Abstract In modern society, intracranial aneurysms have seriously affected people’s life. To better study and treat intracranial aneurysm, animal models are ideal candidates to perform biological research and preclinical endovascular device testing. Rabbit aneurysm model is one of the most commonly used animal models, and the rabbit aneurysms share similarities in histology, morphology, and hemodynamic aspects with human intracranial aneurysms, which is an ideal model for intracranial...
Abstract Background Computational fluid dynamics (CFD) are important in evaluating the hemodynamics of intracranial aneurysm rupture, and the setting of inflow boundary conditions is critical. We evaluated intracranial aneurysm hemodynamics based on generalized versus patient-specific inflow boundary conditions to examine the effect of different hemodynamic results on the discrimination of intracranial aneurysm rupture status. ...
Mark above section as read
Oxidative stress and neuronal apoptosis are considered crucial therapeutic targets against early brain injury (EBI) after subarachnoid hemorrhage (SAH). Emerging evidence indicates that mitochondrial dysfunction is the main reason for oxidative stress and neuronal apoptosis. MitoNEET, an outer mitochondrial membrane protein, has been shown to regulate mitochondrial function. However, whether mitoNEET activation attenuates oxidative stress and neuronal apoptosis after SAH remains unknown. This study...
Hypoxia as a microenvironment is essential for the development of neural stem/progenitor cells (NSCs/NPCs). Our previous studies showed that mild hypoxia can promote proliferation of NPCs. However, the underlying mechanisms are remaining unknown. In the present study, we explored the impact of hypoxia on miR-210 secretion and its effect on cell viability. We found that short time or long time of hypoxia treatment could increase the expression of miR-210, but also promoted its secretion into the medium....
Mark above section as read
No abstract available
Background: Investigation of visual field defects (VFDs) is important to decide the treatment and to predict the prognosis in patients with a pituitary mass. The aim of this study was to evaluate the correlation among 2 diagnostic modalities—MRI and optical coherence tomography (OCT)—and VFDs. Methods: Consecutive patients who showed the presence of a pituitary mass on MRI and in whom ophthalmic examinations were performed were recruited. Height and volume of the mass, sagittal and...
Background: To describe a case of bilateral brain infarction associated with iatrogenic ophthalmic artery occlusion after cosmetic facial filler injection and to elucidate the pathogenic mechanism of bilateral brain infarction. Methods: Case report and review of the literature. Results: A case of unilateral blindness due to iatrogenic ophthalmic artery occlusion accompanied by bilateral brain infarction after cosmetic facial filler injection is described. Fluorescein angiographic...
Background: To evaluate the effect of fingolimod in visual function and neuroretinal structures in patients with multiple sclerosis (MS) for a period of 1 year. Methods: This longitudinal and observational cohort study included 78 eyes of 78 patients with MS treated with fingolimod. All subjects were evaluated every 3 months during 12 months and compared with 32 patients treated with interferon beta. All patients were examined for high-contrast and low-contrast (2.5% and 1.25%) visual...
Purpose: To determine whether the vestibular–ocular reflexes (VORs) can be affected by central nervous system injury in children with cortical visual impairment (CVI). Methods: Retrospective case series. Twenty consecutive children with CVI who presented to a pediatric ophthalmology practice over an 18-month period were included in the study. Horizontal and vertical VORs were assessed by a pediatric neuro-ophthalmologist using the standard doll's head maneuver. MRI studies were independently...
Abstract: The initiation and continuation of immune-based therapies to treat and prevent complications of inflammatory neuro-ophthalmologic disorders during the 2019 novel coronavirus (COVID-19) pandemic is the subject of considerable debate. In each case, a treatment decision must be reached based on best clinical practices for the disorder, patient comorbidities, the current state of knowledge about the pathogenesis and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
Abstract: A 39-year-old woman presented with acute visual loss in her right eye. Brain and orbit MRI demonstrated T2 hyperintensity along a long section of her right optic nerve, chiasm, and tract with no evidence of decussation of the inflammation. Subsequent seropositivity for the aquaporin 4 antibody confirmed a diagnosis of neuromyelitis optica. Posterior pathway involvement is typical in neuromyelitis optica and supports the hypothesis that the condition is an astrocytopathy. Furthermore,...
No abstract available
Background: During the last decade, our understanding of cerebrospinal fluid (CSF) physiology has dramatically improved, thanks to the discoveries of both the glymphatic system and lymphatic vessels lining the dura mater in human brains. Evidence Acquisition: We detail the recent basic science findings in the field of CSF physiology and connect them with our current understanding of the pathophysiology of idiopathic intracranial hypertension (IIH). Results: Transverse sinus...
Background: The tortuosity of the optic nerve can be quantified radiologically by measuring the angle of optic nerve deformation (the “optic nerve angle” [ONA]). In patients with idiopathic intracranial hypertension (IIH), lowering the intracranial pressure (ICP) to a normal range by lumbar puncture leads to straightening of the optic nerve and an increase in the measured sagittal ONA on MRI. It is uncertain whether there is any correlation between ONA and cerebrospinal fluid (CSF) opening pressure...
Background: We prospectively evaluated the sensitivity and specificity of ocular ultrasonography (OUS) to distinguish papilledema from pseudopapilledema. Methods: Forty-nine study participants, with optic disc elevation, underwent neuro-ophthalmic evaluation, OUS, fundus photography, and optical coherence tomography (OCT) of the optic nerve head at the initial and follow-up visits (≤6 months apart). Participants were classified as having papilledema if there was a change in optic nerve...
Background: Over the past decade, there has been a remarkable advancement in the understanding of autoimmune etiologies of encephalitis. The first identified generation of paraneoplastic encephalitis tends to occur in older populations, responds poorly to immunotherapy, and is mediated by T-cell damage with antibodies directed toward intracellular antigens. A new generation of autoimmune encephalitides has been described, which are mediated by antibodies to cell-surface proteins, tend to occur...
Background: The purpose of the study is to evaluate the agreement of the foveopapillary angle (FPA) on conventional fundus photography (c-FPA) with the FPA on scanning laser ophthalmoscopy (SLO) imaging (SLO-FPA) in patients with fourth nerve palsy and healthy controls (HCs). Methods: The FPA was measured in both eyes of 25 patients and 25 HCs in synedra View (c-FPA) and with the integrated algorithm of the Heidelberg Spectralis OCT (SLO-FPA). The primary endpoint was the agreement...
Background: A possible benefit of optical coherence tomography (OCT) in the approach to tumors involving the optic chiasm may be the ability to foresee visual deterioration. This study investigated the value of OCT in watchful waiting for compressive optic neuropathy as the primary management of suprasellar masses. Methods: The research was conducted as a 2-year observational study of a patient cohort with conservatively managed mass lesions involving the optic chiasm on MRI. Threshold...
Background: Peripapillary and macular microvasculature alterations after nonarteritic ischemic optic neuropathy (NAION) have been investigated in several studies. We aimed to explore the vascular changes from acute NAION (aNAION) to chronic NAION (cNAION). Methods: This prospective observational study composed of 16 eyes with aNAION and 40 healthy age-matched controls. Eyes with NAION were followed up for more than 6 months after acute event. Optical coherence tomography angiography...
No abstract available
Abstract: Inner nuclear layer (INL) microcysts have been reported in diseases affecting the optic nerve. The new ocular imaging techniques detect minimal structural alterations at the macula and correlate these findings to different etiologies with less invasive procedures. The relationship between ganglion cells distribution at the macula and chiasmal nerve fibers enables the diagnosis and location of neurological lesions by new generation optical coherence tomography (SD-OCT) imaging devices....
Background: Administrative health claims data have been used for research in neuro-ophthalmology, but the validity of International Classification of Diseases (ICD) codes for identifying neuro-ophthalmic conditions is unclear. Evidence Acquisition: We performed a systematic literature review to assess the validity of administrative claims data for identifying patients with neuro-ophthalmic disorders. Two reviewers independently reviewed all eligible full-length articles and used a standardized...
Abstract: A 78 year-old woman has experienced multiple episodes of transient right third nerve palsy over the course of 15 years and has undergone multiple imaging studies as well as investigations for myasthenia gravis and giant cell arteritis in search for the diagnosis. When seen after the most recent episode, MRI with contrast and Fast-Imaging Employing Steady-State Acquisition protocol revealed a subtle enlargement and enhancement of the cisternal and proximal cavernous portions of the...
Background: The visual, ocular motor and vestibular systems have intimate neural and close anatomical relationship that dictates their assessment in a patient with dizziness and vertigo. Results: Recognition of the pearls and pitfalls of a targeted clinical examination HINTS/HINTS “Plus” allows the clinician to probe at the bedside the most crucial hypothesis in a patient with acute isolated vestibular syndrome, “Is this a stroke?” Conclusion: By applying a methodical approach...
No abstract available
Background: Misclassification bias is introduced into medical claims–based research because of reliance on diagnostic coding rather than full medical record review. We sought to characterize this bias for idiopathic intracranial hypertension (IIH) and evaluate strategies to reduce it. Methods: A retrospective review of medical records was conducted using a clinical data warehouse containing medical records and administrative data from an academic medical center. Patients with 1 or more...
Background: Papilledema can be a manifestation of neurologic Lyme borreliosis (LB). The clinical manifestations and progression of these cases have not been comprehensively documented to date. We aimed to describe clinical and diagnostic features and to assess patient outcomes in cases of papilledema secondary to neurologic LB. Methods: We searched MEDLINE, EMBASE, and the Cochrane Database from inception to August 2019. We did not restrict our search by study design or by publication...
Mark above section as read
Related Articles Early obliteration of pediatric brain arteriovenous malformations after stereotactic radiosurgery: an international multicenter study. J Neurosurg Pediatr. 2020 Jun 26;:1-8 Authors: Burke RM, Chen CJ, Ding D, Buell TJ, Sokolowski JD, Lee CC, Kano H, Kearns KN, Tzeng SW, Yang HC, Huang PP, Kondziolka D, Ironside N, Mathieu D, Iorio-Morin C, Grills IS, Feliciano C, Barnett GH, Starke RM, Lunsford LD, Sheehan JP Abstract OBJECTIVE:...
Related Articles Multiple hippocampal transections for refractory pediatric mesial temporal lobe epilepsy: seizure and neuropsychological outcomes. J Neurosurg Pediatr. 2020 Jun 26;:1-10 Authors: Marashly A, Koop J, Loman M, Kim I, Maheshwari M, Lew SM Abstract OBJECTIVE: Temporal lobe epilepsy (TLE) is the most common focal epilepsy across adult and pediatric age groups. It is also the most amenable to surgery, with excellent long-term seizure...
Mark above section as read
Publication date: Available online 27 June 2020Source: Brain Research BulletinAuthor(s): Ying Hu, Xiaobing Li, Lijia Wang, Baosan Han, Shengdong Nie
Publication date: Available online 27 June 2020Source: Brain Research BulletinAuthor(s): Yun Cao, Bingjin Liu, Weiqi Xu, Lin Wang, Fangxiao Shi, Na Li, Ying Lei, Jianzhi Wang, Qing Tian, Xinwen Zhou
Publication date: Available online 26 June 2020Source: Brain Research BulletinAuthor(s): Michiko Nakamura, Il-Sung Jang, Toshitaka Yamaga, Naoki Kotani, Norio Akaike
Publication date: Available online 26 June 2020Source: Brain Research BulletinAuthor(s): Milorad Dragic, Milica Zeljkovic, Ivana Stevanovic, Tihomir Ilic, Nela Ilic, Nadezda Nedeljkovic, Milica Ninkovic
Publication date: Available online 25 June 2020Source: Brain Research BulletinAuthor(s): Suk-Yun Kang, Se Kyun Bang, O Sang Kwon, Su-Yeon Seo, Kwang-Ho Choi, Seong Jin Cho, Hwa Seung Yoo, Jin Sun Lee, Hyun-Woo Kim, Yeonhee Ryu
Publication date: September 2020Source: Brain Research Bulletin, Volume 162Author(s): Hong-Mei Niu, Deng-Lei Ma, Ming-Yang Wang, Xiao-Ping Chen, Li Zhang, Ya-Li Li, Lan Zhang, Lin Li
Publication date: Available online 24 June 2020Source: Brain Research BulletinAuthor(s): S.V. Demyanenko, V.A. Dzreyan, A.B. Uzdensky
Mark above section as read
Rationale: Histone deacetylase inhibitors (HDACi) may overcome endocrine resistance in estrogen receptor positive (ER+) metastatic breast cancer. We tested whether 18F-Fluoroestradiol (18F-FES)-PET imaging would elucidate pharmacodynamics of combination HDACi and endocrine therapy. Methods: Patients with ER+/HER2- metastatic breast cancer with prior clinical benefit from endocrine therapy but later progression on aromatase inhibitor (AI) therapy were given vorinostat (400mg daily) sequentially...
68Ga-FAPI-2/4/46 have already been proposed as promising PET-tracers. However, the short half-life of 68Ga (T1/2 68 min) creates problems with manufacture and delivery. 18F (T1/2 110 min) labeling would result in a more practical large scale production and a cold-kit formulation would improve the spontaneous availability. The NOTA-chelator ligand FAPI-74 can be labeled with both 18F-AlF (Aluminum-Fluoride) and 68Ga. Here we describe the in-vivo evaluation of 18F-FAPI-74 and a proof-of-mechanism of...
INTRODUCTION: Radioembolization is a treatment option for colorectal cancer (CRC) patients with inoperable, chemorefractory hepatic metastases. Personalized treatment requires established dose thresholds. Hence, the aim of this study was to explore the relation between dose and effect (i.e. response and toxicity) in CRC patients treated with holmium-166 (166Ho) radioembolization. MATERIALS AND METHODS: CRC patients treated in the HEPAR II and SIM studies were analyzed. Absorbed doses were estimated...
Mark above section as read
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Avital Perry, Lucas P. Carlstrom, Christopher S. Graffeo
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Daniel Munger, Brannan O'Neill, Ryan Priest
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Viraat Harsh, Preeti K. Gond, Anil Kumar
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Jian Yang, Chenglong Zhao, Tao Wang, Chengzhang Zhu, Jian-Ru Xiao
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Matthew B. Potts, Michael C. Hurley, Sameer A. Ansari, Ali Shaibani, Scott R. Geraghty, Thomas J. Grobelny, Babak S. Jahromi
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Takuma Sumi, Shunsuke Kawamoto, Shunsuke Fukaya, Keisuke Ueki, Phyo Kim
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Emine Karabuk, Pinar Kadirogullari, Talat Umut Kutlu Dilek, Enes Ozluk, Gulsah Ozturk
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Seby John, Syed Irteza Hussain, Mohammed Samy Elhammady, Ramon Navarro, Khalil Zahra
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Alice Goia, Elisabeth Garrido, Margaux Lefebvre, Olivier Langlois, Stéphane Derrey, Chrysanthi Papagiannaki, Vianney Gilard
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Pietro Trombatore, Emilio Lozupone, Simona Gaudino, Luca Milonia, Andrea Alexandre, Iacopo Valente, Francesco D'Argento, Paolo Frassanito, Alessandro Pedicelli
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Yoon-Hee Choo, Youngbeom Seo, Joonhyuk Choi
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Pankaj K. Singh, Mohit Agrawal, Shashwat Mishra, Deepak Agrawal, Dattaraja Sawarkar, Amandeep Jagdevan, Satish Verma, Ramesh Doddamani, Rajesh Meena, Kanwaljeet Garg, Poodipedi S. Chandra, Shashank S. Kale
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Anthony S. Larson, Stephen J. Haines, Webster H. Pilcher, Taylor E. Piva, Andrew W. Grande
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Aladine A. Elsamadicy, Andrew B. Koo, Wyatt B. David, Margot Sarkozy, Isaac G. Freedman, Benjamin C. Reeves, Maxwell Laurans, Luis Kolb, Daniel M. Sciubba
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Svetozar Matanov, Alexander Sirakov, Krasimir Minkin, Stanimir Sirakov
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Guiroy Alfredo, Gagliardi Martín, Cabrera Juan Pablo, Coombes Nicolás, Arruda André, Taboada Néstor, Asdrúbal Falavigna
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Matías Baldoncini, Amparo Saenz, Juan F. Villalonga, Alvaro Campero, Julio Fernandez, Federico Sánchez-Gonzalez, Paulo Kadri, Kumar Vasudevan, Ossama AlMefty
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Keiji Wada, Ryo Tamaki, Tomohisa Inoue, Kenji Hagiwara, Ken Okazaki
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Chiara Negwer, Patrick Hiepe, Bernhard Meyer, Sandro M. Krieg
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Sean N. Neifert, Michael L. Martini, Trevor Hardigan, Travis R. Ladner, R. Loch Macdonald, Eric Karl Oermann
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Robert G. Grossman, Jonathan Lee, David S. Baskin, Richard Harper, Gavin W. Britz
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Joshua Bakhsheshian, Ben A. Strickland, John C. Liu
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Han-Dong Lee, Chang-Hoon Jeon, Nam-Su Chung, Seungmin Chung, Hyung-Keun Song
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Laligam N. Sekhar, Gordana Juric-Sekhar, Zeeshan Qazi, Anoop Patel, Lynn B. McGrath, James Pridgeon, Niveditha Kalavakonda, Blake Hannaford
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Thibault Remacle, Stephane Mauviel, Henri-Jean Renwart, Keyvan Ghassempour, Frederic Belle, Olivier Lückers, Vincent Bex, Jean-Michel Remacle, Vincent Bonhomme
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Douglass Tucker, Marisa C. Penn, Andrew Brunswick, Vedang Uttarwar, Angad Gogia, Michael Marietta, Cheng Yu, John Carmichael, Eric Chang, Gabriel Zada
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): James Feghali, Yangyiran Xie, Yuxi Chen, Sean Li, Judy Huang
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Aaron A. Cohen-Gadol
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Ryan G. Chiu, Ravi S. Nunna, Neha Siddiqui, Syed I. Khalid, Mandana Behbahani, Ankit I. Mehta
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Régis Takoukam, Ulrick S. Kanmounye, Faith C. Robertson, Kathrin Zimmerman, Stéphane Nguembu, Jean W. Lartigue, Kee B. Park, Bello Figuim, Ignatius Esene
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Yuichi Nagata, Kazuhito Takeuchi, Taiki Yamamoto, Akihiro Mizuno, Toshihiko Wakabayashi
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Gang-Un Kim, Gun Woo Lee
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Abdelsimar T. Omar, Jeric L. Arbizo, Kimberly Mae C. Ong, Christine Mae G. Olivar, Jonathan P. Rivera, Charlotte M. Chiong, Arsenio Claro A. Cabungcal, Kathleen Joy O. Khu
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Tong Li, Bin Zhu, Xiaoguang Liu
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Toru Umehara, Manabu Kinoshita, Masaki Hayama, Takashi Shikina, Yasunori Fujimoto, Yohei Maeda, Hidenori Inohara, Haruhiko Kishima
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Jacob Chen Ming Low, David Rowland, Haider Kareem
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Douglas R. Taylor, Jaafar Basma, G. Morgan Jones, Jock Lillard, David Wallace, Sonia Ajmera, Andrew J. Gienapp, L. Madison Michael
Publication date: Available online 27 June 2020Source: World NeurosurgeryAuthor(s): Pious D. Patel, Katherine A. Kelly, Rebecca A. Reynolds, Robert W. Turer, Sanjana Salwi, S. Trent Rosenbloom, Christopher M. Bonfield, Robert P. Naftel
Publication date: Available online 26 June 2020Source: World NeurosurgeryAuthor(s): Joshua H. Weinberg, Ahmad Sweid, Daniel Joffe, Keenan Piper, Rawad Abbas, Zubin Hussain, Brigitte Anderson, Michael Reid Gooch, Nabeel Herial, Stavropoula Tjoumakaris, David Hasan, Hekmat Zarzour, Robert H. Rosenwasser, Pascal Jabbour
Publication date: Available online 26 June 2020Source: World NeurosurgeryAuthor(s): Lina Raffaella Barzaghi, Luigi Albano, Claudia Scudieri, Carmen Rosaria Gigliotti, Francesco Nadin, Antonella del Vecchio, Pietro Mortini
Publication date: Available online 26 June 2020Source: World NeurosurgeryAuthor(s): T. Garzon-Muvdi, R. Maxwell, A. Luksik, R. Kessler, J. Weingart, A. Olivi, C. Bettegowda, R. Tamargo, H. Brem, M. Lim
Publication date: Available online 26 June 2020Source: World NeurosurgeryAuthor(s): John Gerrard Hanrahan, Charlotte Burford, Gideon Adegboyega, Marios Nicolaides, Louis Boyce, Kendra Wong, Michail Sideris
Publication date: Available online 26 June 2020Source: World NeurosurgeryAuthor(s): Abdulaziz Oqalaa Almubarak, Fatima Fakhroo, Meshari Rashed Alhuthayl, Imad Kanaan, Homoud Aldahash
Publication date: Available online 28 May 2020Source: World NeurosurgeryAuthor(s): Baris Ozoner, Abuzer Gungor, Teyyup Hasanov, Zafer Orcun Toktas, Turker Kilic
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου