Related Articles NCLX prevents cell death during adrenergic activation of the brown adipose tissue. Nat Commun. 2020 07 03;11(1):3347 Authors: Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS Abstract A sharp increase in mitochondrial Ca2+ marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca2+ deleterious effects are poorly...
Sat Aug 29, 2020 16:05
Related Articles Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial. Br J Dermatol. 2019 07;181(1):175-185 Authors: Leskur D, Bukić J, Petrić A, Zekan L, Rušić D, Šešelja Perišin A, Petrić I, Stipić M, Puizina-Ivić N, Modun D Abstract BACKGROUND: Sodium lauryl sulfate (SLS)-induced contact dermatitis is a commonly used model for testing the effects of different topical formulations. According...
Sat Aug 29, 2020 16:05
Related Articles Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cell Mol Immunol. 2019 10;16(10):783-790 Authors: Wang HC, Wong TH, Wang LT, Su HH, Yu HY, Wu AH, Lin YC, Chen HL, Suen JL, Hsu SH, Chen LC, Zhou Y, Huang SK Abstract Aryl hydrocarbon receptor (AhR), a cellular chemical sensor, controls cellular homeostasis, and sphingosine-1-phosphate...
Sat Aug 29, 2020 16:05
Related Articles Association between autophagy and rapid eye movement sleep loss-associated neurodegenerative and patho-physio-behavioral changes. Sleep Med. 2019 11;63:29-37 Authors: Chauhan AK, Mallick BN Abstract Rapid eye movement (REM) sleep is a unique physiological process at least expressed in mammals. Its disturbance affects many psycho-somato-physiological processes including cardio-vascular-respiratory systems, brain excitability,...
Fri Aug 28, 2020 16:09
Related Articles Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Rep. 2019 07 16;28(3):792-803.e4 Authors: Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP, Liu J Abstract Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell...
Fri Aug 28, 2020 16:09
Abstract Aging is associated with declines in cognitive performance, which are mediated in part by neuroinflammation, characterized by astrocyte activation and higher levels of pro-inflammatory cytokines; however, the upstream drivers are unknown. We investigated the potential role of the gut microbiome–derived metabolite trimethylamine N-oxide (TMAO) in modulating neuroinflammation and cognitive function with aging. Study 1: In middle-aged and older humans (65 ± 7 years), plasma...
Sat Aug 29, 2020 03:00
Related Articles Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs. Comput Biol Chem. 2020 Aug 22;88:107366 Authors: Pasquier C, Robichon A Abstract Perfect annealing between microRNAs (miRNAs) and messenger RNAs (mRNAs) was computationally searched at a broad scale in the human genome to determine whether theoretical pairing...
Sun Aug 30, 2020 23:07
Related Articles Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Nat Commun. 2020 Aug 28;11(1):4343 Authors: Park DR, Kim J, Kim GM, Lee H, Kim M, Hwang D, Lee H, Kim HS, Kim W, Park MC, Shim H, Lee SY Abstract Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying...
Sun Aug 30, 2020 23:07
Related Articles Ferric Uptake Regulator Fur Coordinates Siderophore Production, Defense against Iron Toxicity and Oxidative Stress, and Contributes to Virulence in Chromobacterium violaceum. Appl Environ Microbiol. 2020 Aug 28;: Authors: de Souza Santos RER, Batista BB, da Silva Neto JF Abstract Iron is a highly reactive metal that participates in several processes in prokaryotic and eukaryotic cells. Hosts and pathogens compete for iron in...
Sun Aug 30, 2020 23:07
Related Articles Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer. J Exp Clin Cancer Res. 2020 Aug 28;39(1):172 Authors: Li X, Zhang C, Zhao T, Su Z, Li M, Hu J, Wen J, Shen J, Wang C, Pan J, Mu X, Ling T, Li Y, Wen H, Zhang X, You Q Abstract BACKGROUND: Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its...
Sun Aug 30, 2020 23:07
Related Articles Ameliorated Autoimmune Arthritis and Impaired B Cell Receptor-Mediated Ca2+ Influx in Nkx2-3 Knock-out Mice. Int J Mol Sci. 2020 Aug 26;21(17): Authors: Khanfar E, Olasz K, Gábris F, Gajdócsi E, Botz B, Kiss T, Kugyelka R, Berki T, Balogh P, Boldizsár F Abstract B cells play a crucial role in the pathogenesis of rheumatoid arthritis. In Nkx2-3-deficient mice (Nkx2-3-/-) the spleen's histological structure is fundamentally changed;...
Sun Aug 30, 2020 23:07
Related Articles ATM Protein Kinase: Old and New Implications in Neuronal Pathways and Brain Circuitry. Cells. 2020 Aug 26;9(9): Authors: Pizzamiglio L, Focchi E, Antonucci F Abstract Despite that the human autosomal recessive disease ataxia telangiectasia (A-T) is a rare pathology, interest in the function of ataxia-telangiectasia mutated protein (ATM) is extensive. From a clinical point of view, the role of ATM in the central nervous system...
Sun Aug 30, 2020 23:07
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/08/29PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 29, 2020 14:35
64 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/08/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Aug 28, 2020 18:19
Related Articles Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats. EBioMedicine. 2020 Aug 26;59:102968 Authors: O'Connor KM, Lucking EF, Bastiaanssen TFS, Peterson VL, Crispie F, Cotter PD, Clarke G, Cryan JF, O'Halloran KD Abstract BACKGROUND: Evidence is accruing to suggest that microbiota-gut-brain...
Sun Aug 30, 2020 23:09
Related Articles Short-term effects of dietary bovine milk on fatty acid composition of human milk: A preliminary multi-analytical study. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 May 28;1154:122189 Authors: Cutignano A, Siano F, Romano R, Aiello A, Pizzolongo F, Berni Canani R, Paparo L, Nocerino R, Di Scala C, Addeo F, Picariello G Abstract The fatty acid (FA) composition of human milk (HM) from N = 9 Italian healthy donors following...
Sun Aug 30, 2020 23:09
Related Articles A multidisciplinary weight loss intervention in obese adolescents with and without sleep-disordered breathing improves cardiometabolic health, whether SDB was normalized or not. Sleep Med. 2020 Jun 30;75:225-235 Authors: Roche J, Corgosinho FC, Isacco L, Scheuermaier K, Pereira B, Gillet V, Moreira GA, Pradella-Hallinan M, Tufik S, de Mello MT, Mougin F, Dâmaso AR, Thivel D Abstract OBJECTIVES: Pediatric obesity and sleep-disordered...
Sun Aug 30, 2020 23:09
Related Articles Targeted Gene Expression Analysis of Human Deep Veins. J Vasc Surg Venous Lymphat Disord. 2020 Aug 26;: Authors: Shaydakov ME, Diaz JA, Comerota AJ, Lurie F Abstract OBJECTIVE: Endothelial-derived molecules involved in thrombosis and hemostasis have been investigated mainly in arteries and in experimental animals. The actual presence and integral function of these molecules in the human deep venous system have received less...
Sun Aug 30, 2020 23:09
Related Articles Long-term effects of maternal cannabis vapor exposure on emotional reactivity, social behavior, and behavioral flexibility in offspring. Neuropharmacology. 2020 Aug 26;:108288 Authors: Weimar HV, Wright HR, Warrick CR, Brown AM, Lugo JM, Freels TG, McLaughlin RJ Abstract The use of cannabis during pregnancy is a growing public health concern. As more countries implement legislation permitting recreational cannabis use, there...
Sun Aug 30, 2020 23:09
Related Articles Gene therapy: An updated overview on the promising success stories. Malays J Pathol. 2020 Aug;42(2):171-185 Authors: Rashid RA, Ankathil R Abstract Gene therapy is a method of treatment of disease aimed at its molecular level. The progress of gene therapy, however, was as promising as it was tardy mainly due to the limitations in the resources and financial part of its development as well as owing to the rarity of most diseases...
Sun Aug 30, 2020 23:09
Related Articles Genetics meets proteomics: perspectives for large population-based studies. Nat Rev Genet. 2020 Aug 28;: Authors: Suhre K, McCarthy MI, Schwenk JM Abstract Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the complex processes influencing human biology. Proteins represent intermediate phenotypes for disease and provide insight into how genetic and non-genetic risk factors are mechanistically...
Sun Aug 30, 2020 23:09
Related Articles Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å. Nat Commun. 2020 Aug 28;11(1):4331 Authors: Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL Abstract Gap junctions establish direct pathways for cells to transfer metabolic and electrical messages. The local lipid environment is known to affect the structure, stability and intercellular channel activity of...
Sun Aug 30, 2020 23:09
Related Articles Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells. Chin J Physiol. 2020 Jul-Aug;63(4):179-186 Authors: Lin YY, Sun D, Wu YL Abstract PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) remain mostly unclear. PKC activator phorbol 12-myristate 13-acetate...
Sun Aug 30, 2020 23:09
Related Articles Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Viola HM, Shah AA, Johnstone VPA, Cserne Szappanos H, Hodson MP, Hool LC Abstract Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin...
Sun Aug 30, 2020 23:09
Related Articles Investigation of pituitary adenylate cyclase activating polypeptide (PACAP) in human amniotic fluid samples. Reprod Biol. 2020 Aug 25;: Authors: Toth D, Veszpremi B, Koppan M, Tamas A, Szogyi D, Brubel R, Nemeth J, Shams M, Reglodi D Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide acting as a hormone, a neuromodulator, a neurotransmitter, a trophic factor and is involved in a variety of...
Sun Aug 30, 2020 23:09
Related Articles Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan. Auris Nasus Larynx. 2020 Aug 25;: Authors: Kato K, Ikeda R, Suzuki J, Hirano-Kawamoto A, Kamakura Y, Fujiu-Kurachi M, Hyodo M, Izumi SI, Koyama S, Sasaki K, Nakajima J, Karaho T, Kimura Y, Kumai Y, Fujimoto Y, Nito T, Oku Y, Kurosawa H, Kuriyama S, Katori Y Abstract OBJECTIVE: Current interventions of dysphagia are not generalizable,...
Sun Aug 30, 2020 23:09
Related Articles Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure. J Clin Med. 2020 Aug 26;9(9): Authors: Tharp C, Mestroni L, Taylor M Abstract Titin is the largest human protein and an essential component of the cardiac sarcomere. With multiple immunoglobulin(Ig)-like domains that serve as molecular springs, titin contributes significantly to the passive...
Sun Aug 30, 2020 23:09
Related Articles Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson's Disease. Cells. 2020 Aug 26;9(9): Authors: Xicoy H, Brouwers JF, Wieringa B, Martens GJM Abstract Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons from the substantia nigra (SN) that project to the dorsal striatum (caudate-putamen). To better understand the molecular mechanisms underlying PD, we...
Sun Aug 30, 2020 23:09
184 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/08/29PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 29, 2020 16:33
217 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/08/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Aug 28, 2020 16:43
1043 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/30PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Aug 30, 2020 22:20
3148 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/29PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 29, 2020 14:37
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου