Related Articles Oral pigmented lesions: a retrospective analysis from Brazil. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Albuquerque DM, Cunha JL, Roza AL, Arboleda LP, Silva AR, Lopes MA, Vargas PA, Jorge J, Almeida OP, Abrahão AC, Agostini M, Romañach MJ Abstract BACKGROUND: Pigmented lesions are uncommon in the oral mucosa, and studies investigating the incidence and types of these lesions are desired to improve the diagnostic...
Sat Aug 29, 2020 16:04
Related Articles Clinical presentation of burning mouth syndrome in patients with oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Alberdi-Navarro J, Aguirre-Urizar JM, Ginestal-Gómez E Abstract BACKGROUND: To analyze the presence of burning mouth syndrome (BMS) in a group of patients diagnosed with oral lichenoid disease (OLD). MATERIAL AND METHODS: A retrospective study of 217 patients diagnosed with OLD;...
Fri Aug 28, 2020 16:24
Related Articles Tumors of the labial mucosa: a retrospective study of 1045 biopsies. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Kalogirou EM, Balta MG, Koufatzidou M, Tosiou A, Tosios KI, Nikitakis NG Abstract BACKGROUND: To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and...
Fri Aug 28, 2020 16:24
Related Articles Challenging management of gingival squamous cell carcinoma: a 10 years single-center retrospective study on Northern-Italian patients. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Arduino PG, Carbone M, Gambino A, Cabras M, Cannarsa F, Macciotta A, Conrotto D, Broccoletti R Abstract BACKGROUND: Aim of this study was to describe the outcome of patients with gingival squamous cell carcinoma (GSCC), and to recognize aspects...
Fri Aug 28, 2020 16:24
Related Articles Intraoral soft tissue lipomas: clinicopathological features from 91 cases diagnosed in a single Oral Pathology service. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Pires FR, Souza L, Arruda R, Cantisano MH, Picciani BL, Dos Santos TC Abstract BACKGROUND: intraoral soft tissue lipomas are relatively uncommon mesenchymal neoplasms. Few papers have been published comparing the clinicopathological features of these tumors...
Fri Aug 28, 2020 16:24
Related Articles Immediate post-extraction implants placed in acute periapical infected sites with immediate prosthetic provisionalization: a 1-year prospective cohort study. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Muñoz-Cámara D, Gilbel-Del Águila O, Pardo-Zamora G, Camacho-Alonso F Abstract BACKGROUND: Few studies have reported the outcomes of immediate placement at infected post-extraction sites. The aim of this study was to...
Fri Aug 28, 2020 16:24
Related Articles Study on the association between sleep disorders versus oral health related variables. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Pereira D, Progiante P, Pattussi M, Grossi P, Grossi M Abstract BACKGROUND: To study the association between sleep quality and oral health related variables, which still have conflicts in the literature. MATERIAL AND METHODS: This was a population-based case-control study between...
Fri Aug 28, 2020 16:24
Related Articles Improving accuracy of the intermediate splint in substantial intermaxillary sagittal discrepancies using an extra anterior anchorage point: technical note. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Hernández-Alfaro F, Rosemberg V, Masià-Gridilla J, Valls-Ontañón A Abstract BACKGROUND: To describe a technical feature that increases the stability of the intermediate splint in patients where bimaxillary surgery with...
Fri Aug 28, 2020 16:24
Related Articles Analysis of bacterial communities of infected primary teeth in a Mexican population. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Salas-López EK, Casas-Flores S, López-Lozano NE, Layseca-Espinosa E, García-Sepúlveda CA, Niño-Moreno PD, Pozos-Guillén A Abstract BACKGROUND: The objective of this study was to describe the bacterial communities associated with pediatric patients with endodontic infections of temporal teeth...
Fri Aug 28, 2020 16:24
Related Articles Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year's experience. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Delbet-Dupas C, Devoize L, Mulliez A, Barthélémy I, Dang NP Abstract BACKGROUND: Numerous biochemical datas support the noxious role of anti-inflammatory drugs on immune response. Those observations are often put forward for unfavorable evolution of odontogenic infection...
Fri Aug 28, 2020 16:24
Related Articles Prevalence of endodontic infection in patients with Crohn´s disease and ulcerative colitis. Med Oral Patol Oral Cir Bucal. 2020 Aug 27;: Authors: Poyato-Borrego M, Segura-Egea JJ, Martín-González J, Jiménez-Sánchez MC, Cabanillas-Balsera D, Areal-Quecuty V, Segura-Sampedro JJ Abstract BACKGROUND: Previous studies have linked apical periodontitis (AP) to inflammatory bowel disease (IBD). The aim of this study was to compare the...
Fri Aug 28, 2020 16:24
Related Articles Shorter Interval between Onset and Admission to Convalescent Rehabilitation Wards Is Associated with Improved Outcomes in Ischemic Stroke Patients. Tohoku J Exp Med. 2020;252(1):15-22 Authors: Yoshimura Y, Wakabayashi H, Momosaki R, Nagano F, Shimazu S, Shiraishi A Abstract As Japan's population ages, there is a growing interest in regional health care coordination. Our study aimed to evaluate whether the interval between onset...
Fri Aug 28, 2020 15:12
Related Articles Study of the Portal Branches Arising from the Cranial Part of the Umbilical Portion of the Left Portal Vein: Implications for Anatomic Right Hepatic Trisectionectomy. World J Surg. 2020 Aug 28;: Authors: Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M Abstract BACKGROUND: In "anatomic" right hepatic trisectionectomy for advanced perihilar cholangiocarcinoma, the left hepatic duct is...
Sun Aug 30, 2020 13:55
Related Articles Early Prediction of Post-hepatectomy Liver Failure in Patients Undergoing Major Hepatectomy Using a PHLF Prognostic Nomogram. World J Surg. 2020 Aug 28;: Authors: Chin KM, Koh YX, Syn N, Teo JY, Goh BKP, Cheow PC, Chung YFA, Ooi LL, Chan CY, Lee SY Abstract BACKGROUND: Liver resection (LR) is the main modality of treatment for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). Post-hepatectomy liver failure...
Sun Aug 30, 2020 13:55
Related Articles The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients with Traumatic Brain Injury Specifically: A Systematic Review and Meta-Analysis. World J Surg. 2020 Aug 28;: Authors: Rösli D, Schnüriger B, Candinas D, Haltmeier T Abstract BACKGROUND: Accidental hypothermia is a known predictor for worse outcomes in trauma patients, but has not been comprehensively assessed in a meta-analysis so far....
Sun Aug 30, 2020 13:55
Related Articles Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study. World J Surg. 2020 Aug 28;: Authors: Dick L, Green J, Brown J, Kennedy E, Cassidy R, Othman S, Berlansky M Abstract INTRODUCTION: Covid-19 has had a significant impact on all aspects of health care. We aimed to characterise the trends in emergency general surgery at a district general hospital in Scotland. METHODS: A prospective...
Sun Aug 30, 2020 13:55
Related Articles Percutaneous Cholecystostomy Placement in Cases of Non-operative Cholecystitis: A Retrospective Cohort Analysis. World J Surg. 2020 Aug 28;: Authors: Gandhi K, Du Plessis R, Klopper J, Kloppers C Abstract BACKGROUND: Acute (calculous) cholecystitis (AC) is an extremely common surgical presentation, managed by cholecystectomy. Percutaneous cholecystostomy (PC) is an alternative; however, its safety and efficacy, along with subsequent...
Sun Aug 30, 2020 13:55
Related Articles Management of Locally Advanced and Unresectable Small Bowel Neuroendocrine Tumours. World J Surg. 2020 Aug 28;: Authors: Koea J, Commonwealth Neuroendocrine Tumour Research Collaborative (CommNETs) Surgical Section Abstract Three subtypes of small bowel neuroendocrine tumours (SBNETs) have been described: Type A: SBNET with resectable mesenteric disease that does not involve the mesenteric root; Type B: "Borderline resectable"...
Sun Aug 30, 2020 13:55
Related Articles A Last Resort When There is No Blood: Experiences and Perceptions of Intraoperative Autotransfusion Among Medical Doctors Deployed to Resource-Limited Settings. World J Surg. 2020 Aug 27;: Authors: Sjöholm A, Älgå A, von Schreeb J Abstract BACKGROUND: Four and a half million people die globally every year due to traumatic injuries. One major cause of preventable death is bleeding. Blood for transfusion is often unavailable in...
Sat Aug 29, 2020 13:41
Related Articles Posterior Retroperitoneoscopic Versus Laparoscopic Transperitoneal Adrenalectomy: A Systematic Review by an Updated Meta-Analysis. World J Surg. 2020 Aug 27;: Authors: Gavriilidis P, Camenzuli C, Paspala A, Di Marco AN, Palazzo FF Abstract BACKGROUND: Two main minimal access adrenalectomy techniques are available: laparoscopic transperitoneal (LTA) and posterior retroperitoneoscopic adrenalectomy (PRA). This study aims to compare...
Sat Aug 29, 2020 13:41
Related Articles Spinal Dural Arteriovenous Fistula: Diagnosis, Outcomes, and Prognostic Factors. World Neurosurg. 2020 Aug 25;: Authors: Ronald AA, Yao B, Winkelman RD, Piraino D, Masaryk TJ, Krishnaney AA Abstract INTRODUCTION: Typically, the clinical presentation of spinal dural arteriovenous fistulae (SDAVFs) is insidious and patients' symptoms are regularly attributed to other conditions. Although previous studies have characterized patient...
Sat Aug 29, 2020 16:09
Related Articles Foraminal origin of the dorsal scapular nerve: an anatomical study. World Neurosurg. 2020 Aug 25;: Authors: Jack A, Shah V, Jacques LG Abstract BACKGROUND: Although distal dorsal scapular nerve (DSN) anatomy has been well characterized, a paucity of literature exists detailing its proximal origin. To our knowledge, this is the first study examining the DSN origin and its anatomy relative to the C5 nerve root which may help localize...
Sat Aug 29, 2020 16:09
Related Articles Intracranial Tumor Control Following Immune-Related Adverse Events and Discontinuation of Immunotherapy for Melanoma. World Neurosurg. 2020 Aug 24;: Authors: Zhang M, Rodrigues AJ, Bhambhvani HP, Fatemi P, Pollom EL, Gibbs IC, Thomas RP, Soltys SG, Hancock SL, Chang SD, Reddy SA, Gephart MH, Li G Abstract PURPOSE: Immunotherapy for melanoma patients with brain metastasis has significantly improved outcomes; however, they have...
Fri Aug 28, 2020 17:41
Related Articles Effects of medical comorbidities on the surgical outcomes of deep brain stimulation for Parkinson's disease: a retrospective, single-institution study. World Neurosurg. 2020 Aug 24;: Authors: Werner C, Mathkour M, Scullen T, Houghton D, Lea G, Dallapiazza RF, Kahn L, Smith RD Abstract OBJECTIVE: Advancing age and greater number of medical comorbidities are well-known risk factors for higher rates of surgical complications and...
Fri Aug 28, 2020 17:41
Related Articles Incidence, Management, and Outcomes of Spinal Giant Cell Tumor of Bone in Adult Patients: A National Cancer Database Analysis. World Neurosurg. 2020 Aug 24;: Authors: Patel S, Chiu RG, Rosinski CL, Ansari D, Chaker AN, Nunna RS, Behbahani M, Mehta AI Abstract OBJECTIVE: Giant cell tumors (GCTs) make up 5% of all primary bone tumors with spinal GCTs making up 2-15% of all GCTs. The standard of care for spinal GCT is maximal surgical...
Fri Aug 28, 2020 17:41
Related Articles Treatment Strategy for Giant Invasive Macroprolactinoma with Spontaneous Cerebrospinal Fluid Rhinorrhea: A Case Report and Literature Review. World Neurosurg. 2020 Aug 24;: Authors: Abe D, Ogiwara T, Nakamura T, Ichinose S, Fujii Y, Hanaoka Y, Ito K, Horiuchi T Abstract BACKGROUND: Spontaneous cerebrospinal fluid (CSF) rhinorrhea associated with untreated prolactinomas is rare, which is in contrast to medical treatment-induced...
Fri Aug 28, 2020 17:41
Related Articles Demographic and clinical determinants of neck pain in idiopathic cervical dystonia. J Neural Transm (Vienna). 2020 Aug 26;: Authors: Tinazzi M, Erro R, Mascia MM, Esposito M, Ercoli T, Ferrazzano G, Di Biasio F, Pellicciari R, Eleopra R, Bono F, Bertolasi L, Barone P, Scaglione CLM, Pisani A, Altavista MC, Cotelli MS, Ceravolo R, Cossu G, Zibetti M, Moja MC, Girlanda P, Maderna L, Albanese A, Petracca M, Magistrelli L, Misceo S, Minafra B, Romano...
Fri Aug 28, 2020 14:22
Related Articles Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells. Aging (Albany NY). 2020 Aug 29;12: Authors: Li J, Zhou Y, Yan Y, Zheng Z, Hu Y, Wu W Abstract Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid...
Sun Aug 30, 2020 13:34
Related Articles Proteome landscape and spatial map of mouse primordial germ cells. Sci China Life Sci. 2020 Aug 26;: Authors: Wang P, Miao Y, Li XH, Zhang N, Wang Q, Yue W, Sun SC, Xiong B, Qiao J, Li M Abstract Primordial germ cells (PGCs) are precursors of both male and female gametes as fundamental materials for organism development. The transcriptome, methylome, and chromatin accessibility profiles of PGCs in both mice and humans have...
Sun Aug 30, 2020 13:34
Related Articles Combination of ERK2 and STAT3 Inhibitors Promotes Anticancer Effects on Acute Lymphoblastic Leukemia Cells. Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):517-527 Authors: Jasek-Gajda E, Jurkowska H, JasiŃska M, Litwin JA, Lis GJ Abstract BACKGROUND/AIM: Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and...
Sun Aug 30, 2020 13:34
Related Articles The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin. Nutrients. 2020 Aug 26;12(9): Authors: Bostan M, Petrică-Matei GG, Radu N, Hainarosie R, Stefanescu CD, Diaconu CC, Roman V Abstract Natural compounds can modulate all three major phases of carcinogenesis. The role of the natural compounds such as resveratrol (RSV) and curcumin (CRM) in modulation of anticancer...
Sun Aug 30, 2020 13:34
Related Articles Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma. Medicines (Basel). 2020 Aug 26;7(9): Authors: Sugita Y, Takao K, Uesawa Y, Nagai J, Iijima Y, Sano M, Sakagami H Abstract Since many anticancer drugs show severe adverse effects such as mucositis, peripheral neurotoxicity, and extravasation, it was crucial to explore new compounds with much reduced...
Sun Aug 30, 2020 13:34
Related Articles In-Vitro and In-Silico Evaluations of Heterocyclic-Containing Diarylpentanoids as Bcl-2 Inhibitors Against LoVo Colorectal Cancer Cells. Molecules. 2020 Aug 26;25(17): Authors: Leong SW, Chia SL, Abas F, Yusoff K Abstract In the present study, we investigated the in-vitro anti-cancer potential of six diarylpentanoids against a panel of BRAF- and KRAS-mutated colorectal cancer cell lines including T84, SW620, LoVo, HT29,...
Sun Aug 30, 2020 13:34
Related Articles Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives. J Inorg Biochem. 2020 Jul 17;211:111175 Authors: Yang QY, Cao QQ, Zhang YL, Xu XF, Deng CX, Kumar R, Zhu XM, Wang XJ, Liang H, Chen ZF Abstract The rare earth metal Gd(III), Yb(III), Lu(III), Eu(III), Tb(III) and Ho(III) complexes 1-6 with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (H-L)...
Sat Aug 29, 2020 13:32
Related Articles Composition, antioxidant activity, and neuroprotective effects of anthocyanin-rich extract from purple highland barley bran and its promotion on autophagy. Food Chem. 2020 Aug 16;339:127849 Authors: Zhang Y, Yin L, Huang L, Tekliye M, Xia X, Li J, Dong M Abstract Anthocyanin-rich purple highland barley has attracted great attention recently due to its health benefits in humans. The composition of the purified anthocyanin extract...
Sat Aug 29, 2020 13:32
Related Articles Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11. Cell Chem Biol. 2020 Aug 26;: Authors: Dickson P, Simanski S, Ngundu JM, Kodadek T Abstract We previously reported a peptoid ligand for the proteasomal ubiquitin receptor Rpn13 called KDT-11 and demonstrated that this compound is toxic to multiple myeloma cells, but not non-malignant cells. Here, we show that...
Sat Aug 29, 2020 13:32
Related Articles Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia. Cell Oncol (Dordr). 2020 Aug 28;: Authors: Carlos JAEG, Lima K, Coelho-Silva JL, de Melo Alves-Paiva R, Moreno NC, Vicari HP, de Souza Santos FP, Hamerschlak N, Costa-Lotufo LV, Traina F, Machado-Neto JA Abstract PURPOSE: Acute lymphoblastic leukemia (ALL) is an aggressive hematological cancer with limited therapeutic...
Sat Aug 29, 2020 13:32
Related Articles Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin. Radiat Environ Biophys. 2020 Aug 28;: Authors: Liu B, Chen W, Li H, Li F, Jin X, Li Q Abstract Although radiotherapy, especially carbon-ion radiotherapy, is an effective treatment modality against non-small-cell lung cancer (NSCLC), studies using radiation combined with sensitizer for improving the efficacy...
Sat Aug 29, 2020 13:32
Related Articles Antitumor Effects of Fucoidan Via Apoptotic and Autophagic Induction on HSC-3 Oral Squamous CellCarcinoma. Asian Pac J Cancer Prev. 2020 Aug 01;21(8):2469-2477 Authors: Chantree P, Surarak T, Sangpairoj K, Aguilar P, Hitakomate E Abstract OBJECTIVE: Many studies suggested that fucoidan has anticancer potential. The objective of the present study was to determine the cytotoxic effects and mechanism of cell death induced...
Sat Aug 29, 2020 13:32
Related Articles Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract. Biosci Rep. 2020 Aug 28;: Authors: Lee CC, Hsiao CY, Lee SC, Huang XF, Chang KF, Lee MS, Hsieh MC, Tsai NM Abstract The oral cancer incidence rate is slowly increasing and is now the fifth leading cause of cancer-related death due to its high metastasis and recurrence rate. Juniperus communis is used as a traditional...
Sat Aug 29, 2020 13:32
Related Articles Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic pathways of apoptosis. Invest New Drugs. 2020 Aug 28;: Authors: Mohamed MF, Sroor FM, Ibrahim NS, Salem GS, El-Sayed HH, Mahmoud MM, Wagdy MM, Ahmed AM, Mahmoud AT, Ibrahim SS, Ismail MM, Eldin SM, Saleh FM, Hassaneen HM, Abdelhamid IA Abstract Two novel chemotherapeutic...
Sat Aug 29, 2020 13:32
Related Articles Punicalagin triggers ergosterol biosynthesis disruption and cell cycle arrest in Cryptococcus gattii and Candida albicans : Action mechanisms of punicalagin against yeasts. Braz J Microbiol. 2020 Aug 27;: Authors: Silva TC, de Ávila RI, Zara ALSA, Santos AS, Ataídes F, Freitas VAQ, Costa CR, Valadares MC, Silva MDRR Abstract Punicalagin is a phenolic compound extracted from Lafoensia pacari A. St.-Hil (Lythraceae) leaves....
Sat Aug 29, 2020 13:32
Related Articles Depiction of tumor stemlike features and underlying relationships with hazard immune infiltrations based on large prostate cancer cohorts. Brief Bioinform. 2020 Aug 28;: Authors: Zhang C, Chen T, Li Z, Liu A, Xu Y, Gao Y, Xu D Abstract Prostate cancer stemness (PCS) cells have been reported to drive tumor progression, recurrence and drug resistance. However, there is lacking systematical assessment of stemlike indices and...
Sat Aug 29, 2020 13:32
Related Articles Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration. Oxid Med Cell Longev. 2020;2020:1904178 Authors: Mahendra CK, Tan LTH, Pusparajah P, Htar TT, Chuah LH, Lee VS, Low LE, Tang SY, Chan KG, Goh BH Abstract Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but...
Sat Aug 29, 2020 13:32
Related Articles Long non-coding RNA MALAT1 suppresses the proliferation and migration of endothelial progenitor cells in deep vein thrombosis by regulating the Wnt/β-catenin pathway. Exp Ther Med. 2020 Oct;20(4):3138-3146 Authors: Du B, Wang J, Zang S, Mao X, Du Y Abstract Deep vein thrombosis (DVT) is one of the most common circulating vascular diseases with an incidence of ~0.1% worldwide. Although anticoagulant medication remains to...
Sat Aug 29, 2020 13:32
Related Articles Salmonella enterica serovar Typhimurium inhibits the innate immune response and promotes apoptosis in a ribosomal/TRP53-dependent manner in swine neutrophils. Vet Res. 2020 Aug 27;51(1):105 Authors: Huang T, Jiang C, Yang M, Xiao H, Huang X, Wu L, Yao M Abstract Neutrophils are the first barriers for resisting the invasion, proliferation, and damage caused by Salmonella Typhimurium. However, the mechanisms that control...
Sat Aug 29, 2020 13:32
Related Articles Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization. J Biomed Sci. 2020 Aug 27;27(1):90 Authors: Petragnano F, Pietrantoni I, Camero S, Codenotti S, Milazzo L, Vulcano F, Macioce G, Giordani I, Tini P, Cheleschi S, Gravina GL, Festuccia C, Rossetti A, Delle Monache S, Ordinelli A, Ciccarelli C, Mauro A, Barbara B, Antinozzi C, Schiavetti A, Maggio R, Di Luigi L, Polimeni...
Sat Aug 29, 2020 13:32
Related Articles Cell-size regulation in budding yeast does not depend on linear accumulation of Whi5. Proc Natl Acad Sci U S A. 2020 06 23;117(25):14243-14250 Authors: Barber F, Amir A, Murray AW Abstract Cells must couple cell-cycle progress to their growth rate to restrict the spread of cell sizes present throughout a population. Linear, rather than exponential, accumulation of Whi5, was proposed to provide this coordination by causing a...
Sat Aug 29, 2020 13:32
Related Articles Wasabi Compound 6-(Methylsulfinyl) Hexyl Isothiocyanate Induces Cell Death with Coexisting Mitotic Arrest and Autophagy in Human Chronic Myelogenous Leukemia K562 Cells. Biomolecules. 2019 11 23;9(12): Authors: Wu KM, Liao HF, Chi CW, Kou YR, Chen YJ Abstract A natural compound from Wasabia japonica, 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC) was investigated for its anti-leukemia activity and mechanism of action. It...
Sat Aug 29, 2020 13:32
Related Articles Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis. Cell Cycle. 2019 08;18(16):1868-1881 Authors: Yong YX, Yang H, Lian J, Xu XW, Han K, Hu MY, Wang HC, Zhou LM Abstract MicroRNAs (miRNAs) have emerged as key mediators of posttranscriptional gene silencing in both pathogenic and pathological aspects of ischemic stroke...
Sat Aug 29, 2020 13:32
Related Articles Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models. J Nat Prod. 2019 05 24;82(5):1301-1311 Authors: Ling T, Lang WH, Craig J, Potts MB, Budhraja A, Opferman J, Bollinger J, Maier J, Marsico TD, Rivas F Abstract Natural products continue to provide a platform to study biological systems. A bioguided study of cancer cell models led us to a new member of the jatrophane natural products from...
Sat Aug 29, 2020 13:32
Related Articles Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 05 06;58(19):6321-6326 Authors: Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and there are FDA-approved CDK4/6 inhibitors for treating patients with metastatic breast cancer. However, due to conservation of...
Sat Aug 29, 2020 13:32
Related Articles Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem. 2020 Aug 17;207:112716 Authors: Zhu H, Sun H, Liu Y, Duan Y, Liu J, Yang X, Li W, Qin S, Xu S, Zhu Z, Xu J Abstract A series of novel vinyl selenone derivatives were designed, synthesized and evaluated as the tubulin polymerization inhibitors using a bioisosteric strategy. Among them,...
Fri Aug 28, 2020 14:26
Related Articles Enhanced anti-cancer activity of chitosan loaded Morinda citrifolia essential oil against A549 human lung cancer cells. Int J Biol Macromol. 2020 Aug 24;: Authors: Rajivgandhi G, Saravanan K, Ramachandran G, Li JL, Yin L, Quero F, Alharbi NS, Kadaikunnan S, Khaled JM, Manoharan N, Li WJ Abstract In the present study, the chemical composition of Morinda citrifolia essential oils was determined by gas chromatography-mass...
Fri Aug 28, 2020 14:26
Related Articles Myricetin: versatile plant based flavonoid for cancer treatment by inducing cell cycle arrest and ROS-reliant mitochondria-facilitated apoptosis in A549 lung cancer cells and in silico prediction. Mol Cell Biochem. 2020 Aug 26;: Authors: Rajendran P, Maheshwari U, Muthukrishnan A, Muthuswamy R, Anand K, Ravindran B, Dhanaraj P, Balamuralikrishnan B, Chang SW, Chung WJ Abstract Myricetin is categorized under the secondary...
Fri Aug 28, 2020 13:27
Related Articles Pharmacological Properties of Pt(II) and Pt(IV) Complexes with 2,2'-Dipyridylamine; the Comparative In Vitro Thereof. Cell Biochem Biophys. 2020 Aug 27;: Authors: Aghmasheh S, Ostad SN, Abedi A Abstract Pt-based drugs such as cisplatin are frontline drugs used for the treatment of different solid malignancies. However, they represent major problems, such as severe side effects and drug resistance. To find out the structure-activity...
Fri Aug 28, 2020 13:27
Related Articles A Role for Malignant Brain Tumor Domain-Containing Protein 1 in Human Endometrial Stromal Cell Decidualization. Front Cell Dev Biol. 2020;8:745 Authors: Chadchan SB, Maurya VK, Krekeler GL, Jungheim ES, Kommagani R Abstract Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells,...
Fri Aug 28, 2020 13:27
Related Articles Nimotuzumab Combined With Irradiation Enhances the Inhibition to the HPV16 E6-Promoted Growth of Cervical Squamous Cell Carcinoma. Front Oncol. 2020;10:1327 Authors: Xu Z, Shu H, Zhang F, Luo W, Li Y, Chu J, Zhao Q, Lv Y Abstract Human papillomavirus (HPV) 16 E6 has been proved to increase the radiosensitivity and lead to the EGFR overexpression in cervical cancer cells. In this study, to investigate the inhibition of nimotuzumab-mediated...
Fri Aug 28, 2020 13:27
Related Articles 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression. Front Oncol. 2020;10:1319 Authors: Chen CY, Fang JY, Chen CC, Chuang WY, Leu YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH Abstract Magnolia officinalis is widely used in Southeast Asian countries for the treatment of fever, headache, diarrhea, and stroke. Magnolol is a phenolic...
Fri Aug 28, 2020 13:27
Related Articles p28 Bacterial Peptide, as an Anticancer Agent. Front Oncol. 2020;10:1303 Authors: Yaghoubi A, Khazaei M, Avan A, Hasanian SM, Cho WC, Soleimanpour S Abstract Cancer remains a major cause of morbidity and mortality irrespective of the type of conventional chemotherapy. Therefore, there is an urgent need for new and effective anticancer therapeutic agents. Bacterial proteins and their derivative peptides appear as a promising...
Fri Aug 28, 2020 13:27
Related Articles Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity. Front Oncol. 2020;10:1289 Authors: Huang X, Zhang X, Xu J, Wang X, Zhang G, Tang T, Shen X, Liang T, Bai X Abstract The efficacy of cancer immunotherapy depends on the fine interplay between tumoral immune checkpoints and host immune system. However, the up-to-date clinical performance of checkpoint blockers in cancer therapy revealed that higher-level...
Fri Aug 28, 2020 13:27
Related Articles Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells. Oncotarget. 2020 Aug 11;11(32):3069-3077 Authors: Clark RA, Lee S, Qiao J, Chung DH Abstract INTRODUCTION: Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase exhibiting high affinity for reduced folate carrier-1 with antineoplastic and immunosuppressive activities, similar to methotrexate. Despite advances...
Fri Aug 28, 2020 13:27
Related Articles 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells. Evid Based Complement Alternat Med. 2020;2020:7375862 Authors: Shen GN, Wang C, Luo YH, Wang JR, Wang R, Xu WT, Zhang Y, Zhang Y, Zhang DJ, Jin CH Abstract Two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (HEDMNQ) and 2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone...
Fri Aug 28, 2020 13:27
Related Articles Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. Front Genet. 2020;11:867 Authors: Chen W, Wang X, Wei G, Huang Y, Shi Y, Li D, Qiu S, Zhou B, Cao J, Chen M, Qin P, Jin W, Ni T Abstract Replicative senescence is a hallmark of aging, which also contributes to individual aging. Mouse embryonic fibroblasts (MEFs) provide a convenient...
Fri Aug 28, 2020 13:27
Related Articles Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p. Front Genet. 2020;11:838 Authors: Liu X, Zou H, Zhao Y, Chen H, Liu T, Wu Z, Yang C, Li Q, Li Y Abstract Lung cancer is the most deadly malignancy in the last decade, accounting for about 1.6 million deaths every year globally. Tanshinone is the constituent of Salvia miltiorrhiza; it has been found that they influence tumorigenesis. However, the role of...
Fri Aug 28, 2020 13:27
Related Articles Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer. Drug Des Devel Ther. 2020;14:3301-3313 Authors: Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J Abstract Objective: To investigate the effect of erianin on tumor growth and immune response in human colorectal cancer cells (CRC). Methods: The effect of erianin on tumor growth was determined by CCK8 and colony formation assay. Western...
Fri Aug 28, 2020 13:27
Related Articles Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity. Drug Des Devel Ther. 2020;14:3111-3130 Authors: Mourad AAE, Mourad MAE, Jones PG Abstract Introduction: In order to develop novel anticancer HDAC/tubulin dual inhibitors, a novel series of α-phthalimido-substituted chalcones-based hybrids was synthesized...
Fri Aug 28, 2020 13:27
Related Articles ASF1B promotes cervical cancer progression through stabilization of CDK9. Cell Death Dis. 2020 Aug 26;11(8):705 Authors: Liu X, Song J, Zhang Y, Wang H, Sun H, Feng X, Hou M, Chen G, Tang Q, Ji M Abstract Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result in poor outcomes and developing the novel targets and therapeutic strategies are urgently needed. Recent studies have...
Fri Aug 28, 2020 13:27
Related Articles Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling. J Virol. 2020 Aug 26;: Authors: Salamango DJ, McCann JL, Demir Ö, Becker JT, Wang J, Lingappa JR, Temiz NA, Brown WL, Amaro RE, Harris RS Abstract HIV-1 Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A-E)....
Fri Aug 28, 2020 13:27
Related Articles Antiproliferative activity of green, black tea and olive leaves polyphenols subjected to biosorption and in vitro gastrointestinal digestion in Caco-2 cells. Food Res Int. 2020 Oct;136:109317 Authors: Jilani H, Cilla A, Barberá R, Hamdi M Abstract Olive (Olea europaea L.) leaves and tea (Camellia sinensis) are rich sources of bioactive compounds, especially polyphenols. Our previous studies have evidenced the potential...
Fri Aug 28, 2020 13:27
Related Articles Transport, metabolism and remedial potential of functional food extracts (FFEs) in Caco-2 cells monolayer: A review. Food Res Int. 2020 Oct;136:109240 Authors: Iftikhar M, Iftikhar A, Zhang H, Gong L, Wang J Abstract Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and transport mechanism of functional foods and drugs across the intestinal epithelium in order to study their antioxidant,...
Fri Aug 28, 2020 13:27
Related Articles Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage. Cell Rep. 2020 Aug 25;32(8):108077 Authors: Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, Lee JH Abstract DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the...
Fri Aug 28, 2020 13:27
Related Articles Decorin in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1272:17-38 Authors: Baghy K, Reszegi A, Tátrai P, Kovalszky I Abstract The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer....
Fri Aug 28, 2020 13:27
Related Articles Alerting the immune system to DNA damage: micronuclei as mediators. Essays Biochem. 2020 Aug 26;: Authors: MacDonald KM, Benguerfi S, Harding SM Abstract Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells. In response to such lesions, the DNA damage response (DDR) activates cell-cycle checkpoints,...
Fri Aug 28, 2020 13:27
Related Articles Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway. Sci Rep. 2020 Aug 25;10(1):14156 Authors: Zou ZV, Gul N, Lindberg M, Bokhari AA, Eklund EM, Garellick V, Patel AAH, Dzanan JJ, Titmuss BO, Le Gal K, Johansson I, Tivesten Å, Forssell-Aronsson E, Bergö MO, Staffas A, Larsson E, Sayin VI, Lindahl P Abstract Recent data suggest that the transcription factor Zfp148 represses activation of...
Fri Aug 28, 2020 13:27
Related Articles [Effect of circular RNA hsa_circ_0008898 on oral squamous cell carcinoma and its mechanism]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2020 Aug 09;55(8):578-585 Authors: Zhou HX, Wang LY, Chen S, Wang DD, Fang Z Abstract Objective: To investigate the effect and molecular mechanism of hsa_circ_0008898 on the cell proliferation, migration, invasion and tumor formation of oral squamous cell carcinoma (OSCC). Methods: Quantitative...
Fri Aug 28, 2020 13:27
Related Articles Exploration of the effects of the CYCLOPS gene RBM17 in hepatocellular carcinoma. PLoS One. 2020;15(6):e0234062 Authors: Li C, Ge S, Zhou J, Peng J, Chen J, Dong S, Feng X, Su N, Zhang L, Zhong Y, Deng L, Tang X Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal and malignant tumours worldwide. New therapeutic targets for HCC are urgently needed. CYCLOPS (copy number alterations yielding cancer liabilities...
Fri Aug 28, 2020 13:27
Related Articles 2'-Hydroxyflavanone inhibits the progression of pancreatic cancer cells and sensitizes the chemosensitivity of EGFR inhibitors via repressing STAT3 signaling. Cancer Lett. 2020 02 28;471:135-146 Authors: Yue Y, Qian W, Li J, Wu S, Zhang M, Wu Z, Ma Q, Wang Z Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and chemotherapy is still an important treatment. It is urgent to develop new...
Fri Aug 28, 2020 13:27
microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma.
Related Articles microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma. Cell Death Dis. 2019 09 26;10(10):723 Authors: Lu Z, Li X, Xu Y, Chen M, Chen W, Chen T, Tang Q, He Z Abstract The sekelsky mothers against dpp3 (Smad3) functions as a transcriptional modulator activated by transforming growth factor-β (TGF-β). Accumulated evidences indicated that Smad3 played the important roles in carcinogenesis...
Fri Aug 28, 2020 13:27
Related Articles Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol. 2019 11 21;26(11):1573-1585.e10 Authors: Bakail M, Gaubert A, Andreani J, Moal G, Pinna G, Boyarchuk E, Gaillard MC, Courbeyrette R, Mann C, Thuret JY, Guichard B, Murciano B, Richet N, Poitou A, Frederic C, Le Du MH, Agez M, Roelants C, Gurard-Levin ZA, Almouzni G, Cherradi N, Guerois R, Ochsenbein F Abstract Anti-silencing...
Fri Aug 28, 2020 13:27
Related Articles The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 07 16;28(3):698-711.e5 Authors: Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, Xiang P, Zhang X, Wei Q, Hou L, Yin B, Yuan J, Qiang B, Shu P, Peng X Abstract Histone methylation is essential for regulating gene expression during organogenesis to maintain stem cells and execute a proper differentiation program...
Fri Aug 28, 2020 13:27
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