IJMS, Vol. 21, Pages 6212: TRPV1 Hyperfunction Involved in Uremic Toxin Indoxyl Sulfate-Mediated Renal Tubular Damage International Journal of Molecular Sciences doi: 10.3390/ijms21176212 Authors: Chien-Lin Lu Chun-Hou Liao Kuo-Cheng Lu Ming-Chieh Ma Indoxyl sulfate (IS) is accumulated during severe renal insufficiency and known for its nephrotoxic properties. Transient receptor potential vanilloid 1 (TRPV1) is present in the kidney and acts as a renal sensor. However, the mechanism...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6211: Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles International Journal of Molecular Sciences doi: 10.3390/ijms21176211 Authors: Ha Thi Thu Do Jungsook Cho Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments....
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6214: Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia International Journal of Molecular Sciences doi: 10.3390/ijms21176214 Authors: Mohammad Zakir Hossain Hiroshi Ando Shumpei Unno Junichi Kitagawa Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia....
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6209: Phototaxis of the Unicellular Red Alga Cyanidioschyzon merolae Is Mediated by Novel Actin-Driven Tentacles International Journal of Molecular Sciences doi: 10.3390/ijms21176209 Authors: Sascha Maschmann Karin Ruban Johanna Wientapper Wilhelm J. Walter Phototaxis, which is the ability to move towards or away from a light source autonomously, is a common mechanism of unicellular algae. It evolved multiple times independently in different plant lineages....
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6206: Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis International Journal of Molecular Sciences doi: 10.3390/ijms21176206 Authors: Joanna Pleńkowska Magdalena Gabig-Cimińska Paweł Mozolewski This review discusses how oxidative stress (OS), an imbalance between oxidants and antioxidants in favor of the oxidants, increased production of reactive oxygen species (ROS)/reactive nitrogen species (RNS), and decreased concentration/activity...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6196: Focal Accumulation of ROS Can Block Pyricularia oryzae Effector BAS4-Expression and Prevent Infection in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21176196 Authors: Yafei Chen Sarmina Dangol Juan Wang Nam-Soo Jwa The reactive oxygen species (ROS) burst is the most common plant immunity mechanism to prevent pathogen infection, although the exact role of ROS in plant immunity has not been fully elucidated. We investigated the...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6208: Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21176208 Authors: Greta Bianchi Sonia Longhi Rita Grandori Stefania Brocca The abundance of intrinsic disorder in the protein realm and its role in a variety of physiological and pathological cellular events have strengthened the interest of the scientific community in...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6207: Involvement of Fusobacterium Species in Oral Cancer Progression: A Literature Review Including Other Types of Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21176207 Authors: Natsumi Fujiwara Naoya Kitamura Kaya Yoshida Tetsuya Yamamoto Kazumi Ozaki Yasusei Kudo Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. It has recently been shown that there is correlation...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6201: Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins? International Journal of Molecular Sciences doi: 10.3390/ijms21176201 Authors: Carla Fiorentini Francesca Carlini Elena Angela Pia Germinario Zaira Maroccia Sara Travaglione Alessia Fabbri Accumulating evidence indicates that the human intestinal microbiota can contribute to the etiology of colorectal cancer. Triggering factors, including inflammation and bacterial infections,...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6205: In Vivo Optical Reporter-Gene-Based Imaging of Macrophage Infiltration of DNCB-Induced Atopic Dermatitis International Journal of Molecular Sciences doi: 10.3390/ijms21176205 Authors: Sang Bong Lee Hyeonsoo Park Jae-Eon Lee Kil-Soo Kim Yong Hyun Jeon This study was conducted to monitor the macrophage infiltration of atopic dermatitis (AD)-like skin lesions and to evaluate the effects of anti-AD therapeutic agents in immunocompetent mice via optical...