Κυριακή 30 Αυγούστου 2020


Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
Related Articles Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force. J Cell Physiol. 2020 Aug 27;: Authors: Wang Y, Zhou J, Tang C, Yu J, Zhu W, Guo J, Wang Y Abstract Integrin plays a prominent role in neurite outgrowth by transmitting both mechanical and chemical signals. Integrin expression is closely associated with Astragaloside IV (AS-IV), the main component extracted...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways.
Related Articles Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways. J Cell Physiol. 2020 Aug 27;: Authors: Liao S, Feng W, Liu Y, Wang Z, Ding X, Song F, Lin X, Song H, Kc A, Su Y, Liang J, Xu J, Liu Q, Zhao J Abstract Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
Related Articles lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression. J Cell Physiol. 2020 Aug 27;: Authors: Zhuang L, Ding W, Ding W, Zhang Q, Xu X, Xi D Abstract Long noncoding RNAs (lncRNAs) participate in many biological processes by affecting gene expression at the posttranscriptional level. lncRNAs are dysregulated in colorectal cancer (CRC) and this dysregulation is closely...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
A novel prognostic index of hepatocellular carcinoma based on immunogenomic landscape analysis.
Related Articles A novel prognostic index of hepatocellular carcinoma based on immunogenomic landscape analysis. J Cell Physiol. 2020 Aug 27;: Authors: Xiao H, Wang B, Xiong HX, Guan JF, Wang J, Tan T, Lin K, Zou SB, Hu ZG, Wang K Abstract Changes in immune responses to hepatocellular carcinoma (HCC) are closely related to the occurrence, development, and prognosis of this disease. Exploring the role of immune-related genes (IRGs) in HCC would...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
Postnatal growth retardation is associated with deteriorated intestinal mucosal barrier function using a porcine model.
Related Articles Postnatal growth retardation is associated with deteriorated intestinal mucosal barrier function using a porcine model. J Cell Physiol. 2020 Aug 27;: Authors: Qi M, Tan B, Wang J, Liao S, Li J, Cui Z, Shao Y, Ji P, Yin Y Abstract Individuals with postnatal growth retardation (PGR) are prone to developing chronic diseases. Abnormal development in small intestine is casually implicated in impaired growth. However, the exact mechanism...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
Corneal endothelial expansion using human umbilical cord mesenchymal stem cell-derived conditioned medium.
Related Articles Corneal endothelial expansion using human umbilical cord mesenchymal stem cell-derived conditioned medium. J Cell Physiol. 2020 Aug 27;: Authors: Duan S, Zhang Y, Yuan F, Jiang A, Sang Y, Huang G Abstract Rabbit corneal endothelial cells are frequently used in pharmacological experiments and are useful for corneal transplant experiments. We performed the present study to analyze the effect of conditioned medium (CM) derived...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
miR-130b-3p regulates M1 macrophage polarization via targeting IRF1.
Related Articles miR-130b-3p regulates M1 macrophage polarization via targeting IRF1. J Cell Physiol. 2020 Aug 27;: Authors: Guo Q, Zhu X, Wei R, Zhao L, Zhang Z, Yin X, Zhang Y, Chu C, Wang B, Li X Abstract Polarized macrophages can be broadly classified into classically activated macrophages (M1) and alternatively activated macrophages (M2) in response to the microenvironment signals. Interferon regulatory factor 1 (IRF1) has been demonstrated...
pubmed: "j cell physiol"[jou...
Fri Aug 28, 2020 14:07
Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives.
Related Articles Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives. J Inorg Biochem. 2020 Jul 17;211:111175 Authors: Yang QY, Cao QQ, Zhang YL, Xu XF, Deng CX, Kumar R, Zhu XM, Wang XJ, Liang H, Chen ZF Abstract The rare earth metal Gd(III), Yb(III), Lu(III), Eu(III), Tb(III) and Ho(III) complexes 1-6 with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (H-L)...
pubmed: "j inorg biochem"[jo...
Sat Aug 29, 2020 13:30
Boyd L O'Dell, PhD (1916-2019).
Related Articles Boyd L O'Dell, PhD (1916-2019). J Nutr. 2020 Aug 28;: Authors: Rucker RB, Starcher B PMID: 32856085 [PubMed - as supplied by publisher]
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
Building the Evidence Base around Poultry Production for Nutrition.
