Related ArticlesBipolar androgen therapy in prostate cancer: Current evidences and future perspectives. Crit Rev Oncol Hematol. 2020 May 24;152:102994 Authors: Leone G, Buttigliero C, Pisano C, Di Stefano RF, Tabbò F, Turco F, Vignani F, Scagliotti GV, Di Maio M, Tucci M Abstract Testosterone suppression by androgen deprivation therapy is the cornerstone of prostate cancer treatment. New-generation hormone therapies improved overall survival in castration-resistant...
Tue Jun 02, 2020 15:23
Related ArticlesAssessing successful completion of calorie restriction studies for the prevention and treatment of cancer. Nutrition. 2020 Apr 19;78:110829 Authors: Champ CE, Klement RJ Abstract OBJECTIVES: Calorie restriction (CR) >20% has been hypothesized to aid cancer prevention and treatment. Yet, to our knowledge, there is a lack of reported studies in humans describing tolerance, adherence, or efficacy, and unpublished and incomplete dietary...
Tue Jun 02, 2020 15:23
Related ArticlesSingle-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways. Cytometry B Clin Cytom. 2020 Jun 01;: Authors: Bonaccorso P, Bugarin C, Buracchi C, Fazio G, Biondi A, Lo Nigro L, Gaipa G Abstract BACKGROUND: The PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T-cell acute lymphoblastic leukemias (T-ALLs). Although loss-of-function of phosphatase...
Tue Jun 02, 2020 15:23
Related ArticlesTreatment of early-stage mycosis fungoides: results from the PROspective Cutaneous Lymphoma International Study (PROCLIPI study). Br J Dermatol. 2020 Jun 01;: Authors: Quaglino P, Prince HM, Cowan R, Vermeer M, Papadavid L, Bagot M, Servitjie O, Berti E, Guenova E, Stadler R, Querfeld C, Busschots AM, Hodak E, Patsatsi A, Sanches J, Maule M, Yoo J, Kevin M, Fava P, Ribero S, Zocchi L, Rubatto M, Fierro MT, Wehkamp U, Marshalko M, Mitteldorf C, Akilov O,...
Tue Jun 02, 2020 15:23
Related ArticlesArtificial intelligence (AI) in urology-Current use and future directions: An iTRUE study. Turk J Urol. 2020 May 27;: Authors: Shah M, Naik N, Somani BK, Hameed BMZ Abstract OBJECTIVE: Artificial intelligence (AI) is used in various urological conditions such as urolithiasis, pediatric urology, urogynecology, benign prostate hyperplasia (BPH), renal transplant, and uro-oncology. The various models of AI and its application in urology...
Tue Jun 02, 2020 15:23
Related ArticlesManagement of oligometastatic and oligoprogressive renal cell carcinoma: state of the art and future directions. Expert Rev Anticancer Ther. 2020 Jun 01;:1-11 Authors: Donini M, Buti S, Massari F, Mollica V, Rizzo A, Montironi R, Bersanelli M, Santoni M Abstract INTRODUCTION: The aim of this paper was to perform a narrative review of the literature on the available approaches in the treatment of two emerging subpopulations of metastatic...
Tue Jun 02, 2020 15:23
Related ArticlesPathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass. Acta Physiol (Oxf). 2020 Jun 01;:e13516 Authors: Looijaard SMLM, Te Lintel Hekkert ML, Wüst RCI, Otten RHJ, Meskers CGM, Maier AB Abstract Low skeletal muscle mass is highly prevalent in older cancer patients and affects 5% to 89% depending on the type and stage of cancer. Low skeletal muscle mass is associated with poor...
Tue Jun 02, 2020 15:23
Related ArticlesManagement of glioblastoma: State of the art and future directions. CA Cancer J Clin. 2020 Jun 01;: Authors: Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M Abstract Glioblastoma is the most common malignant primary brain tumor. Overall, the prognosis for patients with this disease is poor, with a median survival of <2 years. There is a slight predominance in males, and incidence increases with age. The standard approach...
