E-cadherin behaves like a glue in healthy tissues, keeping epithelial cells connected and organized. Discovered 43 years ago, this transmembrane glycoprotein connects epithelial cells together at adherent junctions at their lateral surfaces, helping to maintain their polarized, differentiated…
Thu Aug 27, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01119C, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rianne van Outersterp, Jonathan Martens, Giel Berden, Valerie Koppen, Filip Cuyckens, Jos OomensDistinguishing positional isomers, such as compounds having different substitution patterns on an aromatic ring, presents a significant challenge for mass spectrometric analyses and is a frequently encountered difficulty in, for...The...
Fri Aug 28, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01201G, PaperJhih-Siang Chen, Pin-Fan Chen, Hana Tzu-Han Lin, Nien-Tsu HuangInflammation is a complex biological response of the human body to external or internal stimuli, such as invading pathogens, defected cells, or irritant analytes. One important indicator to identify inflammation...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Aug 28, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN01134G, CommunicationChunyu Li, Xixian Wang, Jian Xu, Bo MaWe present an easy-to-follow modular method that combines liquid molding with standard SU-8 lithography to create customized integrated microfluidic devices for the changing needs of users.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Aug 28, 2020 02:00
Publication date: Available online 28 August 2020Source: CortexAuthor(s): Durjoy Lahiri
Fri Aug 28, 2020 15:33
Related Articles Making Your AI Smarter: Continuous Learning Artificial Intelligence for Radiology. Radiology. 2020 Aug 25;:202664 Authors: McMillan AB PMID: 32845217 [PubMed - as supplied by publisher]
Fri Aug 28, 2020 15:01
Related Articles Radiomics to Predict Invasiveness of Part-Solid Adenocarcinoma of the Lung. Radiology. 2020 Aug 25;:202273 Authors: Nishino M PMID: 32845216 [PubMed - as supplied by publisher]
Fri Aug 28, 2020 15:01
Related Articles Emerging Techniques Bring Diffusion-weighted Imaging of the Breast into Focus. Radiology. 2020 Aug 25;:203044 Authors: Partridge SC PMID: 32845215 [PubMed - as supplied by publisher]
Fri Aug 28, 2020 15:01
Abstract Purpose To synthesize and characterize poly(hydroxybutyrate) (PHB) and norbixin membranes to evaluate them for genotoxicity in rats and wound healing in mice by histological staining. Methods For the evaluation of genotoxicity, male rats ( Rattus novegicus ) were divided into three groups (n= 5): 5% PHB/Norbixin membrane introduced into the peritoneum by laparotomy; B – negative control; C – positive control (intraperitoneal dose of cyclophosphamide 50 mg/kg). For the evaluation of biocompatibilty,...
Fri Aug 28, 2020 14:48
Abstract Although radiotherapy, especially carbon-ion radiotherapy, is an effective treatment modality against non-small-cell lung cancer (NSCLC), studies using radiation combined with sensitizer for improving the efficacy of radiotherapy are still needed. In this work, we aimed to investigate in NSCLC A549 and H1299 cell lines the effects of different linear energy transfer (LET) radiations combined with diverse sensitizing compounds. Cells pretreated with the CHK1/CHK2 inhibitor...
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-17983-yThe asymmetry between El Niño and La Niña episodes in the tropical Pacific is often not well represented in models. Here, the authors show that this asymmetry is related to subsurface nonlinear dynamical heating and that a realistic representation of this process can potentially improve tropical climate projections.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-18217-xUnderstanding the behavior of jammed granular matter is important for a range of phenomena, from materials science to geology. Wang et al. uncover relations between stress correlations and emergence of localized shear bands due to external shear stress, which breaks the rotational symmetry.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-18097-1Author Correction: Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-18212-2Here, the authors present a dual-mode solid state thermal rectification effect using a heterogeneous irradiated-pristine polyethylene nanofiber junction as a nanoscale thermal diode, in which heat flow can be rectified in both directions by changing the working temperature.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-18160-xThe failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-18120-5The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induced stabilization to the channel.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-17359-2There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.
Fri Aug 28, 2020 03:00
Nature Communications, Published online: 28 August 2020; doi:10.1038/s41467-020-17863-5Controlled membrane synthesis in liposomes is a prerequisite for synthetic systems emulating the fundamental properties of living cells. Here authors present that a de novo synthesized metabolic pathway converts precursors into a variety of lipids, including the constituents of the parental liposome.
Fri Aug 28, 2020 03:00
Philanthropists, charity leaders and policy-makers have increasingly recognised that the process of giving resources needs to be grounded in evidence—sometimes referred to as ‘evidence-based’ or ‘data-driven’ ...
