Publication date: Available online 27 August 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Mayada ElSherif
Thu Aug 27, 2020 17:50
Publication date: Available online 27 August 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Cinthia Giselle Pérez, Paula Gabaldon Masse, Alejandro Cocciaglia, Hugo Rodríguez
Thu Aug 27, 2020 17:50
Publication date: Available online 26 August 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Xavier León, Gerard Pujals, Constanza Bulboa, Jacinto García, Montserrat López, Miquel Quer
Thu Aug 27, 2020 17:50
Publication date: Available online 26 August 2020Source: Auris Nasus LarynxAuthor(s): Sertac Yetiser
Thu Aug 27, 2020 19:55
Publication date: Available online 26 August 2020Source: Auris Nasus LarynxAuthor(s): Masamitsu Hyodo, Yasuo Hisa, Noriko Nishizawa, Koichi Omori, Osamu Shiromoto, Eiji Yumoto, Tetsuji Sanuki, Asuka Nagao, Kahori Hirose, Taisuke Kobayashi, Kento Asano, Masahiko Sakaguchi
Thu Aug 27, 2020 19:55
Abstract Objectives The primary aim of the study is to provide recommendations for the investigation and management of patients with new onset loss of sense of smellduring the COVID‐19 pandemic Design After undertaking a literature review, we used the RAND/UCLA methodology with a multi‐step process to reach consensus about treatment options, onward referral andimaging. Setting and participants An expert panel consisting of 15 members was assembled. A literature review was undertaken...
Thu Aug 27, 2020 12:39
Abstract Objectives Manuka honey attacks biofilms, which contribute to bacterial persistence in cystic fibrosis sinusitis. The primary objective was to determine feasibility of investigating manuka honey as an irrigation treatment for cystic fibrosis sinusitis and secondarily to assess the treatment’s preliminary effectiveness. Design Prospective, single‐blinded (clinician only), randomized, parallel two‐armpilot trial. Setting Tertiary rhinology clinic. Participants Subjects...
Thu Aug 27, 2020 18:53
Condition: Nasopharyngeal CarcinomaInterventions: Radiation: Photon; Radiation: Proton; Radiation: Carbon ionSponsor: Shanghai Proton and Heavy Ion CenterRecruiting
Thu Aug 27, 2020 19:00
Condition: Squamous Cell Carcinoma of Head and NeckIntervention: Other: optimised managementSponsor: Centre Henri BecquerelNot yet recruiting
Thu Aug 27, 2020 19:00
Condition: Hip FracturesInterventions: Device: Stryker© ADAPT™ platform; Radiation: Traditional fluoroscopySponsor: Columbia UniversityNot yet recruiting
Thu Aug 27, 2020 19:00
Condition: Vitamin D Deficiency, Nasal PolyposisInterventions: Drug: vitamin D supplementation; Drug: usual therapy for nasal polyposisSponsor: Ain Shams UniversityRecruiting
Thu Aug 27, 2020 19:00
Purpose of review This article reviews recent literature on repair of peripheral nerve injuries in the head and neck with a focus on autografts, allografts, nerve conduits, and technical considerations. Recent findings Contemporary nerve grafting techniques offer the potential to improve peripheral nerve outcomes and reduce donor site morbidity. A variety of donor nerves autografts have been described that offer favorable outcomes for segmental reconstruction of facial nerve defects. Recent...
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Purpose of review Treatment of auditory dysfunction is dependent on inner ear drug delivery, with microtechnologies playing an increasingly important role in cochlear access and pharmacokinetic profile control. This review examines recent developments in the field for clinical and animal research environments. Recent findings Micropump technologies are being developed for dynamic control of flow rates with refillable reservoirs enabling timed delivery of multiple agents for protection or...
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Purpose of review Clinician researchers face the pressures of meeting academic benchmarks combined with advancing new therapies to patients. The vast majority of drug discoveries fail in translation. A new method of meeting the challenges of preclinical therapeutic translation is presented using the example of tympanic regeneration. Recent findings The key to a design-thinking approach to therapeutic translation is to ‘begin with the end in mind’ by widening the scope of the problem, with...
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Purpose of review We review the literature on the use of audiometric protocols in the guidance of when to obtain MRI for detection of vestibular schwannoma. This discussion will focus on the sensitivity, specificity, and cost-effective analysis of audiometric criteria of asymmetric sensorineural hearing loss (ASNHL) when used to decide when MRI scans should be performed. Recent findings The sensitivity for detecting vestibular schwannomas when invoking published audiometric protocols for...
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Purpose of review To review the principles of oncolytic virotherapy and summarize the recent preliminary evidence on the efficacy of oncolytic virotherapy for cholesteatoma (CHST) treatment in vitro in human CHST cells and in a gerbil CHST model. Recent findings The use of oncolytic virotherapy for nonmalignant lesions is innovative. In-vitro results showed that oncolytic herpes simplex virus 1 (oHSV) selectively targets and kills CHST cells. In a gerbil model of CHST, local oHSV injections...
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Purpose of review To review reconstruction techniques following total laryngectomy, partial laryngopharyngectomy, and total laryngopharyngectomy with an emphasis on long-term swallow and speech outcomes. Recent findings Recent literature has shown that the use of fasciocutaneous free flaps in the reconstruction of laryngectomy defects may lead to improved speech and swallow outcomes as compared with regional or free musculocutaneous flaps. Radial forearm and anterolateral thigh are the most...
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Purpose of review Insulin-like growth factor 1 (IGF-1) is a hormone necessary for the development, growth, and maintenance of various organs, and has been used as a therapeutic agent in clinical settings. This review aimed to illustrate its role in the auditory systems and its potential use as a therapeutic in the field of otology. Recent findings Previous animal studies have indicated the critical role of IGF-1 in the development and maintenance of the auditory system, especially in the...
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Purpose of review One of the most common diseases of the tympanic membrane is a perforation, and tympanoplasty is one of the more common procedures in otolaryngology. Tympanic membrane regeneration and bioengineering aim to improve the success rate of the procedure, increase the availability of different scaffolds and provide innovative tools that will simplify the surgical technique and make it accessible for surgeons with varying expertise level. This review aims to raise awareness of current...
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Purpose of review Middle ear cholesteatoma is an epithelial lesion that expands into the middle ear, resulting in bone destruction. However, the pathogenesis of this has been unknown. The purpose of this review is to understand the role of keratinocyte growth factor (KGF) during epithelial stem and/or progenitor cell proliferation in middle ear cholesteatoma. Recent findings Many researchers have investigated the molecular mechanism of middle ear cholesteatoma to establish a conservative...
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Purpose of review Cochlear implants have been used to treat bilateral deafness for over 40 years. A more recent development has been the application of this technology toward single-sided deafness (SSD) and asymmetric hearing loss (AHL), culminating in the Food and Drug Administration (FDA) approval in the United States for this indication in July of 2019. This review examines the recent literature on cochlear implants for SSD and AHL, focusing on speech perception, sound localization, tinnitus,...
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Purpose of review This article reviews literature on the use of optical coherence tomography (OCT) in otology and provides the reader with a timely update on its current clinical and research applications. The discussion focuses on the principles of OCT, the use of the technology for the diagnosis of middle ear disease and for the delineation of in-vivo cochlear microarchitecture and function. Recent findings Recent advances in OCT include the measurement of structural and vibratory properties...
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Purpose of review The current article reviews literature on the contemporary management of superior semicircular canal dehiscence syndrome (SSCDS). Approaches to management and surgical techniques are compared along with a discussion of the use of more standardized, objective outcome measures. Recent findings Considerable debate still exists as to what approach and technique is most appropriate for patients with SSCDS and how to best measure postoperative outcomes. However, it is increasingly...
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Purpose of review Of the tumors found in the cerebellopontine angle (CPA), vestibular schwannomas are by far the most common. Modern diagnostic imaging enables excellent visualization of the CPA and detection of very small tumors while optimizing patient comfort and time. This review addresses the current imaging tools available for diagnosis of vestibular schwannomas. Recent findings The current gold-standard imaging study for vestibular schwannomas is a gadolinium-enhanced T1-weighted MRI....
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