Key points The basolateral amygdala (BLA), the nucleus basalis magnocellularis (NBM), and the gustatory cortex (GC) are involved in taste processing, taste memory formation, and conditioned taste aversion (CTA) learning, but their fine‐temporal interactions that support these cognitive functions are not well understood. We found that the formation of novel‐taste and CTA memories in the GC depend on a distinct late response (700–3000 ms) of BLA projection neurons. In contrast, BLA activity was...
Fri Aug 28, 2020 21:52
Key points Reducing Na+ intake reduces the partial pressure of oxygen in the renal cortex and activates the renin‐angiotensin‐aldosterone system. In the absence of high blood pressure, these consequences of dietary Na+ reduction may be detrimental for the kidney. In a normotensive animal experimental model, reducing Na+ intake for two weeks increased renal oxygen consumption that was normalized by mineralocorticoid receptor blockade. Furthermore, blockade of angiotensin II AT1 receptor restored...
Fri Aug 28, 2020 21:51
Key points We performed a prospective electrostimulation study of the motor homunculus in 100 patients without motor deficit or brain lesion in the precentral gyrus in order to acquire accurate MNI coordinates of the functional areas. The analysis of 248 body coordinates in the precentral gyrus showed rare inter‐individual variations in the medial‐to‐lateral somatotopic movement organization with quite similar intensity thresholds. Electrostimulation only induced basic and stereotyped movements....
Fri Aug 28, 2020 21:50
Fri Aug 28, 2020 21:48
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Liquid-based cytology is one of the most useful methods to diagnose a patient with serous effusion, especially when malignancy is suspected. As an alternative to the use of liquid-based cytology only, the serous effusion can be further processed using the technique of DNA image cytometry, which may augment diagnostic utility. The aim of this study was to compare the diagnostic yields of liquid-based...
Fri Aug 28, 2020 13:21
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Cervical cancer is a deadly disease. Some microRNAs are involved in tumor invasion and metastasis. Decreased expression of microRNA-199a has been correlated with tumorigenesis. In our study, the quantitative real-time polymerase chain reaction results indicated that microRNA-199a was expressed at lower levels in cervical cancer tissues, and the expression level of B7-H3 was significantly increased compared with...
Fri Aug 28, 2020 13:19
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Our study aimed to investigate the expression level and clinical significance of serum and exhaled breath condensate miR-186 and IL-1β in non-small cell lung cancer patients.Methods:The serum and exhaled breath condensate specimens of 62 non-small cell lung cancer patients and 60 healthy controls were collected to detect miR-186 expression levels by real-time fluorescent quantitative PCR. Enzyme linked...
Thu Aug 27, 2020 13:06
Abstract A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or without biomaterials is unclear. This systematic review (PROSPERO, ref. CRD 42019148959) aimed to critically appraise animal in vivo published data and present the efficacy of PBMT and its potential synergistic effects on grafted bone defects. MEDLINE, CCCT, Scopus, Science Direct, Google Scholar, EMBASE, EBSCO were searched, utilizing the following keywords: bone repair;...
Fri Aug 28, 2020 17:33
Optical coherence tomography angiography (OCTA) is capable of non‐invasively imaging the vascular networks within circulatory tissue beds in vivo. Following improvements in OCTA image quality, it is now possible to extract vascular parameters from imaging data to potentially facilitate the diagnosis and treatment of human disease. In this paper, we present a method for automated mapping of vessel diameter down to the individual capillary level, through gradient‐guided minimum radial distance (MRD)....
Fri Aug 28, 2020 17:18
New Findings What is the central question of this study? To determine whether highly trained male endurance athletes who develop exercise induced arterial hypoxaemia (EIAH) demonstrate reduced peripheral chemoresponsiveness during exercise. What is the main finding and its importance? Those with the lowest arterial saturation during exercise have a smaller ventilatory response to hypercapnia during exercise. There was no significant relationship between the hyperoxic ventilatory...
Fri Aug 28, 2020 21:50
New Findings Skinned cardiac muscle preparations are widely used in physiological and pathophysiological research. The current methods using freshly isolated papillary muscle, ventricular trabeculae, surgically dissected ventricular muscle strips, mechanically blended cardiac muscle bundles, or enzymatically isolated single cardiomyocytes are of low efficiency with restricted applications. We have developed a new method using frozen cardiac papillary muscles and cryosectioning to reliably obtain...
