Shiva Ahmadishoar, Nadia Kazemi Pour, Javid Sadeghi, Mohammad Reza Nahaei, Babak KheirkhahIndian Journal of Medical Microbiology 2020 38(2):162-168 Background: Methicillin-resistant Staphylococcus aureus (MRSA) has become more prevalent all over the world and it is important to determine MRSA prevalence and typing in different regions. The present study was carried out to determine the prevalence and frequency of circulating molecular types of MRSA isolates as well as their antibiotics susceptibility...
Ayan Kumar Das, Mridu Dudeja, Sunil Kohli, Pratima Ray, Manvi Singh, Preet Simran KaurIndian Journal of Medical Microbiology 2020 38(2):200-209 Purpose: Enterococci express high degree of resistance towards wide range of antibiotics. Production of biofilm and many virulence factors along with drug resistance makes it difficult to eradicate the infection from urinary tract. The present study detected the expression of such factors including biofilm production by multidrug-resistant (MDR) enterococci....
Sanam Rasool Wani, Chand Wattal, Reena RaveendranIndian Journal of Medical Microbiology 2020 38(2):169-175 Introduction: Non-tuberculous mycobacteria, although identified as pathogenic to humans long time ago, are emerging as the new threat in the past two decades. Even in tuberculosis endemic country such as India, they are being isolated from the clinical specimens more often than previously. This change in trend is of concern, because they are often misdiagnosed as Mycobacterium tuberculosis...
Savitha Chellappan, Subarna Roy, Jyoti M Nagmoti, Wahida Tabassum, SL Hoti, Mrinal Kanti Bhattacharyya, Praveen Balabaskaran NinaIndian Journal of Medical Microbiology 2020 38(2):213-215 Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium...
Taisir Saber, Yousry A Hawash, Khadiga A Ismail, Amany S Khalifa, Khalaf F Alsharif, Saleh A Alghamdi, Tamer Saber, Emad M EedIndian Journal of Medical Microbiology 2020 38(2):176-182 Purpose: Clostridium difficile (C. difficile) is an important causative agent of nosocomial diarrhoea and has become a major worldwide public health concern. The current study was conducted to determine the prevalence of C. difficile infection (CDI) amongst patients with nosocomial diarrhoea in a large tertiary...
Mitkumar Dharsandiya, Kinjal Shah, Ketan Patel, Tushar Patel, Amrish Patel, Atul PatelIndian Journal of Medical Microbiology 2020 38(2):219-221 SARS-CoV-2 predominantly involves the lungs producing acute lung injury, but it can also give rise to a variety of complications involving the central nervous system, gastrointestinal system, kidney and also viral sepsis. With this case report, we are discussing unusual series of complication from acute lung injury, followed by viral sepsis then encephalitis,...
Ganapuram J Archana, Akhauri Yash Sinha, Madhavi Annamanedi, Kandala Pavan Asrith, Satyajit B Kale, Nitin V Kurkure, Swapnil P Doijad, Kammili Nagamani, Nagendra R HegdeIndian Journal of Medical Microbiology 2020 38(2):183-191 Context: Infections with methicillin-resistant Staphylococcus aureus (MRSA) greatly influence clinical outcome. Molecular characterisation of MRSA can help to predict their spread and to institute treatment and hospital protocols. Aim: The aim of this study is to understand...
Sangeeta Joshi, Ruchira Misra, Suverna Kirolikar, Sujata MushrifIndian Journal of Medical Microbiology 2020 38(2):226-228 Brevibacteria are a part of the normal skin flora and may be dismissed in blood cultures as contaminants. They have been reported as opportunistic pathogens in immunocompromised patients. We report a catheter-related bloodstream infection with Brevibacterium casei in a 6-year-old child with aplastic anaemia. Treatment with appropriate antibiotics along with the removal of...
Aline Pecanha Muzy Dias, Lorrayne Cardoso Guimarães, Livia B. D V. Petrucci, Jéssica A Z. Pinheiro, Marcos Gabriel Pinheiro, Felipe Rodrigues E Silva, Helvécio C C. Póvoa, Fábio Aguiar-AlvesIndian Journal of Medical Microbiology 2020 38(2):192-199 Context: Nosocomial infections arise from many microorganisms, including Staphylococcus aureus. Aims: The aim of this study is to determine the molecular epidemiology of circulating methicillin-resistant S. aureus (MRSA) clones among patients attending...
Swati Khullar, Jyoti Rawre, Neena Khanna, Vishnubhatla Sreenivas, Benu DhawanIndian Journal of Medical Microbiology 2020 38(2):235-236
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Abstract Pathogenic variants in the MBTPS1 gene encoding the Site 1 protease have been described so far only in one growth retarded patients with skeletal deformities, large ears, a triangular face reminiscent to Silver–Russell syndrome (SRS), and elevated blood lysosomal enzymes. We now report on the identification of a second adult patient homozygous for one of the two published pathogenic MBTPS1 variants (p.Asp365Gly) by Whole Exome Sequencing (WES), and a comparable phenotype. With this case,...
Abstract Spondyloepiphyseal dysplasia type Stanescu (SED‐S) is a very rare type II collagenopathy. We describe an 8‐year‐old boy who presented with short trunk, C2‐C3 vertebral fusion, hand, foot, leg and thigh pain, stiffness and limited joint mobility, and waddling gait. Radiographs showed platyspondyly with anterior wedging and endplate irregularities, broad femoral necks, and large epiphyses and epiphyseal equivalents. Differential diagnosis included progressive pseudorheumatoid dysplasia and...
Abstract Griscelli syndrome type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic variants in the RAB27A gene and characterized by partial albinism, immunodeficiency, and occasional hematological and neurological involvement. We reviewed and analyzed the medical records of 12 individuals with GS2 from six families belonging to a highly consanguineous Qatari tribe and with a recurrent pathogenic variant in the RAB27A gene (NM_004580.4: c.244C > T, p.Arg82Cys). Detailed demographic,...
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As of August 24, 2020, nearly 5.7 million cases of Covid-19 had been reported in the United States, with more than 176,000 deaths. Although there is debate about the accuracy of these specific numbers — many people with mild symptoms are never tested for Covid, for example, and especially early in…
Wed Aug 26, 2020 03:00
The Covid-19 pandemic has revealed quality deficits in U.S. health care that have been present for decades. In 2003, my colleagues and I reported that on average, U.S. adults received about 55% of recommended care for the leading causes of death and disease. Despite nearly two decades of…
Thu Aug 27, 2020 03:00
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Abstract Purpose The New Mexico Graduation Reality and Dual-role Skills (GRADS) program provides services for expectant and parenting students at high schools. The GRADS program has operated since 1989, serving more than 17,000 youth. This study summarizes the GRADS program model and program administrators’ lessons learned from implementing this comprehensive, large-scale program. ...
Abstract Until recently, federal programs had not explicitly focused on improving the outcomes of highly vulnerable teen parents. Established in 2010, the Pregnancy Assistance Fund (PAF) aims to improve the health, social, educational, and economic outcomes for expectant and parenting teens and young adults, their children, and their families, through providing grants to states and tribes. This article introduces the Maternal and Child Health Journal supplement “Supporting Expectant...
Abstract Objectives Roughly 10% of pregnant women are current smokers. Improving smoking cessation in this population before and during pregnancy is essential to prevent adverse fetal outcomes. This study aimed to examine cessation messages targeting American women. Methods An obstetrics–gynecological clinic-based sample of female, current smokers...
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Key points The basolateral amygdala (BLA), the nucleus basalis magnocellularis (NBM), and the gustatory cortex (GC) are involved in taste processing, taste memory formation, and conditioned taste aversion (CTA) learning, but their fine‐temporal interactions that support these cognitive functions are not well understood. We found that the formation of novel‐taste and CTA memories in the GC depend on a distinct late response (700–3000 ms) of BLA projection neurons. In contrast, BLA activity was...
Key points Reducing Na+ intake reduces the partial pressure of oxygen in the renal cortex and activates the renin‐angiotensin‐aldosterone system. In the absence of high blood pressure, these consequences of dietary Na+ reduction may be detrimental for the kidney. In a normotensive animal experimental model, reducing Na+ intake for two weeks increased renal oxygen consumption that was normalized by mineralocorticoid receptor blockade. Furthermore, blockade of angiotensin II AT1 receptor restored...
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