Related Articles A Simple and Efficient Method for Visualizing Individual Cells in vivo by Cre-Mediated Single-Cell Labeling by Electroporation (CREMSCLE). Front Neural Circuits. 2020;14:47 Authors: Schohl A, Chorghay Z, Ruthazer ES Abstract Efficient methods for visualizing cell morphology in the intact animal are of great benefit to the study of structural development in the nervous system. Quantitative analysis of the complex arborization...
Fri Aug 28, 2020 18:41
Related Articles New Optical Tools to Study Neural Circuit Assembly in the Retina. Front Neural Circuits. 2020;14:44 Authors: Rangel Olguin AG, Rochon PL, Krishnaswamy A Abstract During development, neurons navigate a tangled thicket of thousands of axons and dendrites to synapse with just a few specific targets. This phenomenon termed wiring specificity, is critical to the assembly of neural circuits and the way neurons manage this feat is...
Fri Aug 28, 2020 18:41
Related Articles An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex. Front Neural Circuits. 2020;14:40 Authors: Bennett M Abstract The neocortex performs a wide range of functions, including working memory, sensory perception, and motor planning. Despite this diversity in function, evidence suggests that the neocortex is made up of repeating subunits ("macrocolumns"), each of which is largely identical in circuitry....
Fri Aug 28, 2020 18:41
Related Articles Commentary: Clinical Improvements in Comorbid Gambling/Cocaine Use Disorder (GD/CUD) Patients Undergoing Repetitive Transcranial Magnetic Stimulation (rTMS). Front Neural Circuits. 2020;14:39 Authors: Ou H, Zhang Y, He W PMID: 32848631 [PubMed - in process]
Fri Aug 28, 2020 18:41
Related Articles LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures. Oncoimmunology. 2020;9(1):1736792 Authors: Gestermann N, Saugy D, Martignier C, Tillé L, Fuertes Marraco SA, Zettl M, Tirapu I, Speiser DE, Verdeil G Abstract Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer,...
Fri Aug 28, 2020 17:27
Related Articles Cognitive functioning, patient health communication, and worry mediate pain predictive effects on health-related quality of life in youth with sickle cell disease. Pediatr Blood Cancer. 2020 Aug 29;:e28680 Authors: Varni JW, Panepinto JA Abstract OBJECTIVES: The objective was to investigate the serial mediating effects of perceived cognitive functioning, patient health communication, and disease-specific worry in the relationship...
Sun Aug 30, 2020 14:47
Related Articles The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2020 Aug 28;: Authors: Bigaran A, Zopf E, Gardner J, La Gerche A, Murphy DG, Howden EJ, Baker MK, Cormie P Abstract BACKGROUND: Growing evidence suggests that men exposed to androgen deprivation therapy (ADT) have an increased risk...
Sun Aug 30, 2020 14:47
Related Articles Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity. Nat Commun. 2020 Aug 28;11(1):4324 Authors: Grabovska Y, Mackay A, O'Hare P, Crosier S, Finetti M, Schwalbe EC, Pickles JC, Fairchild AR, Avery A, Cockle J, Hill R, Lindsey J, Hicks D, Kristiansen M, Chalker J, Anderson J, Hargrave D, Jacques TS, Straathof K, Bailey S, Jones C, Clifford SC, Williamson D Abstract...
Sun Aug 30, 2020 14:47
Related Articles Assessment of tumor suppressor promoter methylation in healthy individuals. Clin Epigenetics. 2020 Aug 28;12(1):131 Authors: Poduval DB, Ognedal E, Sichmanova Z, Valen E, Iversen GT, Minsaas L, Lønning PE, Knappskog S Abstract BACKGROUND: The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue...
Sun Aug 30, 2020 14:47
Related Articles Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study. World J Surg Oncol. 2020 Aug 28;18(1):230 Authors: Lee CS, Won DD, Oh SN, Lee YS, Lee IK, Kim IH, Choi MH, Oh ST Abstract BACKGROUND: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short-...
Sun Aug 30, 2020 14:47
Related Articles Safety and efficacy evaluation of encorafenib plus binimetinib for the treatment of advanced BRAF-mutant melanoma patients. Expert Opin Drug Saf. 2020 Aug 28;: Authors: Indini A, Mandalà M Abstract INTRODUCTION: Approximately 40-50% of patients with cutaneous melanoma harbour point mutations in BRAF. BRAF and MEK inhibitors in combination are now a standard therapy for advanced BRAF V600-mutated melanoma. Nevertheless, survival...
Sat Aug 29, 2020 13:30
Related Articles The long and winding road to effective immunotherapy in patients with adrenocortical carcinoma. Future Oncol. 2020 Aug 28;: Authors: Grisanti S, Cosentini D, Laganà M, Volta AD, Palumbo C, Massimo Tiberio GA, Sigala S, Berruti A PMID: 32857613 [PubMed - as supplied by publisher]
Sat Aug 29, 2020 13:30
Related Articles CD38 as immunomodulator in cancer. Future Oncol. 2020 Aug 28;: Authors: Li Y, Yang R, Chen L, Wu S Abstract CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 protein was previously considered as a cell activation marker, and today monoclonal antibodies targeting CD38 have witnessed great achievements in multiple myeloma and promoted...
Sat Aug 29, 2020 13:30
Related Articles The use of multi-omics data and approaches in breast cancer immunotherapy: a review. Future Oncol. 2020 Aug 28;: Authors: Leung KL, Verma D, Azam YJ, Bakker E Abstract Breast cancer is projected to be the most common cancer in women in 2020 in the USA. Despite high remission rates treatment side effects remain an issue, hence the interest in novel approaches such as immunotherapies which aim to utilize patients' immune systems...
Sat Aug 29, 2020 13:30
Related Articles Teleoncology or telemedicine for oncology patients during the COVID-19 pandemic: the new normal for breast cancer survivors? Future Oncol. 2020 Aug 28;: Authors: Yildiz F, Oksuzoglu B Abstract Background: Telemedicine is seen as a savior during the COVID-19 pandemic. Materials & methods: This study is a descriptive cross-sectional study conducted with cancer patients who were interviewed via telemedicine from a tertiary...
Sat Aug 29, 2020 13:30
Related Articles Enteral nutritional support in patients undergoing chemoradiotherapy for esophageal carcinoma. Future Oncol. 2020 Aug 28;: Authors: Wang B, Jiang X, Tian D, Geng W Abstract Esophageal cancer patients are at a high risk of malnutrition. Both the disease itself and chemoradiotherapy will lead to the deterioration of nutritional status. The development of nutritional oncology promotes the application of enteral nutrition in tumor...
Sat Aug 29, 2020 13:30
Related Articles Estrogen receptor-β expression of ovarian tumors and its association with ovarian cancer risk factors. Cancer Epidemiol Biomarkers Prev. 2020 Aug 20;: Authors: Shafrir AL, Babic A, Gates Kuliszewski M, Rice MS, Townsend MK, Hecht JL, Tworoger SS Abstract BACKGROUND: Differential associations between ovarian cancer risk factors and estrogen receptor-α (ERα) ovarian tumor expression have been noted; however, no research has assessed...
Sat Aug 29, 2020 13:30
Related Articles Long Term Outcomes for Extraskeletal Myxoid Chondrosarcoma: A SEER Database Analysis. Cancer Epidemiol Biomarkers Prev. 2020 Aug 20;: Authors: Wagner MJ, Chau B, Loggers ET, Pollack SM, Kim TS, Kim EY, Thompson MJ, Harwood JL, Cranmer LD Abstract BACKGROUND: Extraskeletal myxoid chondrosarcoma (EMCS) is a rare tumor that typically has an indolent course but high rate of recurrence. We queried the Surveillance, Epidemiology,...
Sat Aug 29, 2020 13:30
Related Articles Avelumab and axitinib combination therapy for the treatment of advanced renal cell carcinoma. Future Oncol. 2020 Aug 28;: Authors: Soleimani M, Nappi L, Kollmannsberger C Abstract Owing to an improved understanding of the immunobiological profile of renal cell carcinoma (RCC), the past few years have ushered in significant changes in systemic therapies for advanced stage RCC. First-line treatment with single agent tyrosine kinase...
Sat Aug 29, 2020 13:30
Related Articles Characteristics of male triple negative breast cancer: A population-based study. Breast J. 2020 Aug 27;: Authors: Ghani S, Sochat M, Luo J, Tao Y, Ademuyiwa F Abstract Male triple negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), is a very rare entity, comprising only a very small percentage of all male breast...
Sat Aug 29, 2020 13:30
Related Articles Analysis of the Survival Impact of Postoperative Chemotherapy After Preoperative Chemotherapy and Resection for Gastric Cancer. Ann Surg Oncol. 2020 Aug 27;: Authors: Drake JA, Stiles ZE, Tsao MW, Deneve JL, Glazer ES, Yakoub D, Grothey A, Somer BG, Dickson PV Abstract BACKGROUND: Perioperative chemotherapy is a standard-of-care treatment for patients with gastric cancer. However, the impact of the postoperative chemotherapy...
Sat Aug 29, 2020 13:30
Related Articles Clinical Impact of Percentage of Natural Killer Cells and Natural Killer-Like T Cell Population in Acute Myeloid Leukemia. J Hematol. 2020 Sep;9(3):62-70 Authors: Jamal E, Azmy E, Ayed M, Aref S, Eisa N Abstract Background: Natural killer (NK) function defects have been seen in many hematological malignancies, including acute myeloid leukemia (AML). AML is associated with deficient human leukocyte antigen (HLA) expression on...
Sat Aug 29, 2020 13:30
Related Articles Targeting cluster of differentiation 47 improves the efficacy of anti-cytotoxic T-lymphocyte associated protein 4 treatment via antigen presentation enhancement in pancreatic ductal adenocarcinoma. Exp Ther Med. 2020 Oct;20(4):3301-3309 Authors: Song X, Lu Z, Xu J Abstract Treatment with cluster of differentiation 47 (CD47) monoclonal antibody has exhibited promising antitumor effects in various preclinical cancer models. However,...
Sat Aug 29, 2020 13:30
Related Articles Integrated Genomic Characterization of the Human Immunome in Cancer. Cancer Res. 2020 Aug 27;: Authors: Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS Abstract Alterations in immune-related pathways are common hallmarks of cancer. A comprehensive understanding of how cancer mutations rewire immune signaling networks and functional output across...
Sat Aug 29, 2020 13:30
Related Articles Role of norms in variation in cancer centers' end-of-life quality: qualitative case study protocol. BMC Palliat Care. 2020 Aug 27;19(1):136 Authors: Knutzen KE, Schifferdecker KE, Murray GF, Alam SS, Brooks GA, Kapadia NS, Butcher R, Barnato AE Abstract BACKGROUND: A critical barrier to improving the quality of end-of-life (EOL) cancer care is our lack of understanding of the mechanisms underlying variation in EOL treatment...
Sat Aug 29, 2020 13:30
Related Articles Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization. J Biomed Sci. 2020 Aug 27;27(1):90 Authors: Petragnano F, Pietrantoni I, Camero S, Codenotti S, Milazzo L, Vulcano F, Macioce G, Giordani I, Tini P, Cheleschi S, Gravina GL, Festuccia C, Rossetti A, Delle Monache S, Ordinelli A, Ciccarelli C, Mauro A, Barbara B, Antinozzi C, Schiavetti A, Maggio R, Di Luigi L, Polimeni A,...
Sat Aug 29, 2020 13:30
Related Articles Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial. BMC Anesthesiol. 2020 Aug 27;20(1):215 Authors: Chutipongtanate A, Prukviwat S, Pongsakul N, Srisala S, Kamanee N, Arpornsujaritkun N, Gesprasert G, Apiwattanakul N, Hongeng S, Ittichaikulthol W, Sumethkul V, Chutipongtanate S Abstract BACKGROUND: Volatile anesthetic...
Sat Aug 29, 2020 13:30
Related Articles Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: final analysis of the GioTag study. Future Oncol. 2020 Aug 28;: Authors: Hochmair MJ, Morabito A, Hao D, Yang CT, Soo RA, Yang JC, Gucalp R, Halmos B, Märten A, Cufer T Abstract Aim: Final overall survival (OS) and time on treatment analysis of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) who received...
Sat Aug 29, 2020 13:30
Related Articles Integrating Two-Dimensional Gas and Liquid Chromatography-Mass Spectrometry for Untargeted Colorectal Cancer Metabolomics: A Proof-of-Principle Study. Metabolites. 2020 Aug 25;10(9): Authors: Yuan F, Kim S, Yin X, Zhang X, Kato I Abstract Untargeted metabolomics is expected to lead to a better mechanistic understanding of diseases and thus applications of precision medicine and personalized intervention. To further increase...
Sat Aug 29, 2020 13:30
Related Articles Pioglitazone, Nuclear Receptors, and Aerodigestive Prevention. Cancer Prev Res (Phila). 2019 Oct;12(10):641-644 Authors: Ondrey FG Abstract There has been intense interest in nuclear receptor targeting for cancer prevention. With the exception of estrogen antagonism in breast carcinoma there has not been widespread adoption or success of this strategy in clinical cancer prevention. Keith and colleagues have performed a careful...
Sat Aug 29, 2020 13:30
Related Articles Iron metabolism in high altitude residents. J Appl Physiol (1985). 2020 Aug 27;: Authors: Muckenthaler MU, Mairbäurl H, Gassmann M Abstract High altitude residents cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here we review available data on how iron metabolism adapts when living in a...
Fri Aug 28, 2020 13:07
Related Articles Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis. Neoplasma. 2020 Aug 28;: Authors: Švajdler M, Němcová J, Dubinský P, Metelková A, Švajdler P, Straka Ľ, Sakař R, Daum O, Michal M, Skálová A, Mezencev R Abstract Sinonasal cancers represent a highly heterogeneous group of head and neck cancers, for which etiological and prognostic significance...
Fri Aug 28, 2020 13:07
Related Articles Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA Netw Open. 2020 Aug 03;3(8):e2014205 Authors: Bhatia S, Hageman L, Chen Y, Wong FL, McQuaid EL, Duncan C, Mascarenhas L, Freyer D, Mba N, Aristizabal P, Walterhouse D, Lew G, Kempert PH, Russell TB, McNall-Knapp RY, Jacobs S, Dang H, Raetz E, Relling MV,...
Fri Aug 28, 2020 13:07
Related Articles Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer. Chin Med J (Engl). 2020 Aug 25;: Authors: Bian L, Xu FR, Jiang ZF Abstract Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined...
Fri Aug 28, 2020 13:07
Related Articles Are Some Randomized Clinical Trials Impossible? J Pediatr Orthop. 2020 Aug 25;: Authors: Rios JJ, Richards BS, Stevenson DA, Oberlander B, Viskochil D, Gross AM, Dombi E, Widemann BC, Plotkin SR, May CJ, Ullrich NJ, Goldstein RY, Jain V, Schorry EK, NFCTC Consortium Abstract Congenital tibial pseudarthrosis is a rare condition seen in neurofibromatosis type 1 (NF1), and treatment is complex. A randomized, placebo-controlled...
Fri Aug 28, 2020 13:07
Related Articles Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results. Curr Opin Oncol. 2020 Aug 26;: Authors: Goncalves A, Mezni E, Bertucci F Abstract PURPOSE OF REVIEW: Recently, both immune checkpoint inhibitors and poly(ADP-ribose) polymerase inhibitors have demonstrated clinical benefit in some subsets of HER2-negative breast cancer patients. A biological...
Fri Aug 28, 2020 13:07
Related Articles Integrating immunotherapy in the (neo)adjuvant setting of early breast cancer. Curr Opin Oncol. 2020 Aug 26;: Authors: Chan JJ, Tan TJY, Dent RA Abstract PURPOSE OF REVIEW: Breast cancer is a relative latecomer in the success story of immuno-oncology. In this review, we focus on the preclinical and clinical lines of evidence to justify the evaluation of immune checkpoint inhibition (ICI) for the curative-intent treatment of...
Fri Aug 28, 2020 13:07
Related Articles Interorgan communication in development and cancer. Wiley Interdiscip Rev Dev Biol. 2020 Aug 27;:e394 Authors: Alvarez-Ochoa E, Froldi F, Cheng LY Abstract Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells...
Fri Aug 28, 2020 13:07
Related Articles Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma. Future Oncol. 2020 Aug 27;: Authors: Kogushi K, LoPresti M, Ikeda S Abstract Background: Synovial sarcoma (SS) is a rare, aggressive soft tissue sarcoma with a poor prognosis after metastasis. The objective of this study was to conduct a systematic review of the clinical evidence for therapeutic options for adults with metastatic...
Fri Aug 28, 2020 13:07
Related Articles A mediation analysis to explain socio-economic differences in bladder cancer survival. Cancer Med. 2020 Aug 26;: Authors: Russell B, Hemelrijck MV, Gårdmark T, Holmberg L, Kumar P, Bellavia A, Häggström C Abstract INTRODUCTION: This study aims to disentangle heterogeneity in the survival of bladder cancer (BC) patients of different socioeconomic status (SES) by identifying potential mediators of the relationship. METHODS:...
Fri Aug 28, 2020 13:07
Related Articles Immune Response Evaluation and Treatment with Immune Checkpoint Inhibitors Beyond Clinical Progression: Response Assessments for Cancer Immunotherapy. Curr Oncol Rep. 2020 Aug 27;22(11):116 Authors: Mushti SL, Mulkey F, Tang S, Singh H, Lemery SJ, Goldberg KB, Sridhara R, Keegan P, Kluetz PG, Pazdur R, Theoret MR, Beaver JA Abstract PURPOSE OF REVIEW: This review provides a comprehensive assessment of recent literature reports...
Fri Aug 28, 2020 13:07
Related Articles Atorvastatin in combination with radiotherapy and temozolomide for glioblastoma: a prospective phase II study. Invest New Drugs. 2020 Aug 27;: Authors: Altwairgi AK, Alghareeb WA, AlNajjar FH, Alhussain H, Alsaeed E, Balbaid AAO, Aldanan S, Orz Y, Alsharm AA Abstract Glioblastoma is a fast-growing primary brain tumor observed in adults with the worst prognosis. Preclinical studies have demonstrated the encouraging anticancer...
Fri Aug 28, 2020 13:07
Related Articles CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future. Front Oncol. 2020;10:1387 Authors: Uddin F, Rudin CM, Sen T Abstract A series of recent discoveries harnessing the adaptive immune system of prokaryotes to perform targeted genome editing is having a transformative influence across the biological sciences. The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated...
Fri Aug 28, 2020 13:07
Related Articles Phase II Study of Ipilimumab in Men With Metastatic Prostate Cancer With an Incomplete Response to Androgen Deprivation Therapy. Front Oncol. 2020;10:1381 Authors: Graff JN, Stein MN, Surana R, Al Rabadi L, Liu E, Fong L, Bailey S, Latour E, Newby TA, Moran AE, Beer TM Abstract Background: Phase 3 studies of immune checkpoint inhibitors have not shown a survival benefit in prostate cancer, but some patients have a profound anticancer...
Fri Aug 28, 2020 13:07
Related Articles Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms. Front Oncol. 2020;10:1338 Authors: Zahnreich S, Poplawski A, Hartel C, Eckhard LS, Galetzka D, Hankeln T, Löbrich M, Marron M, Mirsch J, Ritter S, Scholz-Kreisel P, Spix C, Schmidberger H Abstract The purpose of the present study was to investigate whether former childhood cancer patients who...
Fri Aug 28, 2020 13:07
Related Articles Therapeutic Implications of Epidermal Growth Factor Receptor (EGFR) in the Treatment of Metastatic Gastric/GEJ Cancer. Front Oncol. 2020;10:1312 Authors: Adashek JJ, Arroyo-Martinez Y, Menta AK, Kurzrock R, Kato S Abstract Gastric cancer remains third leading cause of global cancer mortality and is the fifth most common type of cancer in the United States. A select number of gastric cancers harbor alterations in EGFR and/or...
Fri Aug 28, 2020 13:07
Related Articles Patient Characteristics Influence Activated Signal Transducer and Activator of Transcription 3 (STAT3) Levels in Primary Breast Cancer-Impact on Prognosis. Front Oncol. 2020;10:1278 Authors: Nilsson L, Sandén E, Khazaei S, Tryggvadottir H, Nodin B, Jirström K, Borgquist S, Isaksson K, Jernström H Abstract Background: Activated signal transducer and activator of transcription 3 (pSTAT3) is often present in breast cancer, but...
Fri Aug 28, 2020 13:07
Related Articles The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment. Front Oncol. 2020;10:1221 Authors: Dimou A, Syrigos KN Abstract Immunotherapy options for patients with cancer have emerged following decades of research on immune responses against tumors. Most treatments in this category harness T cells with specificity for tumor associated antigens, neoantigens, and cancer-testis antigens. GSK3β is a serine-threonine kinase...
Fri Aug 28, 2020 13:07
Related Articles Succinylcholine-Induced Masseter Muscle Rigidity Successfully Managed With Propofol and Laryngeal Mask Airway: A Case Report and Brief Review. Cureus. 2020 Jul 24;12(7):e9376 Authors: Sheikh MM, Riaz A, Umair HM, Waqar M, Muneeb A Abstract Masseter muscle rigidity following administration of succinylcholine for induction of general anesthesia is considered an early warning sign for the possibility of an episode of dreaded complication...
Fri Aug 28, 2020 13:07
Related Articles Atrial fibrillation and cancer; understanding the mysterious relationship through a systematic review. J Community Hosp Intern Med Perspect. 2020 May 21;10(2):127-132 Authors: Lateef N, Kapoor V, Ahsan MJ, Latif A, Ahmed U, Mirza M, Anwar F, Holmberg M Abstract Background: Atrial Fibrillation (AFib) is the most common cardiac arrhythmia, occurring in ≈1% of the general population. An increased risk of malignancy among patients...
Fri Aug 28, 2020 13:07
Related Articles Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models. Oncotarget. 2020 Aug 11;11(32):3048-3060 Authors: Mainetti LE, Rico MJ, Kaufman CD, Grillo MC, Guercetti J, Baglioni MV, Del Giúdice A, Capitani MC, Fusini M, Rozados VR, Scharovsky OG Abstract Metronomic chemotherapy refers to the minimum biologically effective doses of a chemotherapy agent given as a continuous...
Fri Aug 28, 2020 13:07
Related Articles Current Status and Future Perspectives of Immunotherapy in Middle-Income Countries: A Single-Center Early Experience. World J Oncol. 2020 Aug;11(4):150-157 Authors: Bou Akl I, Berro J, Tfayli A, Shamseddine A, Mukherji D, Temraz S, El Cheikh J, Alameh IA, Assi HI Abstract Background: Immunotherapy agents offer novel treatment options in advanced cancers. However, their use is limited in developing countries lacking unifying...
Fri Aug 28, 2020 13:07
Related Articles A Study of Artificial Sweeteners and Thyroid Cancer Risk. J Clin Med Res. 2020 Aug;12(8):492-498 Authors: Singh N, Singh Lubana S, Arora S, Sachmechi I Abstract Background: In recent decades, data from certain observational studies have stirred controversy over artificial sweeteners by linking them with certain malignancies. As the incidences of artificial sweetener consumption and thyroid cancer are both increasing, our study...
Fri Aug 28, 2020 13:07
Related Articles Exceptional response to nivolumab of a heavily pre-treated patient with metastatic renal-cell cancer: from a case report to molecular investigation and future perspectives. Ther Adv Med Oncol. 2020;12:1758835920946152 Authors: Dimitrakopoulos FD, Kourea E, Nasioulas G, Papadopoulou E, Nikolakopoulos A, Spyropoulou D, Kottorou A, Karatzas A, Kalofonos HP, Koutras A Abstract Immunotherapy may result in long-lasting exceptional...
Fri Aug 28, 2020 13:07
Related Articles The Enigma of Low COVID-19 Fatality Rate in India. Front Genet. 2020;11:854 Authors: Samaddar A, Gadepalli R, Nag VL, Misra S Abstract Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly evolved into a pandemic. Though its origin has been linked to the Wuhan City of China's Hubei Province in December 2019, recent...
Fri Aug 28, 2020 13:07
Related Articles Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study. Front Immunol. 2020;11:1983 Authors: Riesner K, Cordes S, Peczynski C, Kalupa M, Schwarz C, Shi Y, Mertlitz S, Mengwasser J, van der Werf S, Peric Z, Koenecke C, Schoemans H, Duarte RF, Basak GW, Penack O Abstract Despite its involvement in various immune functions, including the allogeneic...
Fri Aug 28, 2020 13:07
Related Articles A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes. Front Immunol. 2020;11:1704 Authors: Schäfer D, Henze J, Pfeifer R, Schleicher A, Brauner J, Mockel-Tenbrinck N, Barth C, Gudert D, Al Rawashdeh W, Johnston ICD, Hardt O Abstract A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However,...
Fri Aug 28, 2020 13:07
Related Articles Hematopoietic Cell Transplantation for Chronic Granulomatous Disease in Japan. Front Immunol. 2020;11:1617 Authors: Yanagimachi M, Kato K, Iguchi A, Sasaki K, Kiyotani C, Koh K, Koike T, Sano H, Shigemura T, Muramatsu H, Okada K, Inoue M, Tabuchi K, Nishimura T, Mizukami T, Nunoi H, Imai K, Kobayashi M, Morio T Abstract Hematopoietic cell transplantation (HCT) is established as a curative treatment for severe chronic granulomatous...
Fri Aug 28, 2020 13:07
Related Articles Watch and wait approach in rectal cancer: Current controversies and future directions. World J Gastroenterol. 2020 Aug 07;26(29):4218-4239 Authors: López-Campos F, Martín-Martín M, Fornell-Pérez R, García-Pérez JC, Die-Trill J, Fuentes-Mateos R, López-Durán S, Domínguez-Rullán J, Ferreiro R, Riquelme-Oliveira A, Hervás-Morón A, Couñago F Abstract According to the main international clinical guidelines, the recommended treatment...
Fri Aug 28, 2020 13:07
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