Thu Aug 27, 2020 03:00
Presentation of Case. Dr. Jacob M. Rosenberg: A 53-year-old woman was transferred to this hospital because of progressive headache, gait instability, and weight loss. Approximately 2 months before the patient’s evaluation at this hospital, vertigo developed and resolved spontaneously. One day…
Thu Aug 27, 2020 03:00
To the Editor: Rural and indigenous populations are disproportionately affected by cardiovascular disease, with a higher prevalence of cardiovascular risk factors than urban populations, as well as harsher environmental conditions, reduced access to services, and greater difficulty in attracting…
Thu Aug 27, 2020 03:00
Antibiotic resistance represents a major crisis that limits the care of many patients. Demonstrating that large-scale efforts to control this problem have saved lives would help secure the ongoing and expanded funding and support needed to sustain action. However, data causally linking national and…
Thu Aug 27, 2020 03:00
Background: Assessment of prognosis is of major importance when deciding on a therapeutic strategy in patients with pulmonary arterial hypertension (PAH). Objectives: The aim of this study was to investigate the prognostic value of pulmonary hemodynamics during exercise and changes during treatment in patients with PAH. Methods: Consecutive incident patients (n = 49) with PAH undergoing right heart catheterization at rest and during a constant workload cycle exercise in supine position were included....
Fri Aug 28, 2020 08:57
Current Anthropology, Ahead of Print.
Thu Aug 27, 2020 06:20
Abstract Obesity is a problem in captive chimpanzee colonies that can lead to increased risk for disease; therefore, implementation of effective weight management strategies is imperative. To properly implement a weight management program, captive managers should be able to noninvasively identify and assess overweight or obese individuals. Traditional means of categorizing obese individuals involve sedating the animals to obtain body weights or skin fold measurements. The current study aimed...
Thu Aug 27, 2020 21:34
A remarkable increase has occurred in the number of highly targeted drugs that have efficacy in patients with advanced cancers that harbor specific genomic alterations. Prime examples are the NTRK inhibitors that target NTRK fusions, which are found in only approximately 0.3% of cancers. As many as…
Thu Aug 27, 2020 03:00
The RET proto-oncogene encodes a transmembrane receptor tyrosine kinase that is constitutively activated through two distinct mechanisms: mutations involving the cysteine-rich or kinase domains, and structural rearrangements leading to the fusion of RET to a 5′ upstream partner. Collectively, these…
Thu Aug 27, 2020 03:00
The RET proto-oncogene encodes a transmembrane receptor tyrosine kinase that is involved in normal embryonic development. Fusions between sequences that encode the kinase domain containing the carboxy terminal region of RET and various upstream gene partners lead to abnormal expression and…
Thu Aug 27, 2020 03:00
Introduction SARS‐CoV‐2 has been identified as the pathogen causing the outbreak of Coronavirus Disease 2019(COVID‐19) commencing in Wuhan, China, in December 2019. Multiple reports have shown subjective loss of taste and smell as an early and hallmark symptom for COVID‐19. Method A retrospective study was performed in our clinical practice during July 2020 on patients positive for SARS‐CoV‐2 via PCR. All patients were categorized into 3 groups (supertasters, tasters, & nontasters) via...
Thu Aug 27, 2020 20:55
Abstract Working memory is a foundational construct of cognitive psychology, where it is thought to be a capacity that enables us to keep information in mind and to use that information to support goal directed behavior. Philosophers have recently employed working memory to explain central cognitive processes, from consciousness to reasoning. In this paper, I show that working memory cannot meet even a minimal account of natural kindhood, as the functions of maintenance and manipulation...
Fri Aug 28, 2020 03:00
Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is esse...
Thu Aug 27, 2020 03:00
Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact...
Thu Aug 27, 2020 03:00
Background: The jaw-opening exercise (JOE) is designed to strengthen the suprahyoid muscles. However, it is difficult to apply this strength-training exercise to subjects in a systematic fashion. Objective: This study examined the effect of resistive JOE on suprahyoid muscle activity and tongue strength in the elderly through the use of an elastic band. Methods: Eight elderly people aged ≥65 years participated in this study. Participants wore an elastic loop around their head and mandible. The strength...
Fri Aug 28, 2020 07:50
The 40-something father and husband had fallen down the stairs 2 weeks earlier and was reporting chest pain and difficulty breathing. He’d already sought care at two other facilities. An x-ray obtained during his first visit was negative for rib fractures, and he was sent home with no pain…
Tue Aug 18, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου