32577904 [PubMed - as supplied by publisher]
Thu Jun 25, 2020 16:36
Related Articles Further arguments against both the first description of cholesteatoma by Hippocrates, and the allusion to the tympanic membrane in the Ebers Papyrus. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Mudry A PMID: 32577903 [PubMed - as supplied by publisher]
Thu Jun 25, 2020 16:36
Related Articles Olfactory and gustatory abnormalities in COVID-19 cases. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Altin F, Cingi C, Uzun T, Bal C Abstract PURPOSE: At the time of writing, there is a pandemic affecting virtually every country on Earth. There is considerable discussion amongst clinicians as well as lay people about anosmia and ageusia in COVID-19 sufferers. We aimed to report the results from comprehensive olfactory...
Thu Jun 25, 2020 16:36
Related Articles Isolated olfactory cleft involvement in SARS-CoV-2 infection: prevalence and clinical correlates. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Spoldi C, Castellani L, Pipolo C, Maccari A, Lozza P, Scotti A, Pisani A, De Donato G, Portaleone S, Cariati M, Felisati G, Saibene AM Abstract PURPOSE: Smell alterations are a symptom of COVID-19 and have been associated with olfactory cleft mucosal thickening (OCMT). Although their...
Thu Jun 25, 2020 16:36
Related Articles Evaluation of percutaneous dilatational tracheostomy under laryngosuspension. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Moulin M, Aboussouan MP, Castellanos PF, Atallah I Abstract PURPOSE: To describe the technique and outcomes of percutaneous tracheostomy under laryngosuspension. METHODS: A consecutive series of patients who underwent percutaneous tracheostomy under laryngosuspension were reviewed for outcomes....
Thu Jun 25, 2020 16:36
Related Articles An analysis of the histomorphometric and clinical significance of mucosal biofilm in tonsil tissue of the children with a history of recurrent/chronic tonsillitis in both the mother and father. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Bulut F, Cumbul A, Safak AS Abstract PURPOSE: The aim of this study is to analyse the histomorphometric and clinical features of the mucosal biofilm in tonsil tissue of children with a...
Thu Jun 25, 2020 16:36
Related Articles In reply to the letter to the editor regarding "Micro-metastasis and Isolated tumour cells: The span between Elective Neck Dissection versus Neck Observation in Early oral cancer". Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Ahmed ANA PMID: 32577898 [PubMed - as supplied by publisher]
Thu Jun 25, 2020 16:36
The nasal tent: an adjuvant for performing endoscopic endonasal surgery in the Covid era and beyond.
Related Articles The nasal tent: an adjuvant for performing endoscopic endonasal surgery in the Covid era and beyond. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Maharaj SH Abstract PURPOSE: To propose a cost-effective reproducible barrier method to safely perform endoscopic endonasal surgery during the Covid-19 pandemic. METHODS: This manuscript highlights the use of a clear, cost-effective disposable plastic sheet that is draped...
Thu Jun 25, 2020 16:36
Related Articles Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin. Eur Arch Otorhinolaryngol. 2020 Jun 23;: Authors: Custódio M, Sedassari BT, Altemani A, Rodrigues MFSD, Nunes FD, de Sousa SCOM Abstract PURPOSE: To investigate the expression of upstream and downstream targets of mTOR signalling pathway in the secretory carcinoma of salivary gland origin (SCsg). ...
Thu Jun 25, 2020 16:36
This cross-sectional study characterizes the prevalence of age-related hearing loss in people 80 years and older using data from the National Health and Nutrition Examination Survey.
Thu Jun 25, 2020 03:00
This systematic review assesses whether hearing loss occurs after any disruption of the inner ear for surgical treatment of Meniere disease and removal of cholesteatoma or vestibular schwannoma.
Thu Jun 25, 2020 03:00
This Viewpoint highlights the potential role of exercise prehabilitation in patients scheduled to undergo major surgery for head and neck cancer.
Thu Jun 25, 2020 03:00
This Patient Page describes the particular risks the coronavirus disease 2019 pandemic presents for patients with a laryngectomy and how best to mitigate risk.
Thu Jun 25, 2020 03:00
A 57-year-old African American man presents with an occasionally pruritic, brown pigmented lesion on the hard palate that histologically demonstrates soft tissue covered by benign-appearing stratified squamous epithelium. What is your diagnosis?
Thu Jun 25, 2020 03:00
A 45-year-old male professional voice user presents with dysphonia, throat tightness, and voice roughness; laryngoscopy revelated a firm lesion in the left paraglottic space extending to the lateral aspect of the true vocal fold. What is your diagnosis?
Thu Jun 25, 2020 03:00
Neurofibromatosis type 2 (NF2) is a rare genetic disease involving multiple tumors of the central and peripheral nervous systems. Most patients with NF2 have bilateral vestibular schwannomas; nonvestibular sch...
Fri Jun 26, 2020 03:00
The purpose of this study is to determine if removal of ethmoid cell septations as commonly performed in endoscopic sinus surgery leads to a change in orbital wall fracture patterns and the force required to c...
Fri Jun 26, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Thu Jun 25, 2020 03:00
LaryngorhinootologieDOI: 10.1055/a-1197-6978 Hintergrund Die Ösophagoskopie als Teil der Panendoskopie ist ein wichtiger Bestandteil der Diagnostik und Nachsorge von Patienten mit Kopf-Hals-Plattenepithelkarzinomen (HNSCC). Zweitkarzinome haben gravierenden Einfluss auf die Therapie der Primärerkrankung. Diese Arbeit soll prüfen, ob die routinemäßige Ösophagoskopie gerechtfertigt ist oder ob prädiktive Faktoren eine Selektion von Patienten mit erhöhtem Risikoprofil erlauben. ...
Fri Jun 26, 2020 02:00
Laryngorhinootologie 2020; 99: 464-472DOI: 10.1055/a-1175-1587 Einleitung Eine erhöhte psychosoziale Arbeitsbelastung kann negativen Einfluss auf die Gesundheit haben. Ein probates Mittel zur Erfassung ist das Gratifikationskrisenmodell. Eine Einordung dieser Betrachtung für HNO-Ärzte in Weiterbildung in Deutschland liegt bislang nicht vor, sodass eine erste Umfrage zur aktuellen Weiterbildungssituation durchgeführt wurde. Material und Methoden Die Online-Umfrage beinhaltete...
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 496-498DOI: 10.1055/a-1123-3735© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 443-444DOI: 10.1055/a-1167-0281© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 483-493DOI: 10.1055/a-1026-2845Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal mucosa, lasting for more than 12 weeks. By now approximately 15 % of the European and American population are affected, which indicates that CRS is a serious health problem. Beside other subgroups the most important classification is CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). Standard-of-care therapies include nasal saline solution as well...
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 444-446DOI: 10.1055/a-1155-1137© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 450-452DOI: 10.1055/a-1157-9398Die medikamentös induzierte Schlafendoskopie (MISE) stellt ein Verfahren zur Beurteilung der oberen Atemwege unter Sedierung bei Patienten mit obstruktiver Schlafapnoe (OSA) dar und wurde erstmalig bereits im Jahr 1991 von Croft und Pringle beschrieben 1. Ungeklärt ist bisher, inwiefern die MISE mit dem natürlichen Schlaf vergleichbar ist. Eastwood und Kollegen beschrieben letztendlich eine Korrelation hinsichtlich der Kollapsneigung in...
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 446-447DOI: 10.1055/a-1168-1440© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 440-441DOI: 10.1055/a-1123-3559© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 448-449DOI: 10.1055/a-1123-3680© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 494-495DOI: 10.1055/a-1123-3724© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
Laryngorhinootologie 2020; 99: 480-482DOI: 10.1055/a-1123-3702© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 25, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1190-4445 Hintergrund Metamizol war 2018 das am zweithäufigsten verordnete Medikament in Deutschland trotz des bekannten Risikos einer Agranulozytose und der strengen Indikationsstellung. 25 % der Verordnungen sind laut Stammschulte et al. Off-Label-Use. Obwohl eine Blutbildkontrolle in der Fachinformation ausdrücklich empfohlen wird, findet diese seitens der Mehrheit der Metamizol-verschreibenden Ärzte nicht routinemäßig statt. Material und...
Thu Jun 25, 2020 02:00
Immune-related adverse events (irAEs) are a frequent complication of immunotherapy, but neurological irAEs are rare and varied. Here, we present a case of cerebral amyloid angiopathy-related inflammation (CAA-ri) attributable to nivolumab monotherapy, which has not been previously reported. The context of immunotherapy and availability of serial imaging also provide unique insights into the pathogenesis and evolution of CAA-ri. Routine surveillance neuroimaging in a patient with metastatic melanoma,...
Tue Jun 23, 2020 03:00
In the setting of metastatic uveal melanoma (mUM), prognosis is dismal and treatment options are limited. MEK inhibition using selumetinib has led to promising results with improved progression-free survival. While immune checkpoint inhibitors such as programmed cell death-1 (PD-1) blockade therapy (anti-PD-1) has shown discrete efficacy in mUM, combining MEK inhibitors (MEKi) to anti-PD-1 might be an option as such combinations have shown synergistic efficacy in metastatic cutaneous melanoma. We...
Tue Jun 23, 2020 03:00
The incidence of melanoma has increased more dramatically than any other malignancy in the last years. In this study, we compared the numbers of publications between melanoma and other cancers over the last 20 years, and we aimed to understand the relationship between publications on melanoma and other cancers using publication rates and frequencies. We conducted a systematic search through PubMed using search terms ‘melanoma’ and ‘cancer’ to identify the numbers of publications on melanoma and other...
Tue Jun 23, 2020 03:00
Desmoplastic melanoma (DM) is a rare and histopathologically as well as prognostically distinct subset of melanoma that arises in chronically sun-damaged skin. DM is typically and relatively indolent in nature with most cases not progressing to metastatic disease. DM has been managed with both radiation and surgical approaches. Medical options for the treatment of metastatic DM have traditionally been limited. Recent advances in immunotherapies have shown promising responses in DM ushering in a new...
Tue Jun 23, 2020 03:00
Introduction: Tinnitus is prevalent in 66–88% of cochlear implant users. The reason for this high prevalence is that hearing impairment is the most common cause of tinnitus. Objective: This study aims to determine the effect of cochlear implant and to compare the severity of tinnitus and depression in adult cochlear implant users with tinnitus. Methods: Patients diagnosed with tinnitus filled out the Tinnitus Handicap Inventory and the Beck Depression Inventory during CI candidate evaluation. The...
Fri Jun 26, 2020 15:02
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
Sat Jun 27, 2020 04:01
In 2018, the Joint Councils of the American Otological Society and the American Neurotology Society adopted a statement on diversity and inclusion for programs henceforth. That statement stands as a landmark touch point in our societies that heralds the engagement of all our members as we all work to advance knowledge and skills in otology and neurotology. I was asked to write this piece for Otology & Neurotology, and re-publication in this Clinics series establishes a baseline understanding...
Sat Jun 27, 2020 04:01
Pain Management for the Otolaryngologist
Sat Jun 27, 2020 04:01
Abstract Glossopharyngeal Neuralgia is often difficult to diagnose in view of its symptoms that overlap with many other regional causes. This subset of patients commonly visits otolaryngologists, dentists, oncologists only to be referred to the other and finally to the psychiatrist when the diagnosis is overlooked. We hereby present a prospective observation study of 26 cases of Glossopharyngeal neuralgia. In our observation we found a prevalence of 0.2% for glossopharyngeal neuralgia...
Sun Jun 28, 2020 03:00
Abstract COVID-19 infection has spread widely over past 5 months to become a pandemic of global proportions affecting almost every country. While HCPs are expected to tackle this crisis by working in hospital and intensive care setting, there is real risk of them contracting infection and even dying. This article aims to report cases of healthcare personnel (HCPs) contracting COVID19 in various settings in a tertiary care hospital, a designated COVID centre, with view to disseminate...
Sat Jun 27, 2020 03:00
Abstract Ossicular discontinuity is the most common cause of conductive hearing loss. The use of ossicular graft material in ossicular chain reconstruction significantly improves the result in hearing. This study was conducted to compare and analyze the outcome of ossicular reconstruction using allogenic septal spur cartilage and autologous cortical bone in terms of hearing results and graft uptake rates. Study design: randomized clinical trial. Study included 112 patients visiting...
Sat Jun 27, 2020 03:00
Abstract To compare the efficacies and post operative outcomes of patients with nasal packing with merocel, intranasal splints and merocel along with intra-nasal infant feeding tubes following septo-turbinoplasty, in patients with nasal obstruction secondary to septal deviation and inferior turbinate hypertrophy. A prospective study was done in 60 patients of symptomatic deviated nasal septum with inferior turbinate hypertrophy. Septoturbinoplasty was performed. Patients’ nasal...
Sat Jun 27, 2020 03:00
Abstract Oral cavity is the most common site of cancer in India, tongue forms the most common single subsite. Neck node involvement plays an important prognostic role in disease-free survival and overall survival. Most of the nodal metastasis are occult and only an elective neck dissection can disclose the nodal metastasis, which is accepted only when the risk of metastasis exceeds 15–20%. Contralateral nodal metastasis(CLNM) are rarely analyzed due to sparse event.Retrospective...
Sat Jun 27, 2020 03:00
Abstract Rhinoplasty is a surgery where the result depends on precision in assessment, shaping and placing grafts. The grafts should be accurately measured with the help of precise measuring instruments. There is a need of instruments which allow precise slicing, measuring and re-sizing of the grafts. Other than depending on multiple instruments for slicing and measuring, we need a single instrument with multiple functions. We have developed a simple tool for measurements in Rhinoplasty...
Sat Jun 27, 2020 03:00
Hypothesis: The aim of this study is to investigate how a mastoidectomy surgery affects bone conduction (BC) sound transmission using a whole head finite element model. Background: Air conduction (AC) and BC hearing thresholds are normally used to evaluate the effect of an ear surgery. It is then assumed that the BC hearing thresholds are unaffected by the surgery. Moreover, BC hearing aids are used in cases of unilateral or conductive hearing loss in heads that have undergone a mastoidectomy...
Wed Jun 24, 2020 03:00
Objective: To investigate whether ultrasound is a reliable diagnostic tool to identify magnet dislocation in patients with cochlear implant. Design: Retrospective analysis. Setting: A tertiary referral medical center. Patients: Patients with cochlear implant who presented with the suspicion of magnet dislocation between January 1, 2009 and July 31, 2019. Interventions: Preinterventional ultrasound with subsequent surgical magnet repositioning. Main Outcome...
Wed Jun 24, 2020 03:00
No abstract available
Wed Jun 24, 2020 03:00
To celebrate the 250th anniversary of the birth of the great classical composer, Ludwig van Beethoven (1770–1827), we point out how his hearing loss affected him and how the primitive hearing aids at that time helped mitigate his hearing loss. From the age of 26, Beethoven began to suffer from a fluctuating, progressive hearing loss (“my hearing grew worse and worse”), This started in his left ear (“in my left ear, with which this illness of my ears had started”), where he had difficulty hearing...
Wed Jun 24, 2020 03:00
Objective: To examine the high frequency horizontal vestibular ocular-reflex (hVOR) during acute attacks of vertigo in Menière's disease (MD). Study Design: Retrospective case series and literature review. Setting: Tertiary academic medical center. Patients: Patients with clinical diagnosis of unilateral “definite MD.” Intervention: Review of medical records. Main Outcome Measures: Spontaneous nystagmus and the dynamic hVOR gain change at different...
Wed Jun 24, 2020 03:00
Publication date: Available online 28 June 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): J.-B. Morvan, D. Rivière, M. Danguy des Déserts, G. Bonfort, Q. Mathais, P. Pasquier
Sun Jun 28, 2020 13:56
Publication date: Available online 27 June 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L. Jan, P. Boute, F. Mouawad
Sat Jun 27, 2020 19:39
Publication date: Available online 27 June 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Turki Al-driweesh, Fatemah Altheyab, Mazyad Alenezi, Sultan Alanazy, Turki Aldrees
Sat Jun 27, 2020 16:40
Publication date: Available online 26 June 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Trombetta Andrea, Cossovel Francesca, Grasso Domenico Leonardo, Barbi Egidio
Sat Jun 27, 2020 16:40
Publication date: Available online 26 June 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Firas Alfwaress, Mahmoud Alomari
Sat Jun 27, 2020 16:40
Publication date: Available online 25 June 2020Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-facialeAuthor(s): J.-B. Morvan, D. Rivière, M. Danguy des Déserts, G. Bonfort, Q. Mathais, P. Pasquier
Fri Jun 26, 2020 20:56
Abstract In this paper, a new matrix‐based method is proposed to real‐time determine the guidewire position inside an arterial system. The guidewire path is obtained by the optimal path method, particularly, the fusiform ternary tree method according to the principle of minimum output value of root node. An adaptive sampling strategy, and an optimization strategy based on proximal end and distal end of the guidewire are proposed to change the guidewire position for obtaining an ideal guidewire path....
Fri Jun 26, 2020 19:14
Objectives/Hypothesis The male singing voice through puberty undergoes many changes that present challenges for the singer and choral director. The purpose of this study was to discuss the endoscopic findings seen in prepubescent choir singers. Study Design Single‐institution prospective study. Methods Subjects were recruited from the Cincinnati Boychoir and were described as Cooksey stage unchanged or mid‐voice I, as described by the Boychoir artistic director. Vocal history was obtained...
Fri Jun 26, 2020 20:58
Objective Mean corpuscular volume (MCV) has been shown in to be a reliable prognostic marker in other cancers; however, no evidence exists on its use in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the association between MCV, hemoglobin, platelet count and albumin concentration, and survival in stage III/IVA‐B HNSCC treated with concurrent chemoradiotherapy. Study Design: Retrospective cohort study. Methods In this multicenter retrospective study, we analyzed...
Fri Jun 26, 2020 20:34
Objectives Transoral surgery of the larynx with rigid instruments is not always possible. This may result in insufficient therapy or in an increased need for open surgery. For these patients, alternative surgical systems are needed. Here, we demonstrate a curved prototype for laryngeal surgery equipped with flexible instruments. Study Design Pre‐clinical user study in an ex vivo porcine laryngeal model. Methods The prototype was built from established medical devices, namely a hyperangulated...
Thu Jun 25, 2020 20:44
Objective The cellular diversity of the inner ear has presented a technical challenge in obtaining molecular insight into its development and function. The application of technological advancements in cell type–specific expression enable clinicians and researchers to leap forward from classic genetics to obtaining mechanistic understanding of congenital and acquired hearing loss. This understanding is essential for development of therapeutics to prevent and reverse diseases of the inner ear, including...
Wed Jun 24, 2020 22:00
Wed Jun 24, 2020 20:01
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