Publication date: Available online 26 August 2020Source: Clinical NeurophysiologyAuthor(s): Patricia Rodrigo-Armenteros, Juan María Uterga-Valiente, Juncal Zabala-Del-Arco, Silvia Taramundi-Argüeso, Markel Erburu-Iriarte, Lander Antón-Méndez, Juan José Gómez-Muga, Juan Carlos Garcia-Monco
Thu Aug 27, 2020 20:39
Publication date: Available online 26 August 2020Source: Clinical NeurophysiologyAuthor(s): Nick Kane
Thu Aug 27, 2020 20:39
New Findings What is the central question of this study? The role of BRIP1 polymorphisms in COPD. What is the main finding and its importance? Variation of rs10744996C > A in BRIP1 increases the susceptibility of Mongolian population to COPD. The expression of BRIP1 was significantly reduced after in CSE treated airway epithelial cells. Abstract Cigarette smoke is a major environmental pollutant that can induce DNA damage in humans.The development and progressionof chronic...
Thu Aug 27, 2020 15:51
New Findings What is the central question of this study? Estradiol (E2) plays an important role in regulating skeletal muscle strength in females. Here, we asked to what extent E2 deficiency affects recovery of strength and satellite cell number when muscle is challenged by multiple injuries. What is the main finding and its importance? E2 deficiency impairs the adaptive potential of skeletal muscle following repeated injuries, as measured by muscle mass and strength. The impairment...
Thu Aug 27, 2020 15:51
Abstract Acute pancreatitis (AP) is a dysfunctional pancreas disease marked by severe inflammation. Long non-coding RNAs (lncRNAs) involving in the regulation of inflammatory responses have been frequently mentioned. The purpose of this study was to ensure the function and action mode of lncRNA maternally expressed gene 3 (MEG3) in caerulein-induced AP cell model. HPDE cells were treated with caerulein to establish an AP model in vitro....
Thu Aug 27, 2020 03:00
Key points Many mammals are born with immature motor systems that develop through a critical period of postnatal development In rodents, postnatal maturation of movement occurs from rostral to caudal, correlating with maturation of descending supraspinal and local spinal circuits We asked whether development of fundamental electrophysiological properties of spinal motoneurons follows the same rostro‐caudal sequence We show that in both regions, repetitive firing parameters increase and excitability...
Thu Aug 27, 2020 13:08
Key points Temporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca2+ signalling in many aspects of epilepsy but the precise Ca2+ channels that regulate this syndrome are not clear. Here, we report that mice lacking the store‐operated Ca2+ channel, Orai1, in the brain show markedly stronger seizures in response to the chemoconvulsants, kainic acid and pilocarpine. Electrophysiological analysis...
Thu Aug 27, 2020 11:23
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