Pathogens, Vol. 9, Pages 715: Brainstem Encephalitis Caused by Listeria monocytogenes Pathogens doi: 10.3390/pathogens9090715 Authors: Pengxu Wei Ruixue Bao Yubo Fan International outbreaks of listerial infections have become more frequent in recent years. Listeria monocytogenes, which usually contaminates food, can cause potentially fatal infections. Listerial cerebritis is a rare disease that is encountered mostly in immunocompromised or elderly patients. However, listerial brainstem...
Sun Aug 30, 2020 03:00
Pathogens, Vol. 9, Pages 712: Comparative Analysis of Streptococcus pneumoniae Type I Restriction-Modification Loci: Variation in hsdS Gene Target Recognition Domains Pathogens doi: 10.3390/pathogens9090712 Authors: Melissa B. Oliver W. Edward Swords Streptococcus pneumoniae (pneumococcus) is a respiratory commensal pathogen that causes a range of infections, particularly in young children and the elderly. Pneumococci undergo spontaneous phase variation in colony opacity phenotype,...
Sat Aug 29, 2020 03:00
Pathogens, Vol. 9, Pages 714: Human Mucosal IgA Immune Responses against Enterotoxigenic Escherichia coli Pathogens doi: 10.3390/pathogens9090714 Authors: Saman Riaz Hans Steinsland Kurt Hanevik Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines against ETEC, and the most reliable immune correlate of protection...
Sat Aug 29, 2020 03:00
Pathogens, Vol. 9, Pages 713: Comparison of the Pathogenic Potential of Campylobacter jejuni, C. upsaliensis and C. helveticus and Limitations of Using Larvae of Galleria mellonella as an Infection Model Pathogens doi: 10.3390/pathogens9090713 Authors: Krunoslav Bojanić Els Acke Wendi D. Roe Jonathan C. Marshall Angela J. Cornelius Patrick J. Biggs Anne C. Midwinter Campylobacter enteritis in humans is primarily associated with C. jejuni/coli infection. Other species...
Sat Aug 29, 2020 03:00
Pathogens, Vol. 9, Pages 711: First Report of Pathogenic Bacterium Kalamiella piersonii Isolated from Urine of a Kidney Stone Patient: Draft Genome and Evidence for Role in Struvite Crystallization Pathogens doi: 10.3390/pathogens9090711 Authors: Punchappady Devasya Rekha Asif Hameed Muhammed A. P. Manzoor Mangesh V. Suryavanshi Sudeep D. Ghate A. B. Arun Sneha S. Rao Athmika Sukesh Kumar Bajire M. Mujeeburahiman C.-C. Young Uropathogenic bacteria are widely...
Sat Aug 29, 2020 03:00
Pathogens, Vol. 9, Pages 710: Impact of Neospora caninum Infection on the Bioenergetics and Transcriptome of Cerebrovascular Endothelial Cells Pathogens doi: 10.3390/pathogens9090710 Authors: Hany M. Elsheikha Mamdowh Alkurashi Suzy Palfreman Marcos Castellanos Kenny Kong Evita Ning Nashwa A. Elsaied Kalotina Geraki William MacNaughtan In this work, the effects of the protozoan Neospora caninum on the bioenergetics, chemical composition, and elemental content...
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 225: Characterization of Resveratrol, Oxyresveratrol, Piceatannol and Roflumilast as Modulators of Phosphodiesterase Activity. Study of Yeast Lifespan Pharmaceuticals doi: 10.3390/ph13090225 Authors: Adrián Matencio Francisco García-Carmona José Manuel López-Nicolás Our desire to live longer has led to an ever-increasing number of novel antiaging products. However, few molecules have any real effect and new ones need to be studied before they can...
Sun Aug 30, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 223: The Possible Contribution of P-Glycoprotein in the Protective Effect of Paeonol against Methotrexate-Induced Testicular Injury in Rats Pharmaceuticals doi: 10.3390/ph13090223 Authors: Morsy Abdel-Aziz Abdel-Hafez Venugopala Nair Abdel-Gaber Paeonol, a phenolic ingredient in the genus Paeonia, possesses antioxidant and anti-inflammatory effects. Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its germ cell...
Sat Aug 29, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 222: Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes Pharmaceuticals doi: 10.3390/ph13090222 Authors: Rohitash Jamwal Benjamin J. Barlock Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat in the liver. An international consensus panel has recently proposed to rename the disease to metabolic dysfunction associated with fatty liver disease (MAFLD). The disease can range from simple steatosis...
Sat Aug 29, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 224: Ganoderma lucidum Ethanol Extracts Enhance Re-epithelialization and Prevent Keratinocytes from Free-Radical Injury Pharmaceuticals doi: 10.3390/ph13090224 Authors: Abate Pepe Randino Pisanti Basilicata Covelli Bifulco Cabri D’Ursi Campiglia Rodriquez Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer...
Sat Aug 29, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 220: Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue Pharmaceuticals doi: 10.3390/ph13090220 Authors: Stanislav Sukhikh Olga Babich Alexander Prosekov Nikolai Patyukov Svetlana Ivanova Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which...
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 221: Bullous Central Serous Chorioretinopathy: A Rare and Atypical Form of Central Serous Chorioretinopathy. A Systematic Review Pharmaceuticals doi: 10.3390/ph13090221 Authors: Francesco Sartini Martina Menchini Chiara Posarelli Giamberto Casini Michele Figus Bullous central serous chorioretinopathy (bCSCR) is a rare variant of the central serous chorioretinopathy, complicated by an exudative retinal detachment with shifting fluid. This systematic...
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 219: Towards Better Delivery of Cannabidiol (CBD) Pharmaceuticals doi: 10.3390/ph13090219 Authors: Sophie Anne Millar Ryan Francis Maguire Andrew Stephen Yates Saoirse Elizabeth O’Sullivan Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low bioavailability, low water solubility, and variable pharmacokinetic profiles....
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 217: Recent Advances Regarding the Therapeutic Potential of Adapalene Pharmaceuticals doi: 10.3390/ph13090217 Authors: Aura Rusu Corneliu Tanase Georgiana-Andreea Pascu Nicoleta Todoran Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors. The comedolytic, anti-inflammatory, antiproliferative, and immunomodulatory are the known ADP...
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 218: Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells Pharmaceuticals doi: 10.3390/ph13090218 Authors: Yun Soo Jeong Thuy Giang Lam Seho Jeong Sang-Gun Ahn Multidrug resistance is a significant clinical crisis in cancer treatment and has been linked to the cellular expression of multidrug efflux transporters. The aim of this study was to examine the effects...
Fri Aug 28, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 216: Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases Pharmaceuticals doi: 10.3390/ph13090216 Authors: Lucia Palmas Matteo Aroffu Giacomo L. Petretto Elvira Escribano-Ferrer Octavio Díez-Sales Iris Usach José-Esteban Peris Francesca Marongiu Mansureh Ghavam Sara Fais Germano Orrù Rita Abi Rached Maria Letizia Manca Maria Manconi...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 828: Optimization and Evaluation of Poly(lactide-co-glycolide) Nanoparticles for Enhanced Cellular Uptake and Efficacy of Paclitaxel in the Treatment of Head and Neck Cancer Pharmaceutics doi: 10.3390/pharmaceutics12090828 Authors: Mohamed Haider Amr Elsherbeny Jayalakshmi Jagal Anna Hubatová-Vacková Iman Saad Ahmed The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake and...
Sun Aug 30, 2020 03:00
Pharmaceutics, Vol. 12, Pages 827: Miktoarm Star Polymers: Branched Architectures in Drug Delivery Pharmaceutics doi: 10.3390/pharmaceutics12090827 Authors: Victor Lotocki Ashok Kakkar Delivering active pharmaceutical agents to disease sites using soft polymeric nanoparticles continues to be a topical area of research. It is becoming increasingly evident that the composition of amphiphilic macromolecules plays a significant role in developing efficient nanoformulations. Branched architectures...
Sun Aug 30, 2020 03:00
Pharmaceutics, Vol. 12, Pages 826: Toxicologic Evaluation for Amorphous Silica Nanoparticles: Genotoxic and Non-Genotoxic Tumor-Promoting Potential Pharmaceutics doi: 10.3390/pharmaceutics12090826 Authors: Gwang-Hoon Lee Yun-Soon Kim Euna Kwon Jun-Won Yun Byeong-Cheol Kang Amorphous silica nanoparticles (SiO2NPs) have been widely used in medicine including targeted drug/DNA delivery, cancer therapy, and enzyme immobilization. Nevertheless, SiO2NPs should be used with caution...
Sat Aug 29, 2020 03:00
Pharmaceutics, Vol. 12, Pages 825: Repurposing Heparin as Antimalarial: Evaluation of Multiple Modifications Toward In Vivo Application Pharmaceutics doi: 10.3390/pharmaceutics12090825 Authors: Elena Lantero Carlos Raúl Aláez-Versón Pilar Romero Teresa Sierra Xavier Fernàndez-Busquets Heparin is a promising antimalarial drug due to its activity in inhibiting Plasmodium invasion of red blood cells and to the lack of resistance evolution by the parasite against it, but its...
Sat Aug 29, 2020 03:00
Pharmaceutics, Vol. 12, Pages 824: Pharmacokinetics of Shikimic Acid Following Intragastric and Intravenous Administrations in Rats Pharmaceutics doi: 10.3390/pharmaceutics12090824 Authors: Keumhan Noh Hyun-Moon Back Beom Soo Shin Wonku Kang Shikimic acid, a critical starting material for the semi-total synthesis of oseltamivir to treat and prevent influenza, exerts many pharmacological effects. However, the optimal bioanalytical method has not been adequately defined. We used...
Sat Aug 29, 2020 03:00
Pharmaceutics, Vol. 12, Pages 822: Reply to “Comment on Casiraghi et al. ‘Mucoadhesive Budesonide Formulation for the Treatment of Eosinophilic Esophagitis’ 2020, 12, 211” Pharmaceutics doi: 10.3390/pharmaceutics12090822 Authors: Antonella Casiraghi Chiara Grazia Gennari Umberto Maria Musazzi Marco Aldo Ortenzi Susanna Bordignon Paola Minghetti The paper entitled “Mucoadhesive Budesonide Formulation for the Treatment of Eosinophilic Esophagitis Pharmaceutics...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 823: In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration Pharmaceutics doi: 10.3390/pharmaceutics12090823 Authors: Julia C. Berkmann Aaron X. Herrera Martin Carlotta Pontremoli Kai Zheng Christian H. Bucher Agnes Ellinghaus Aldo R. Boccaccini Sonia Fiorilli Chiara Vitale Brovarone Georg N. Duda Katharina Schmidt-Bleek Bone...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 818: Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study Pharmaceutics doi: 10.3390/pharmaceutics12090818 Authors: Simone Bordignon Paolo Cerreia Vioglio Elena Amadio Federica Rossi Emanuele Priola Dario Voinovich Roberto Gobetto Michele R. Chierotti We report on the preparation, characterization, and bioavailability properties of three...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 820: Rheology by Design: A Regulatory Tutorial for Analytical Method Validation Pharmaceutics doi: 10.3390/pharmaceutics12090820 Authors: Ana Simões Margarida Miranda Catarina Cardoso Francisco Veiga andCarla Vitorino The increasing demand for product and process understanding as an active pursuit in the quality guideline Q8 and, more recently, on the draft guideline on quality and equivalence of topical products, has unveiled the tremendous potential...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 819: Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation with Hydroxypropyl-β-Cyclodextrin Pharmaceutics doi: 10.3390/pharmaceutics12090819 Authors: Alessandra Adrover Laura di Muzio Jordan Trilli Chiara Brandelli Patrizia Paolicelli Stefania Petralito Maria Antonietta Casadei Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide,...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 817: Nicardipine Loaded Solid Phospholipid Extrudates for the Prevention of Cerebral Vasospasms: In Vitro Characterization Pharmaceutics doi: 10.3390/pharmaceutics12090817 Authors: Christin Zlomke Johannes Albrecht Karsten Mäder The aim of the study was to develop nicardipine loaded phospholipid extrudates as an alternative for PLA/PLGA-based implants for the prevention of cerebral vasospasms. Extrudates of different mixtures of saturated and unsaturated...
Fri Aug 28, 2020 03:00
Pharmaceutics, Vol. 12, Pages 821: Silver Nanomaterials for Wound Dressing Applications Pharmaceutics doi: 10.3390/pharmaceutics12090821 Authors: Priya Dharshini Krishnan Dominik Banas Ramya Devi Durai Daniil Kabanov Bozena Hosnedlova Marta Kepinska Carlos Fernandez Branislav Ruttkay-Nedecky Hoai Viet Nguyen Awais Farid Jiri Sochor Vedha Hari B Narayanan Rene Kizek Silver nanoparticles (AgNPs) have recently become very attractive for the scientific...
Fri Aug 28, 2020 03:00
Pharmacy, Vol. 8, Pages 156: Long-Lasting, Patient-Controlled, Procedure-Free Contraception: A Review of Annovera with a Pharmacist Perspective Pharmacy doi: 10.3390/pharmacy8030156 Authors: Jennifer J. Virro Kathleen Besinque Christiane E. Carney Danielle Gross Brian Bernick Sebastian Mirkin Annovera (segesterone acetate and ethinyl estradiol vaginal system) is a US Food and Drug Administration FDA-approved long-lasting, reversible contraceptive that is fully administered...
Fri Aug 28, 2020 03:00
Plants, Vol. 9, Pages 1122: Dynamics and Functions of Stress Granules and Processing Bodies in Plants Plants doi: 10.3390/plants9091122 Authors: Geng-Jen Jang Jyan-Chyun Jang Shu-Hsing Wu RNA granules, such as stress granules and processing bodies, can balance the storage, degradation, and translation of mRNAs in diverse eukaryotic organisms. The sessile nature of plants demands highly versatile strategies to respond to environmental fluctuations. In this review, we discuss recent...
Sun Aug 30, 2020 03:00
Plants, Vol. 9, Pages 1121: Glucosinolate Profile and Glucosinolate Biosynthesis and Breakdown Gene Expression Manifested by Black Rot Disease Infection in Cabbage Plants doi: 10.3390/plants9091121 Authors: Mehede Hassan Rubel Md. Abuyusuf Ujjal Kumar Nath Arif Hasan Khan Robin Hee Jeong Jung Hoy Taek Kim Jong In Park Ill Sup Nou Cabbage (Brassica oleracea var. capitata) is an economically important crop in the family Brassicaceae. Black rot disease is a top ranked...
Sun Aug 30, 2020 03:00
Plants, Vol. 9, Pages 1120: Expression Fluctuations of Genes Involved in Carbohydrate Metabolism Affected by Alterations of Ethylene Biosynthesis Associated with Ripening in Banana Fruit Plants doi: 10.3390/plants9091120 Authors: Yan Xia Chien-Hsiang Chiu Yi-Yin Do Pung-Ling Huang The banana is a typical climacteric fruit that undergoes ethylene dependent ripening. During fruit ripening, ethylene production triggers a developmental cascade that results in a series of physiological...
Sun Aug 30, 2020 03:00
Plants, Vol. 9, Pages 1119: Chemical Composition of a Supercritical Fluid (Sfe-CO2) Extract from Baeckea frutescens L. Leaves and Its Bioactivity Against Two Pathogenic Fungi Isolated from the Tea Plant (Camellia sinensis (L.) O. Kuntze) Plants doi: 10.3390/plants9091119 Authors: Hao Jiang Mengting Zhang Li Qin Dongxu Wang Feng Yu Wenhui Liang Chuankui Song Daniel Granato Colletotrichum gloeosporioides and Pseudopestalotiopsis camelliae-sinensis are the two most...
Sat Aug 29, 2020 03:00
Plants, Vol. 9, Pages 1118: Russet Susceptibility in Apple is Associated with Skin Cells that Are Larger, More Variable in Size, and of Reduced Fracture Strain Plants doi: 10.3390/plants9091118 Authors: Khanal Le Si Knoche Russeting is an economically important surface disorder in apple (Malus × domestica Borkh.). Indirect evidence suggests an irregular skin structure may be the cause of the phenomenon. The objective of this study was to characterize epidermal...
Sat Aug 29, 2020 03:00
Plants, Vol. 9, Pages 1117: Genetic Architecture of Cereal Leaf Beetle Resistance in Wheat Plants doi: 10.3390/plants9091117 Authors: Tobias Würschum Willmar L. Leiser Simon M. Langer Matthew R. Tucker Thomas Miedaner Wheat production can be severely damaged by endemic and invasive insect pests. Here, we investigated resistance to cereal leaf beetle in a panel of 876 winter wheat cultivars, and dissected the genetic architecture underlying this insect resistance by association...
Fri Aug 28, 2020 03:00
Plants, Vol. 9, Pages 1116: Comparative Genomics and Phylogenetic Analyses of Christia vespertilionis and Urariopsis brevissima in the Tribe Desmodieae (Fabaceae: Papilionoideae) Based on Complete Chloroplast Genomes Plants doi: 10.3390/plants9091116 Authors: Xue-Li Zhao Zhang-Ming Zhu Taxonomic and phylogenetic relationships of Christia, Urariopsis, Uraria and related genera within the tribe Desmodieae (Fabaceae: Papilionoideae) have long been controversial. Here, we report the complete...
Fri Aug 28, 2020 03:00
Plants, Vol. 9, Pages 1111: Plukenetia huayllabambana Fruits: Analysis of Bioactive Compounds, Antibacterial Activity and Relative Action Mechanisms Plants doi: 10.3390/plants9091111 Authors: Armel Jackson Seukep Minxia Fan Satyajit Dey Sarker Victor Kuete Ming-Quan Guo Plukenetia huayllabambana is an edible plant traditionally used to cure wounds and various infections. The present work assessed, for the first time, the antibacterial efficacy of solvent fractions from P....
Fri Aug 28, 2020 03:00
Plants, Vol. 9, Pages 1114: Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo Plants doi: 10.3390/plants9091114 Authors: Eunkuk Park Chang Gun Lee Jeonghyun Kim Eunguk Lim Seokjin Hwang Seung Hee Yun Yoonjoong Yong Hyesoo Jeong Ji Ae Kim Hyun-Seok Jin Seon-Yong Jeong Osteoporosis is a porous bone disease caused by bone density loss, which increases the risk of fractures. Cornus officinalis...
Fri Aug 28, 2020 03:00
Plants, Vol. 9, Pages 1113: Understory Vegetation Change Following Woodland Reduction Varies by Plant Community Type and Seeding Status: A Region-Wide Assessment of Ecological Benefits and Risks Plants doi: 10.3390/plants9091113 Authors: Thomas A. Monaco Kevin L. Gunnell Woodland encroachment is a global issue linked to diminished ecosystem services, prompting the need for restoration efforts. However, restoration outcomes can be highly variable, making it difficult to interpret the...
Fri Aug 28, 2020 03:00
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