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6210: P2 Receptors Influence hMSCs Differentiation towards Endothelial Cell and Smooth Muscle Cell Lineages International Journal of Molecular Sciences doi: 10.3390/ijms21176210 Authors: Yu Zhang Patrick Babczyk Andreas Pansky Matthias Ulrich Kassack Edda Tobiasch Background: Human mesenchymal stem cells (hMSCs) have shown their multipotential including differentiating towards endothelial and smooth muscle cell lineages, which triggers a new interest...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6202: MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections International Journal of Molecular Sciences doi: 10.3390/ijms21176202 Authors: Jigar P. Sethiya Melanie A. Sowards Mary Jackson Elton Jeffrey North Outside of Mycobacterium tuberculosis and Mycobacterium leprae, nontuberculous mycobacteria (NTM) are environmental mycobacteria (>190 species) and are classified as slow- or rapid-growing mycobacteria. Infections caused...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6200: MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function International Journal of Molecular Sciences doi: 10.3390/ijms21176200 Authors: Zoe Grewers Andreas Krueger The selection of T cells during intra-thymic d evelopment is crucial to obtain a functional and simultaneously not self-reactive peripheral T cell repertoire. However, selection is a complex process dependent on T cell receptor (TCR) thresholds that remain...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6199: Fock-Space Coupled Cluster Theory: Systematic Study of Partial Fourth Order Triples Schemes for Ionization Potential and Comparison with Bondonic Formalism International Journal of Molecular Sciences doi: 10.3390/ijms21176199 Authors: Suhita Basumallick Sourav Pal Mihai V. Putz In this paper, we have made a systematic study of partial fourth order perturbative schemes due to triples to compute the ionization potential within Fock-space multi-reference...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6198: Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae International Journal of Molecular Sciences doi: 10.3390/ijms21176198 Authors: Rishikesh Kumar Gupta Iga Wasilewska Oksana Palchevska Jacek Kuźnicki Stromal interaction molecule (STIM) proteins play a crucial role in store-operated calcium entry (SOCE) as endoplasmic reticulum Ca2+ sensors. In neurons, STIM2 was shown to have distinct...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6197: The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection International Journal of Molecular Sciences doi: 10.3390/ijms21176197 Authors: Rochelin Dalangin Anna Kim Robert E. Campbell Neurotransmission between neurons, which can occur over the span of a few milliseconds, relies on the controlled release of small molecule neurotransmitters, many of which are amino acids. Fluorescence imaging provides the necessary speed to follow...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6204: The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21176204 Authors: Natasha Irrera Massimo Russo Giovanni Pallio Alessandra Bitto Federica Mannino Letteria Minutoli Domenica Altavilla Francesco Squadrito Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6195: ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation International Journal of Molecular Sciences doi: 10.3390/ijms21176195 Authors: Lushang Jiang Min Ji Park Charles J. Cho Kihak Lee Min Kyo Jung Chan Gi Pack Seung-Jae Myung Suhwan Chang ADAR (adenosine deaminase acting on RNA) catalyzes the deamination of adenosine to generate inosine, through its binding to double-stranded RNA (dsRNA),...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6192: Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels International Journal of Molecular Sciences doi: 10.3390/ijms21176192 Authors: Diego Méndez Diego Arauna Francisco Fuentes Ramiro Araya-Maturana Iván Palomo Marcelo Alarcón David Sebastián Antonio Zorzano Eduardo Fuentes Platelet activation plays a key role in cardiovascular diseases. The generation of mitochondrial reactive oxygen species (ROS) has been described...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6193: Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21176193 Authors: Ala Litman-Zawadzka Marta Łukaszewicz-Zając Mariusz Gryko Agnieszka Kulczyńska-Przybik Bogusław Kędra Barbara Mroczko Background: The mortality rate of pancreatic cancer (PC) is equal to its incidence and the majority of PC patients die within a few months of diagnosis. Therefore, a search for...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6191: Characterization of the Heavy-Metal-Associated Isoprenylated Plant Protein (HIPP) Gene Family from Triticeae Species International Journal of Molecular Sciences doi: 10.3390/ijms21176191 Authors: Heng Zhang Xu Zhang Jia Liu Ying Niu Yiming Chen Yongli Hao Jia Zhao Li Sun Haiyan Wang Jin Xiao Xiue Wang Heavy-metal-associated (HMA) isoprenylated plant proteins (HIPPs) only exist in vascular plants. They play important roles in responses...