Fri Aug 28, 2020 21:48
Abstract Non‐syndromic autosomal recessive hearing loss is an extremely heterogeneous disease caused by mutations in more than 80 genes. We examined Czech patients with early/prelingual non‐syndromic, presumably genetic hearing loss (NSHL) without known cause after GJB2 gene testing. Four hundred and twenty one unrelated patients were examined for STRC gene deletions with quantitative comparative fluorescent PCR (QCF PCR), 197 unrelated patients with next generation sequencing by custom...
Fri Aug 28, 2020 21:48
Abstract Progeroid disorders make up a heterogeneous group of very rare hereditary diseases characterized by clinical signs that often mimic physiological ageing in a premature manner. Apart from Hutchinson‐Gilford progeria syndrome, one of the best‐investigated progeroid disorders, a wide spectrum of other premature ageing phenotypes exist, which differ significantly in their clinical presentation and molecular pathogenesis. NGS‐based approaches have made it feasible to determine the...
Fri Aug 28, 2020 20:53
ABSTRACT Purpose To assess stress distribution in full‐crowns with a composite buildup and endocrowns under axial or oblique loads, both with different ferrules (1 or 2 mm) and ceramic materials (glass ceramic or hybrid ceramic). Materials and Methods Sixteen models were analyzed with finite element analysis. No‐separation contacts were considered between restoration/resin cement and resin cement/tooth. The contact between the fixation cylinder and the root was considered perfectly bonded....
Fri Aug 28, 2020 13:41
Abstract Purpose : To investigate the effect of different milling protocols for different ceramic materials on the trueness and precision of milled ceramic crowns. Materials and Methods : A definitive impression from a patient requiring a ceramic crown was used to fabricate forty glass ceramic crowns (Vitablocs mark II, Vita Zahnfabric) milled with wet, hard milling protocol, and 40 zirconia crowns (In Coris TZI, Dentsply, Sirona) milled with dry, soft milling protocol, using a 5‐axis milling...
Fri Aug 28, 2020 11:41
Abstract Background Diagnostic tests for fish allergy are hampered by the large number of under‐investigated fish species. Four salmon allergens are well‐characterized and registered with the WHO/IUIS while no catfish allergens have been described so far. In 2008, freshwater‐cultured catfish production surpassed that of salmon, the globally most‐cultured marine species. We aimed to identify, quantify and compare all IgE‐binding proteins in salmon and catfish. Methods Seventy‐seven pediatric...
Fri Aug 28, 2020 18:50
Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Background:Effective asthma management requires a multidisciplinary approach that includes; the physician, the patient, and the patient’s family.Objectives:The current study aimed to assess the roles played by community pharmacists toward asthma control together with the barriers hindering their practice and possible strategies to overcome those barriers.Methods:A multi-centered cross-sectional study was conducted. Data was collected...
Fri Aug 28, 2020 14:39
The volumetric ratio of the tongue to the oral cavity has been recognized to be one of the important factors for the maintenance of stable occlusion. Oral cavity capacity is changed after orthognathic surgery ...
Fri Aug 28, 2020 03:00
The U.S. Food and Drug Administration (FDA) has approved MED-EL's RONDO 3 Audio Processor for the SYNCHRONY Cochlear Implant System,which is anticipated to be available later this year. New MED-EL recipients can swap out an unopened RONDO 2 Audio Processor for a RONDO 3 Audio Processor through the RONDO Swap Program.RONDO 3 offers wireless streaming, wireless charging with a rechargeable battery that lasts up to 24 hours, and compatibility with all hearing aids worn on the opposite side. This allows...
Fri Aug 28, 2020 13:53
The first global consensus on the use of cochlear implants for the management of adults living with hearing loss was published today in JAMA Otolaryngology.1 The paper was authored by a new panel, including 31 hearing experts from surgical and audiology backgrounds representing more than 13 countries.According to Craig Buchman, M.D., head of the Department of Otolaryngology at Washington University School of Medicine in St. Louis, the consensus paper is a major landmark in the treatment of hearing...
Fri Aug 28, 2020 13:37
MAICO Diagnostics will hold a free webinar titled, "Newborn Hearing Screening, Improving your Experience and Outcomes," on September 15, 2020, at 12:00 p.m. to 1:00 p.m. (CST) to be presented by Kathy Murphy, MA, the newborn hearing screening product manager at MAICO Diagnostics.Nurses are responsible for performing various screening procedures on newborns before hospital discharge. Hearing screening is typically viewed as the most challenging and time-consuming of the required procedures. The experience...
Thu Aug 27, 2020 18:02
Fuel Medical has partnered with The American Institute of Balance (AIB) to help its audiology and otolaryngology members incorporate, or expand, patient-centered, diagnostic vestibular services. Founded in 1992 by CEO Richard E. Gans, PhD. AIB provides current and scientifically robust clinical protocols and information through its classes, workshops, online education, and certification programs.“We are proud to partner with the largest ENT and medically-based audiology network in the industry....
Thu Aug 27, 2020 16:32
A new study by Auditory Insight found that despite booming consumer interest in online hearing testing, none of the leading tests consistently use best practices to encourage patients to pursue treatment with hearing aids.Hearing aid companies report that patient usage of online hearing tests has increased by as much as 500% since the onset of the coronavirus pandemic in late March 2020. "Online hearing tests are the gateway to care," says Nancy M. Williams, lead study author and Auditory Insight...
Thu Aug 27, 2020 16:28
Surgical Infections, Ahead of Print.
Wed Aug 26, 2020 10:00
Surgical Infections, Ahead of Print.
Thu Aug 20, 2020 10:00
When you only have fossils to go off of, it's hard to tell which dinosaur traits, like size and ornamentation, are related to the animals' sex, and which traits are related to other things like age. But a new kind of statistical analysis can often estimate the degree of sexual variation in a dataset of fossils.
Thu Aug 27, 2020 03:07
Researchers has discovered a new group of Chlamydiae - named the Anoxychlamydiales - living under the ocean floor without oxygen. These have genes that allow them to survive without oxygen while making hydrogen gas. The researchers found that our single-cell ancestors 'caught' these hydrogen-producing genes from ancient Chlamydiae up to two-billion years ago - an event that was critical for the evolution of all complex life alive today.
Wed Aug 26, 2020 21:13
Bryozoans are a diverse phylum of marine and freshwater colonial invertebrates containing approximately 6,300 described living species. Bryozoans grow by budding new physiologically connected colony members (zooids) from a founding individual that forms from a metamorphosed larva. In some species these zooids come in different shapes and sizes and are specialized to serve different tasks within the. A complex interaction of genotype, environment, and developmental pathway shapes zooid fate, however,...
Fri Aug 28, 2020 22:15
Social wasps of the genus Vespula have spread to nearly all landmasses worldwide and have become significant pests in their introduced ranges, affecting economies and biodiversity. Comprehensive genome assemblies and annotations for these species are required to develop the next generation of control strategies and monitor existing chemical control. We sequenced and annotated the genomes of the common wasp (Vespula vulgaris), German wasp (Vespula germanica), and the western yellowjacket (Vespula...
Fri Aug 28, 2020 22:15
With the development of high-throughput genotyping techniques, selection signatures in the genome of domestic pigs have been extensively interrogated in the last decade. The Duroc, a major commercial pig breed famous for its fast growth rate and high lean ratio, has not been extensively studied focusing on footprints of intensively artificial selection in their genomes by a lot of re-sequencing data. The goal of this study was to investigate genomic regions under artificial selection and their contribution...
Fri Aug 28, 2020 22:15
Abstract Patients with idiopathic rapid‐eye‐movement (REM) sleep behaviour disorder (iRBD) have a high risk of converting into manifest α‐synucleinopathies. Eye movements (EMs) are controlled by neurons in the lower brainstem, midbrain and frontal areas, and may be affected by the early neurodegenerative process seen in iRBD. Studies have reported impairment of the oculomotor function in patients with Parkinson's disease (PD) during wakefulness, but no studies have investigated EMs during sleep....
Fri Aug 28, 2020 15:33
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02099
Fri Aug 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02624
Fri Aug 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03002
Fri Aug 28, 2020 07:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου