Sepsis-induced myocardial depression has high mortality and is very common in intensive care units. Previous studies have found that microRNAs play an important role in regulating sepsis-induced myocardial depression. miR-150-5p is involved in many biological processes; however, the mechanism underlying its role in sepsis-induced myocardial depression is still unclear. In this study, we generated rat models of septic shock induced by lipopolysaccharide. Whole genomic RNA sequencing was performed...
Sun Aug 30, 2020 17:05
Aim. To investigate the expression of glucose transporter 3 (GLUT3) and hypoxia-inducible factor-1α protein (HIF-1α) in meningiomas and analyze the correlation between GLUT3 and HIF-1α expression with the pathological grade of peritumoral brain edema (PTBE) of meningiomas. Methods. In this cross-sectional study, we analyzed meningioma specimens from 160 patients collected from January 1, 2014, to December 1, 2017, by dividing them into a low-grade (WHO I) or high-grade (WHO II and WHO III) group....
Sun Aug 30, 2020 16:50
Any bioassay to test new chemically synthesized larvicides or phytolarvicides against Culicidae and more harmful mosquito species, such as Aedes aegypti and Aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as Zika virus, or Anopheles gambiae, a vector for malaria and philariasis, requires thousands of well-developed larvae, preferably at the fourth instar stage. The natural morphogenetic cycle of Aedes spp., in the field or in the laboratory, may...
Sat Aug 29, 2020 17:35
Background. Previous studies of the relationship between diet and depression have focused on single nutrients or food. Recent research suggested that dietary patterns may offer more information than an individual nutrient in assessing disease risk. We designed this study to assess the association between dietary patterns and depressive symptoms in the adult population of China. Methods. We identified 372 Chinese residents for this research. Factor analysis was used to extract dietary patterns from...
Sat Aug 29, 2020 16:50
Nursing is a high-risk occupation with high exposure to stress. The physical and mental health of nurses is directly related to the quality of medical services. Therefore, the sleep quality of nurses should not be ignored. In this study, the method of cluster random sampling was adopted from May to September 2019, and a questionnaire survey was conducted among 521 surgical nurses from five affiliated hospitals of Xinjiang Medical University. The relationship between mental health and sleep quality...
Sat Aug 29, 2020 16:20
The ascomycete Cordyceps genus has been used as valued traditional Chinese medicine. Cordyceps kyushuensis is a unique species of Cordyceps, which parasitizes on the larvae of Clanis bilineata Walker, and its major component cordycepin and aqueous extract are known to have many pharmacological effects. However, the physiological function of water-soluble polysaccharides has not been explored in detail. In this study, to resolve these doubts, we extracted and separated Cordyceps-derived polysaccharides...
Sat Aug 29, 2020 10:05
Background. Neuropathic pain (NP) is a devastating complication following nerve injury, and it can be alleviated by regulating neuroimmune direction. We aimed to explore the neuroimmune mechanism and identify some new diagnostic or therapeutic targets for NP treatment via bioinformatic analysis. Methods. The microarray GSE18803 was downloaded and analyzed using R. The Venn diagram was drawn to find neuroimmune-related differentially expressed genes (DEGs) in neuropathic pain. Gene Ontology (GO),...
Sat Aug 29, 2020 10:05
Objective. To investigate the effects of HuR protein on the treatment of chronic lymphocytic leukemia (CLL). Methods. LCL lymphoblast cells and B lymphocytes were subjected to HuR overexpression (OV) or interference (IV). Western blot was used to observe the protein expression of human tumor necrosis factor-associated factor 1 (TRAF1), human inhibitor of nuclear factor kappa-B kinase α (IKK-α), NF-κB-inducing kinase (NIK), and p52. Flow cytometry was performed to evaluate apoptosis, and the mRNA...
Fri Aug 28, 2020 17:05
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways
We aim to investigate the role of THAP11 (thanatos-associated protein11) in gastric cancer and its regulation mechanisms. THAP11 expression was analyzed in 51 pairs of GC tissues and the corresponding paracancerous tissues by qRT-PCR and Western blot. After THAP11 was overexpressed or knocked-down, cell proliferation, cell cycle, and apoptosis were detected in MKN-45 cells. We found that THAP11 was significantly downregulated in GC tissues and GC cell lines. Functionally, THAP11 overexpression markedly...
Fri Aug 28, 2020 17:05
Background. Anion gap (AG) has been proved to be associated with prognosis of many cardiovascular diseases. This study is aimed at exploring the association of AG with inhospital all-cause mortality and adverse clinical outcomes in coronary care unit (CCU) patients. Method. All data of this study was extracted from Medical Information Mart for Intensive Care III (MIMIC-III, version 1.4) database. All patients were divided into four groups according to AG quartiles. Primary outcome was inhospital...
Fri Aug 28, 2020 16:50
Periodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth. In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties. In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, the in vitro degradation and antibacterial performance were examined. The pH variation and Mg2+...
Fri Aug 28, 2020 16:50
Abstract A monolithic, fully coupled fluid‐structure interaction (FSI) computational framework was developed to account for dissection flap motion in acute type B aortic dissection (TBAD). Analysis of results included wall deformation, pressure, flow, wall shear stress (WSS), von. Mises stress and comparison of hemodynamics between rigid wall and FSI models. Our FSI model mimicked realistic wall deformation that resulted in maximum compression of the distal true lumen (TL) by 21.4%. The substantial...
Sun Aug 30, 2020 11:10
Abstract Myocardial infarction (MI) is the most common cause of a heart failure, which occurs due to myocardial ischemia leading to left ventricular (LV) remodeling. LV remodeling particularly occurs at the ischemic area and the region surrounds it, known as the border zone. The role of the border zone in initiating LV remodeling process urges the investigation on the correlation between early border zone changes and remodeling outcome. Thus, this study aims to simulate a preliminary conceptual...
Fri Aug 28, 2020 15:31
Since the COVID-19 pandemic began, companies around the world have been working on solutions to improve how the world responds to the crisis. LG, the giant South Korean electronics manufacturer, has just announced that it has developed a face mask that is an air purifier that cleans the air and makes it easy to breathe at the same time. The LG PuriCare Wearable Air Purifier features two replaceable H13 HEPA filters that the firm already employs in its house air purifiers. Two built-in...
Fri Aug 28, 2020 20:25
Background During fertility treatment, diminished ovarian reserve (DOR) is a challenge that can seriously affect a patient’s reproductive potential. However, the pathogenesis of DOR is still unclear and its treatment options are limited. This study aimed to explore DOR’s molecular mechanisms. Methods We used R software to analyze the mRNA microarray dataset E-MTAB-391 downloaded from ArrayExpress, screen for differentially...
Fri Aug 28, 2020 03:00
Background Exosomes are nano-sized extracellular vesicles containing different biomolecules such as proteins and microRNAs (miRNAs) that mediate intercellular communication. Recently, numerous studies have reported the important functions of exosomal miRNAs in disease development and the potential clinical application as diagnostic biomarkers. Up to now, the most commonly used methods to extract exosomes are ultracentrifugation (UC) and precipitation-based commercial kit (e.g., ExoQuick)....
Fri Aug 28, 2020 03:00
Background Cold and frost are two serious factors limiting the yield of many crops worldwide, including the tea plant (Camellia sinensis (L.) Kuntze). The acclimatization of tea plant from tropical to temperate climate regions resulted in unique germplasm in the North–Western Caucasus with extremely frost-tolerant genotypes. Methods The aim of the current research was to evaluate the physiological, biochemical and genetic...
Fri Aug 28, 2020 03:00
The question of whether animals have some sort of self-awareness is a topic of continued debate. A necessary precondition for self-awareness is the ability to visually discriminate the self from others, which has traditionally been investigated through mirror self-recognition experiments. Although great apes generally pass such experiments, interpretations of results have remained controversial. The aim of this study was to investigate how bonobos (Pan paniscus) respond to different types of images...
Fri Aug 28, 2020 03:00
Fungal endophytes are a ubiquitous feature of plants, yet for many fungi the benefits of endophytism are still unknown. The Foraging Ascomycete (FA) hypothesis proposes that saprotrophic fungi can utilize leaves both as dispersal vehicles and as resource havens during times of scarcity. The presence of saprotrophs in leaf endophyte communities has been previously observed but their ability to transfer to non-foliar saprobic substrates has not been well investigated. To assess this ability, we conducted...
Fri Aug 28, 2020 03:00
The usually positive inter-specific relationship between geographical range size and the abundance of local bird populations comes with exceptions. On continents, the majority of these exceptions have been described from tropical montane areas in Africa, where geographically-restricted bird species are unusually abundant. We asked how the local abundances of passerine and non-passerine bird species along an elevational gradient on Mt. Wilhelm, Papua New Guinea relate to their geographical range size....
Fri Aug 28, 2020 03:00
It is known that an eye-like image promotes generosity. It is also known that the evaluation of the visual deliciousness of food is improved in the presence of an emotionally positive stimulus. The purpose of the present study was to examine whether the presence of open eyes (OPEN) causes generous behavior altering the evaluation of the visual deliciousness of food, and how the images of open and closed eyes (CLOSED) affect human emotions. Seventeen women participated in the present study. A picture...
Fri Aug 28, 2020 03:00
Background Fungal GATA-type transcription factors (GATA-TFs) are a class of transcriptional regulators involved in various biological processes. However, their functions are rarely analyzed systematically, especially in edible or medicinal fungi, such as Tolypocladium guangdongense, which has various medicinal and food safety properties with a broad range of potential applications in healthcare products and the pharmaceutical industry. ...
Fri Aug 28, 2020 03:00
Publication date: Available online 28 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Yolanda D. Tseng, Bradford S. Hoppe, Katerina Dedeckova, Chirayu G. Patel, Christine E. Hill-Kayser, David M. Miller, Amit Maity, Nancy P. Mendenhall, Raymond B. Mailhot, Torunn I. Yock, Sujith Baliga, Clayton B. Hess, Karen M. Winkfield, Pranshu Mohindra, Lane R. Rosen, Henry Tsai, John Chang, William F. Hartsell, John P. Plastaras
Sat Aug 29, 2020 23:05
Publication date: Available online 28 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Tingting Huang, Justine Debelius, Alexander Ploner, Xiling Xiao, Tingting Zhang, Kai Hu, Zhe Zhang, Rensheng Wang, Weimin Ye
Sat Aug 29, 2020 23:05
Publication date: Available online 28 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Joseph Abi Jaoude, Majd Kayali, Evandro de Azambuja, Maha Makki, Hani Tamim, Arafat Tfayli, Nagi El Saghir, Fady Geara, Martine Piccart, Philip Poortmans, Youssef H. Zeidan
Fri Aug 28, 2020 16:54
Publication date: Available online 28 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Eliot Nicolas, Nadjoua Khalifa, Cyril Laporte, Youlia Kirova
Fri Aug 28, 2020 16:54
Publication date: Available online 27 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): William A. Hall, Eric Paulson, Brian J. Davis, Daniel E. Spratt, Todd M. Morgan, David Dearnaley, Alison C. Tree, Jason A. Efstathiou, Mukesh Harisinghani, Ashesh B. Jani, Mark K. Buyyounouski, Thomas M. Pisansky, Phuoc T. Tran, R. Jeffrey Karnes, Ronald C. Chen, Fabio L. Cury, Jeff M. Michalski, Seth A. Rosenthal, Bridget F. Koontz, Anthony C. Wong
Fri Aug 28, 2020 16:54
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