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6194: Cell Therapies under Clinical Trials and Polarized Cell Therapies in Pre-Clinical Studies to Treat Ischemic Stroke and Neurological Diseases: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21176194 Authors: Masahiro Hatakeyama Itaru Ninomiya Yutaka Otsu Kaoru Omae Yasuko Kimura Osamu Onodera Masanori Fukushima Takayoshi Shimohata Masato Kanazawa Stroke remains a major cause of serious disability because...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6181: Tuning Adipogenic Differentiation in ADSCs by Metformin and Vitamin D: Involvement of miRNAs International Journal of Molecular Sciences doi: 10.3390/ijms21176181 Authors: Sara Cruciani Giuseppe Garroni Francesca Balzano Renzo Pala Emanuela Bellu Maria Laura Cossu Giorgio Carlo Ginesu Carlo Ventura Margherita Maioli Fat tissue represents an important source of adipose-derived stem cells (ADSCs), which can differentiate towards several...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6189: In Silico Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype International Journal of Molecular Sciences doi: 10.3390/ijms21176189 Authors: Kuntarat Arunrungvichian Sumet Chongruchiroj Jiradanai Sarasamkan Gerrit Schüürmann Peter Brust Opa Vajragupta The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6190: Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate International Journal of Molecular Sciences doi: 10.3390/ijms21176190 Authors: Karolina Bossak-Ahmad Marta D. Wiśniewska Wojciech Bal Simon C. Drew Tomasz Frączyk The tripeptide NH2–Gly–His–Lys–COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the human...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6186: Supramolecular Chirality in Azobenzene-Containing Polymer System: Traditional Postpolymerization Self-Assembly Versus In Situ Supramolecular Self-Assembly Strategy International Journal of Molecular Sciences doi: 10.3390/ijms21176186 Authors: Xiaoxiao Cheng Tengfei Miao Yilin Qian Zhengbiao Zhang Wei Zhang Xiulin Zhu Recently, the design of novel supramolecular chiral materials has received a great deal of attention due to rapid developments...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6188: Using All-Atom Potentials to Refine RNA Structure Predictions of SARS-CoV-2 Stem Loops International Journal of Molecular Sciences doi: 10.3390/ijms21176188 Authors: Christina Bergonzo Andrea L. Szakal A considerable amount of rapid-paced research is underway to combat the SARS-CoV-2 pandemic. In this work, we assess the 3D structure of the 5′ untranslated region of its RNA, in the hopes that stable secondary structures can be targeted, interrupted,...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6185: Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia International Journal of Molecular Sciences doi: 10.3390/ijms21176185 Authors: Efstathios Katharopoulos Natascia Di Lorgi Paula Fernandez-Alvarez Amit V. Pandey Michael Groessl Shraddha Dubey Núria Camats Flavia Napoli Giuseppa Patti Marilea Lezzi Mohamad Maghnie Christa E. Flück...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6187: Extended Exhaled Nitric Oxide Analysis in Interstitial Lung Diseases: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21176187 Authors: Paolo Cameli Elena Bargagli Laura Bergantini Miriana d’Alessandro Maria Pieroni Giovanni A. Fontana Piersante Sestini Rosa Metella Refini Fractional exhaled nitric oxide (FeNO) is a well-known and widely accepted biomarker of airways inflammation that can be useful in the...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6184: Close Temporal Relationship between Oscillating Cytosolic K+ and Growth in Root Hairs of Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21176184 Authors: Xiangzhong Sun Yuping Qiu Yang Peng Juewei Ning Guangjie Song Yanzhu Yang Mengyu Deng Yongfan Men Xingzhong Zhao Yichuan Wang Hongwei Guo Yanqing Tian Root hair elongation relies on polarized cell expansion at the growing tip. As a major osmotically...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6182: Overexpression of MdARD4 Accelerates Fruit Ripening and Increases Cold Hardiness in Tomato International Journal of Molecular Sciences doi: 10.3390/ijms21176182 Authors: Tianli Guo Xiuzhi Zhang Yuxing Li Chenlu Liu Na Wang Qi Jiang Junyao Wu Fengwang Ma Changhai Liu Ethylene plays an important role in stress adaptation and fruit ripening. Acireductone dioxygenase (ARD) is pivotal for ethylene biosynthesis. However, the response of ARD...
Thu Aug 27, 2020 03:00
IJMS, Vol. 21, Pages 6183: Tumor Suppressor Role of hsa-miR-193a-3p and -5p in Cutaneous Melanoma International Journal of Molecular Sciences doi: 10.3390/ijms21176183 Authors: Beatrice Polini Sara Carpi Stefano Doccini Valentina Citi Alma Martelli Sara Feola Filippo Maria Santorelli Vincenzo Cerullo Antonella Romanini Paola Nieri Background: Remarkable deregulation of several microRNAs (miRNAs) is demonstrated in cutaneous melanoma. hsa-miR-193a-3p is reported...
Thu Aug 27, 2020 03:00
IJNS, Vol. 6, Pages 70: CAH Newborn Screening in India: Challenges and Opportunities International Journal of Neonatal Screening doi: 10.3390/ijns6030070 Authors: Aashima Dabas Meenakshi Bothra Seema Kapoor Congenital adrenal hyperplasia (CAH) is a common treatable disorder which is associated with life-threatening adrenal crisis, sexual ambiguity, and/or abnormal growth if undiagnosed. Newborn screening is a cost-effective tool to detect affected babies early after birth to optimize...
Thu Aug 27, 2020 03:00
JCDD, Vol. 7, Pages 33: Is There a Link Between Nutrition, Genetics, and Cardiovascular Disease? Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7030033 Authors: Ghoch Shamieh Cardiovascular diseases (CVDs) are a group of disorders that mainly include coronary, cerebrovascular and rheumatic heart diseases [1].[...]
Thu Aug 27, 2020 03:00
JCM, Vol. 9, Pages 2778: Clinical Application of Forced Oscillation Technique (FOT) in Early Detection of Airway Changes in Smokers Journal of Clinical Medicine doi: 10.3390/jcm9092778 Authors: Prem Bhattarai Stephen Myers Collin Chia Heinrich C. Weber Sally Young Andrew D. Williams Sukhwinder Singh Sohal The forced oscillation technique (FOT) is a non-invasive method to assess airway function by emitting oscillatory signals into the respiratory tract during tidal ventilation....
Thu Aug 27, 2020 03:00
JCM, Vol. 9, Pages 2780: Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors Journal of Clinical Medicine doi: 10.3390/jcm9092780 Authors: Antonio Vena Marco Berruti Andrea Adessi Pietro Blumetti Michele Brignole Renato Colognato Germano Gaggioli Daniele Roberto Giacobbe Luisa Bracci-Laudiero Laura Magnasco Alessio Signori Lucia Taramasso Marco Varelli Nicoletta Vendola Lorenzo Ball Chiara Robba Denise Battaglini...
Thu Aug 27, 2020 03:00
JCM, Vol. 9, Pages 2779: Clinical Characteristics, Treatments, and Outcomes of Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Results from a Multicenter National Registry Journal of Clinical Medicine doi: 10.3390/jcm9092779 Authors: Pawel Gasior Aneta Desperak Marek Gierlotka Krzysztof Milewski Krystian Wita Zbigniew Kalarus Joanna Fluder Maciej Kazmierski Paweł E. Buszman Mariusz Gasior Wojciech Wojakowski Background:...
Thu Aug 27, 2020 03:00
JCM, Vol. 9, Pages 2781: A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort Journal of Clinical Medicine doi: 10.3390/jcm9092781 Authors: Flores-Guerrero Gruppen Connelly Shalaurova Otvos Garcia Bakker Dullaart Objective: Evaluate the ability of a newly developed diabetes risk score, the Diabetes Risk Index (DRI), to predict incident...
Thu Aug 27, 2020 03:00
JCM, Vol. 9, Pages 2776: Efficacy of Plasma-Polymerized Allylamine Coating of Zirconia after Five Years Journal of Clinical Medicine doi: 10.3390/jcm9092776 Authors: Rohr Fricke Bergemann Nebe Fischer Plasma-polymerized allylamine (PPAAm) coatings of titanium enhance the cell behavior of osteoblasts. The purpose of the present study was to evaluate a PPAAm nanolayer on zirconia after a storage period of 5 years. Zirconia specimens were directly coated with PPAAm (ZA0)...
Thu Aug 27, 2020 03:00
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