Related Articles Building the Evidence Base around Poultry Production for Nutrition. J Nutr. 2020 Aug 28;: Authors: Lutter CK PMID: 32856076 [PubMed - as supplied by publisher]
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
A Systematic Scoping Review of How Healthcare Organizations Are Facilitating Access to Fruits and Vegetables in Their Patient Populations.
Related Articles A Systematic Scoping Review of How Healthcare Organizations Are Facilitating Access to Fruits and Vegetables in Their Patient Populations. J Nutr. 2020 Aug 28;: Authors: Veldheer S, Scartozzi C, Knehans A, Oser T, Sood N, George DR, Smith A, Cohen A, Winkels RM Abstract BACKGROUND: There is compelling evidence on the impact of diet as preventative medicine, and with rising health care costs healthcare organizations are attempting...
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
High Rumen-Degradable Starch Diet Promotes Hepatic Lipolysis and Disrupts Enterohepatic Circulation of Bile Acids in Dairy Goats.
Related Articles High Rumen-Degradable Starch Diet Promotes Hepatic Lipolysis and Disrupts Enterohepatic Circulation of Bile Acids in Dairy Goats. J Nutr. 2020 Aug 28;: Authors: Shen J, Han X, Zheng L, Liu S, Jin C, Liu T, Cao Y, Lei X, Yao J Abstract BACKGROUND: High rumen-degradable starch (RDS) diets decrease milk fat. The increase of LPS in plasma associated with increased RDS impairs liver function, immune response and lipid metabolism,...
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice.
Related Articles Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice. J Nutr. 2020 Aug 28;: Authors: Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X Abstract BACKGROUND: It is unclear how high fructose consumption induces disparate metabolic responses in genetically diverse mouse...
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
Maternal Food Insecurity is Positively Associated with Postpartum Mental Disorders in Ontario, Canada.
Related Articles Maternal Food Insecurity is Positively Associated with Postpartum Mental Disorders in Ontario, Canada. J Nutr. 2020 Aug 28;: Authors: Tarasuk V, Gundersen C, Wang X, Roth DE, Urquia ML Abstract BACKGROUND: Household food insecurity has been associated with pregnancy complications and poorer birth outcomes in the United States and with maternal mental disorders in the United Kingdom, but there has been little investigation of...
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
Maternal Nitrate and Nitrite Intakes during Pregnancy and Risk of Islet Autoimmunity and Type 1 Diabetes: The DIPP Cohort Study.
Related Articles Maternal Nitrate and Nitrite Intakes during Pregnancy and Risk of Islet Autoimmunity and Type 1 Diabetes: The DIPP Cohort Study. J Nutr. 2020 Aug 28;: Authors: Mattila M, Niinistö S, Takkinen HM, Tapanainen H, Reinivuo H, Åkerlund M, Suomi J, Ahonen S, Ilonen J, Toppari J, Knip M, Veijola R, Virtanen SM Abstract BACKGROUND: High dietary intake of nitrate and nitrite might increase the risk of type 1 diabetes. To our knowledge,...
pubmed: "j nutr"[jour]
Sat Aug 29, 2020 13:16
Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass.
Related Articles Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass. J Nutr. 2020 Aug 27;: Authors: Lewis LN, Hayhoe RPG, Mulligan AA, Luben RN, Khaw KT, Welch AA Abstract BACKGROUND: Age-related loss of skeletal muscle mass contributes to poor outcomes including sarcopenia, physical disability, frailty, type 2 diabetes, and mortality. Vitamin C has physiological...
pubmed: "j nutr"[jour]
Fri Aug 28, 2020 13:06
Determinants of renal oxygen metabolism during low Na+ diet: effect of angiotensin II AT1 and aldosterone receptor blockade.
Related Articles Determinants of renal oxygen metabolism during low Na+ diet: effect of angiotensin II AT1 and aldosterone receptor blockade. J Physiol. 2020 Aug 28;: Authors: Patinha D, Carvalho C, Persson P, Pihl L, Fasching A, Friederich-Persson M, O'Neill J, Palm F Abstract KEY POINTS: Reducing Na+ intake reduces the partial pressure of oxygen in the renal cortex and activates the renin-angiotensin-aldosterone system. In the absence of high...
pubmed: "j physiol"[jour]
Sat Aug 29, 2020 15:24
Temporally-precise basolateral amygdala activation is required for the formation of taste memories in gustatory cortex.
Related Articles Temporally-precise basolateral amygdala activation is required for the formation of taste memories in gustatory cortex. J Physiol. 2020 Aug 28;: Authors: Arieli E, Gerbi R, Shein-Idelson M, Moran A Abstract KEY POINTS: The basolateral amygdala (BLA), the nucleus basalis magnocellularis (NBM), and the gustatory cortex (GC) are involved in taste processing, taste memory formation, and conditioned taste aversion (CTA) learning,...
pubmed: "j physiol"[jour]
Sat Aug 29, 2020 15:24
A subpopulation of L6b neurons provide driver-like input to the posteromedial thalamus.
Related Articles A subpopulation of L6b neurons provide driver-like input to the posteromedial thalamus. J Physiol. 2020 Aug 28;: Authors: Buchan MJ PMID: 32857864 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Sat Aug 29, 2020 15:24
Functional architecture of the motor homunculus detected by electrostimulation.
Related Articles Functional architecture of the motor homunculus detected by electrostimulation. J Physiol. 2020 Aug 28;: Authors: Roux FE, Niare M, Charni S, Giussani C, Durand JB Abstract KEY POINTS: We performed a prospective electrostimulation study of the motor homunculus in 100 patients without motor deficit or brain lesion in the precentral gyrus in order to acquire accurate MNI coordinates of the functional areas. The analysis of 248...
pubmed: "j physiol"[jour]
Sat Aug 29, 2020 15:24



Functional architecture of the motor homunculus detected by electrostimulation.
Related Articles Functional architecture of the motor homunculus detected by electrostimulation. J Physiol. 2020 Aug 28;: Authors: Roux FE, Niare M, Charni S, Giussani C, Durand JB Abstract KEY POINTS: We performed a prospective electrostimulation study of the motor homunculus in 100 patients without motor deficit or brain lesion in the precentral gyrus in order to acquire accurate MNI coordinates of the functional areas. The analysis of 248...
pubmed: "j physiol"[jour]
Sat Aug 29, 2020 15:24
August Krogh: Physiology genius and compassionate humanitarian.
Related Articles August Krogh: Physiology genius and compassionate humanitarian. J Physiol. 2020 Aug 27;: Authors: Poole DC, Pittman RN, Musch TI, Østergaard L PMID: 32853399 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
Spinal motoneuron firing properties mature from rostral to caudal during post-natal development of the mouse.
Related Articles Spinal motoneuron firing properties mature from rostral to caudal during post-natal development of the mouse. J Physiol. 2020 Aug 27;: Authors: Smith CC, Brownstone RM Abstract KEY POINTS: Many mammals are born with immature motor systems that develop through a critical period of postnatal development In rodents, postnatal maturation of movement occurs from rostral to caudal, correlating with maturation of descending supraspinal...
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
Emerging views of how changes in T3 influence prenatal metabolic maturation.
Related Articles Emerging views of how changes in T3 influence prenatal metabolic maturation. J Physiol. 2020 Aug 27;: Authors: Patel E, Smith R PMID: 32851657 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.
Related Articles Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels. J Physiol. 2020 Aug 27;: Authors: Hori K, Tsujikawa S, Novakovic MM, Yamashita M, Prakriya M Abstract KEY POINTS: Temporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca2+ signalling in many aspects of epilepsy but the precise Ca2+ channels that...
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
Insulin-stimulated glucose uptake partly relies on p21-activated kinase 2 (PAK2), but not PAK1, in mouse skeletal muscle.
Related Articles Insulin-stimulated glucose uptake partly relies on p21-activated kinase 2 (PAK2), but not PAK1, in mouse skeletal muscle. J Physiol. 2020 Aug 26;: Authors: Møller LLV, Jaurji M, Kjøbsted R, Joseph GA, Madsen AB, Knudsen JR, Lundsgaard AM, Andersen NR, Schjerling P, Jensen TE, Krauss RS, Richter EA, Sylow L Abstract KEY POINTS: Muscle-specific genetic ablation of PAK2, but not whole-body PAK1 knockout, impairs glucose tolerance...
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
Charged residues at the pore extracellular half of the glycine receptor facilitate channel gating: a potential role played by electrostatic repulsion.
Related Articles Charged residues at the pore extracellular half of the glycine receptor facilitate channel gating: a potential role played by electrostatic repulsion. J Physiol. 2020 Aug 26;: Authors: Tian Y, Chen S, Shan Q Abstract KEY POINTS: The Arg271Gln mutation of the glycine receptor (GlyR) causes hereditary hyperekplexia. This mutation dramatically compromises GlyR function; however, the underlying mechanism is not yet known. This study,...
pubmed: "j physiol"[jour]
Fri Aug 28, 2020 15:07
NuMA interaction with chromatin is vital for proper chromosomes decondensation at the mitotic exit.
Related Articles NuMA interaction with chromatin is vital for proper chromosomes decondensation at the mitotic exit. Mol Biol Cell. 2020 Aug 26;:mbcE20060415 Authors: Rajeevan A, Keshri R, Kapoor S, Kotak S Abstract NuMA is an abundant long coiled-coil protein that plays a prominent role in spindle organization during mitosis. In interphase, NuMA is localized to the nucleus and hypothesized to control gene expression and chromatin organization....
pubmed: "mol biol cell"[jour...
Fri Aug 28, 2020 16:37
XK is a partner for VPS13A: A molecular link between Chorea-Acanthocytosis and McLeod syndrome.
Related Articles XK is a partner for VPS13A: A molecular link between Chorea-Acanthocytosis and McLeod syndrome. Mol Biol Cell. 2020 Aug 26;:mbcE19080439T Authors: Park JS, Neiman AM Abstract Vps13 is a highly conserved lipid transfer protein found at multiple inter-organelle membrane contact sites where it mediates distinct processes. In yeast, recruitment of Vps13 to different contact sites occurs via various partner proteins. In humans, four...
pubmed: "mol biol cell"[jour...
Fri Aug 28, 2020 16:37
Dynamics of Tpm1.8 domains on actin filaments with single molecule resolution.
Related Articles Dynamics of Tpm1.8 domains on actin filaments with single molecule resolution. Mol Biol Cell. 2020 Aug 26;:mbcE19100586 Authors: Bareja I, Wioland H, Janco M, Nicovich PR, Jégou A, Romet-Lemonne G, Walsh J, Böcking T Abstract Tropomyosins regulate dynamics and functions of the actin cytoskeleton by forming long chains along the two strands of actin filaments that act as gatekeepers for the binding of other actin-binding proteins....
pubmed: "mol biol cell"[jour...
Fri Aug 28, 2020 16:37
Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles.
Related Articles Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles. Mol Biol Cell. 2020 Aug 26;:mbcE19030133 Authors: Davies BA, Morton LO, Jefferson JR, Rozeveld CN, Doskey LC, LaRusso NF, Katzmann DJ Abstract Intercellular communication is critical for organismal homeostasis and defects can contribute to human disease states. Polarized epithelial cells execute distinct signaling...
pubmed: "mol biol cell"[jour...
Fri Aug 28, 2020 16:37
A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.
Related Articles A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D, University of California, San Francisco MS-EPIC Team, Guo CY, Green AJ, Bove RM, DeRisi JL, Gelfand JM, Cree BAC, Zamvil SS, Baranzini SE, Hauser SL, Wilson MR Abstract...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease.
Related Articles Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Viola HM, Shah AA, Johnstone VPA, Cserne Szappanos H, Hodson MP, Hool LC Abstract Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Multivalent weak interactions enhance selectivity of interparticle binding.
Related Articles Multivalent weak interactions enhance selectivity of interparticle binding. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Scheepers MRW, van IJzendoorn LJ, Prins MWJ Abstract Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
A chemical dynamics study on the gas phase formation of thioformaldehyde (H2CS) and its thiohydroxycarbene isomer (HCSH).
Related Articles A chemical dynamics study on the gas phase formation of thioformaldehyde (H2CS) and its thiohydroxycarbene isomer (HCSH). Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Doddipatla S, He C, Kaiser RI, Luo Y, Sun R, Galimova GR, Mebel AM, Millar TJ Abstract Complex organosulfur molecules are ubiquitous in interstellar molecular clouds, but their fundamental formation mechanisms have remained largely elusive. These processes...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo.
Related Articles Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: He X, Yin X, Wu J, Wickström SL, Duo Y, Du Q, Qin S, Yao S, Jing X, Hosaka K, Wu J, Jensen LD, Lundqvist A, Salter AI, Bräutigam L, Tao W, Chen Y, Kiessling R, Cao Y Abstract Lymphocyte-based immunotherapy has emerged as a breakthrough in cancer therapy for both hematologic and solid malignancies....
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Related Articles Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Mokrushina YA, Golovin AV, Smirnov IV, Chatziefthimiou SD, Stepanova AV, Bobik TV, Zalevsky AO, Zlobin AS, Konovalov KA, Terekhov SS, Stepanov AV, Pipiya SO, Shamborant OG, Round E, Belogurov AA, Bourenkov G, Makarov AA, Wilmanns M, Xie J, Blackburn GM, Gabibov AG, Lerner RA ...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Low-dimensional dynamics for working memory and time encoding.
Related Articles Low-dimensional dynamics for working memory and time encoding. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Cueva CJ, Saez A, Marcos E, Genovesio A, Jazayeri M, Romo R, Salzman CD, Shadlen MN, Fusi S Abstract Our decisions often depend on multiple sensory experiences separated by time delays. The brain can remember these experiences and, simultaneously, estimate the timing between events. To understand the mechanisms underlying...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Statistical prediction of the future impairs episodic encoding of the present.
Related Articles Statistical prediction of the future impairs episodic encoding of the present. Proc Natl Acad Sci U S A. 2020 Aug 28;: Authors: Sherman BE, Turk-Browne NB Abstract Memory is typically thought of as enabling reminiscence about past experiences. However, memory also informs and guides processing of future experiences. These two functions of memory are often at odds: Remembering specific experiences from the past requires storing...
pubmed: "proc natl acad sci ...
Sun Aug 30, 2020 23:14
Developing a population-state decision system for intelligently reprogramming extracellular electron transfer in Shewanella oneidensis.
Related Articles Developing a population-state decision system for intelligently reprogramming extracellular electron transfer in Shewanella oneidensis. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Li FH, Tang Q, Fan YY, Li Y, Li J, Wu JH, Luo CF, Sun H, Li WW, Yu HQ Abstract The unique extracellular electron transfer (EET) ability has positioned electroactive bacteria (EAB) as a major class of cellular chassis for genetic engineering aimed...
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.
Related Articles Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Burnett DL, Schofield P, Langley DB, Jackson J, Bourne K, Wilson E, Porebski BT, Buckle AM, Brink R, Goodnow CC, Christ D Abstract Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses....
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
The cryoelectron microscopy structure of the human CDK-activating kinase.
Related Articles The cryoelectron microscopy structure of the human CDK-activating kinase. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Greber BJ, Perez-Bertoldi JM, Lim K, Iavarone AT, Toso DB, Nogales E Abstract The human CDK-activating kinase (CAK), a complex composed of cyclin-dependent kinase (CDK) 7, cyclin H, and MAT1, is a critical regulator of transcription initiation and the cell cycle. It acts by phosphorylating the C-terminal...
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.
Related Articles Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Chen X, Shi M, Tong X, Kim HK, Wang LX, Schneewind O, Missiakas D Abstract Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs)....
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Baboons, bonds, biology, and lessons about early life adversity.
Related Articles Baboons, bonds, biology, and lessons about early life adversity. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Hawkley LC, Capitanio JP PMID: 32855299 [PubMed - as supplied by publisher]
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress.
Related Articles Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Zhou Y, Kastritis PL, Dougherty SE, Bouvette J, Hsu AL, Burbaum L, Mosalaganti S, Pfeffer S, Hagen WJH, Förster F, Borgnia MJ, Vogel C, Beck M, Bartesaghi A, Silva GM Abstract Subpopulations of ribosomes are responsible for fine tuning the control of protein synthesis in dynamic environments....
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Nonholomorphic Ramanujan-type congruences for Hurwitz class numbers.
Related Articles Nonholomorphic Ramanujan-type congruences for Hurwitz class numbers. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Beckwith O, Raum M, Richter OK Abstract In contrast to all other known Ramanujan-type congruences, we discover that Ramanujan-type congruences for Hurwitz class numbers can be supported on nonholomorphic generating series. We establish a divisibility result for such nonholomorphic congruences of Hurwitz class...
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
Fusogen-mediated neuron-neuron fusion disrupts neural circuit connectivity and alters animal behavior.
Related Articles Fusogen-mediated neuron-neuron fusion disrupts neural circuit connectivity and alters animal behavior. Proc Natl Acad Sci U S A. 2020 Aug 27;: Authors: Giordano-Santini R, Kaulich E, Galbraith KM, Ritchie FK, Wang W, Li Z, Hilliard MA Abstract The 100-y-old neuron doctrine from Ramón y Cajal states that neurons are individual cells, rejecting the process of cell-cell fusion in the normal development and function of the nervous...
pubmed: "proc natl acad sci ...
Sat Aug 29, 2020 14:47
"Proc Natl Acad Sci U S A"[jour]; +37 new citations
37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/08/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
pubmed: "proc natl acad sci ...
Fri Aug 28, 2020 14:44
Είστε «μακαρονάδες»; Τι σημαίνει αυτό για την υγεία σας;
Έχετε σκεφτεί πως, εκείνη η γνωστή ατάκα από την ελληνική ταινία «τρώτε μακαρόνια!», θα μπορούσε να αποτελεί συμβουλή για καλύτερη υγεία; Αν όχι, τότε τα νέα για τους λάτρεις των ζυμαρικών πέρα από έκπληξη θα φέρουν και ικανοποίηση. Σύμφωνα με πρόσφατα ευρήματα που δημοσιεύονται στο Frontiers in Nutrition, η κατανάλωση του αγαπημένου φαγητού από παιδιά και ενήλικες έδειξε σημαντική υπεροχή της συνολικής ποιότητας στη διατροφή και την πρόσληψη θρεπτικών συστατικών σε σχέση με όσους δεν συμπεριλαμβάνουν...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 14:19
Καθιστική ζωή: Ποιοι Ευρωπαίοι «αγαπούν» το καθισιό – Τι ισχύει για την Ελλάδα
Διαρκή αύξηση στον χρόνο καθιστικής συμπεριφοράς των ενηλίκων, τόσο στην Ευρωπαϊκή Ένωση ως σύνολο, όσο και για άνδρες και γυναίκες χωριστά, καταγράφει ισπανική μελέτη, η οποία αναδεικνύει κατά τους υπογράφοντες τον περιορισμένο αντίκτυπο των τρεχουσών πολιτικών και παρεμβάσεων σε ευρωπαϊκό επίπεδο για την καθιστική ζωή, η οποία συνιστά πρόκληση για τη δημόσια υγεία. Ερευνητές του Πανεπιστημίου «Βασιλιάς Χουάν Κάρλος» της Ισπανίας ανέλυσαν δεδομένα για 96.000 ενήλικες που αντλήθηκαν από τέσσερις...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 13:38
Κορωνοϊός: Γιατί οι άνδρες είναι ευάλωτοι, ενώ οι γυναίκες όχι
Στη διαφορετική ανοσολογική απόκριση ανδρών και γυναικών απέναντι στην «επίθεση» της COVID-19 ενδέχεται να κρύβεται ο αυξημένος κίνδυνος που διατρέχουν οι πρώτοι να εκδηλώσουν βαρύτερη μορφή της νόσου, βάσει των ευρημάτων νέας μελέτης του Πανεπιστημίου του Γέιλ που δημοσιεύεται στο Nature. Ήδη από την αρχή της πανδημίας έχει παρατηρηθεί ότι οι άνδρες, και ιδιαίτερα οι ηλικιωμένοι, διατρέχουν πολύ μεγαλύτερο κίνδυνο να καταλήξουν από τον ιό SARS-CoV-2 συγκριτικά με τις γυναίκες αντίστοιχης ηλικίας....
