IB4+ non‐peptidergic DRG neurons form small cell clusters, whereas CGRP+ peptidergic ones are isolated. This configuration is maintained in diabetic mice. The marker of satellite glial cells glutamine synthetase was altered in diabetes according to the cell phenotype: it was increased around CGRP+ neurons and reduced around IB4+ ones. Ultrastructurally, the glial coverage was increased at the interface between IB4+ cluster cells in diabetic mice, with a reduction in the direct contact points between...
Wed Jun 24, 2020 22:05
Femoral neck anteversion (FNA) is the angle between the femoral neck and femoral shaft, which affects the biomechanics of the hip. FNA changes substantially throughout growth, which may relate to motor development, and varies by up to 30° within adults. Several methods can be used to assess FNA, which may yield different values by up to 20° in the same participant. Treatment for clinically problematic FNA is usually de‐rotational osteotomy; passive, non‐operative methods do not have any effect....
Wed Jun 24, 2020 22:00
Three‐dimensional visualisation of the ventral activation network (VAN) activation peaks superimposed on a grid of MNI coordinates. The SLF III connects the supramarginal gyrus to the ventral portion of the precentral gyrus and the pars opercularis. The arcuate fasciculus connects the middle and inferior temporal gyrus and the middle and inferior frontal gyrus. We reconstructed the structural connectivity of the VAN, and considered it in the context if the pathophysiology of unilateral neglect...
Wed Jun 24, 2020 21:55
During the metamorphosis from yellow to silver eels (Anguilla anguilla ), the cranial musculoskeletal system changes to prepare the eel for its 6500 km migration. Both the jaw and respiratory muscles increase in size, with the latter potentially being beneficial for swimming in deeper, and thus less oxygenated waters. Accordingly, the overall skull dimensions increase in size, most likely to accommodate the enlarging eyes and muscles ABSTRACT The European eel (Anguilla anguilla ) has been extensively...
Wed Jun 24, 2020 20:02
Sat Jun 27, 2020 12:15
Abstract Therapeutic advances using targeted biologicals and small molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune and inflammatory diseases particularly for some patients with severe, treatment‐resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen...
Sat Jun 27, 2020 12:14
The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens
Abstract The impact of climate change on the environment, biosphere and biodiversity has become more evident in the recent years. Human activities have increased atmospheric concentrations of carbon dioxide (CO2) and other greenhouse gases. Change in climate and the correlated global warming affects the quantity, intensity and frequency of precipitation type as well as the frequency of extreme events such as heat waves, droughts, thunderstorms, floods and hurricanes. Respiratory health can be particularly...
Fri Jun 26, 2020 17:55
Abstract The “coronavirus disease 2019 (COVID‐19)” outbreak was first reported in December 2019 (China). Since then, this disease has rapidly spread across the globe and in March 2020 the World Health Organization (WHO) declared the COVID‐19 pandemic.1 Since the outbreak was first announced, our journal has extensively focused on the clinical features, outcomes, diagnosis, immunology, and pathogenesis of COVID‐19 and its infectious agent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Fri Jun 26, 2020 17:54
Abstract With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS‐CoV‐2‐induced Coronavirus disease‐19 (COVID‐19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development...
Thu Jun 25, 2020 17:42
Abstract Biologics are a promising treatment for immune‐mediated diseases in which the predominant pathogenic pathway is targeted. The use of biologics therapyfor epidermal barrier function‐impairingpathologiesfollows 3 strategies: tapering ofT helper (Th) 2responses; neutralization of non‐type 2 pathways such as Th17; or blockade of acute phase reactions such as those driven by interleukin (IL)‐6(1). Initially, the treatment of eczematous disorders focused on the Th2 response without considering...
Wed Jun 24, 2020 17:14
Abstract Objectives The cranium is generally considered more reliable than the postcranium for assessing primate taxonomy, although recent research suggests that pelvic shape may be equally reliable. However, little research has focused on intrageneric taxonomic discrimination. Here, we test the relative taxonomic efficacy of the cranium and os coxa for differentiating two macaque species, with and without considering sexual dimorphism. Materials and methods Geometric morphometric analyses...
Sat Jun 27, 2020 22:00
Abstract Background In 2007–2009, a major yellow fever virus (YFV) outbreak in Northern Argentina decimated the local howler monkey (Alouatta) population. Aims To evaluate whether the surviving howler monkeys possess advantageous genetic variants inherited from monkeys alive prior to the YFV outbreak, we explored the relationship between Toll‐like receptor (TLR) 7 and TLR8 gene variation and YFV susceptibility. Methods We used samples from Alouatta individuals in Misiones, Argentina...
Thu Jun 25, 2020 14:25
Abstract Objectives The Osteological Paradox posits that skeletal lesions may differentially be interpreted as representing resilience or frailty. However, specific consideration of the etiologies and demographic distributions of individual skeletal indicators can inform the criteria on which to differentiate stress, frailty, and resilience. Adopting a life history approach and adaptive plasticity model, this study proposes a framework for the analysis and interpretation of a commonly reported...
Wed Jun 24, 2020 12:40
Sat Jun 27, 2020 20:29
This study aimed to show the surgical outcomes of the non‐functional pancreatic neuroendocrine tumours (NF‐PNETs) and evaluate the factors predicting disease‐specific survival for well‐differentiated NF‐PNETs (grade G1 and G2 tumours without synchronous distant metastasis). A total of 103 NF‐PNETs (40%) were identified for analysis. Age >52 years and tumour grade G2 might be independent predictors of poor disease‐specific survival for patients with well‐differentiated NF‐PNETs. Abstract...
Fri Jun 26, 2020 14:15
Wed Jun 24, 2020 20:25
Several preoperative factors influence outcomes from emergency laparotomy. Multiple physiological derangements and comorbidity factors worsen mortality post‐operatively. Increased body mass index (obese and overweight categories) are the only factors found to be protective against post‐operative death following emergency laparotomy. Abstract Background Emergency laparotomy (EL) is a common procedure with high mortality leading to several efforts to record and reduce mortality. Risk scores...
Wed Jun 24, 2020 14:59
A scoping review of the literature of patients with head and neck neoplasms presenting with obstructive sleep apnoea. This review highlights the importance of thorough head and neck examination, including flexible nasendoscopy, in the assessment of adult patients presenting with obstructive sleep apnoea. Abstract Background Obstructive sleep apnoea (OSA) can be caused by neoplasms involving the upper aerodigestive tract. Currently, many of these patients have this diagnosis missed, as...
Wed Jun 24, 2020 14:53
Abstract Ascites due to Mycobacterium avium intracellulare (MAI) infection is extremely rare and associated with a poor outcome. The cytomorphology of this condition has not been previously reported. We present a unique case of a 45‐year‐old woman with iatrogenic immunodeficiency who developed MAI‐associated chylous ascites. The ascitic fluid cytology showed numerous lymphocytes and foamy histiocytes with abundant intracytoplasmic MAI organisms. The diagnosis was confirmed by tissue biopsy showing...
Sat Jun 27, 2020 19:28
Wed Jun 24, 2020 21:24
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo conduct a systematic literature review of imaging techniques and findings in patients with peribiliary liver metastasis.MethodsSeveral electronic datasets were searched from January 1990 to June 2017 to identify studies assessing the use of different imaging techniques for the detection and staging of peribiliary metastases.ResultsThe search identified 44 studies, of which six met the inclusion criteria and were...
Sat Jun 27, 2020 13:39
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo predict dietary self-efficacy behaviors in high glycosylated hemoglobin A1c (HbA1c) patients using type D personality (TDP) and other psychosocial measures.MethodsA cross-sectional, predictive research design was implemented. Participants were type 2 diabetes mellitus patients diagnosed more than 2 years prior to the study. Data were collected for demographics, dietary self-efficacy and psychological measures. Spearman’s...
Fri Jun 26, 2020 15:19
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo establish and evaluate a swine model of traumatic cardiac arrest (TCA) induced by haemorrhage and ventricular fibrillation.MethodsThirteen male pigs were divided into a sham group (n = 5) and TCA group (n = 8). Animals in the sham-operated group underwent intubation and monitoring but not haemorrhage and resuscitation, while animals in the TCA group underwent 40% blood volume haemorrhage over 20 min followed by...
Fri Jun 26, 2020 15:17
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe role and mechanism of tetrathiomolybdate (TM) in cancer-associated fibroblasts (CAFs) in colon cancer using three-dimensional (3D) culture were investigated, and the associations between the focal adhesion kinase (FAK) pathway and epithelial–mesenchymal transition (EMT) in CAFs were explored.MethodsA 3D co-culture model of colon cancer LOVO cells with CAFs and normal fibroblasts (NFs) was established using Matrigel...
Fri Jun 26, 2020 15:14
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe current study investigated the effect of c-Jun NH2-terminal kinase (JNK) expression on the growth of transplanted breast cancer tumors in mice.MethodsA breast cancer transplantation model was established in BALB/c mice, which were then treated with SP600125 (30 mg/kg) for 24 days. After sacrificing the mice, the inhibitory effects of SP600125 on breast cancer growth were calculated by weighing tumors. Moreover,...
Fri Jun 26, 2020 15:12
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the potential association between the ratio of the second digit length to the fourth digit length (2D:4D) and schizophrenia, to provide evidence regarding the pathogenesis of schizophrenia.MethodsIn this study, we enrolled 843 patients with schizophrenia (387 men and 456 women), all of whom met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV),...
Fri Jun 26, 2020 13:17
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the feasibility of locked intramedullary nailing, rather than locking plate fixation combined with fibular allograft augmentation, for initial varus proximal humeral fractures.MethodsThis prospective pilot study enrolled patients with initial varus proximal humeral fractures that were treated with a locking intramedullary nail. Radiography was performed to evaluate fracture healing. Data about the visual...
Fri Jun 26, 2020 13:15
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study was performed to investigate the influence of lower limb muscle strength on the walking function of advanced-age patients with diabetes.MethodsIn this cross-sectional descriptive study, data were collected from 202 advanced-age patients with diabetes. All patients completed questionnaires, the one-leg stance test, the timed up-and-go test, the 30-s sit-to-stand test, and plantar pressure platform measurements....
Fri Jun 26, 2020 13:14
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe ETView VivaSight single lumen airway tube (ETView) is a tracheal tube incorporating a video camera. We carried out a meta-analysis of previous simulation studies by inexperienced personnel to determine if the ETView could improve the success rate of first-attempt intubation.MethodsWe collected data from randomized controlled trials comparing the use of the ETView VivaSight single lumen versus a conventional endotracheal...
Fri Jun 26, 2020 13:12
Journal of International Medical Research, Volume 48, Issue 6, June 2020. BackgroundThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations are common for calculating estimated glomerular filtration rate (eGFR). Unlike CKD, the key pathological change of diabetic kidney disease (DKD) is glomerulosclerosis.MethodsTo conduct a meta-analysis of the diagnostic performance of the CKD-EPI and MDRD equations in diabetic patients, we searched...
Fri Jun 26, 2020 13:12
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveAutoantibody-related congenital heart block (ACHB) is a passively acquired autoimmune disease. This study aimed to examine the pathogenesis, clinical manifestations, and treatment of ACHB.MethodThe clinical data of two fetuses with first-degree ACHB were retrospectively analyzed.ResultsTwo pregnant women were strongly positive for anti-Sjögren’s syndrome-related antigen A (SSA) antibody. Among these two cases, one...
Fri Jun 26, 2020 13:10
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Esophageal squamous cell cancer with distant metastases has a poor prognosis. The metastatic sites usually involve the liver, bones, and lungs. Treatment of metastatic disease is essentially palliative and based on chemoradiotherapy. A 57-year-old man with a solitary metastatic mass of 82 × 58 mm in the left liver was treated on 19 October 2012. Irinotecan and cisplatin combination chemotherapy and nimotuzumab targeted therapy...
Fri Jun 26, 2020 13:10
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the relationship between therapeutic efficacy in children with asthma and interleukin-13 (IL-13) rs20541 polymorphisms.MethodsFifty children with moderate-to-severe asthma were assigned to the GG, GA, and AA groups according to the IL-13 gene locus rs20541 polymorphism. The patients received budesonide inhalation suspension 1 mg twice daily combined with fluticasone propionate 80 µg/inhalation. The improvement...
Fri Jun 26, 2020 13:09
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Dermoid cysts are rare benign tumors that arise from ectopic epiblastic inclusions and account for 0.4% to 1.5% of all tumors. They are usually 1 to 5 cm in size and composed of a pasty semisolid material. The orbital dermoid cyst is the most common type. Dermoid cysts can also occur in the spinal cord, ovaries, and pancreas. We encountered a 24-year-old man with a dermoid cyst over the left sternoclavicular joint. He reported...
Fri Jun 26, 2020 13:08
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the differences in amino acid metabolism in aqueous humor of patients with cataract, according to diabetes status, using a 1H-nuclear magnetic resonance approach.MethodsAqueous humor samples from patients with age-related cataract, with or without diabetes, were collected during cataract surgery. All samples underwent nuclear magnetic resonance spectra analysis to characterize their metabolic function....
Fri Jun 26, 2020 13:07
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the clinical efficacy of corneal collagen cross-linking (CXL) in the treatment of infectious corneal diseases.MethodsThis study retrospectively analyzed the clinical efficacy of CXL in 65 eyes with infectious keratitis in Jinan Second People’s Hospital from December 2016 to June 2018. During 6 months of follow-up after CXL treatment, the results of confocal microscopy and anterior segment optical coherence...
Fri Jun 26, 2020 13:05
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveInterventions for hyperinsulinemia (HINS), an early indicator of type 2 diabetes mellitus (T2DM), can significantly reduce the T2DM risk. This study aims to determine how dipeptidyl peptidase-4 (DPP-4) inhibition prevents HINS progression to T2DM through ameliorating hepatic steatosis.MethodsKKay mice were used as a HINS model and they underwent exercise or received a DPP-4 inhibitor, MK0626. Hepatic steatosis was...
Fri Jun 26, 2020 13:05
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the germinal centers and is characterized by the neoplastic proliferation of spindled to ovoid cells. As there have been only five cases reported in the literature until now, the diagnostic and therapeutic information available to clinicians regarding thyroid FDCS is fairly limited. To our knowledge,...
Fri Jun 26, 2020 13:01
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to investigate the effects of neuromuscular blocking drugs on the viability of human umbilical vein endothelial cells (HUVECs) and to investigate whether they cause vascular complications due to cell proliferation.MethodsHUVECs were cultivated with 5% CO2 at 37°C in a predefined supplemented medium over 7 days until confluence of cell monolayers. Assays were conducted during the exponential growth...
Fri Jun 26, 2020 13:01
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to evaluate the association between plasma P-selectin levels and the severity of coronary heart disease (CHD) in a Chinese Han population.MethodsWe enrolled 219 patients with CHD and 168 healthy individuals without CHD as a control group. Coronary stenosis was evaluated based on the number of diseased coronary arteries and the Gensini scoring system. P-selectin levels were quantified by enzyme-linked...
Fri Jun 26, 2020 12:59
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveIntracerebral hemorrhage (ICH) is a common cerebrovascular disease with high mortality and poor prognosis. Therefore, the biological function and underlying molecular mechanism of miR-26a in inflammatory injury following ICH was investigated.MethodsThe potential role of miR-26a was investigated in lipopolysaccharide (LPS)-treated microglial cells by quantitative real-time PCR. To explore the potential role of HMGA2...
Fri Jun 26, 2020 12:12
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells.MethodsA chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and dithiocarbamate scaffolds. The anticancer effects of different concentrations of the chalcone derivative were compared in esophageal cancer cells.ResultsThis chalcone displayed strong...
Fri Jun 26, 2020 12:08
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to compare the pregnancy outcomes between women receiving frozen embryo transfer (FET) with hormone replacement treatment (HRT) with and without gonadotropin-releasing hormone agonist (GnRHa) pretreatment.MethodsAll consecutive women undergoing HRT cycles (2936 cycles) or HRT with GnRHa pretreatment (HRT + GnRHa, 303 cycles) at our reproductive center between January 2015 and December 2017 were analyzed...
Fri Jun 26, 2020 11:41
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo explore the roles of human mesenchymal stem cell (hMSC) death-associated protein kinase 1 (DAPK1) in modulating CD4+ T lymphocyte proliferation.MethodsHuman MSCs and peripheral blood mononuclear cells were isolated and cocultured in vitro for 3 days. Lentiviral-mediated RNA interference (LV-sh-DAPK1) was used to silence DAPK1 expression in hMSCs. Expression of DAPK1 was assessed by western blotting. Transcriptional...
Fri Jun 26, 2020 10:57
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveMicro RNA (miR)-363 has many important biological functions in cancers, but its roles in esophageal squamous cell carcinoma (ESCC) remain unclear.MethodsWe used reverse transcription PCR to quantify the expression of miR-363 in 80 ESCC tissues and analyzed its relationship with clinicopathological factors and overall survival. The effects of miR-363 on cell proliferation, apoptosis, and invasion were detected using...
Fri Jun 26, 2020 10:56
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo compare the efficacy of postoperative adjuvant treatment (gonadotropin-releasing hormone agonists [GnRHas] and oral contraceptives [OCs]) and expectant treatment in preventing recurrent dysmenorrhea following conservative laparoscopic surgery for deep infiltrating endometriosis (DIE) with dysmenorrhea.MethodsA prospective cohort study was conducted in Shanghai, China. In total, 147 patients with dysmenorrhea who...
Fri Jun 26, 2020 10:48
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe purpose of this study was to compare the pregnancy outcomes among young patients with occult premature ovarian insufficiency (OPOI), advanced-age patients with diminished ovarian reserve (DOR), and advanced-age patients with normal ovarian reserve.MethodsWe retrospectively reviewed 324 women who underwent their first cycles of in vitro fertilization/intracytoplasmic sperm injection. The women were divided into...
Fri Jun 26, 2020 10:46
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveAbnormal autophagy plays a role in the pathogenesis of various diseases. This study aimed to evaluate associations between the clinical manifestations of chronic otitis media (COM) and expression of autophagy markers.MethodsAssociations between presence of bacteria, otorrhea, and conductive and sensorineural hearing loss and levels of autophagy-related mRNAs were investigated in 47 patients with COM.ResultsAutophagy-related...
Fri Jun 26, 2020 08:59
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Sarcomatoid carcinoma is a rare type of gallbladder cancer with no specific clinical manifestation. The final diagnosis depends on pathological and immunohistochemical examination. Sarcomatoid carcinoma is characterized by early lymphatic metastasis, rapid progression, a high short-term recurrence rate, and a worse prognosis than adenocarcinoma. This report describes a 60-year-old woman with poorly differentiated adenocarcinoma...
Fri Jun 26, 2020 08:56
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the hyperintense signal (HIS) performance on diffusion-weighted imaging (DWI) in diagnosing cerebral venous thrombosis (CVT).MethodsSeventy-eight patients with CVT hospitalized from January 2004 to January 2015 were retrospectively studied alongside 78 controls without intracranial organic diseases. Diagnostic accuracy indices of HIS on DWI or T2-weighted imaging (T2WI) to diagnose CVT at different sites...
Fri Jun 26, 2020 05:36
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients.MethodsA total of 317 consecutive patients who were referred for coronary angiography were prospectively enrolled. Before cardiac catheterization, a PAV test was performed to measure changes in pulsatile...
Fri Jun 26, 2020 05:34
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Primary hepatic neuroendocrine tumors (PHNETs) are a group of extremely rare tumors that are difficult to differentiate from common hepatic malignancies on routine imaging studies. By presenting a case of PHNET, we herein introduce our experience with the diagnosis, differential diagnosis, and management of patients with this rare disease. The patient was preoperatively diagnosed with hepatic hydatidosis but postoperatively...
Fri Jun 26, 2020 05:32
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Azithromycin (AZM) has been used to treat chronic inflammatory airway diseases because it regulates cell–cell contact between airway epithelial cells. Airway mucus hypersecretion is an important component of chronic respiratory diseases. Mucin 5AC (MUC5AC) is the major mucin produced by airway epithelial cells, and hypersecretion of MUC5AC is a sign of various pulmonary inflammatory diseases. Recently, it was found that matrix...
Fri Jun 26, 2020 05:31
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo identify atypical hyperplasia (AH) of the breast by shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS), and to explore the molecular fingerprinting characteristics of breast AH.MethodsBreast hyperplasia was studied in 11 hospitals across China from January 2015 to December 2016. All patients completed questionnaires on women’s health. The differences between patients with and without breast AH were...
Fri Jun 26, 2020 05:29
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesCelecoxib is a selective cyclooxygenase (COX)-2 inhibitor that is commonly used to reduce the incidence of gastrointestinal (GI) complications in patients with rheumatoid arthritis (RA). CELBESTA® is a generic equivalent to CELEBREX®, a celecoxib preparation. This study compared the efficacy and safety of CELBESTA® and CELEBREX® in patients with RA.MethodsThis was a multicenter, double-blind, double-dummy, active-controlled,...
Fri Jun 26, 2020 05:26
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe sedative effects of dexmedetomidine (Dex) are similar to natural sleep, with easy wakening following Dex administration, and Dex has minor effects on breathing, reducing emergence agitation in children. The aim of this study was to systematically evaluate the effects of Dex on recovery quality in children following general anaesthesia with sevoflurane, to aid clinical decision making.MethodsRelevant randomized...
Thu Jun 25, 2020 12:01
Publication date: Available online 26 June 2020Source: Revista de Logopedia, Foniatría y AudiologíaAuthor(s): Rosa Fernández Valero, Ana Maria Serrano, Robert Alexander McWilliam, Margarita Cañadas
Sun Jun 28, 2020 02:53
We all know that there are ''good'' and ''bad'' bacteria, but scientists have little insight into how bacteria become ''bad'' or ''pathogenic'' and cause disease. Now, a team of scientists has described how mutations resulting in the malformation of the lipopolysaccharide transporter -- an essential protein for bacterial growth-- caused a non-pathogenic Escherichia coli strain to become pathogenic.
Thu Jun 25, 2020 17:25
In biology, phylogenetic trees represent the evolutionary history and diversification of species -- the ''family tree'' of Life. Phylogenetic trees not only describe the evolution of a group of organisms but can also be constructed from the organisms within a particular environment or ecosystem, such as the human microbiome. In this way, they can describe how this ecosystem evolved and what its functional capabilities might be.
Fri Jun 26, 2020 19:50
Researchers used microCT to study and re-study arthropod fossils from the early Cambrian in the Chengjiang biota in the Yunnan Province of China. Their latest study shows with unprecedented clarity the head morphology of the species Leanchoilia illecebrosa and demonstrates the presence of a labrum thus supporting the hypothesis that megacheirans are distant relatives of modern chelicerates (e.g. horseshoe crabs, scorpions and spiders).
Thu Jun 25, 2020 21:48
Paper wasps eavesdrop on fighting rivals to rapidly assess potential opponents without personal risk. This new finding adds to mounting evidence that even mini-brained insects have an impressive capacity to learn, remember and make social deductions about others.
Thu Jun 25, 2020 19:27
Sled dogs are much older and have adapted to Arctic conditions much earlier than previously thought. Researchers show that ancestors of modern sled dogs have worked and lived with humans for over 9,500 years.
Thu Jun 25, 2020 21:48
Researchers think that local parasites are influencing why barn swallows in Europe, the Middle East and Colorado are choosing their mates differently. Their new research finds that these parasites could be playing an important role in changing the traits displayed to attract mates early in the process of the creation of new species.
Wed Jun 24, 2020 22:16
Medical researchers have developed a new approach to improving the effectiveness of antibiotics in bacterial infections. The study outlines ways to controlling antibiotic resistance through targeted gene interactions.
Wed Jun 24, 2020 22:15
Scientists investigated cooperation dynamics in wild chimpanzees (Tai, Ivory Coast) and bonobos (LuiKotale, DCR) using a snake model. While chimpanzees cooperate to defend their territory, bonobos do not. The study reveals no differences in both species' social intelligence but supports theories linking territoriality and in-group cooperation in humans since chimpanzees were more motivated to cooperate by informing others of a threat as compared to bonobos.
Wed Jun 24, 2020 17:00
Abstract Pace-of-life syndromes (POLS) describe covariations between life history (such as growth rate and age at maturity), behaviour (e.g. activity or boldness) and physiology (e.g. metabolic rate) along an axis from fast to slow lifestyles. This powerful concept can be applicable at a range of scales, from broad interspecific contrasts to the individual intra-population level, though its generality has recently been questioned. Using two species of African annual fishes with...
Sat Jun 27, 2020 03:00
Abstract Intrathyroid thymic carcinoma (ITTC) is a rare malignant neoplasm considered to be a eutopic thymic carcinoma (TC) arising ectopically in the thyroid. Histopathologically, ITTC resembles squamous cell carcinoma of the thymus with positive TC markers such as CD5 and c-KIT. Despite these similar histological findings, ITTC is clinically less aggressive than TC. In this study, we compared clinical, histological, and genetic characteristics of ITTCs and TCs. We collected...
Sat Jun 27, 2020 03:00
Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma (UC). To evaluate the predictive and prognostic value of PD-L1 on response and survival in UC patients after cystectomy, chemotherapy, or anti-PD-1/PD-L1 therapy, a systematic review of PubMed, Embase, Web of Science, and the Cochrane Library was performed. A total of 2154 patients from 14 published studies were included. In all UC patients after cystectomy, tumour cell (TC)...
Sat Jun 27, 2020 21:05
Genome-wide association studies (GWAS) of coronary artery disease (CAD) have revealed multiple genetic risk loci. We assessed the association of 47 genome-wide significant single-nucleotide polymorphisms (SNPs) at 43 CAD loci with coronary stenosis in a Pakistani sample comprising 663 clinically ascertained and angiographically confirmed cases. Genotypes were determined using the iPLEX Gold technology. All statistical analyses were performed using R software. Linkage disequilibrium (LD) between significant...
Sat Jun 27, 2020 09:35
The purpose of this study was to detect clinical variations between lung adenocarcinoma patients with and without ocular metastasis (OM) to identify risk factors for OM and assess the diagnostic values. We included 1153 patients with lung adenocarcinoma in this study. Independent -tests and chi-square tests were used to compare patients’ clinical characteristics. Statistically significant parameters were analyzed by binary logistic regression to detect risk factors of OM. The results showed that...
Thu Jun 25, 2020 15:50
Although it has been proved that the epigenetic modification of DNA and histones is involved in the pathogenesis of systemic lupus erythematosus (SLE), there is no study to explore whether the modification of N6-methyladenosine (m6A) in RNA is involved. In this study, the mRNA levels of m6A “writers” (METTL3, MTEEL14, and WTAP), “erasers” (FTO and ALKBH5), and “readers” (YTHDF2) in peripheral blood were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The results...
Thu Jun 25, 2020 15:50
Among adults who own hearing aids, 20 percent don't actually use these devices, a new study found.Researchers from the University of Manchester, along with audiologists from the Betsi Cadwaladr University Health Board in North Wales, analyzed data from the annual National Survey for Wales, which contains the largest sample on hearing aid use in the United Kingdom, and published their findings in the International Journal of Audiology.This investigation found that approximately 20 percent of adults...
Fri Jun 26, 2020 14:59
Among adults who own hearing aids, 20 percent don't actually use these devices, a new study found.Researchers from the University of Manchester, along with audiologists from the Betsi Cadwaladr University Health Board in North Wales, analyzed data from the annual National Survey for Wales, which contains the largest sample on hearing aid use in the United Kingdom, and published their findings in the International Journal of Audiology.This investigation found that approximately 20 percent of adults...
Fri Jun 26, 2020 14:59
Abstract Objectives To describe the prevalence of overweight and obesity among children under 5 years old, assess the indicators of breastfeeding practices, and explore the associations between breastfeeding practices and early childhood overweight/obesity. Methods The survey was conducted in 20 counties in central and western China in...
Sun Jun 28, 2020 00:17
The aim of this study was to determine the amount of deviation in nasolabial shape in patients with a cleft compared with an average non-cleft face, and to assess whether this difference is related to nasolabial aesthetics. Three-dimensional stereophotogrammetric images of 60 patients with a unilateral cleft were used. To quantify shape differences, four average non-cleft faces were constructed from stereophotogrammetric images of 141 girls and 60 boys. Three-dimensional shape differences were calculated...
Sat Jun 27, 2020 03:00
Intraoperative imaging is increasingly used by surgeons and has become an integral part of many surgical procedures. This study was performed to provide an overview of the current literature on the intraoperative use of cone beam computed tomography (CBCT) imaging in maxillofacial surgery. A bibliographic search of PubMed was conducted in March 2020, without time limitation, using “intraoperative imaging” AND “maxillofacial surgery” AND “cone beam computed tomography” as key words. Ninety-one articles...
Sat Jun 27, 2020 03:00
Bone degradation of the condylar surface is seen in temporomandibular joint osteoarthritis (TMJ OA); however, the initial changes occur in the subchondral bone. This cross-sectional study was performed to evaluate 23 subchondral bone imaging biomarkers for TMJ OA. The sample consisted of high-resolution cone beam computed tomography scans of 84 subjects, divided into two groups: TMJ OA (45 patients with TMJ OA) and control (39 asymptomatic subjects). Six regions of each mandibular condyle scan were...
Sat Jun 27, 2020 03:00
This study sought to determine the rate of sinus membrane perforation in patients undergoing crestal sinus grafting, as well as the effect of Schneiderian membrane thickness and residual bone height (RBH) on membrane perforation, using cone beam computed tomography. The study included 25 patients undergoing 44 crestal sinus grafting procedures. The sites for crestal sinus grafting were divided into a control group (RBH≥5mm) and a test group (RBH<5mm). All sinus grafting procedures were also categorised...
Fri Jun 26, 2020 03:00
Zygomatic fibrous dysplasia is a slowly progressive disorder of bone, which commonly causes facial asymmetry. Precise surgical recontouring can effectively improve facial aesthetics. The aim of this study was to quantitatively evaluate the effectiveness of surgical navigation guidance in correcting zygomatic asymmetry. The study included 26 patients with unilateral zygomatic fibrous dysplasia who underwent bony recontouring. They were divided into two groups according to the use of intraoperative...
Thu Jun 25, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου