Biomedicines, Vol. 8, Pages 312: Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies Biomedicines doi: 10.3390/biomedicines8090312 Authors: André Huss Makbule Senel Ahmed Abdelhak Benjamin Mayer Jan Kassubek Albert C. Ludolph Markus Otto Hayrettin Tumani Serum neurofilament light chain (NfL) has been shown to correlate with neuroaxonal damage in multiple sclerosis (MS) and various...
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1256: Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases Biomolecules doi: 10.3390/biom10091256 Authors: Toufic Kassouf Grzegorz Sumara The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and has been implicated in regulation of virtually all cellular processes. MAPKs are divided into two groups, conventional and atypical MAPKs. Conventional MAPKs are further classified into four sub-families:...
Sat Aug 29, 2020 03:00
Biomolecules, Vol. 10, Pages 1255: GFP Fusion to the N-Terminus of MotB Affects the Proton Channel Activity of the Bacterial Flagellar Motor in Salmonella Biomolecules doi: 10.3390/biom10091255 Authors: Yusuke V. Morimoto Keiichi Namba Tohru Minamino The bacterial flagellar motor converts the energy of proton flow through the MotA/MotB complex into mechanical works required for motor rotation. The rotational force is generated by electrostatic interactions between the stator protein...
Sat Aug 29, 2020 03:00
Biomolecules, Vol. 10, Pages 1254: Identification and Target-Modification of SL-BBI: A Novel Bowman–Birk Type Trypsin Inhibitor from Sylvirana latouchii Biomolecules doi: 10.3390/biom10091254 Authors: Xi Chen Dong Chen Linyuan Huang Xiaoling Chen Mei Zhou Xinping Xi Chengbang Ma Tianbao Chen Lei Wang The peptides from the ranacyclin family share similar active disulphide loop with plant-derived Bowman–Birk type inhibitors, some of which have the dual...
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1253: The Morphoregulatory Role of Thidiazuron: Metabolomics-Guided Hypothesis Generation for Mechanisms of Activity Biomolecules doi: 10.3390/biom10091253 Authors: Lauren A. E. Erland Ryland T. Giebelhaus Jerrin M. R. Victor Susan J. Murch Praveen K. Saxena Thidiazuron (TDZ) is a diphenylurea synthetic herbicide and plant growth regulator used to defoliate cotton crops and to induce regeneration of recalcitrant species in plant tissue culture....
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1250: Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites Biomolecules doi: 10.3390/biom10091250 Authors: Florian Pennarubia Emilie Pinault Bilal Al Jaam Caroline E. Brun Abderrahman Maftah Agnès Germot Sébastien Legardinier The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved...
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1252: Computational Methods and Software Tools for Functional Analysis of miRNA Data Biomolecules doi: 10.3390/biom10091252 Authors: Adrian Garcia-Moreno Pedro Carmona-Saez miRNAs are important regulators of gene expression that play a key role in many biological processes. High-throughput techniques allow researchers to discover and characterize large sets of miRNAs, and enrichment analysis tools are becoming increasingly important in decoding which miRNAs...
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1251: Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism Biomolecules doi: 10.3390/biom10091251 Authors: Nermin Eissa Petrilla Jayaprakash Holger Stark Dorota Łażewska Katarzyna Kieć-Kononowicz Bassem Sadek Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder defined by persistent deficits in social interaction...
Fri Aug 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1249: Fully-Connected Neural Networks with Reduced Parameterization for Predicting Histological Types of Lung Cancer from Somatic Mutations Biomolecules doi: 10.3390/biom10091249 Authors: Kazuma Kobayashi Amina Bolatkan Shuichiro Shiina Ryuji Hamamoto Several challenges appear in the application of deep learning to genomic data. First, the dimensionality of input can be orders of magnitude greater than the number of samples, forcing the model to...
Fri Aug 28, 2020 03:00
Biosensors, Vol. 10, Pages 111: Selective Nonenzymatic Amperometric Detection of Lactic Acid in Human Sweat Utilizing a Multi-Walled Carbon Nanotube (MWCNT)-Polypyrrole Core-Shell Nanowire Biosensors doi: 10.3390/bios10090111 Authors: Young Min Choi Hana Lim Ho-Nyun Lee Young Min Park Jin-Seong Park Hyun-Jong Kim Lactic acid plays an important role as a biochemical indicator for sports medicine and clinical diagnosis. The detection of lactic acid in sweat is a promising...
Fri Aug 28, 2020 03:00
Biosensors, Vol. 10, Pages 110: Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems Biosensors doi: 10.3390/bios10090110 Authors: Erika Ferrari Cecilia Palma Simone Vesentini Paola Occhetta Marco Rasponi Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to...
Fri Aug 28, 2020 03:00
Brain Sciences, Vol. 10, Pages 599: Conditioned Pain Modulation Effectiveness: An Experimental Study Comparing Test Paradigms and Analyzing Potential Predictors in a Healthy Population Brain Sciences doi: 10.3390/brainsci10090599 Authors: María del Rocío Ibancos-Losada María C. Osuna-Pérez María Yolanda Castellote-Caballero Ángeles Díaz-Fernández Conditioned pain modulation (CPM) is an endogenous pain inhibition phenomenon that can be summarized simply as one type of pain being...
Sun Aug 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 598: A Time Series-Based Point Estimation of Stop Signal Reaction Times: More Evidence on the Role of Reactive Inhibition-Proactive Inhibition Interplay on the SSRT Estimations Brain Sciences doi: 10.3390/brainsci10090598 Authors: Mohsen Soltanifar Keith Knight Annie Dupuis Russell Schachar Schachar Escobar The Stop Signal Reaction Time (SSRT) is a latency measurement for the unobservable human brain stopping process, and was formulated by...
Sat Aug 29, 2020 03:00
Brain Sciences, Vol. 10, Pages 597: Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis Brain Sciences doi: 10.3390/brainsci10090597 Authors: Nicole R. Nissim Paul J. Moberg Roy H. Hamilton Noninvasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), paired with behavioral language therapy,...
Fri Aug 28, 2020 03:00
Brain Sciences, Vol. 10, Pages 596: Crowding Effects Across Depth are Fixation-Centered for Defocused Flankers and Observer-Centered for Defocused Targets Brain Sciences doi: 10.3390/brainsci10090596 Authors: Lisa V. Eberhardt Anke Huckauf Depth needs to be considered to understand visual information processing in cluttered environments in the wild. Since differences in depth depend on current gaze position, eye movements were avoided by short presentations in a real depth setup....
Fri Aug 28, 2020 03:00
Brain Sciences, Vol. 10, Pages 595: Effects of Various Doses of Caffeine Ingestion on Intermittent Exercise Performance and Cognition Brain Sciences doi: 10.3390/brainsci10090595 Authors: Cuicui Wang Yuechuan Zhu Cheng Dong Zigui Zhou Xinyan Zheng To date, no study has examined the effects of caffeine on prolonged intermittent exercise performance that imitates certain team-sports, and the suitable concentration of caffeine for improved intermittent exercise performance remains...
Fri Aug 28, 2020 03:00
Brain Sciences, Vol. 10, Pages 594: Through Predictive Personalized Medicine Brain Sciences doi: 10.3390/brainsci10090594 Authors: Giuseppe Giglia Giuditta Gambino Pierangelo Sardo Neuroblastoma (NBM) is a deadly form of solid tumor mostly observed in the pediatric age. Although survival rates largely differ depending on host factors and tumor-related features, treatment for clinically aggressive forms of NBM remains challenging. Scientific advances are paving the way to improved...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2458: Sonographic Risk Stratification Systems for Thyroid Nodules as Rule-Out Tests in Older Adults Cancers doi: 10.3390/cancers12092458 Authors: Giorgio Grani Gabriela Brenta Pierpaolo Trimboli Rosa Falcone Valeria Ramundo Marianna Maranghi Piernatale Lucia Sebastiano Filetti Cosimo Durante Ultrasonographic risk-stratification systems (RSS), including various Thyroid Imaging Reporting and Data Systems (TIRADS), were proposed to improve...
Sun Aug 30, 2020 03:00
Cancers, Vol. 12, Pages 2459: STAT3, the Challenge for Chemotherapeutic and Radiotherapeutic Efficacy Cancers doi: 10.3390/cancers12092459 Authors: Yang Liu Li Xu Chemoradiotherapy is one of the most effective and extensively used strategies for cancer treatment. Signal transducer and activator of transcription 3 (STAT3) regulates vital biological processes, such as cell proliferation and cell growth. It is constitutively activated in various cancers and limits the application...
Sun Aug 30, 2020 03:00
Cancers, Vol. 12, Pages 2457: Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer Cancers doi: 10.3390/cancers12092457 Authors: Michela Roberto Giulia Arrivi Francesca Lo Bianco Stefano Cascinu Fabio Gelsomino Francesco Caputo Krisida Cerma Michele Ghidini Margherita Ratti Claudio Pizzo Corrado Ficorella Alessandro Parisi Alessio Cortellini Federica Urbano Maria Letizia Calandrella Emanuela Dell’Aquila Alessandro Minelli...
Sun Aug 30, 2020 03:00
Cancers, Vol. 12, Pages 2454: Deep Sequencing Analysis Identified a Specific Subset of Mutations Distinctive of Biphasic Malignant Pleural Mesothelioma Cancers doi: 10.3390/cancers12092454 Authors: Federica Torricelli Filippo Lococo Teresa Severina Di Stefano Eugenia Lorenzini Simonetta Piana Riccardo Valli Ottavio Rena Giulia Veronesi Andrea Billè Alessia Ciarrocchi Malignant Pleural Mesothelioma (MPM) is a heterogeneous disease. Morphologically, three different...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2456: Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration Cancers doi: 10.3390/cancers12092456 Authors: Thome Lacle Voß Bortolussi Pantazis Schmidt Conrad Jacob Timmesfeld Bartsch Pagenstecher Tumor-cell infiltration is a major obstacle to successful therapy for brain tumors. Membrane-type matrix metalloproteinases (MT-MMPs), a metzincin subfamily...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2453: Radiomics at a Glance: A Few Lessons Learned from Learning Approaches Cancers doi: 10.3390/cancers12092453 Authors: Enrico Capobianco Jun Deng Processing and modeling medical images have traditionally represented complex tasks requiring multidisciplinary collaboration. The advent of radiomics has assigned a central role to quantitative data analytics targeting medical image features algorithmically extracted from large volumes of images. Apart from the...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2455: The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12092455 Authors: Augustus M. C. Tilley Cory M. Howard Sangita Sridharan Boopathi Subramaniyan Nicole R. Bearss Sawsan Alkhalili Dayanidhi Raman The CXCR4-LASP1 axis is an emerging target in the field of breast cancer metastasis. C-X-C chemokine receptor type 4 (CXCR4) mediates directed cell migration when activated by its cognate ligand...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2452: A Review of Clinical Practice Guidelines and Treatment Recommendations for Cancer Care in the COVID-19 Pandemic Cancers doi: 10.3390/cancers12092452 Authors: Alberto Zaniboni Michele Ghidini Francesco Grossi Alice Indini Francesca Trevisan Alessandro Iaculli Lorenzo Dottorini Giovanna Moleri Alessandro Russo Ivano Vavassori Alessandra Brevi Emanuele Rausa Luigi Boni Daniele Dondossola Nicola Valeri Antonio Ghidini Gianluca...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2451: Extracellular Neuroglobin as a Stress-Induced Factor Activating Pre-Adaptation Mechanisms against Oxidative Stress and Chemotherapy-Induced Cell Death in Breast Cancer Cancers doi: 10.3390/cancers12092451 Authors: Marco Fiocchetti Virginia Solar Fernandez Marco Segatto Stefano Leone Paolo Cercola Annalisa Massari Francesco Cavaliere Maria Marino Components of tumor microenvironment, including tumor and/or stromal cells-derived factors,...
Sat Aug 29, 2020 03:00
Cancers, Vol. 12, Pages 2449: Deciphering the Immune Microenvironment on a Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by an Immediately Implementable Multiplex Fluorescence Immunostaining Protocol Cancers doi: 10.3390/cancers12092449 Authors: Adrien Guillot Marlene S. Kohlhepp Alix Bruneau Felix Heymann Frank Tacke Technological breakthroughs have fundamentally changed our understanding on the complexity of the tumor microenvironment at the single-cell...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2450: Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells Cancers doi: 10.3390/cancers12092450 Authors: Aneta Gandalovičová Anna-Marie Šůchová Vladimír Čermák Ladislav Merta Daniel Rösel Jan Brábek The invasive behaviour of cancer cells underlies metastatic dissemination; however, due to the large plasticity of invasion modes, it is challenging to target. It is now widely accepted that...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2447: Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome Cancers doi: 10.3390/cancers12092447 Authors: Gil Bar-Sela Idan Cohen Salvatore Campisi-Pinto Gil M. Lewitus Lanuel Oz-Ari Ayellet Jehassi Avivit Peer Ilit Turgeman Olga Vernicova Paula Berman Mira Wollner Mor Moskovitz David Meiri Cannabis or its derivatives are widely used by patients with cancer to help with cancer...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2448: Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead Cancers doi: 10.3390/cancers12092448 Authors: Yuan Lyu Steven Kopcho Folnetti A. Alvarez Bryson C. Okeoma Chioma M. Okeoma BST-2 is a novel driver of cancer progression whose expression confers oncogenic properties to breast cancer cells. As such, targeting BST-2 in tumors may be an effective therapeutic approach against breast cancer. Here, we...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2445: Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice Cancers doi: 10.3390/cancers12092445 Authors: Yu-Ming Liu Tsung-Han Wu Yi-Han Chiu Hang Wang Tsung-Lin Li Simon Hsia Yi-Lin Chan Chang-Jer Wu (1) Background: Radiotherapy (RT) is one of the major treatments for non-small cell lung cancer, but RT-associated toxicities usually impede its anticancer effect. Nutrient supplementation...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2446: Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms Cancers doi: 10.3390/cancers12092446 Authors: Sophie Allain-Maillet Adrien Bosseboeuf Nicolas Mennesson Mégane Bostoën Laura Dufeu Eun Ho Choi Cédric Cleyrat Olivier Mansier Eric Lippert Yannick Le Bris Jean-Marc Gombert François Girodon Magali Pettazzoni Edith Bigot-Corbel Sylvie...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2444: Objective Evaluation of Risk Factors for Radiation Dermatitis in Whole-Breast Irradiation Using the Spectrophotometric L*a*b Color-Space Cancers doi: 10.3390/cancers12092444 Authors: Alexander M. C. Böhner David Koch Frederic Carsten Schmeel Fred Röhner Felix Schoroth Gustavo R. Sarria Alina-Valik Abramian Brigitta Gertrud Baumert Frank Anton Giordano Leonard Christopher Schmeel Background: Radiation-induced dermatitis (RID) is...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2443: The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future Cancers doi: 10.3390/cancers12092443 Authors: Miguel A. Ortega Oscar Fraile-Martínez Luis G. Guijarro Carlos Casanova Santiago Coca Melchor Álvarez-Mon Julia Buján Natalio García-Honduvilla Ángel Asúnsolo Breast cancer is the most prevalent and incident female neoplasm worldwide. Although survival rates have considerably...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2441: Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis Cancers doi: 10.3390/cancers12092441 Authors: Timmy Richardo Pongphol Prattapong Chawalit Ngernsombat Nurulfitri Wisetyaningsih Hisashi Iizasa Hironori Yoshiyama Tavan Janvilisri Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which...
Fri Aug 28, 2020 03:00
Cancers, Vol. 12, Pages 2442: Repurposing of α1-Adrenoceptor Antagonists: Impact in Renal Cancer Cancers doi: 10.3390/cancers12092442 Authors: Meredith Mihalopoulos Zachary Dovey Maddison Archer Talia G. Korn Kennedy E. Okhawere William Nkemdirim Hassan Funchess Ami Rambhia Nihal Mohamed Steven A. Kaplan Reza Mehrazin Dara Lundon Che-Kai Tsao Ketan K. Badani Natasha Kyprianou Renal cancer ranks twelfth in incidence among cancers worldwide. Despite...
Fri Aug 28, 2020 03:00
Cells, Vol. 9, Pages 1997: Adipose-Derived Stromal/Stem Cells Cells doi: 10.3390/cells9091997 Authors: Patrick C. Baer Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs).[...]
Sun Aug 30, 2020 03:00
Cells, Vol. 9, Pages 1995: Establishment and Evaluation of an In Vitro System for Biophysical Stimulation of Human Osteoblasts Cells doi: 10.3390/cells9091995 Authors: Martin Stephan Julius Zimmermann Annett Klinder Franziska Sahm Ursula van Rienen Peer W. Kämmerer Rainer Bader Anika Jonitz-Heincke While several studies investigated the effects of mechanical or electrical stimulation on osseointegration and bone fracture healing, little is known about the molecular...
Sun Aug 30, 2020 03:00
Cells, Vol. 9, Pages 1996: Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells doi: 10.3390/cells9091996 Authors: Elina S. Chermnykh Elena V. Alpeeva Ekaterina A. Vorotelyak Transglutaminases (TGMs) contribute to the formation of rigid, insoluble macromolecular complexes, which are essential for the epidermis and hair follicles to perform protective and barrier functions against the environment. During differentiation, epidermal keratinocytes undergo...
Sun Aug 30, 2020 03:00
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