Object: In this report, we aimed to analyze the outcome results of our patients who underwent percutaneous trigeminal tractotomy (TR) and nucleotomy (NC) procedures, which are defined as destructive procedures targeting the descending trigeminal tractus and nucleus caudalis of the spinal trigeminal nucleus, respectively, for intractable craniofacial pain. Methods: The medical records of a total of 12 patients who underwent a total of 14 computed tomography (CT)-guided TR-NC procedures at our clinics...
Fri Aug 28, 2020 07:58
Publication date: Available online 30 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Emre Gökçen, Mehmet Hamamcı
Sun Aug 30, 2020 21:21
Publication date: Available online 30 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Keita Tominaga, Tomohiro Kawaguchi, Miki Fujimura, Atsushi Saito, Mika Watanabe, Teiji Tominaga
Sun Aug 30, 2020 21:21
Publication date: Available online 29 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Omid joodi khanghah, Alireza Nourazarian, Fatemeh Khaki‐Khatibi, Masoud Nikanfar, Delara Laghousi, Amir Mansour Vatankhah, Sepideh Moharami
Sun Aug 30, 2020 21:21
Publication date: Available online 28 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Jan-Helge Klingler, Florian Volz, Niklas Lützen, Ori Staszewski, Jürgen Beck
Sat Aug 29, 2020 14:51
Publication date: Available online 28 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Peicong Ge, Qian Zhang, Xun Ye, Xingju Liu, Xiaofeng Deng, Jia Wang, Rong Wang, Yan Zhang, Dong Zhang, Jizong Zhao
Sat Aug 29, 2020 14:51
Publication date: Available online 28 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Khodayar Goshtasbi, Mehdi Abouzari, Sina Soltanzadeh-Zarandi, Brooke Sarna, Ariel Lee, Frank P.K. Hsu, Hamid R. Djalilian
Sat Aug 29, 2020 14:51
Abstract Evidence suggests that the posterior cerebellum is involved in emotional processing. Specific mechanisms by which the cerebellum contributes to the perception of and reaction to the emotional state of others are not well‐known. It is likely that perceived emotions trigger anticipatory/preparatory motor changes. However, the extent to which the cerebellum modulates activity of the motor cortex to contribute to emotional processing has not been directly investigated. In this study, we assessed...
Fri Aug 28, 2020 16:35
Human sensorimotor control of dexterous manipulation relies on afferent sensory signals. Explicit tactile feedback is generally not available to prosthetic hand users, who have to rely on incidental informatio...
Fri Aug 28, 2020 03:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Aug 26, 2020 10:00
Related Articles Enhancing access to the suprasellar region: the transcallosal translamina terminalis approach. J Neurosurg Pediatr. 2020 Aug 28;:1-6 Authors: Aldave G Abstract Craniopharyngioma represents one of the most challenging brain tumors to treat. Surgery may be the definitive treatment, and multiple surgical approaches have been described, each based on different anatomical considerations. Some approaches require working through narrow...
Sat Aug 29, 2020 13:53
Related Articles Middle fossa approach for a pediatric facial nerve meningioma. J Neurosurg Pediatr. 2020 Aug 28;:1-5 Authors: Rennert RC, Levy DM, Plonsker J, Steinberg JA, Friedman RA, Crawford JR, Levy ML Abstract Pediatric cerebellopontine angle (CPA) meningiomas are extremely rare and are usually treated with a retrosigmoid surgical approach or radiation. The authors present the use of a middle fossa approach for the treatment of a symptomatic...
Sat Aug 29, 2020 13:53
Related Articles Infection of arachnoid cyst associated with vasospasm and stroke in a pediatric patient: case report. J Neurosurg Pediatr. 2020 Aug 28;:1-5 Authors: Gale JR, Nowicki KW, Wolfe RM, Sefcik RK, Abel TJ Abstract Arachnoid cysts are relatively common and benign intraarachnoid membrane outpouchings containing CSF-like fluid. The majority of arachnoid cysts remain stable and asymptomatic and do not require intervention in the pediatric...
Sat Aug 29, 2020 13:53
Related Articles Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage. J Neurosurg Pediatr. 2020 Aug 28;:1-11 Authors: Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA Abstract OBJECTIVE: Neonatal intraventricular hemorrhage (IVH) leads to posthemorrhagic hydrocephalus (PHH), brain injury, and long-term disability. Current therapy for IVH is based...
Sat Aug 29, 2020 13:53
Related Articles Aventricular hemispherotomy: technical note. J Neurosurg Pediatr. 2020 Aug 28;:1-6 Authors: Brimley C, Buch VP, Pisapia JM, Kennedy BC Abstract Hemispheric disconnection in the form of hemispherectomy or hemispherotomy is the most effective way of treating intractable hemispheric epilepsy. Anatomical hemispherectomy approaches have largely been abandoned in most cases due to a higher risk of superficial hemosiderosis, intraoperative...
Sat Aug 29, 2020 13:53
Publication date: Available online 30 August 2020Source: Brain Research BulletinAuthor(s): Mithun Singh Rajput, Nilesh Prakash Nirmal, Devashish Rathore, Rashmi Dahima
Sun Aug 30, 2020 15:06
Publication date: Available online 30 August 2020Source: Brain Research BulletinAuthor(s): Feng Tai, Che Wang, Xin Deng, Ruojin Li, Zimeng Guo, Haiying Quan, Song Li
Sun Aug 30, 2020 15:06
Publication date: Available online 29 August 2020Source: Brain Research BulletinAuthor(s): Zhezhe Sun, Ke Wu, Lei Gu, Lijie Huang, Qichuan Zhuge, Su Yang, Zhenzhong Wang
Sun Aug 30, 2020 15:06
Publication date: Available online 29 August 2020Source: Brain Research BulletinAuthor(s): Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shentu
Sun Aug 30, 2020 15:06
Publication date: Available online 28 August 2020Source: Brain Research BulletinAuthor(s): Nahanna Zimmermann Menezes de Carvalho, Gabriela Bortolança Chiarotto, Danielle Bernardes, Paula Regina Gelinski Kempe, Alexandre Leite Rodrigues de Oliveira
Sat Aug 29, 2020 19:59
Rationale: The International Atomic Energy Agency (IAEA) instituted a Coordinated Research Project (CRP) on the "Evaluation and Optimization of Pediatric Imaging" addressing the lack of consistency in this field. The purpose was to develop and test an optimization schema for the practices of pediatric radiology and nuclear medicine. Methods: A 5-step optimization schema was developed. Once a protocol optimization is identified, the steps are: 1) identification of the imaging situation, 2) collection...
Sat Aug 29, 2020 00:02
Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an immunosuppressive microenvironment and reduces the response to radiotherapy. In this prospective imaging trial, we investigated potential interactions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor for treatment response in HNSCC patients. Methods: 49 patients receiving definitive chemoradiation for locally advanced HNSCCs underwent pre-therapeutic biopsies and peri-therapeutic...
Sat Aug 29, 2020 00:02
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific membrane antigen (PSMA)-targeting radiotherapeutic agents. The aim of this study was to develop improved radiotherapeutic agents that combine an optimized linker and optimized albumin binders to maximize the tumor-to-kidney absorbed dose ratio. Methods: 68Ga-labeled DOTA-conjugated lysine-ureido-glutamate-based PSMA-targeting agents bearing various linkers or albumin binders were synthesized, and evaluated...
Sat Aug 29, 2020 00:02
Molecular Imaging (MI) yields important insights into relevant biological signatures at an organ-specific and systemic level, which is not achievable with conventional imaging methods and thus provides an essential link between preclinical and clinical research. In this context, new diagnostic probes and imaging methods, revealing comprehensive functional and molecular information, are being provided by MI research, several of which have found their way into clinical application. However, there are...
Sat Aug 29, 2020 00:02
Background: Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SSTR) analogs is a common therapy approach in advanced neuroendocrine neoplasms (NEN). Recently, SSTR antagonists have shown promising results for imaging and therapy due to a higher number of binding sites compared with commonly used agonists. We evaluated PRRT with SSTR agonist 177Lu-DOTATOC and antagonist 177Lu-DOTA-JR11 longitudinally in an orthotopic murine pancreatic NEN model expressing human...
Sat Aug 29, 2020 00:02
The aims were to decrease 177Lu-SPECT (single-photon emission computed tomography) acquisition time by reducing the number of projections and to circumvent image degradation by adding deep learning–generated synthesized projections. Methods: We constructed a deep convolutional U-structured network for generating synthetic intermediate projections (CUSIP). The number of SPECT investigations was 352 for training, 37 for validation, and 15 for testing. The input was every fourth projection of 120...
Sat Aug 29, 2020 00:02
Background: Somatostatin receptor (SSTR)-targeted peptide receptor radionuclide therapy (PRRT) represents a promising approach for treatment-refractory meningiomas. Methods: We performed an individual patient data (IPD) meta-analysis including all published meningioma patients treated with SSTR-targeted PRRT. Main outcomes were toxicity, response to treatment, progression-free survival (PFS), and overall survival (OS). We applied the Kaplan-Meier method to estimate survival probabilities and...
Sat Aug 29, 2020 00:02
The use of synaptic vesicle protein 2A (SV2A) radiotracers with positron emission tomography (PET) imaging could provide a way to measure synaptic density quantitatively in living humans. 11C-UCB-J, previously developed and assessed in nonhuman primates and humans, showed excellent kinetic properties as a PET radioligand. However, it is labeled with the short half-life isotope 11C. We developed a new tracer, an 18F-labeled difluoro-analog of UCB-J (18F-SynVesT-1, a.k.a. 18F-SDM-8), which displayed...
Sat Aug 29, 2020 00:02
Objectives: This is a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype 1 (M1). The objectives of this study were to determine the appropriate kinetic model to quantify the tracer's binding to M1 receptors, and the reliability of the chosen quantification method. Methods: Six healthy subjects completed the test-retest protocol and five healthy subjects completed the baseline-scopolamine blocking protocol. Multiple modeling methods were...
Sat Aug 29, 2020 00:02
Activating mutations in the estrogen receptor (ER) alpha gene (ESR1) result in constitutive transcriptional activity in the absence of estrogen and is associated with endocrine resistance in metastatic ER+ breast cancer. It is not known how activating ESR1 mutations may alter the predictive values of molecular imaging agents for endocrine therapy response. This study investigated the effect of an activating ESR1 mutation on pre-treatment 18F-fluoroestradiol (18F-FES) uptake and early assessment of...
Sat Aug 29, 2020 00:02
Objectives: Recently, a standardized framework system for interpreting somatostatin receptor (SSTR)-targeted PET/CTs, termed SSTR-Reporting and Data System (RADS) 1.0, has been introduced providing reliable standards and criteria for SSTR-targeted imaging. We determined the interobserver reliability of SSTR-RADS for interpretation of 68Ga-DOTATOC PET/CT scans in a multicentric, randomized setting. Methods: A set of 51 randomized 68Ga-DOTATOC PET/CT scans was independently assessed by four blinded...
Sat Aug 29, 2020 00:02
Rationale: Pheochromocytomas and paragangliomas are a rare tumor entity originating from adreno-medullary chromaffin cells in the adrenal medulla or in sympathetic, paravertebral ganglia outside the medulla. Especially small lesions are difficult to detect by conventional CT or MR imaging and even by SPECT imaging with currently available radiotracers (e.g. MIBG). The novel PET-radiotracer F-18-flubrobenguane could change the diagnostic paradigm in suspected pheochromocytomas and paragangliomas due...
Sat Aug 29, 2020 00:02
Rationale: Myocardial infarction (MI) is one of the leading causes of death worldwide and inflammation is central to the tissue response and patient outcomes. The 18kDa translocator protein (TSPO) has been utilized in positron emission tomography (PET) as an inflammatory biomarker. The aims of this study were to: 1) screen novel, fluorinated, TSPO radiotracers for susceptibility to the rs6971 genetic polymorphism using in vitro competition binding assays in human brain and heart, 2) assess whether...
Sat Aug 29, 2020 00:02
Previous histopathological and animal studies have shown axonal impairment and loss of connectivity of the nigrostriatal pathway in Parkinson disease (PD). However, there are conflicting reports from in vivo human studies. 11C-dihydrotetrabenazine (11C-DTBZ) is a vesicular monoamine type 2 transporter PET ligand that allows assessment of nigrostriatal presynaptic dopaminergic terminal integrity. Correlational tractography based on diffusion magnetic resonance imaging can incorporate ligand-specific...
Sat Aug 29, 2020 00:02
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Regin Jay Mallari, Jai Deep Thakur, Chester Griffiths, Howard Krauss, Amy Eisenberg, Garni Barkhoudarian, Daniel F. Kelly
Fri Aug 28, 2020 21:27
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Toshihide Tanaka, Michiyasu Fuga, Akihiko Teshigawara, Yuzuru Hasegawa, Kaichi Nishiwaki, Yuichi Murayama, Hideaki Yokoo
Fri Aug 28, 2020 21:27
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Masato Tanaka, Yoshihiro Fujiwara, Koji Uotani, Praful Maste, Taro Yamauchi
Fri Aug 28, 2020 21:27
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Giovanni Grasso, Sunil Munakomi, Marcello Sallì
Fri Aug 28, 2020 21:27
Publication date: Available online 27 August 2020Source: World NeurosurgeryAuthor(s): Gilbert Dechambenoit
Fri Aug 28, 2020 21:27
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