Objective Recent studies carried on amyotrophic lateral sclerosis patients suggest that the disease may initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed at experimentally testing the corticofugal hypothesis of amyotrophic lateral sclerosis. Methods Sod1 G86R and Fezf2 knockout mouse lines were crossed to generate a model that ubiquitously expresses a mutant of the murine Sod1 gene, a condition sufficient to induce progressive...
Fri Jun 26, 2020 13:52
Objective Impairment of glycinergic neurotransmission leads to complex movement and behavioral disorders. Patients harboring glycine receptor autoantibodies suffer from stiff‐person syndrome or its severe variant progressive encephalomyelitis with rigidity and myoclonus. Enhanced receptor internalization was proposed as the common molecular mechanism upon autoantibody binding. Although functional impairment of glycine receptors following autoantibody binding has recently been investigated, it is...
Fri Jun 26, 2020 13:52
Objective CGRP pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. Methods Middle cerebral artery was occluded for 12–60 minutes in mice. We compared infarct risk and volumes, collateral flow and neurological deficits after pretreatment with olcegepant (single or 10 daily doses of 0.1–1 mg/kg)...
Thu Jun 25, 2020 12:26
Objective To demonstrate that antibodies from patients with anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) and cause psychotic‐like features in mice. Methods Cultured rat hippocampal neurons were treated with cerebrospinal fluid (CSF) from patients with anti‐NMDAR encephalitis or controls, and the effects on clusters of D1R and D2R were quantified. In vivo studies included 71 C57BL/6J mice that were chronically...
Thu Jun 25, 2020 11:38
A schematic diagram illustrating areas of hippocampal volume loss in temporal lobe epilepsy patients with memory impairment. Worse delayed verbal recall correlated with volume loss on the dorsolateral side of the left vs right hippocampus, seen in the images on the left from the superior aspect. The greatest volume loss is shown by dark blue followed by light blue. Impairment of visual delayed recall correlated best with volume loss on the inferior surface of the midportion of the hippocampus on...
Tue Jun 23, 2020 16:36
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Ismail Ibrahim Ismail, Samar Farouk Ahmed, Jasem Y. Al-Hashel, Ehab A. Abdelnabi, Raed Alroughani
Sun Jun 28, 2020 17:23
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Laxman Pandey, Deepa Joseph, Rajnish Arora, Ashok Singh, Naseef Kassim, Rajesh Pasricha, Manoj Gupta
Sat Jun 27, 2020 15:11
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): John C Mach, Joshua Russell
Sat Jun 27, 2020 15:11
Association between adjuvant radiation therapy and overall survival in Pleomorphic Xanthoastrocytoma
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Adham Khalafallah, Maureen Rakovec, Debraj Mukherjee
Sat Jun 27, 2020 15:11
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Francesco Zenga, Federica Penner, Fabio Cofano, Andrea Lavorato, Valentina Tardivo, Marco Maria Fontanella, Diego Garbossa, Roberto Stefini
Sat Jun 27, 2020 15:11
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Sita Jayalakshmi, Madhukar Dhondji, Sudhindra Vooturi, Anuja Patil, Rammohan Vadapalli
Sat Jun 27, 2020 15:11
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Ming Luo, Diuwei Wu, Xuanhe You, Zhipeng Deng, Tingting Xiao, Limin Liu, Yueming Song, Shishu Huang
Thu Jun 25, 2020 18:06
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Graciela Cárdenas, Santiago Aristizábal, Citlaltepetl Salinas, Rosa Delgado-Hernández, Verónica Angeles-Morales, José Soto-Hernández, Laura Rosio Castañón-Olivares, Francisca Hernández
Thu Jun 25, 2020 18:06
Abstract Purpose of Review Patients with brain tumors are susceptible to multiple complications that can affect their survival or quality of life. The scope of these complications is widening due to prolonged overall survival and improved therapies. In this review, we discuss the most common complications in this patient population focusing on the recent literature. We specifically concentrated on tumor-related epilepsy, vasogenic...
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Abstract Purpose of Review Patients with brain tumors presenting to the emergency room with acute neurologic complications may warrant urgent investigations and emergent management. As the neuro-hospitalist will likely encounter this complex patient population, an understanding of the acute neurologic issues will have value. Recent Findings ...
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Abstract Sleep pressure that builds up gradually during the extended wakefulness results in sleep rebound. Several lines of evidence, however, suggest that wake per se may not be sufficient to drive sleep rebound and that rapid eye movement (REM) and non‐rapid eye movement (NREM) sleep rebound may be differentially regulated. In this study, we investigated the relative contribution of brain vs physical activities in REM and NREM sleep rebound by four sets of experiments. First, we forced locomotion...
Thu Jun 25, 2020 17:24
Abstract Aiming to provide an argumentation on the underlying nonlinearity of the overall functional brain network via surrogate data method and graph theory. Taking the functional magnetic resonance imaging (fMRI) data as original data set and then shuffled the time series of each region of interest (ROI) to generate surrogate data sets, corresponding original network and its 400 surrogates were obtained via computing connectivity matrixes. The results show that both the global correlation level...
Thu Jun 25, 2020 17:03
Abstract One of the major challenges for clinicians who treat patients with Disorders of Consciousness (DoCs) concerns the detection of signs of consciousness that distinguish patients in Vegetative State from those in Minimally Conscious State. Recent studies showed how visual responses to tailored stimuli are one of the first evidence revealing that one patient is changing from one state to another. This study aimed to explore the integrity of the neural structures being part of the visual system...
Wed Jun 24, 2020 17:53
Abstract Alterations of the brain extracellular matrix (ECM) can perturb the structure and function of brain networks like the hippocampus, a key region in human memory that is commonly affected in psychiatric disorders. Here, we investigated the potential effects of a genome‐wide psychiatric risk variant in the NCAN gene encoding the ECM proteoglycan neurocan (rs1064395) on memory performance, hippocampal function, and cortical morphology in young, healthy volunteers. We assessed verbal memory...
Wed Jun 24, 2020 17:37
Abstract Microglia are the primary immune cells of the central nervous system and crucial to proper development and maintenance of the brain. Microglia have been recognized to be associated with neurodegenerative diseases and neuroinflammatory disorders. CX3C chemokine receptor 1 (CX3CR1), which is specifically expressed in microglia, regulates microglia homeostatic functions such as microglial activation and is downregulated in aged brain and disease associated microglia in rodents, yet its role...
Wed Jun 24, 2020 11:24
Abstract Dopaminergic deficiency in Parkinson’s disease (PD) has been associated with underactivation of the supplementary motor area and a reduction of voluntary actions. In these patients, awareness of intention to act has been shown to be delayed. However, delayed awareness of intention to act has also been shown in patients with hyperdopaminergic states and an excess of unwilled movements, as in Tourette’s, and in patients with functional movement disorders. Hence, the role...
Sat Jun 27, 2020 03:00
Changes in corticospinal excitability during bilateral and unilateral lower-limb force control tasks
Abstract Ankle dorsiflexion force control is essential for performing daily living activities. However, the involvement of the corticospinal pathway during different ankle dorsiflexion tasks is not well understood. The objective of this study was to compare the corticospinal excitability during: (1) unilateral and bilateral; and (2) ballistic and tonic ankle dorsiflexion force control. Fifteen healthy young adults (age: 25.2 ± 2.8 years) participated in this study. Participants...
Fri Jun 26, 2020 03:00
Gait training with partial body weight support (BWS) has become an established rehabilitation technique. Besides passive unloading mechanisms such as springs or counterweights, also active systems that allow r...
Thu Jun 25, 2020 03:00
Publication date: Available online 27 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Jian Wang, Hu Cheng, Sharlene D. Newman
Sun Jun 28, 2020 21:03
Publication date: Available online 27 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Georg Oeltzschner, Helge J. Zöllner, Steve C.N. Hui, Mark Mikkelsen, Muhammad G. Saleh, Sofie Tapper, Richard A.E. Edden
Sun Jun 28, 2020 21:03
Publication date: Available online 27 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Benjamin G. Schultz, Emmanuel Biau, Sonja A. Kotz
Sun Jun 28, 2020 21:03
Publication date: 1 September 2020Source: Journal of Neuroscience Methods, Volume 343Author(s): Teresa Macheda, Henry C. Snider, James B. Watson, Kelly N. Roberts, Adam D. Bachstetter
Sun Jun 28, 2020 21:03
Journal of Neurotrauma, Ahead of Print.
Wed Jun 24, 2020 10:00
Publication date: Available online 28 June 2020Source: NeuroImageAuthor(s): Yikang Liu, Pablo D. Perez, Zilu Ma, Zhiwei Ma, David Dopfel, Samuel Cramer, Wenyu Tu, Nanyin Zhang
Sun Jun 28, 2020 14:31
Publication date: Available online 27 June 2020Source: NeuroImageAuthor(s): Matthew F. Singh, Todd S. Braver, Michael W. Cole, ShiNung Ching
Sun Jun 28, 2020 14:31
Publication date: Available online 27 June 2020Source: NeuroImageAuthor(s): Siddhesh Thakur, Jimit Doshi, Sarthak Pati, Saima Rathore, Chiharu Sako, Michel Bilello, Sung Min Ha, Gaurav Shukla, Adam Flanders, Aikaterini Kotrotsou, Mikhail Milchenko, Spencer Liem, Gregory S. Alexander, Joseph Lombardo, Joshua D. Palmer, Pamela LaMontagne, Arash Nazeri, Sanjay Talbar, Uday Kulkarni, Daniel Marcus
Sun Jun 28, 2020 14:31
Publication date: Available online 27 June 2020Source: NeuroImageAuthor(s): Jean-Rémi King, François Charton, David Lopez-Paz, Maxime Oquab
Sun Jun 28, 2020 14:31
Publication date: Available online 27 June 2020Source: NeuroImageAuthor(s): Anderson M. Winkler, Olivier Renaud, Stephen M. Smith, Thomas E. Nichols
Sun Jun 28, 2020 14:31
Publication date: Available online 27 June 2020Source: NeuroImageAuthor(s): Reut Avinun, Salomon Israel, Annchen R. Knodt, Ahmad R. Hariri
Sat Jun 27, 2020 19:28
Publication date: Available online 26 June 2020Source: NeuroImageAuthor(s): Andrea Vázquez, Narciso López-López, Alexis Sánchez, Josselin Houenou, Cyril Poupon, Jean-François Mangin, Cecilia Hernández, Pamela Guevara
Sat Jun 27, 2020 19:28
Publication date: Available online 26 June 2020Source: NeuroImageAuthor(s): Stephan Kaczmarz, Fahmeed Hyder, Christine Preibisch
Sat Jun 27, 2020 19:28
Publication date: Available online 26 June 2020Source: NeuroImageAuthor(s): Dragan Rangelov, Jason B. Mattingley
Sat Jun 27, 2020 19:28
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Muwei Li, Yurui Gao, Fei Gao, Adam W. Anderson, Zhaohua Ding, John C. Gore
Sun Jun 28, 2020 14:31
Publication date: Available online 25 June 2020Source: NeuroImageAuthor(s): Vahab Youssofzadeh, Jeffrey Stout, Candida Ustine, William L. Gross, Lisa L. Conant, Colin J. Humphries, Jeffrey R. Binder, Manoj Raghavan
Fri Jun 26, 2020 13:13
Publication date: Available online 25 June 2020Source: NeuroImageAuthor(s): Geoffrey Chern-Yee Tan, Carlton Chu, Lee Yu Teng, Tan Chih King Clarence, John Ashburner, Nicholas W. Wood, Richard SJ. Frackowiak
Fri Jun 26, 2020 13:13
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Teresa Vargas, Katherine S.F. Damme, Vijay A. Mittal
Sun Jun 28, 2020 14:31
Publication date: Available online 25 June 2020Source: NeuroImageAuthor(s): Aino E. Tervo, Johanna Metsomaa, Jaakko O. Nieminen, Jukka Sarvas, Risto J. Ilmoniemi
Fri Jun 26, 2020 13:13
Publication date: Available online 25 June 2020Source: NeuroImageAuthor(s): Shuo Han, Yang An, Aaron Carass, Jerry L. Prince, Susan M. Resnick
Thu Jun 25, 2020 19:05
Publication date: Available online 25 June 2020Source: NeuroImageAuthor(s): Daisuke Koshiyama, Naohiro Okada, Shuntaro Ando, Shinsuke Koike, Noriaki Yahata, Kentaro Morita, Kingo Sawada, Susumu Morita, Shintaro Kawakami, Sho Kanata, Shinya Fujikawa, Noriko Sugimoto, Rie Toriyama, Mio Masaoka, Tsuyoshi Araki, Yukiko Kano, Kaori Endo, Syudo Yamasaki, Atsushi Nishida, Mariko Hiraiwa-Hasegawa
Thu Jun 25, 2020 19:05
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Tatsunori Watanabe, Ippei Nojima, Tatsuya Mima, Hideshi Sugiura, Hikari Kirimoto
Sat Jun 27, 2020 19:28
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Jaime S. Ide, Huey-Ting Li, Yu Chen, Thang M. Le, Clara S.P. Li, Simon Zhornitsky, Chiang-Shan R. Li
Sat Jun 27, 2020 19:28
Publication date: Available online 24 June 2020Source: NeuroImageAuthor(s): Lore M. Peeters, Rukun Hinz, Jan R. Detrez, Stephan Missault, Winnok H. De Vos, Marleen Verhoye, Annemie Van der Linden, Georgios A. Keliris
Thu Jun 25, 2020 19:05
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Claire E. Kelly, Deanne K. Thompson, Sila Genc, Jian Chen, Joseph YM. Yang, Chris Adamson, Richard Beare, Marc L. Seal, Lex W. Doyle, Jeanie LY. Cheong, Peter J. Anderson
Sat Jun 27, 2020 19:28
SUMMARY:Patients with coronavirus disease 2019 (COVID-19) may have symptoms of anosmia or partial loss of the sense of smell, often accompanied by changes in taste. We report 5 cases (3 with anosmia) of adult patients with COVID-19 in whom injury to the olfactory bulbs was interpreted as microbleeding or abnormal enhancement on MR imaging. The patients had persistent headache (n = 4) or motor deficits (n = 1). This olfactory bulb injury may be the mechanism by which the Severe Acute Respiratory Syndrome...
Thu Jun 25, 2020 18:04
SUMMARY:There is increasing evidence to suggest that complications of coronavirus disease 2019 (COVID-19) infection are not only limited to the pulmonary system but can also involve the central nervous system. Here, we report 6 critically ill patients with COVID-19 infection and neuroimaging findings of leukoencephalopathy. While these findings are nonspecific, we postulate that they may be a delayed response to the profound hypoxemia the patients experienced due to the infection. No abnormal enhancement,...
Thu Jun 25, 2020 17:51
SUMMARY:We report a case of bifacial weakness with paresthesia, a recognized Guillain-Barré syndrome subtype characterized by rapidly progressive facial weakness and paresthesia without ataxia or other cranial neuropathies, which was temporally associated with antecedent coronavirus 2019 (COVID-19). This case highlights a potentially novel but critically important neurologic association of the COVID-19 disease process. Herein, we detail the clinicoradiologic work-up and diagnosis, clinical course,...
Thu Jun 25, 2020 17:46
BACKGROUND AND PURPOSE:Conventional single-shot FSE commonly used for fast MRI may be suboptimal for brain evaluation due to poor image contrast, SNR, or image blurring. We investigated the clinical performance of variable refocusing flip angle single-shot FSE, a variation of single-shot FSE with lower radiofrequency energy deposition and potentially faster acquisition time, as an alternative approach to fast brain MR imaging.MATERIALS AND METHODS:We retrospectively compared half-Fourier single-shot...
Thu Jun 25, 2020 17:45
BACKGROUND AND PURPOSE:Coronavirus disease 2019 (COVID-19) is an active worldwide pandemic with diverse complications. Stroke as a presentation has not been strongly associated with COVID-19. The authors aimed to retrospectively review a link between COVID-19 and acute stroke.MATERIALS AND METHODS:We conducted a retrospective case-control study of 41 cases and 82 control subjects matched by age, sex, and risk factors. Cases were patients who underwent stroke alert imaging with confirmed acute stroke...
Thu Jun 25, 2020 17:44
BACKGROUND AND PURPOSE:Prior studies have suggested an association between the presence of cervicofacial venous malformations and intracranial developmental venous anomalies. We reviewed our institutional cohort of patients with cervicofacial venous malformations and examined the spectrum of intracranial venous anomalies, including developmental venous anomalies, cavernous malformations, and dural venous sinus abnormalities.MATERIALS AND METHODS:Consecutive patients who presented to our institution...
Thu Jun 25, 2020 17:42
BACKGROUND AND PURPOSE:The Woven EndoBridge (WEB) device is an established technique for the treatment of intracranial aneurysms. Occasionally, persistent opacification inside the WEB lumen can be observed at follow-up (previously described as Bicêtre Occlusion Scale Score 1). We evaluated potential risk factors of this phenomenon, hypothesizing that initial deviation of the WEB device from the aneurysm axis, size of the aneurysmal neck surface, or inappropriate WEB sizing correlates with Bicêtre...
Thu Jun 25, 2020 17:41
BACKGROUND AND PURPOSE:Patients with intracranial aneurysms may benefit from 4D flow MR imaging because the derived wall shear stress is considered a useful marker for risk assessment and growth of aneurysms. However, long scan times limit the clinical implementation of 4D flow MR imaging. Therefore, this study aimed to investigate whether highly accelerated, high resolution, 4D flow MR imaging at 7T provides reliable quantitative blood flow values in intracranial arteries and aneurysms.MATERIALS...
Thu Jun 25, 2020 17:40
BACKGROUND AND PURPOSE:Intra-arterial chemotherapy for retinoblastoma has dramatically altered the natural history of the disease. The remarkable outcomes associated with a high safety profile have pushed the envelope to offer treatment for patients weighing ≤10 kg. The purpose was to determine the efficacy and safety of IAC infusions performed in infants weighing ≤10 kg with intraocular retinoblastoma.MATERIALS AND METHODS:A retrospective chart review was performed for patients diagnosed with retinoblastoma...
Thu Jun 25, 2020 17:39
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