Abstract Purpose of Review B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies. Recent Findings ...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Aug 18, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Aug 18, 2020 10:00
Abstract Rationale Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzylideneoxymorphone (BOM), might further limit adverse effects because it appears to have lower pharmacological efficacy...
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The Journal of Antibiotics, Published online: 21 August 2020; doi:10.1038/s41429-020-00362-6The Laetiporus polyketide synthase LpaA produces a series of antifungal polyenes
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Strongyloidiasis is caused by the nematode Strongyloides stercoralis which has the unique ability to reproduce and complete its entire life cycle within the human host through its autoinfection cycle. Diagnosis of this infection is important because of its potential to cause fatal hyperinfection syndrome or disseminated infections in those with defective cellular immunity. Parasitological methods based on faecal microscopy and culture often fail to detect low-intensity infections. A multiplex polymerase...
Thu Aug 20, 2020 16:50
High Altitude Medicine &Biology, Ahead of Print.
Mon Aug 17, 2020 10:00
Objective. Cerebral edema is a common complication of brain tumors in the perioperative period. However, there is currently no reliable and convenient method to evaluate the extent of brain edema. The objective is to explore the effectiveness of serum occludin on predicting the extent of perioperative brain edema and outcome in patients with brain tumors. Methods. This prospective study enrolled 55 patients with brain tumors and 24 healthy controls in Sanbo Brain Hospital from June 2019 through November...
Thu Aug 20, 2020 11:50
Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional...
Thu Aug 20, 2020 08:50
Mucosal Immunology, Published online: 20 August 2020; doi:10.1038/s41385-020-00340-zAnimal and translational models of SARS-CoV-2 infection and COVID-19
Thu Aug 20, 2020 03:00
New research on the fin development of the Australian lungfis elucidates how fins evolved into limbs with hands with digits. The main finding is that in lungfish a primitive hand is already present, but that functional fingers and toes only evolved in land animals due to changes in embryonic development.
Wed Aug 19, 2020 22:57
Amber has been reported from the Early Cretaceous Crato Formation, as isolated clasts or within plant tissues. Undescribed cones of uncertain gymnosperm affinity have also been recovered with amber preserved i...
Thu Aug 20, 2020 03:00
Publication date: Available online 20 August 2020Source: American Journal of Infection ControlAuthor(s): Maria A. Corcorran, Svaya Olin, Golo Rani, Keri Nasenbeny, Cheri Constantino-Shor, Charity Holmes, Laura Quinnan-Hostein, William Solan, Gretchen Snoeyenbos Newman, Alison C. Roxby, Alexander L. Greninger, Keith R. Jerome, Santiago Neme, John B. Lynch, Timothy H. Dellit, Seth A. Cohen
Thu Aug 20, 2020 16:28
Publication date: Available online 19 August 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Mohsen Mohamed Elsayyad, Nabil Mahmoud Abdel-Aal, Mohamed Elsayed Helal
Thu Aug 20, 2020 16:24
Publication date: Available online 20 August 2020Source: CortexAuthor(s): Nahid Zokaei, Annie Sillence, Annika Kienast, Daniel Drew, Olivia Plant, Ellie Slavkova, Sanjay G. Manohar, Masud Husain
Thu Aug 20, 2020 16:10
Abstract Objective To investigate the adult outcomes of children with juvenile‐onset recurrent respiratory papillomatosis via long‐term follow‐up. Study Design Retrospective study Setting Beijing Tongren Hospital Participants The study includes 121 patients with recurrent respiratory papillomatosis. Main outcome and measure We followed‐up respiratory papillomatosis patients aged least 14 years and analysed their clinical features based on recurrence‐free time. Results...
Wed Aug 19, 2020 21:35
Publication date: Available online 20 August 2020Source: TalantaAuthor(s): Ruijun Wu, Chunsu Liang, Juncheng Zou, Cong Li, Youqi Yan, Xin Hu, Xiaomei Ling
Thu Aug 20, 2020 15:25
Abstract Introduction Retaining postpartum women living with HIV in ongoing care is critical for the health of the mother–child dyad but low adherence to antiretroviral therapy (ART) and retention in HIV care are a global concern. This issue is particularly salient in South Africa, where approximately 50% of women fall out of the care cascade by 6 months postpartum. The purpose of this secondary analysis is to understand the strategies...
Thu Aug 20, 2020 03:00
Publication date: Available online 20 August 2020Source: Médecine & DroitAuthor(s):
Thu Aug 20, 2020 15:06
Visual detection of howler monkeys for ripe and unripe fruits over leaves. The values are the mean reflectance spectra along the visible spectrum (400–700 nm). Abstract Howler monkeys (platyrrhini) have evolved routine trichromatic color vision independently from catarrhines, which presents an opportunity to test hypotheses concerning the adaptive value of distinguishing reddish from greenish hues. A longstanding hypothesis posits that trichromacy aids in the efficient detection of reddish‐ripe...
Wed Aug 19, 2020 11:01
Myxoid liposarcoma is a malignant adipogenic neoplasm characterized by prominent arborizing capillaries, occasional lipoblasts, and primitive-appearing spindle cells in a myxoid background. A recurrent translocation in myxoid liposarcoma results in an oncoprotein consisting of full-length DDIT3 (CHOP) fused to an N-terminal segment of either FUS (TLS) or, less often, EWSR1. Here, we explore the diagnostic significance of DDIT3 expression in myxoid liposarcoma using a mouse monoclonal antibody recognizing...
Tue Aug 18, 2020 03:00
Thirty-eight ovarian Sertoli-Leydig cell tumors that contained follicles are described; in 33 of them follicles imparted a microscopic appearance resembling that of the juvenile granulosa cell tumor. The average age of the patients (28 y), frequency of androgenic manifestations (40%), and dominant histopathologic features were all typical of Sertoli-Leydig cell tumor, mostly (80%) of intermediate differentiation. The remaining tumors were poorly differentiated; none were well differentiated. The...
Tue Aug 18, 2020 03:00
Abstract Purpose To investigate and compare the translucency and color stability of a newly introduced polymer‐infiltrated ceramic network (PICN) material (Crystal Ultra) to those of clinically well‐established restorative materials. Materials and methods A total of 80 specimens measuring (12 × 14 × 1 mm ± 0.05 mm) were prepared from five CAD/CAM (IPS e.max (IPS), Lava Ultimate (LU), Cerasmart (CS), Vita Enamic (VE), Crystal Ultra (CU)) high translucency (HT) blocks in A2 or equivalent...
Wed Aug 19, 2020 15:44
Abstract Several strands of research indicate that work competes for time with sleep, but to what extent the timing and duration of sleep is affected by work is not known. Retirement offers a quasi‐experimental life transition to study this in a within‐individual study design. The few existing studies report that people sleep longer and later after retirement but mainly rely on self‐reported data or between‐individual analyses. We recruited 100 participants aged 61–72 years who were in paid work...
Wed Aug 19, 2020 16:13
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