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 12:57
Έμφραγμα: Ο απλός τρόπος που βοηθά στη γρήγορη διάγνωσή του
Ένα τεστ σάλιου το οποίο μπορεί να προσφέρει ταχεία διάγνωση του εμφράγματος ανέπτυξαν οι επιστήμονες, σύμφωνα με μια προκαταρκτική έρευνα που παρουσιάστηκε στο συνέδριο της Ευρωπαϊκής Καρδιολογικής Εταιρείας. Η καινοτόμος τεχνική χρειάζεται μόνο ένα δείγμα σάλιου από τους ασθενείς για να παράσχει αποτελέσματα σε μόλις 10 λεπτά, αντίθετα με την τουλάχιστον ωριαία αναμονή των συμβατικών τεστ αίματος. «Υπάρχει μεγάλη ανάγκη για απλά και γρήγορα τεστ τροπονίνης στο προνοσοκομειακό περιβάλλον για ασθενείς...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 12:24
Αρρωστήσατε; Έτσι θα γίνετε καλά εύκολα και γρήγορα
Με πιο ήπια και μικρότερης διάρκειας συμπτώματα λοίμωξης συνδέθηκε η λήψη διατροφικού συμπληρώματος πολυβιταμινών και μετάλλων, με περιεκτικότητα σε ψευδάργυρο και υψηλές ποσότητες βιταμίνης C, σε μελέτη που διενεργήθηκε από το Πανεπιστήμιο του Όρεγκον στις Ηνωμένες Πολιτείες που έρχεται στη δημοσιότητα από τις σελίδες του Nutrition. Οι υπογράφοντες τη μελέτη χαρακτήρισαν εντυπωσιακές τις διαφορές που καταγράφηκαν στην απόκριση του ανοσοποιητικού συστήματος μεταξύ των συμμετεχόντων (συνολικά 45...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 08:45
Η άσκηση που σας χαρίζει γερή καρδιά
Οι στάσεις και οι τεχνικές αναπνοής που περιλαμβάνουν οι ασκήσεις της γιόγκα ενδεχομένως να βοηθούν τους ασθενείς με κολπική μαρμαρυγή να διαχειριστούν τα συμπτώματά τους, σύμφωνα με έρευνα που παρουσιάστηκε στο φετινό Συνέδριο της Ευρωπαϊκής Καρδιολογικής Εταιρείας. Η κολπική μαρμαρυγή είναι η πιο συχνή διαταραχή του καρδιακού ρυθμού, καθώς επηρεάζει έναν στους τέσσερις μεσήλικες στην Ευρώπη και τις ΗΠΑ, προκαλώντας το 20-30% των εγκεφαλικών επεισοδίων και αυξάνοντας τον κίνδυνο θανάτου κατά 1,5...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 08:30
Ευφυΐα: Έτσι θα μεγαλώσετε έξυπνα παιδιά
Μια ομάδα ερευνητών από διάφορα ιδρύματα του Βελγίου διαπίστωσαν ότι τα παιδιά που μεγαλώνουν σε περιοχές φτωχές σε πράσινο έχουν μεγαλύτερες πιθανότητες να σημειώσουν χαμηλό σκορ σε τεστ νοημοσύνης. Στη μελέτη τους που δημοσιεύτηκε στο PLOS Medicine, οι ερευνητές αναλύουν τα στοιχεία σχετικά με το ρόλο της φύσης στην παιδική ευφυΐα. Η συγκεκριμένη σχέση δεν απασχολεί πρώτη φορά την επιστημονική κοινότητα. Παλαιότερες μελέτες είχαν αναδείξει την αρνητική επίπτωση της ανατροφής σε περιοχές με λιγότερο...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 08:20
Καρδιά: Η συνήθεια που σας κάνει κακό – Και πως θα την «κόψετε»
Ανατροπή σε όσα πιστεύαμε μέχρι σήμερα για τα οφέλη του ύπνου κατά τη διάρκεια της ημέρας φέρνει μία νέα επιστημονική μελέτη που παρουσιάστηκε στο Συνέδριο της Ευρωπαϊκής Καρδιολογικής Εταιρείας 2020, η οποία υποστηρίζει ότι ο ύπνος άνω της μίας ώρας μπορεί να ενέχει κινδύνους για την υγεία. «Ο μεσημεριανός ύπνος αποτελεί μια κοινή συνήθεια για τους ανθρώπους σε όλο τον κόσμο και σε γενικές γραμμές θεωρείται καλός για την υγεία. Η κοινή αντίληψη θέλει τον ύπνο μέσα στην ημέρα να βελτιώνει την απόδοση...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 08:05
Κορωνοϊός: Η συχνή παρενέργεια που αυξάνει τον κίνδυνο θανάτου
Σε μια σημαντική ανακάλυψη προχώρησε το Ινστιτούτο Karolinska της Σουηδίας αναφορικά με τη διαφορετική ανοσοαπόκριση σε ασθενείς με COVID-19, παράγοντα καθοριστικό, όπως απεδείχθη, για τη σοβαρότητα της νόσου. Η πρόσφατη μελέτη που εστιάζει στον ρόλο των κυττάρων που ονομάζονται «φυσικοί φονείς» (NK) και την υπερφλεγμονώδη απόκριση του ανοσοποιητικού συστήματος, δημοσιεύεται στο Science Immunology. Τα κύτταρα φυσικοί φονείς αποτελούν έναν τύπο κυττάρων-κλειδί στον έλεγχο των ιογενών λοιμώξεων. Μολονότι...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Fri Aug 28, 2020 08:00


 

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