IJMS, Vol. 21, Pages 6277: The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations International Journal of Molecular Sciences doi: 10.3390/ijms21176277 Authors: João Alexandre Rui Malheiro Diana Dias da Silva Helena Carmo Félix Carvalho João Pedro Silva Recreational use of synthetic cannabinoids (SCs) before and during pregnancy poses a major public health risk, due to the...
Sun Aug 30, 2020 03:00
IJMS, Vol. 21, Pages 6278: The Cruciality of Single Amino Acid Replacement for the Spectral Tuning of Biliverdin-Binding Cyanobacteriochromes International Journal of Molecular Sciences doi: 10.3390/ijms21176278 Authors: Fushimi Hoshino Shinozaki-Narikawa Kuwasaki Miyake Nakajima Sato Kano Narikawa Cyanobacteriochromes (CBCRs), which are known as linear tetrapyrrole-binding photoreceptors, to date can only be detected from cyanobacteria. They can perceive...
Sun Aug 30, 2020 03:00
IJMS, Vol. 21, Pages 6276: Indirect Photodegradation of Sulfamethoxazole and Trimethoprim by Hydroxyl Radicals in Aquatic Environment: Mechanisms, Transformation Products and Eco-Toxicity Evaluation International Journal of Molecular Sciences doi: 10.3390/ijms21176276 Authors: Jiaoxue Yang Guochun Lv Chenxi Zhang Zehua Wang Xiaomin Sun The bacteriostatic antibiotics, sulfamethoxazole (SMX) and trimethoprim (TMP), have frequently been found in wastewater and surface water,...
Sun Aug 30, 2020 03:00
IJMS, Vol. 21, Pages 6275: Pathophysiology of Type 2 Diabetes Mellitus International Journal of Molecular Sciences doi: 10.3390/ijms21176275 Authors: Unai Galicia-Garcia Asier Benito-Vicente Shifa Jebari Asier Larrea-Sebal Haziq Siddiqi Kepa B. Uribe Helena Ostolaza César Martín Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells...
Sun Aug 30, 2020 03:00
IJMS, Vol. 21, Pages 6274: Proteomics and Metabolomics Approaches towards a Functional Insight onto AUTISM Spectrum Disorders: Phenotype Stratification and Biomarker Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21176274 Authors: Maria Vittoria Ristori Stefano Levi Mortera Valeria Marzano Silvia Guerrera Pamela Vernocchi Gianluca Ianiro Simone Gardini Giuliano Torre Giovanni Valeri Stefano Vicari Antonio Gasbarrini Lorenza Putignani...
Sun Aug 30, 2020 03:00
IJMS, Vol. 21, Pages 6273: Tomographic Task-Related Functional Near-Infrared Spectroscopy in Acute Sport-Related Concussion: An Observational Case Study International Journal of Molecular Sciences doi: 10.3390/ijms21176273 Authors: Forcione Chiarelli Perpetuini Davies O’Halloran Hacker Merla Belli Making decisions regarding return-to-play after sport-related concussion (SRC) based on resolution of symptoms alone can expose contact-sport athletes to further...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6272: Tetrapeptide Ac-HAEE-NH2 Protects α4β2 nAChR from Inhibition by Aβ International Journal of Molecular Sciences doi: 10.3390/ijms21176272 Authors: Evgeny P. Barykin Aleksandra I. Garifulina Anna P. Tolstova Anastasia A. Anashkina Alexei A. Adzhubei Yuri V. Mezentsev Irina V. Shelukhina Sergey A. Kozin Victor I. Tsetlin Alexander A. Makarov The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6265: Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies International Journal of Molecular Sciences doi: 10.3390/ijms21176265 Authors: Singh Jamshidi Zomer Piva Mantri Prostate cancer is a major cause of death among men worldwide. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation, as well as potential anti-cancer agents. The aim of this review was to evaluate the effect...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6270: Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models International Journal of Molecular Sciences doi: 10.3390/ijms21176270 Authors: Tibor Krenacs Nora Meggyeshazi Gertrud Forika Eva Kiss Peter Hamar Tamas Szekely Tamas Vancsik The benefits of high-fever range hyperthermia have been utilized in medicine from the Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia, induced by...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6267: Ionic Liquids Toxicity—Benefits and Threats International Journal of Molecular Sciences doi: 10.3390/ijms21176267 Authors: Jolanta Flieger Michał Flieger Ionic liquids (ILs) are solvents with salt structures. Typically, they contain organic cations (ammonium, imidazolium, pyridinium, piperidinium or pyrrolidinium), and halogen, fluorinated or organic anions. While ILs are considered to be environmentally-friendly compounds, only a few reasons support this...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6271: Moving towards Personalized Medicine in Muscle-Invasive Bladder Cancer: Where Are We Now and Where Are We Going? International Journal of Molecular Sciences doi: 10.3390/ijms21176271 Authors: Juan Carlos Pardo Vicenç Ruiz de Porras Andrea Plaja Cristina Carrato Olatz Etxaniz Oscar Buisan Albert Font Neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is the recommended treatment, with the highest level of evidence, for...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6268: Polar Infection of Echovirus-30 Causes Differential Barrier Affection and Gene Regulation at the Blood–Cerebrospinal Fluid Barrier International Journal of Molecular Sciences doi: 10.3390/ijms21176268 Authors: Marie Wiatr Ricardo Figueiredo Carolin Stump-Guthier Peter Winter Hiroshi Ishikawa Ortwin Adams Christian Schwerk Horst Schroten Henriette Rudolph Tobias Tenenbaum Echovirus-30 (E-30) is responsible for the extensive global...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6269: Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1 International Journal of Molecular Sciences doi: 10.3390/ijms21176269 Authors: Alee Choi Sang Eon Park Jang Bin Jeong Suk-joo Choi Soo-young Oh Gyu Ha Ryu Jeehun Lee Hong Bae Jeon Jong Wook Chang Extracellular matrix (ECM) components play an important role in maintaining skeletal muscle function, but excessive...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6266: Immunomodulation and Generation of Tolerogenic Dendritic Cells by Probiotic Bacteria in Patients with Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176266 Authors: Shaghayegh Baradaran Ghavami Abbas Yadegar Hamid Asadzadeh Aghdaei Dario Sorrentino Maryam Farmani Adil Shamim Mir Masoumeh Azimirad Hedieh Balaii Shabnam Shahrokh Mohammad Reza Zali In inflammatory bowel diseases (IBD), the therapeutic...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6264: Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema International Journal of Molecular Sciences doi: 10.3390/ijms21176264 Authors: Michelini Chiurazzi Marino Dell’Orco Manara Baglivo Fiorentino Maltese Pinelli Herbst Dautaj Bertelli Lipedema is an often underdiagnosed chronic disorder that affects subcutaneous adipose tissue almost exclusively in women, which...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6261: Chronic Restraint Stress Inhibits the Response to a Second Hit in Adult Male Rats: A Role for BDNF Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21176261 Authors: Brivio Sbrini Corsini Paladini Racagni Molteni Calabrese Depression is a recurrent disorder, with about 50% of patients experiencing relapse. Exposure to stressful events may have an adverse impact on the long-term course of the disorder and may alter...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6263: Noninvasive Testing for Diagnosis of Stable Coronary Artery Disease in the Elderly International Journal of Molecular Sciences doi: 10.3390/ijms21176263 Authors: Sergey G. Kozlov Olga V. Chernova Elena V. Gerasimova Ekaterina A. Ivanova Alexander N. Orekhov Efficient diagnostic approaches to detect coronary artery disease (CAD) in elderly patients are necessary to ensure optimal and timely treatment. The population of suspected CAD patients older...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6262: Neuroprotection of Retinal Ganglion Cells with AAV2-BDNF Pretreatment Restoring Normal TrkB Receptor Protein Levels in Glaucoma International Journal of Molecular Sciences doi: 10.3390/ijms21176262 Authors: Anna Wójcik-Gryciuk Olga Gajewska-Woźniak Katarzyna Kordecka Paweł M. Boguszewski Wioletta Waleszczyk Małgorzata Skup Intravitreal delivery of brain-derived neurotrophic factor (BDNF) by injection of recombinant protein or by gene therapy...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6259: Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43 International Journal of Molecular Sciences doi: 10.3390/ijms21176259 Authors: Vivoli-Vega Guri Chiti Bemporad TAR DNA-binding protein 43 (TDP-43) is a 414-residue long nuclear protein whose deposition into intraneuronal insoluble inclusions has been associated with the onset of amyotrophic lateral sclerosis (ALS) and other diseases. This protein is...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6258: Exhaustive Search of the Receptor Ligands by the CyCLOPS (Cytometry Cell-Labeling Operable Phage Screening) Technique International Journal of Molecular Sciences doi: 10.3390/ijms21176258 Authors: Irina A. Ishina Ioanna N. Filimonova Maria Y. Zakharova Leyla A. Ovchinnikova Azad E. Mamedov Yakov A. Lomakin Alexey A. Belogurov Effective and versatile screening of the peptide ligands capable of selectively binding to diverse receptors is in...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6260: Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases International Journal of Molecular Sciences doi: 10.3390/ijms21176260 Authors: Vivek Keshri Eric Chabrière Lucile Pinault Philippe Colson Seydina M Diene Jean-Marc Rolain Didier Raoult Pierre Pontarotti The probability of the evolution of a character depends on two factors: the probability of moving from one character state to another...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6256: Two-Player Game in a Complex Landscape: 26S Proteasome, PKA, and Intracellular Calcium Concentration Modulate Mammalian Sperm Capacitation by Creating an Integrated Dialogue—A Computational Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21176256 Authors: Angela Taraschi Costanza Cimini Giulia Capacchietti Marina Ramal-Sanchez Luca Valbonetti Juliana Machado-Simoes Fadl Moussa Israiel Tagaram Samia Mokh Mohamad Al...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6257: Measuring Extracellular Vesicles by Conventional Flow Cytometry: Dream or Reality? International Journal of Molecular Sciences doi: 10.3390/ijms21176257 Authors: Donatella Lucchetti Alessandra Battaglia Claudio Ricciardi-Tenore Filomena Colella Luigi Perelli Ruggero De Maria Giovanni Scambia Alessandro Sgambato Andrea Fattorossi Intense research is being conducted using flow cytometers available in clinically oriented laboratories to...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6254: Intratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers International Journal of Molecular Sciences doi: 10.3390/ijms21176254 Authors: Carolin Kubelt Sönke Peters Hajrullah Ahmeti Monika Huhndorf Lukas Huber Gesa Cohrs Jan-Bernd Hövener Olav Jansen Michael Synowitz Janka Held-Feindt (1) Background: Metabolic reprogramming...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6253: Neutralization of Lipocalin-2 Diminishes Stroke-Reperfusion Injury International Journal of Molecular Sciences doi: 10.3390/ijms21176253 Authors: Guona Wang Yi-Chinn Weng I-Chen Chiang Yu-Ting Huang Yi-Chu Liao Yi-Chun Chen Cheng-Yuan Kao Yu-Li Liu Tsong-Hai Lee Wen-Hai Chou Oxidative stress is a key contributor to the pathogenesis of stroke-reperfusion injury. Neuroinflammatory peptides released after ischemic stroke mediate reperfusion...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6255: Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics International Journal of Molecular Sciences doi: 10.3390/ijms21176255 Authors: Chase M. Walton Samuel M. Jacobsen Blake W. Dallon Erin R. Saito Shantelle L. H. Bennett Lance E. Davidson David M. Thomson Robert D. Hyldahl Benjamin T. Bikman Objective: The rampant growth of obesity worldwide has stimulated explosive research into human metabolism. Energy expenditure...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6252: Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping International Journal of Molecular Sciences doi: 10.3390/ijms21176252 Authors: Francesco Rusconi Tiziana Rubino Elena Battaglioli There is no argument with regard to the physical and psychological stress-related nature of neuropsychiatric disorders. Yet, the mechanisms that facilitate disease onset starting from molecular stress responses are elusive. Environmental stress challenges...
Sat Aug 29, 2020 03:00
IJMS, Vol. 21, Pages 6251: Insights on the Interplay between Cells Metabolism and Signaling: A Therapeutic Perspective in Pediatric Acute Leukemias International Journal of Molecular Sciences doi: 10.3390/ijms21176251 Authors: Laura Anselmi Salvatore Nicola Bertuccio Annalisa Lonetti Arcangelo Prete Riccardo Masetti Andrea Pession Nowadays, thanks to extensive studies and progress in precision medicine, pediatric leukemia has reached an extremely high overall survival...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6250: DoRWA3 from Dendrobium officinale Plays an Essential Role in Acetylation of Polysaccharides International Journal of Molecular Sciences doi: 10.3390/ijms21176250 Authors: Can Si Jaime A. Teixeira da Silva Chunmei He Zhenming Yu Conghui Zhao Haobin Wang Mingze Zhang Jun Duan The acetylation or deacetylation of polysaccharides can influence their physical properties and biological activities. One main constituent of the edible medicinal orchid,...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6248: Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics International Journal of Molecular Sciences doi: 10.3390/ijms21176248 Authors: Huang Dai Shen Gu Wang Liu Chen Sun Since the cell was discovered by humans, it has been an important research subject for researchers. The mechanical response of cells to external stimuli and the biomechanical response inside cells are of great significance...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6249: Proliferation and Cluster Analysis of Neurons and Glial Cell Organization on Nanocolumnar TiN Substrates International Journal of Molecular Sciences doi: 10.3390/ijms21176249 Authors: Abend Steele Schmidt Frank Jahnke Zink Biomaterials employed for neural stimulation, as well as brain/machine interfaces, offer great perspectives to combat neurodegenerative diseases, while application of lab-on-a-chip devices such as multielectrode arrays...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6246: Neurodegeneration, Myelin Loss and Glial Response in the Three-Vessel Global Ischemia Model in Rat International Journal of Molecular Sciences doi: 10.3390/ijms21176246 Authors: Tatiana Anan’ina Alena Kisel Marina Kudabaeva Galina Chernysheva Vera Smolyakova Konstantin Usov Elena Krutenkova Mark Plotnikov Marina Khodanovich (1) Background: Although myelin disruption is an integral part of ischemic brain injury, it is rarely the subject...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6245: Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection International Journal of Molecular Sciences doi: 10.3390/ijms21176245 Authors: Alan Diot Virginie Dyon-Tafani Marine Bergot Jason Tasse Patricia Martins-Simões Jérôme Josse Florent Valour Frédéric Laurent Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6247: Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21176247 Authors: Yongsheng Ruan Hye Na Kim Heather Ogana Yong-Mi Kim Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6244: Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression International Journal of Molecular Sciences doi: 10.3390/ijms21176244 Authors: Amira Mohammed Hasan F. K. F. K. Alghetaa Kathryn Miranda Kiesha Wilson Narendra P. P. Singh Guoshuai Cai Nagireddy Putluri Prakash Nagarkatti Mitzi Nagarkatti Acute Respiratory Distress...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6242: A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21176242 Authors: Alexandra Lucaciu Hannah Kuhn Sandra Trautmann Nerea Ferreirós Helmuth Steinmetz Josef Pfeilschifter Robert Brunkhorst Waltraud Pfeilschifter Julien Subburayalu Rajkumar Vutukuri Emerging evidence suggests a complex...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6243: Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms21176243 Authors: Yohei Tomita Deokho Lee Yukihiro Miwa Xiaoyan Jiang Masayuki Ohta Kazuo Tsubota Toshihide Kurihara Diabetic retinopathy (DR) is one of the leading causes of blindness globally. Retinal neuronal abnormalities occur in the early stage in DR. Therefore, maintaining retinal neuronal...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6232: Identifying the Pressure Points of Acute Cadmium Stress Prior to Acclimation in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21176232 Authors: Jana Deckers Sophie Hendrix Els Prinsen Jaco Vangronsveld Ann Cuypers The toxic metal cadmium (Cd) is a major soil pollutant. Knowledge on the acute Cd-induced stress response is required to better understand the triggers and sequence of events that precede plant acclimation....
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6240: CRISPR-Cas9 DNA Base-Editing and Prime-Editing International Journal of Molecular Sciences doi: 10.3390/ijms21176240 Authors: Ariel Kantor Michelle E. McClements Robert E. MacLaren Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA. Base-editing, the newest evolution of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based technologies, can directly install point-mutations in cellular DNA...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6239: Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion International Journal of Molecular Sciences doi: 10.3390/ijms21176239 Authors: Pedro Enrique Guerrero Laura Miró Bin S. Wong Anna Massaguer Neus Martínez-Bosch Rafael de Llorens Pilar Navarro Konstantinos Konstantopoulos Esther Llop Rosa Peracaula Aberrant sialylation is frequently found in pancreatic ductal adenocarcinoma...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6237: Role of Poly [ADP-ribose] Polymerase 1 in Activating the Kirsten ras (KRAS) Gene in Response to Oxidative Stress International Journal of Molecular Sciences doi: 10.3390/ijms21176237 Authors: Giorgio Cinque Annalisa Ferino Erik B. Pedersen Luigi E. Xodo In pancreatic Panc-1 cancer cells, an increase of oxidative stress enhances the level of 7,8-dihydro-8-oxoguanine (8OG) more in the KRAS promoter region containing G4 motifs than in non-G4 motif G-rich...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6238: uORFs: Important Cis-Regulatory Elements in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21176238 Authors: Ting Zhang Anqi Wu Yaping Yue Yu Zhao Gene expression is regulated at many levels, including mRNA transcription, translation, and post-translational modification. Compared with transcriptional regulation, mRNA translational control is a more critical step in gene expression and allows for more rapid changes of encoded protein...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6241: Induction of Adipose Tissue Browning as a Strategy to Combat Obesity International Journal of Molecular Sciences doi: 10.3390/ijms21176241 Authors: Alina Kuryłowicz Monika Puzianowska-Kuźnicka The ongoing obesity pandemic generates a constant need to develop new therapeutic strategies to restore the energy balance. Therefore, the concept of activating brown adipose tissue (BAT) in order to increase energy expenditure has been revived. In mammals, two developmentally...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6233: N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21176233 Authors: Hideyuki Hara Suehiro Sakaguchi The normal cellular isoform of prion protein, designated PrPC, is constitutively converted to the abnormally folded, amyloidogenic isoform, PrPSc, in prion diseases, which include Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals....
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6235: Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions International Journal of Molecular Sciences doi: 10.3390/ijms21176235 Authors: Tapan Behl Gagandeep Kaur Simona Bungau Rishabh Jhanji Arun Kumar Vineet Mehta Gokhan Zengin Roxana Brata Syed Shams ul Hassan Ovidiu Fratila Current pharmacotherapy of Parkinson’s disease (PD) is...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6236: The Role of the JC Virus in Central Nervous System Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21176236 Authors: Nicholas Ahye Anna Bellizzi Dana May Hassen S. Wollebo Cancer is the second leading cause of mortality worldwide. The study of DNA tumor-inducing viruses and their oncoproteins as a causative agent in cancer initiation and tumor progression has greatly enhanced our understanding of cancer cell biology. The...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6234: Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21176234 Authors: Patrycja Wińska Olena Karatsai Monika Staniszewska Mirosława Koronkiewicz Konrad Chojnacki Maria Jolanta Rędowicz Background: The combination effect of 5-fluorouracil (5-FU) with either...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6231: Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176231 Authors: Huaikai Shi Tsun-Ho Lo Duncan Ma Brenton Condor Brian Lesmana Roxanne J Parungao Kevin H.-Y. Tsai Sarah Kim Hsiao-Ting Chen Pablo A Silveira Zhe Li Mark S Cooper Ulla Simanainen David J Handelsman Peter K Maitz Yiwei Wang...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6230: Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse International Journal of Molecular Sciences doi: 10.3390/ijms21176230 Authors: Robert Root-Bernstein Beth Churchill Miah Turke Opioids and their antagonists alter vitamin C metabolism. Morphine binds to glutathione (l-γ-glutamyl-l-cysteinyl-glycine), an...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6227: The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes International Journal of Molecular Sciences doi: 10.3390/ijms21176227 Authors: Kamila Domińska Karolina Kowalska Kinga Anna Urbanek Dominika Ewa Habrowska-Górczyńska Tomasz Ochędalski Agnieszka Wanda Piastowska Ciesielska The local renin–angiotensin system (RAS) plays an important...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6229: Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family International Journal of Molecular Sciences doi: 10.3390/ijms21176229 Authors: Jinbong Park Seung Ho Baek Lung cancer is the largest cause of cancer-induced deaths. Non-small cell lung cancer (NSCLC) is the most frequently observed subtype of lung cancer....
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6228: Lipid Dynamics, Identification, and Expression Patterns of Fatty Acid Synthase Genes in an Endoparasitoid, Meteorus pulchricornis (Hymenoptera: Braconidae) International Journal of Molecular Sciences doi: 10.3390/ijms21176228 Authors: Jiao Wang Li-Wei Shen Xiao-Rong Xing Yu-Qi Xie Yi-Jiangcheng Li Zhi-Xiang Liu Jun Wang Fu-An Wu Sheng Sheng In insect parasitoids, fatty acid synthases (FASs) have received less attention and their roles...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6226: Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective International Journal of Molecular Sciences doi: 10.3390/ijms21176226 Authors: Barbora Smolková Adam Frtús Mariia Uzhytchak Mariia Lunova Šárka Kubinová Alexandr Dejneka Oleg Lunov The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication....
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6224: Bioinformatics Methods in Medical Genetics and Genomics International Journal of Molecular Sciences doi: 10.3390/ijms21176224 Authors: Yuriy L. Orlov Ancha V. Baranova Tatiana V. Tatarinova Medical genomics relies on next-gen sequencing methods to decipher underlying molecular mechanisms of gene expression. This special issue collects materials originally presented at the “Centenary of Human Population Genetics” Conference-2019, in...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6225: Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application International Journal of Molecular Sciences doi: 10.3390/ijms21176225 Authors: Kamila Białkowska Piotr Komorowski Maria Bryszewska Katarzyna Miłowska Cell cultures are very important for testing materials and drugs, and in the examination of cell biology and special cell mechanisms. The most popular models of cell culture are...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6223: Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21176223 Authors: Wolfgang Kreisel Denise Schaffner Adhara Lazaro Jonel Trebicka Irmgard Merfort Annette Schmitt-Graeff Peter Deibert Liver cirrhosis is a frequent condition with high impact on patients’ life expectancy and health care systems. Cirrhotic portal hypertension...
Fri Aug 28, 2020 03:00
IJMS, Vol. 21, Pages 6222: Enantiomerization of Axially Chiral Biphenyls: Polarizable MD Simulations in Water and Butylmethylether International Journal of Molecular Sciences doi: 10.3390/ijms21176222 Authors: Veronika Zeindlhofer Phillip Hudson Ádám Márk Pálvölgyi Matthias Welsch Mazin Almarashi H. Lee Woodcock Bernard Brooks Katharina Bica-Schröder Christian Schröder In this study, we investigate the influence of chiral and achiral cations on the enantiomerization...
Fri Aug 28, 2020 03:00
IJNS, Vol. 6, Pages 71: Update on the Swedish Newborn Screening for Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency International Journal of Neonatal Screening doi: 10.3390/ijns6030071 Authors: Rolf H. Zetterström Leif Karlsson Henrik Falhammar Svetlana Lajic Anna Nordenström Congenital adrenal hyperplasia (CAH) was the fourth disorder added to the national Swedish neonatal screening program in 1986, and approximately 115,000 newborns are screened annually....
Fri Aug 28, 2020 03:00
JCM, Vol. 9, Pages 2808: Evaluation of the Accero Stent for Stent-Assisted Coiling of Unruptured Wide-Necked Intracranial Aneurysm Treatment with Short-Term Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9092808 Authors: Wojciech Poncyljusz Kinga Kubiak Leszek Sagan Bartosz Limanówka Katarzyna Kołaczyk Background: Stent-assisted coiling is an effective method of treating intracranial aneurysms. The aim of the study was to assess the safety and efficacy of the new...
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