Related ArticlesConsequences of climate-induced vegetation changes exceed those of human disturbance for wild impala in the Serengeti ecosystem. Conserv Physiol. 2020;8(1):coz117 Authors: Hunninck L, May R, Jackson CR, Palme R, Røskaft E, Sheriff MJ Abstract In East Africa, climate change is predicted to reduce vegetation quality, and pervasive human disturbance has already resulted in significant declines in biodiversity. We studied the combined effects...
Tue Jun 02, 2020 14:06
Related ArticlesHow might non nutritional sucking protect from sudden infant death syndrome. Med Hypotheses. 2020 May 22;143:109868 Authors: Zavala Abed B, Oneto S, Abreu AR, Chediak AD Abstract Epidemiology has identified an association between the use of pacifiers and protection from sudden infant death syndrome (SIDS). The use of pacifiers for SIDS prevention fails to gain adoption partly because there is no widely accepted physiologic mechanism to...
Tue Jun 02, 2020 16:45
Related ArticlesClinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. Anatol J Cardiol. 2020 Jun;23(6):334-341 Authors: Gürün Kaya A, Gülbay B, Acıcan T Abstract OBJECTIVE: Obstructive sleep apnea (OSA) is associated with elevated blood pressure (BP) and increases the risk of developing cardiovascular diseases. This study aimed to determine the clinical and polysomnographic features...
Tue Jun 02, 2020 16:45
Related ArticlesBlocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA. Front Cell Neurosci. 2020;14:97 Authors: Du P, Wang J, Han Y, Feng J Abstract Studies have shown that diabetes can cause cognitive dysfunction, and cognitive dysfunction in patients with diabetes combined with obstructive sleep apnea (OSA) is more severe. LncRNAs are known to be associated with type 2 diabetes mellitus (T2DM)...
Tue Jun 02, 2020 14:05
Edaravone improves intermittent hypoxia-induced cognitive impairment and hippocampal damage in rats.
Related ArticlesEdaravone improves intermittent hypoxia-induced cognitive impairment and hippocampal damage in rats. Biol Pharm Bull. 2020 May 30;: Authors: Ling J, Yu Q, Li Y, Yuan X, Wang X, Liu W, Guo T, Duan Y, Li L Abstract Oxidative stress plays an essential role in obstructive sleep apnea-hypopnea syndrome-induced cognitive dysfunction in children. This study investigated the effects of edaravone, a potent free radical scavenger, on intermittent...
Tue Jun 02, 2020 14:05
Related ArticlesTargeting intermittent hypoxia downstream pathways for biomarker discovery and new treatment perspectives in cutaneous melanoma. Eur Respir J. 2019 02;53(2): Authors: Minovès M, Pépin JL, Godin-Ribuot D PMID: 30769330 [PubMed - indexed for MEDLINE]
Tue Jun 02, 2020 14:05
Related ArticlesNear-Adult Height After Growth Hormone Treatment in Children Born Prematurely-Data From KIGS. J Clin Endocrinol Metab. 2020 Jul 01;105(7): Authors: Boguszewski MCS, Carlsson M, Lindberg A, Dahlgren J, Aydin F, Camacho-Hübner C, Hokken-Koelega ACS Abstract CONTEXT: Children born prematurely have been treated with growth hormone (GH), and a significant improvement in height during the first years of treatment has been described. ...
Tue Jun 02, 2020 18:06
Related ArticlesDenosumab for fibrous dysplasia: Promising, but questions remain. J Clin Endocrinol Metab. 2020 Jun 01;: Authors: Collins MT, de Castro LF, Boyce AM PMID: 32478399 [PubMed - as supplied by publisher]
Tue Jun 02, 2020 14:03
Related ArticlesHigh-mobility group box 1 protein induces epithelialmesenchymal transition in upper airway epithelial cells. Rhinology. 2020 Jun 01;: Authors: Min HJ, Choe JW, Kim KS, Yoo JH, Kim CH Abstract BACKGROUND: In the treatment of rhinosinusitis, nasal polyps are a major problem, and the epithelial-to-mesenchymal transition (EMT) process is considered pivotal in their development. Although various studies have addressed the role of high mobility...
Tue Jun 02, 2020 14:02
Related ArticlesFaster olfactory adaptation in patients with olfactory deficits: an analysis of results from odor threshold testing. Rhinology. 2020 Jun 01;: Authors: Chen B, Haehner A, Mahmut MK, Hummel T Abstract BACKGROUND: Patients with olfactory deficits often report rapid and lasting olfactory adaptation compared to the time when they had normal olfactory function. However, this phenomenon receives little scientific attention. This retrospective...
Tue Jun 02, 2020 14:02
Condition: HEARING IMPAIRED CHILDRENInterventions: Other: Gaze stability exercises; Other: Brandt-Daroff ExercisesSponsor: Riphah International UniversityNot yet recruiting
Tue Jun 02, 2020 14:00
Conditions: Oral Squamous Cell Carcinoma; Head and Neck Squamous Cell CarcinomaIntervention: Drug: CarrimycinSponsor: Shanghai Jiao Tong University School of MedicineRecruiting
Tue Jun 02, 2020 14:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16571-4White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16340-3Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic development relating to metabolic diseases such as type 2 diabetes.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16585-yHere, the authors implement a mathematical model that describes how Baloxavir antiviral-induced inhibition of influenza virus replication in infected individuals affects the spread of the virus during epidemics, suggesting that both the scaling up and acceleration of treatment would avert substantial influenza morbidity and mortality every year.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16533-w3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing- or cancer cells.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16545-6Seasonal influenza epidemics vary in timing and size, but the causes of the variation remain unclear. Here, the authors analyse a 15-year city-level data set, and find that fluctuations in climatic factors do not predict onset timing, and that while antigenic change does not have a consistent effect on epidemic size, the timing of onset and heterosubtypic competition do.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16604-yThe authors investigate the groundwater table changes in the Kumamoto region (Japan) following the 2016 Mw 7.0 Kumamoto earthquake. Through detailed isotope analysis the study shows how earthquakes can rupture the crust and generate new pathways for aquifers.
Tue Jun 02, 2020 03:00
The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16583-0Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.
Tue Jun 02, 2020 03:00
Nature Communications, Published online: 02 June 2020; doi:10.1038/s41467-020-16491-3Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.
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The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
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Related ArticlesCost per responder for guselkumab versus secukinumab in the United States based on a head-to-head trial of moderate to severe plaque psoriasis. J Dermatolog Treat. 2020 Jun 01;:1-24 Authors: Teeple A, Fitzgerald T Abstract Aims: To estimate cost per response (CPR) in the United States and number-needed-to-treat (NNT) among subjects receiving guselkumab or secukinumab for moderate to severe plaque psoriasis.Materials and methods: Results...
Tue Jun 02, 2020 18:00
Related ArticlesLingual thyroid gland: it's time for awareness. Endocrinol Diabetes Metab Case Rep. 2020 May 29;2020: Authors: Cruz-Dardíz N, Rivera-Santana N, Torres-Torres M, Cintrón-Colón H, Lajud S, Solá-Sánchez E, Mangual-García M, González-Bóssolo A Abstract Summary: Lingual thyroid (LT) gland is the most common type of ectopic thyroid tissue, but it is an extremely rare presentation. We present a case of a 41-year-old Hispanic female patient...
Tue Jun 02, 2020 17:56
Related ArticlesPreliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy. Chem Pharm Bull (Tokyo). 2020;68(6):538-545 Authors: Aoki M, Zhao S, Takahashi K, Washiyama K, Ukon N, Tan C, Shimoyama S, Nishijima KI, Ogawa K Abstract There are various diagnostic and therapeutic agents for prostate cancer using bombesin (BBN) derivatives, but astatine-211 (211At)-labeled BBN derivatives have yet to be studied. This...
Tue Jun 02, 2020 13:59
Related ArticlesSevoflurane inhibits growth factor-induced angiogenesis through suppressing Rac1/paxillin/FAK and Ras/Akt/mTOR. Future Oncol. 2020 Jun 01;: Authors: Wang X, Yao Y, Gao J Abstract Aim: We investigated the direct effects of sevoflurane on angiogenesis and a variety of tumor cells. Materials & methods: The antiangiogenic activity of sevoflurane was determined using angiogenesis and biochemical assays. Results: Sevoflurane at low doses...
Tue Jun 02, 2020 17:58
Related ArticlesClinical consideration for choosing combination therapies in advanced non-small-cell lung cancer: age, Eastern Cooperative Organization performance status 2, steroids and antibiotics. Future Oncol. 2020 Jun 01;: Authors: Giglio A, Nuvola G, Baldini C Abstract Immune checkpoint inhibition completely changed our approach of cancer therapeutics and led to interesting response rate in a wide spectrum of tumors. However, only a portion of...
Tue Jun 02, 2020 17:58
Related ArticlesTargeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives. Curr Cancer Drug Targets. 2020 Jun 01;: Authors: Zhang S, Zhang W, Xiao Y, Qin T, Yue Y, Qian W, Shen X, Ma Q, Wang Z Abstract MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfaces, establishing a selective molecular barrier at the epithelium and mediating signal transduction....
Tue Jun 02, 2020 17:57
Publication date: Available online 1 June 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Zachary C. Spergel, Katie Kennedy, Maria K.C. Alfaro, Stacy L. Dorris, Peter Capucilli
Tue Jun 02, 2020 13:56
Publication date: Available online 1 June 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Stephen Erickson, Aaron Ver Heul, Brian S. Kim
Tue Jun 02, 2020 13:56
Publication date: Available online 1 June 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Matthew Greenhawt, Marcus Shaker
Tue Jun 02, 2020 13:56
Related ArticlesEditorial: Origins of Human Neuropathology: The Significance of Teneurin-Latrophilin Interaction. Front Neurosci. 2020;14:501 Authors: Lovejoy DA, Boucard AA, Tucker RP PMID: 32477060 [PubMed]
Tue Jun 02, 2020 13:54
Related ArticlesIncidental or Intentional? Different Brain Responses to One's Own Action Sounds in Hurdling vs. Tap Dancing. Front Neurosci. 2020;14:483 Authors: Heins N, Pomp J, Kluger DS, Trempler I, Zentgraf K, Raab M, Schubotz RI Abstract Most human actions produce concomitant sounds. Action sounds can be either part of the action goal (GAS, goal-related action sounds), as for instance in tap dancing, or a mere by-product of the action (BAS, by-product...
Tue Jun 02, 2020 13:54
Related ArticlesDeep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus. Front Neurosci. 2020;14:463 Authors: Fomenko A, Lee DJ, McKinnon C, Lee EJ, de Snoo ML, Gondard E, Neudorfer C, Hamani C, Lozano AM, Kalia LV, Kalia SK Abstract Background: Mechanisms of deep brain stimulation (DBS) remain controversial, and spatiotemporal control of brain-wide circuits remains elusive. Adeno-associated...
Tue Jun 02, 2020 13:54
Related ArticlesReduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice. Front Neurosci. 2020;14:453 Authors: Tanaka K, Matsumoto S, Yamada T, Yamasaki R, Suzuki M, Kido MA, Kira JI Abstract Background and Purpose: In the acute phase of ischemia-reperfusion, hypoperfusion associated with ischemia and reperfusion in microvascular regions and disruption of the blood-brain barrier (BBB) contribute to post-ischemic brain...
Tue Jun 02, 2020 13:54
Related ArticlesReactivation of Motor-Related Gamma Activity in Human NREM Sleep. Front Neurosci. 2020;14:449 Authors: Eichenlaub JB, Biswal S, Peled N, Rivilis N, Golby AJ, Lee JW, Westover MB, Halgren E, Cash SS Abstract Models of memory consolidation posit a central role for reactivation of brain activity patterns during sleep, especially in non-Rapid Eye Movement (NREM) sleep. While such "replay" of recent waking experiences has been well-demonstrated...
Tue Jun 02, 2020 13:54
Related ArticlesClosed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo. Front Neurosci. 2020;14:445 Authors: Yang H, Yuan Y, Wang X, Li X Abstract The closed-loop brain stimulation technique plays a key role in neural network information processing and therapies of neurological diseases. Transcranial ultrasound stimulation (TUS) is an established neuromodulation method for the neural oscillation in animals...
Tue Jun 02, 2020 13:54
Related ArticlesModulation of Brain Activity by Selective Attention to Audiovisual Dialogues. Front Neurosci. 2020;14:436 Authors: Leminen A, Verwoert M, Moisala M, Salmela V, Wikman P, Alho K Abstract In real-life noisy situations, we can selectively attend to conversations in the presence of irrelevant voices, but neurocognitive mechanisms in such natural listening situations remain largely unexplored. Previous research has shown distributed activity...
Tue Jun 02, 2020 13:54
Related ArticlesNeurorestoration Approach by Biomaterials in Ischemic Stroke. Front Neurosci. 2020;14:431 Authors: Esteban-Garcia N, Nombela C, Garrosa J, Rascón-Ramirez FJ, Barcia JA, Sánchez-Sánchez-Rojas L Abstract Ischemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural...
Tue Jun 02, 2020 13:54
Related ArticlesTemperature Measurements in the Vicinity of Human Intracranial EEG Electrodes Exposed to Body-Coil RF for MRI at 1.5T. Front Neurosci. 2020;14:429 Authors: Hawsawi HB, Papadaki A, Thornton JS, Carmichael DW, Lemieux L Abstract The application of intracranial electroencephalography (icEEG) recording during functional magnetic resonance imaging (icEEG-fMRI) has allowed the study of the hemodynamic correlates of epileptic activity and of...
Tue Jun 02, 2020 13:54
Related ArticlesA Spiking Neuron and Population Model Based on the Growth Transform Dynamical System. Front Neurosci. 2020;14:425 Authors: Gangopadhyay A, Mehta D, Chakrabartty S Abstract In neuromorphic engineering, neural populations are generally modeled in a bottom-up manner, where individual neuron models are connected through synapses to form large-scale spiking networks. Alternatively, a top-down approach treats the process of spike generation...
Tue Jun 02, 2020 13:54
Related ArticlesSynaptic Plasticity Dynamics for Deep Continuous Local Learning (DECOLLE). Front Neurosci. 2020;14:424 Authors: Kaiser J, Mostafa H, Neftci E Abstract A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, addresses the similarities between learning dynamics employed in deep artificial neural networks and synaptic plasticity...
Tue Jun 02, 2020 13:54
Related ArticlesSex Differences in the Response to Different Tinnitus Treatment. Front Neurosci. 2020;14:422 Authors: Van der Wal A, Luyten T, Cardon E, Jacquemin L, Vanderveken OM, Topsakal V, Van de Heyning P, De Hertogh W, Van Looveren N, Van Rompaey V, Michiels S, Gilles A Abstract Introduction: Tinnitus is a complex symptom requiring a thorough multidisciplinary assessment to construct an individual's tinnitus profile. The Antwerp University Hospital...
Tue Jun 02, 2020 13:54
Related ArticlesAbsence of Rhythm Benefit on Speech in Noise Recognition in Children Diagnosed With Auditory Processing Disorder. Front Neurosci. 2020;14:418 Authors: Sidiras C, Iliadou VV, Nimatoudis I, Bamiou DE Abstract Auditory processing disorder (APD) is a specific deficit in the processing of auditory information along the central auditory nervous system. It is characterized mainly by deficits in speech in noise recognition. APD children may also...
Tue Jun 02, 2020 13:54
Related ArticlesMixed-Precision Deep Learning Based on Computational Memory. Front Neurosci. 2020;14:406 Authors: Nandakumar SR, Le Gallo M, Piveteau C, Joshi V, Mariani G, Boybat I, Karunaratne G, Khaddam-Aljameh R, Egger U, Petropoulos A, Antonakopoulos T, Rajendran B, Sebastian A, Eleftheriou E Abstract Deep neural networks (DNNs) have revolutionized the field of artificial intelligence and have achieved unprecedented success in cognitive tasks such...
Tue Jun 02, 2020 13:54
Related ArticlesSensory- and Action-Oriented Embodiment of Neurally-Interfaced Robotic Hand Prostheses. Front Neurosci. 2020;14:389 Authors: Di Pino G, Romano D, Spaccasassi C, Mioli A, D'Alonzo M, Sacchetti R, Guglielmelli E, Zollo L, Di Lazzaro V, Denaro V, Maravita A Abstract Embodiment is the percept that something not originally belonging to the self becomes part of the body. Feeling embodiment for a prosthesis may counteract amputees' altered image...
Tue Jun 02, 2020 13:54
Related ArticlesCurdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis. Front Neurosci. 2020;14:384 Authors: Yang X, Zheng M, Hao S, Shi H, Lin D, Chen X, Becvarovski A, Pan W, Zhang P, Hu M, Huang XF, Zheng K, Yu Y Abstract A high-fat (HF) diet is a major predisposing factor of neuroinflammation and cognitive deficits. Recently, changes in the gut microbiota have been associated with neuroinflammation and cognitive...
Tue Jun 02, 2020 13:54
Related ArticlesCharacterizing Retinal Ganglion Cell Responses to Electrical Stimulation Using Generalized Linear Models. Front Neurosci. 2020;14:378 Authors: Sekhar S, Ramesh P, Bassetto G, Zrenner E, Macke JH, Rathbun DL Abstract The ability to preferentially stimulate different retinal pathways is an important area of research for improving visual prosthetics. Recent work has shown that different classes of retinal ganglion cells (RGCs) have distinct...
Tue Jun 02, 2020 13:54
Related ArticlesDiurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions. Front Neurosci. 2020;14:375 Authors: Staehle MM, O'Sullivan S, Vadigepalli R, Kernan KF, Gonye GE, Ogunnaike BA, Schwaber JS Abstract Genes that establish the circadian clock have differential expression with respect to solar time in central and peripheral tissues. Here, we find circadian-time-induced...
Tue Jun 02, 2020 13:54
Related ArticlesA Novel Individual Metabolic Brain Network for 18F-FDG PET Imaging. Front Neurosci. 2020;14:344 Authors: Huang SY, Hsu JL, Lin KJ, Hsiao IT Abstract Introduction: Metabolic brain network analysis based on graph theory using FDG PET imaging is potentially useful for investigating brain activity alternation due to metabolism changes in different stages of Alzheimer's disease (AD). Most studies on metabolic network construction have been...
Tue Jun 02, 2020 13:54
Related ArticlesCompensatory Cross-Modal Plasticity Persists After Sight Restoration. Front Neurosci. 2020;14:291 Authors: Mowad TG, Willett AE, Mahmoudian M, Lipin M, Heinecke A, Maguire AM, Bennett J, Ashtari M Abstract Sensory deprivation prompts extensive structural and functional reorganizations of the cortex resulting in the occupation of space for the lost sense by the intact sensory systems. This process, known as cross-modal plasticity, has...
Tue Jun 02, 2020 13:54
Related ArticlesEarly Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning. Front Neurosci. 2020;14:259 Authors: Pan D, Zeng A, Jia L, Huang Y, Frizzell T, Song X Abstract Early detection is critical for effective management of Alzheimer's disease (AD) and screening for mild cognitive impairment (MCI) is common practice. Among several deep-learning techniques...
Tue Jun 02, 2020 13:54
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