Tue Jun 02, 2020 15:23
Related ArticlesContemporary strategies to improve outcomes for peripheral T-cell lymphoma patients following the failure of first-line therapy. Expert Rev Hematol. 2020 Jun 01;:1-9 Authors: Kallam A, Armitage JO Abstract INTRODUCTION: T cell lymphomas are a heterogeneous group, with varying incidences, geographic patterns, and risk factors. Although until recently approached in a manner similar to B cell lymphomas, the treatment outcomes are poor and...
Tue Jun 02, 2020 15:23
Related ArticlesTargeting epigenetics in cancer: therapeutic potential of flavonoids. Crit Rev Food Sci Nutr. 2020 Jun 01;:1-24 Authors: Khan H, Belwal T, Efferth T, Farooqi AA, Sanches-Silva A, Vacca RA, Nabavi SF, Khan F, Prasad Devkota H, Barreca D, Sureda A, Tejada S, Dacrema M, Daglia M, Suntar İ, Xu S, Ullah H, Battino M, Giampieri F, Nabavi SM Abstract Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic...
Tue Jun 02, 2020 15:23
Related ArticlesGiving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients. Asia Pac J Oncol Nurs. 2020 Apr-Jun;7(2):218-224 Authors: van Alphen K, Versluis A, Dercksen W, de Haas H, Lugtenberg R, Tiemensma J, Kroep J, Broadbent E, Kaptein AA, van den Hurk C Abstract Objective: Individuals with cancer experience the impact of chemotherapy on hair loss in different ways. The aim of this pilot study was to explore patients'...
Tue Jun 02, 2020 13:49
Related ArticlesOncology Nursing in Singapore: How It Evolved and What Does the Future Hold? Asia Pac J Oncol Nurs. 2020 Apr-Jun;7(2):129-133 Authors: Chua GP Abstract Cancer is the leading cause of death in Singapore since the early 1980s and has remained so since then, accounting for 29.7% of deaths in 2015. Rapid technological advancements in the treatment of cancer and the development of the specialty of radiation and medical oncology demanded nurses...
Tue Jun 02, 2020 13:49
Related ArticlesUpdate on Biology of Cutaneous T-Cell Lymphoma. Front Oncol. 2020;10:765 Authors: Phyo ZH, Shanbhag S, Rozati S Abstract Cutaneous T cell lymphomas (CTCL) comprise of a heterogeneous group of non-Hodgkin lymphomas derived from skin-homing T cells. Variation in clinical presentation and lack of definitive molecular markers make diagnosis especially challenging. The biology of CTCL remains elusive and clear links between genetic aberrations...
Tue Jun 02, 2020 13:49
Related ArticlesStereotactic Cavity Irradiation or Whole-Brain Radiotherapy Following Brain Metastases Resection-Outcome, Prognostic Factors, and Recurrence Patterns. Front Oncol. 2020;10:693 Authors: El Shafie RA, Dresel T, Weber D, Schmitt D, Lang K, König L, Höne S, Forster T, von Nettelbladt B, Eichkorn T, Adeberg S, Debus J, Rieken S, Bernhardt D Abstract Introduction: Following the resection of brain metastases (BM), whole-brain radiotherapy (WBRT)...
Tue Jun 02, 2020 13:49
Related ArticlesCurrent medulloblastoma subgroup specific clinical trials. Transl Pediatr. 2020 Apr;9(2):157-162 Authors: Thompson EM, Ashley D, Landi D Abstract Medulloblastoma is a heterogeneous disease with at least four distinct molecular subgroups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. Recently there has been considerable progress defining the molecular drivers and prognostic factors of each subgroup. However, this information...
Tue Jun 02, 2020 13:49
Related ArticlesProspects of the Use of Cell Therapy to Induce Immune Tolerance. Front Immunol. 2020;11:792 Authors: Wang Z, Liu X, Cao F, Bellanti JA, Zhou J, Zheng SG Abstract Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being. The traditional immunosuppressive drugs used...
Tue Jun 02, 2020 13:49
Related ArticlesRadiosurgery dose reduction for brain metastases on immunotherapy (RADREMI): A prospective phase I study protocol. Rep Pract Oncol Radiother. 2020 Jul-Aug;25(4):500-506 Authors: McClelland S, Lautenschlaeger T, Zang Y, Hanna NH, Shiue K, Kamer AP, Agrawal N, Ellsworth SG, Rhome RM, Watson GA Abstract Introduction: Up to 20% of patients with brain metastases treated with immune checkpoint inhibitor (ICI) therapy and concomitant stereotactic...
Tue Jun 02, 2020 13:49
Related ArticlesA clinical approach to non-neutropenic fever in children with cancer. J Oncol Pharm Pract. 2020 May 31;:1078155220925161 Authors: AlAzmi A, Jastaniah W, AlDabbagh M, Elimam N Abstract BACKGROUND: There are a limited number of studies that address non-neutropenic fever episodes in children with cancer, and no standard approach exists. METHOD: We opt to retrospectively analyze the efficacy of the current clinical approach for management...
Tue Jun 02, 2020 13:49
Related ArticlesFeasibility and Effects of a Supervised Exercise Program Suitable for Independent Training at Home on Physical Function and Quality of Life in Head and Neck Cancer Patients: A Pilot Study. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420918935 Authors: Felser S, Behrens M, Liese J, Strueder DF, Rhode K, Junghanss C, Grosse-Thie C Abstract Introduction: Head and neck cancer patients often suffer from physical and cognitive impairments after...
Tue Jun 02, 2020 13:49
Related ArticlesStratifying nutritional restriction in cancer therapy: Next stop, personalized medicine. Int Rev Cell Mol Biol. 2020;354:231-259 Authors: Krstic J, Pieber TR, Prokesch A Abstract Dietary interventions combined with cancer drugs represent a clinically valid polytherapy. In particular nutrient restriction (NR) in the form of varied fasting or caloric restriction regimens holds great clinical promise, conceptually due to the voracious anabolic...
Tue Jun 02, 2020 13:49
Related ArticlesManagement of vaso-occlusive episodes in the day hospital decreases admissions in children with sickle cell disease. Br J Haematol. 2019 09;186(6):855-860 Authors: Karkoska K, Appiah-Kubi A, Rocker J, Stoffels G, Aygun B Abstract Acute vaso-occlusive episodes (VOE) are the most common reason for presentation to the Emergency Department (ED) and inpatient admission in people living with sickle cell disease (SCD). The goal of this study...
Tue Jun 02, 2020 13:49
Related ArticlesDiscovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy. Bioorg Chem. 2020 May 24;101:103970 Authors: Hu H, Chen F, Dong Y, Liu Y, Gong P Abstract Owing to the low efficacy and acquired resistance in clinical trials of c-Met inhibitors, based on the synergistic effects between c-Met and HDAC, novel c-Met and HDAC dual inhibitors were designed and synthesized. We introduced 2-pyrrolidinone to form the...
Tue Jun 02, 2020 14:41
Related ArticlesDDB1 promotes the proliferation and hypertrophy of chondrocytes during mouse skeleton development. Dev Biol. 2020 May 29;: Authors: Zhao L, Wang X, Pomlok K, Liao H, Yang G, Yang X, Chen YG Abstract The proliferation and hypertrophy of chondrocytes play important roles in endochondral ossification, which is tightly regulated during skeleton development. However, the regulation mechanism remains largely unknown. Here we show that DDB1...
Tue Jun 02, 2020 14:41
Related ArticlesReduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. Biofactors. 2020 Jun 01;: Authors: Ricciarelli R, Azzi A, Zingg JM Abstract Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors...
Tue Jun 02, 2020 14:41
Related ArticlesWill urinary biomarkers provide a breakthrough in diagnosing cardiac surgery-associated AKI? - A systematic review. Biomarkers. 2020 Jun 01;:1-40 Authors: Hussain ML, Hamid PF, Chakane N Abstract Introduction: Acute kidney injury following cardiac surgery is a dreaded complication contributing to early mortality. Diagnosing AKI using serum creatinine usually results in a delay. To combat this, certain kidney damage specific biomarkers...
Tue Jun 02, 2020 14:41
Related ArticlesCell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. Stem Cells. 2020 Jun 01;: Authors: Jaiswal SK, Oh JJ, DePamphilis ML Abstract Previous efforts to determine whether or not the transcription factor and tumor suppressor protein p53 is required for DNA damage-induced apoptosis in pluripotent embryonic stem cells (ESCs) produced contradictory conclusions. To resolve this...
Tue Jun 02, 2020 14:41
Related ArticlesHsa-miR-3658 downregulates OCT4 gene expression followed by suppressing SW480 cells proliferation and migration. Biochem J. 2020 Jun 01;: Authors: Hosseini F, Soltani B, Baharvand H, Hosseinkhani S Abstract The pluripotency factor, OCT4 gene is a stemness marker that is involved in the tumorigenicity of different cancer types, and knowing about molecular mechanisms of its regulation is crucially important. To date, a few microRNAs...
Tue Jun 02, 2020 14:41
Related ArticlesiRGD targeted hybrid nanoparticles reverses multidrug resistant to effectively combat liver cancer. J Drug Target. 2020 Jun 01;:1-14 Authors: Zhao J, Wen B, Tan Z, Li X, Zhang X Abstract The off-target delivery as well as multi-drug resistance (MDR) are generally recognized as two keys difficulties responsible for the poor performance of chemotherapy in clinical treatment of cancer. With the aim to address the problems, we herein...
Tue Jun 02, 2020 14:41
Related ArticlesTargeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer. Front Pharmacol. 2020;11:631 Authors: Li W, Peng X, Lang J, Xu C Abstract Defects in DNA damage repair may cause genome instability and cancer development. The tumor suppressor gene p53 regulates cell cycle arrest to allow time for DNA repair. The oncoprotein mouse double minute 2 (MDM2) promotes cell survival, proliferation,...
Tue Jun 02, 2020 13:40
Related ArticlesMatrine: A Promising Natural Product With Various Pharmacological Activities. Front Pharmacol. 2020;11:588 Authors: Zhang H, Chen L, Sun X, Yang Q, Wan L, Guo C Abstract Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. At present, a large number of studies have proved that matrine has an anticancer effect can inhibit cancer cell proliferation, arrest cell cycle, induce apoptosis, and...
Tue Jun 02, 2020 13:40
Related ArticlesAnti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. Pharmacol Res. 2020 May 13;158:104901 Authors: Cheong DHJ, Tan DWS, Wong FWS, Tran T Abstract Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due...
Tue Jun 02, 2020 13:40
Related ArticlesBerberine-induced nucleolar stress response in a human breast cancer cell line. Biochem Biophys Res Commun. 2020 May 28;: Authors: Sakaguchi M, Kitaguchi D, Morinami S, Kurashiki Y, Hashida H, Miyata S, Yamaguchi M, Sakai M, Murata N, Tanaka S Abstract We investigated the novel molecular mechanisms of the antitumor effect of berberine. In this study, two different human cell lines (breast cancer MCF7 cells and non-tumorigenic epithelial...
Tue Jun 02, 2020 13:40
Related ArticlesDNA replication and mitotic entry: A brake model for cell cycle progression. J Cell Biol. 2019 12 02;218(12):3892-3902 Authors: Lemmens B, Lindqvist A Abstract The core function of the cell cycle is to duplicate the genome and divide the duplicated DNA into two daughter cells. These processes need to be carefully coordinated, as cell division before DNA replication is complete leads to genome instability and cell death. Recent observations...
Tue Jun 02, 2020 13:40
Related ArticlesRB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. Nucleic Acids Res. 2019 12 02;47(21):11197-11208 Authors: Schade AE, Fischer M, DeCaprio JA Abstract Cell cycle gene expression occurs in two waves. The G1/S genes encode factors required for DNA synthesis and the G2/M genes contribute to mitosis. The Retinoblastoma protein (RB) and DREAM complex (DP, RB-like, E2F4 and MuvB) cooperate to repress all cell...
Tue Jun 02, 2020 13:40
Related ArticlesDelineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation. J Cell Biol. 2019 12 02;218(12):3926-3942 Authors: Roy B, Verma V, Sim J, Fontan A, Joglekar AP Abstract Accurate chromosome segregation during cell division requires the spindle assembly checkpoint (SAC), which detects unattached kinetochores, and an error correction mechanism that destabilizes incorrect...
Tue Jun 02, 2020 13:40
Related ArticlesCDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes. EMBO Rep. 2019 09;20(9):e47592 Authors: Chirackal Manavalan AP, Pilarova K, Kluge M, Bartholomeeusen K, Rajecky M, Oppelt J, Khirsariya P, Paruch K, Krejci L, Friedel CC, Blazek D Abstract CDK12 is a kinase associated with elongating RNA polymerase II (RNAPII) and is frequently mutated in cancer. CDK12 depletion reduces the expression of...
Tue Jun 02, 2020 13:40
Related ArticlesFEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling. FASEB J. 2019 10;33(10):10717-10730 Authors: Zeng X, Qu X, Zhao C, Xu L, Hou K, Liu Y, Zhang N, Feng J, Shi S, Zhang L, Xiao J, Guo Z, Teng Y, Che X Abstract Flap endonuclease 1 (FEN1) is recognized as a pivotal factor in DNA replication, long-patch excision repair, and telomere maintenance. Excessive FEN1 expression has been reported...
Tue Jun 02, 2020 13:40
Related ArticlesIdentification of Ebola Virus Inhibitors Targeting GP2 Using Principles of Molecular Mimicry. J Virol. 2019 08 01;93(15): Authors: Singleton CD, Humby MS, Yi HA, Rizzo RC, Jacobs A Abstract A key step in the Ebola virus (EBOV) replication cycle involves conformational changes in viral glycoprotein 2 (GP2) which facilitate host-viral membrane fusion and subsequent release of the viral genome. Ebola GP2 plays a critical role in virus...
Tue Jun 02, 2020 13:40
Related ArticlesThe zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-κB pathway in hepatocellular carcinoma. J Gastroenterol Hepatol. 2019 Dec;34(12):2196-2205 Authors: Xiang Q, Zhou D, He X, Fan J, Tang J, Qiu Z, Zhang Y, Qiu J, Xu Y, Lai G Abstract BACKGROUND AND AIM: The high mortality and poor prognosis of hepatocellular carcinoma (HCC) have raised the public attention. Gene...
Tue Jun 02, 2020 13:40
Related ArticlesPCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells. Cell Rep. 2019 04 02;27(1):48-58.e7 Authors: Sheng C, Mendler IH, Rieke S, Snyder P, Jentsch M, Friedrich D, Drossel B, Loewer A Abstract To enable reliable cell fate decisions, mammalian cells need to adjust their responses to dynamically changing internal states by rewiring the corresponding signaling networks. Here,...
Tue Jun 02, 2020 13:40
Related ArticlesFibulin-3 Has Anti-Tumorigenic Activities in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2019 08;139(8):1798-1808.e5 Authors: Wang X, Zhang Q, Li C, Qu X, Yang P, Jia J, Song L, Fan W, Jing H, Zheng Y Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Several previous studies have shown that fibulin-3 participates in the occurrence and development of various tumors; however, its role in...
Tue Jun 02, 2020 13:40
Related ArticlesValosin-containing protein is associated with maintenance of meiotic arrest in mouse oocytes†. Biol Reprod. 2019 04 01;100(4):963-970 Authors: Peng H, Chen J, Gao Y, Huo J, Wang C, Zhang Y, Xiao T Abstract Valosin-containing protein (VCP) is a member of the highly conserved AAA (ATPase associated with a variety of cellular activities) superfamily. A previous study has shown that targeted deletion of Vcp in mice results in early embryonic...
Tue Jun 02, 2020 13:40
Publication date: June 2020Source: British Journal of Oral and Maxillofacial Surgery, Volume 58, Issue 5Author(s):
Tue Jun 02, 2020 13:38
Publication date: June 2020Source: British Journal of Oral and Maxillofacial Surgery, Volume 58, Issue 5Author(s):
Tue Jun 02, 2020 13:38
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