Abstract Venous malformations (VMs) are common slow‐flow vascular malformations, which affect almost anywhere of the body. From Jan. 2010 to Oct. 2019, 126 patients with VMs who had complete imaging and follow‐up data were enrolled into this study, including 75 males. The initial treatment age ranged from 5‐72 years. The role of imaging results on the choice of treatment measures and the application were summarized. In this study, we retrospectively analyzed the imaging examinations, treatment measures...
Fri Aug 28, 2020 11:41
Rituximab is a well-established component of treatment regimens for B-cell non-Hodgkin lymphoma. Rituximab binds the CD20 antigen on the surface of B lymphocytes, causing an enhanced clearance of malignant and...
Fri Aug 28, 2020 03:00
Oncogenesis, Published online: 29 August 2020; doi:10.1038/s41389-020-00262-2Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway
Sat Aug 29, 2020 03:00
Oncogenesis, Published online: 28 August 2020; doi:10.1038/s41389-020-00263-1LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1
Fri Aug 28, 2020 03:00
Metal‐containing nanoparticles (M‐NPs) in metal/nitrogen‐doped carbon (M‐N‐C) catalysts have been considered hostile to acid oxygen reduction reaction (ORR). Some works have confirmed that M‐NPs can synergistically increase ORR activity in alkaline media. However, the relation between M‐NPs and the active sites of metal coordinated with nitrogen (MNx) is hard to be established in acid medium due to the poor stability of M‐NPs. Herein, we develop a strategy to successfully construct a new FeCo‐N‐C...
Sat Aug 29, 2020 19:59
The hexameric p97 enzyme plays an integral role in cellular homeostasis. Large changes to the orientation of its N‐terminal domains (NTDs), corresponding to NTD‐down (p97‐ADP) or NTD‐up (p97‐ATP), accompany ATP hydrolysis. The NTDs in a series of p97 disease mutants interconvert rapidly between up and down conformations when p97 is in the ADP‐bound state. While the populations of up and down NTDs can be determined from bulk measurements, information about the cooperativity of the transition between...
Fri Aug 28, 2020 21:49
Tuning the dihedral angle (DA) of axially chiral compounds can impact biological activity, catalyst efficiency, molecular motor performance, or chiroptical properties. Herein, we report gradual, controlled and reversible changes in molecular conformation of a covalently linked binaphthyl moiety, within a 3D polymeric network by the application of a macroscopic stretching force. We managed a direct observation of the DA changes by measuring the circular dichroism signal of an optically pure BINOL‐crosslinked...
Fri Aug 28, 2020 20:48
As a unique structural moiety in natural products, cinnamoyl lipid (CL), was proposed to be assembled via unusual type II polyketide synthases (PKSs). However, their biosynthetic machinery remains to be disclosed. Herein, we demonstrated the assembly line of CL compounds, youssoufenes, which is accomplished by a PKS system uniquely harbouring three phylogenetically different ketosynthase/chain length factor (KS/CLF) complexes (YsfB/C, YsfD/E, and YsfJ/K). Through in vivo gene inactivation, ...
Fri Aug 28, 2020 18:51
This study highlights the importance of following a strict protocol for Nafion® membrane pretreatment for electrochemical nitrogen reduction reaction experiments. It is shown how atmospheric ammonia pollutions can be introduced to the experimental setup through the membranes, therefore, interpreted falsely as catalysis product from N 2 . The sources of ammonia contamination vary drastically between different locations worldwide and even within the same location between days depending on temperature,...
Fri Aug 28, 2020 18:44
A robust surface between molecules and electrodes is very important for constructing molecular and electronic devices. Here, it was first found that Au‐C≡ C bond showed the highest stability under biological conditions containing abundant thiols and the best electrochemical performance compared to Au‐S and Au‐Se bonds. The new finding was also confirmed by theorical calculation. Based on the remarkable performance of Au‐C ≡ C bond, we designed and synthesized a specific molecule for recognition of...
Fri Aug 28, 2020 17:43
Automated chemical oligosaccharide synthesis is an attractive concept that has been successfully applied to a large number of target structures, but requires excess quantities of suitably protected and activated building blocks. Here we demonstrate the use of biocatalysis to supply such reagents for automated synthesis. By using the promiscuous NmLgtB‐B β1‐4 galactosyltransferase from Neisseria meningitidis we demonstrate fast and robust access to the LacNAc motif, common to many cell surface glycans...
Fri Aug 28, 2020 15:45
The [2+2] photocycloaddition is the most valuable and intensively investigated photochemical process. Here we demonstrate that irradiation of N‐acryloyl heterocycles with blue LED light (440 nm) in the presence of an Ir(III) complex leads to efficient and high yielding fused γ‐lactam formation across a range of differentially substituted heterocycles. Quantum calculations show that the reaction proceeds via cyclization in the triplet excited state to yield a 1,4‐diradical; intersystem crossing leads...
Fri Aug 28, 2020 14:51
The construction of controlled biomacromolecular assemblies has become a thriving area of supramolecular chemistry. In this respect, cucurbiturils (CBs), a class of macrocyclic receptors having robust skeletons, hydrophobic cavities, and carbonyl‐laced portals, have been drawn into the limelight because of their advantageous molecular recognition characteristics with a variety of biomacromolecules, including peptides, nucleic acids, and proteins. In this minireview, we focus on the impressive advances...
Fri Aug 28, 2020 14:45
The assembly of complex bacterial glycans presenting rare structural motifs and cis ‐glycosidic linkages is significantly obstructed by the lack of knowledge of the reactivity of the constituting building blocks and the stereoselectivity of the reactions in which they partake. We here report a strategy to map the reactivity of carbohydrate building blocks and apply it to understand the reactivity of the bacterial sugars, caryophyllose, a rare C12‐monosaccharide, containing a characteristic tetrasubstituted...
Fri Aug 28, 2020 13:18
The dealkenylative alkenylation of alkene C(sp3)−C(sp2) bonds has been an unexplored area for C−C bond formation. Reported herein are β‐alkylated styrene derivatives synthesized through the reactions of readily accessible feedstock olefins with β‐nitrostyrenes by ozone/FeII‐mediated radical substitutions. The strategy was applied to the syntheses of the natural product iso‐moracin and the drug (E)‐metanicotine. Abstract The dealkenylative alkenylation of alkene C(sp3)−C(sp2) bonds has been...
Fri Aug 28, 2020 11:48
GaIII complexes (Ga‐1) featuring planar tetradentate N2O2 Salen ligands are shown to demonstrate anticancer activity both in vitro and in vivo. Extensive chemical biology approaches, including transcriptomic and proteomic studies, suggest that PDIA3, a member of the protein disulfide isomerase (PDI) family involved in the endoplasmic reticulum (ER) stress response, is a key anticancer target for Ga‐1. Abstract Gallium(III)‐based drugs have gained momentum in cancer therapy due to their...
Fri Aug 28, 2020 11:35
Localization and tracking of individual membrane receptors on living cells was achieved upon transient binding of aptamer probes through minimally invasive solution diffusion. Probe affinity was modulated by rational engineering of the aptamer sequence. Detection of single molecules is linked to binding affinity, so probes with different affinity provide readouts on different properties, such as diffusive dynamics and receptor density levels. Abstract Tumor cell‐surface markers are usually...
Fri Aug 28, 2020 11:27
Through‐space charge transfer polynorbornenes with fixed and controllable spatial alignment of donor and acceptor in edge‐to‐face/face‐to‐face stacking patterns are demonstrated to exhibit blue thermally activated delayed fluorescence (TADF) together with maximum external quantum efficiency of 18.8 % for non‐doped, solution‐processed OLEDs. Abstract Through‐space charge transfer polynorbornenes with fixed and controllable spatial alignment of donor and acceptor in edge‐to‐face/face‐to‐face...
Fri Aug 28, 2020 11:26
Rod‐shaped liquid metal colloidal motors were fabricated from a eutectic gallium—indium (EGaIn) alloy. On application of an acoustic field, the EGaIn colloidal motors move autonomously and they are able to self‐organize into a flower‐like cluster. Abstract We report the reconfigurable assembly of rod‐shaped eutectic gallium–indium alloy (EGaIn) liquid metal colloidal motors by mimicking the growth behavior of a dandelion. EGaIn nanorods with a diameter of 210 nm and a length of 850 nm were...
Fri Aug 28, 2020 11:24
Biomolecular brush polymers are a unique class of materials. In this Minireview, we examine three families of biomolecular brush polymers with different side chains: 1) oligonucleotides, 2) oligosaccharides, and 3) oligopeptides. These materials display distinctive characteristics such as increased cell‐uptake, resistance to enzymes and bioavailability compared to the biomolecular oligomers on their own as individual sequences. Abstract In this Minireview, we describe synthetic polymers...
Fri Aug 28, 2020 11:24
Polyoxometalate chemistry has shown great application potential in the field of catalysis. This Minireview outlines and discusses the advantages, recent advances, challenges, strategies and future development of POM‐based compounds as photo/electrocatalysts in hydrogen evolution reaction, oxygen evolution reaction, and CO2 reduction reaction. Abstract Photo/electrocatalysis of water (H2O) splitting and CO2 reduction reactions is a promising strategy to alleviate the energy crisis and excessive...
Fri Aug 28, 2020 11:24
A low‐temperature molten‐salt‐assisted method to synthesize nanosheet‐like monometallic antimony or bismuth with high‐yield has been developed. The obtained bismuth nanosheets can effectively and continuously electrocatalyze the reduction of CO2 to formate with a stability of more than one month. Abstract Two‐dimensional (2D) monometallic pnictogens (antimony or Sb, and bismuth or Bi) nanosheets demonstrate potential in a variety of fields, including quantum devices, catalysis, biomedicine...
Fri Aug 28, 2020 11:23
Enantiodivergent [4+2] Cycloaddition of Dienolates by Polyfunctional Lewis Acid/Zwitterion Catalysis
In an efficient approach to catalytic asymmetric [4+2] cycloaddition, acidic prodienes were deprotonated by a betaine species to form a copper dienolate, and the dienophile was activated by hydrogen‐bond formation (see scheme). The polyfunctional catalyst promoted the transformation with high enantioselectivity as well as high turnover numbers. Abstract Diels–Alder reactions have become established as one of the most effective ways to prepare stereochemically complex six‐membered rings....
Fri Aug 28, 2020 11:22
A Redox‐Active Heterobimetallic N‐Heterocyclic Carbene Based on a Bis(imino)pyrazine Ligand Scaffold
Symbiosis: A novel redox‐switchable N‐heterocyclic carbene architecture based on pyrazine‐diimine systems is presented. We demonstrate its ambiphilicity in the reversible activation of alcohols and amines. This scaffold is capable of ligating two metals simultaneously, and the resulting heterobimetallic complexes can be reversibly oxidised and reduced. Abstract A new redox‐active N‐heterocyclic carbene (NHC) architecture is obtained using N‐methylated pyrazinediimine iron complexes as precursors....
Fri Aug 28, 2020 11:22
Very few engineered nanoparticles can be excreted through salivary glands, which often host bacteria or viruses during infection and involve in disease transmission. Renal‐clearable glutathione coated AgNPs can rapidly penetrate into submandibular salivary glands, be efficiently taken up by striated and excretory duct cells, and eventually secreted into saliva. Abstract Salivary elimination is an important pathway for the body to excrete small molecules with digestive enzymes. However,...
Fri Aug 28, 2020 11:21
We used rough‐to‐detailed screening approaches to analyze the structure–activity relationship of T lymphocyte transfection. We identified new lipidoids containing imidazole for effective T lymphocyte transfection and in vivo gene recombination. Overall, our findings establish an improved non‐viral delivery platform of functional mRNA for the direct transfection of T lymphocytes in the body. Abstract Engineering T lymphocytes is an emerging approach in a variety of biomedical applications....
Fri Aug 28, 2020 11:20
Redox homeostasis is one of the main reasons for reactive oxygen species (ROS) tolerance in hypoxic tumors, limiting ROS‐mediated tumor therapy. Herein, we propose a redox dyshomeostasis (RDH) strategy based on a nano‐platform FeCysPW@ZIF‐82@CAT Dz to disrupt redox homeostasis and apply this strategy to improve ROS‐mediated hypoxic tumor therapy. Once endocytosed by tumor cells, the catalase DNAzymes‐loaded zeolitic imidazole framework‐82 (ZIF‐82@CAT Dz) shell can be degraded into Zn2+...
Fri Aug 28, 2020 11:50
Current approaches to design monodisperse protein assemblies require rigid, tight, and symmetric interactions between oligomeric protein units. Here, we introduce a new multivalent interaction‐driven assembly strategy that allows flexible, spaced, and asymmetric assembly between protein oligomers. We discovered that two polygonal protein oligomers (ranging from triangle to hexagon) dominantly form a discrete and stable two‐layered protein prism nanostructure via multivalent interactions between fused...
Thu Aug 27, 2020 21:39
Perovskite lattice distortion induced by residual tensile strain from the thermal expansion mismatch between electron‐transporting layer (ETL) and perovskite film causes a sluggish charge extraction and transfer dynamics in all‐inorganic CsPbBr 3 perovskite solar cells (PSCs) because of their higher crystallization temperatures and thermal expansion coefficients. Herein, the interfacial strain is released by fabricating a WS 2 /CsPbBr 3 van der Waals heterostructure owing to their matched crystal...
Thu Aug 27, 2020 18:39
The structural phase of a metal oxide changes with temperature and pressure. During phase transitions, component ions move in multi‐dimensional metal–oxygen networks. Such macroscopic structural events are robust to changes in particle size, even at scales of around 10 nm, and size effects limiting these transitions are particularly important in, for example, high‐density memory applications of ferroelectrics. In this work, we examine structural transitions of the molecular metal oxide [Na@(SO 3...
Thu Aug 27, 2020 17:12
Abstract Purpose of Review The goal of this paper was to provide a narrative review of human factors considerations for telemedicine. It also sought to provide readers a foundation of human factors thinking and methods that could be employed within their own practice. Recent Findings There are only a handful of articles that discuss the...
Sat Aug 29, 2020 03:00
Antimicrobial resistance (AMR) is of growing concern globally and AMR status in sub-Saharan Africa (SSA) is undefined due to a lack of real-time data recording, surveillance and regulation. World Health Organi...
Fri Aug 28, 2020 03:00
Healthcare-associated infections (HAIs) and antimicrobial use (AMU) are important drivers of antimicrobial resistance, yet there is minimal data from the Pacific region. We sought to determine the point preval...
Fri Aug 28, 2020 03:00
Publication date: Available online 29 August 2020Source: Clinical NeurophysiologyAuthor(s): James Bashford, Mark R. Baker
Sat Aug 29, 2020 21:50
Publication date: Available online 29 August 2020Source: Clinical NeurophysiologyAuthor(s): James H Lee, Robert Boland-Freitas, Christina Liang, James Howells, Karl Ng
Sat Aug 29, 2020 21:50
Publication date: Available online 28 August 2020Source: Clinical NeurophysiologyAuthor(s): Sander De Groote, Lisa Goudman, Peter Van Schuerbeek, Ronald Peeters, Stefan Sunaert, Bengt Linderoth, Jose De Andrés, Philippe Rigoard, Mats De Jaeger, Maarten Moens
Sat Aug 29, 2020 21:50
Publication date: Available online 28 August 2020Source: Clinical NeurophysiologyAuthor(s): Paolo Zanatta, Federico Linassi, Marilena Casartelli, Andrea Rasera, Monica Ferlisi, Federica Basaldella, Giovanna Squintani
Fri Aug 28, 2020 15:42
Publication date: Available online 28 August 2020Source: Clinical NeurophysiologyAuthor(s): A.M. Vallence, H. Fujiyama, B.K. Rurak, K. Wansbrough, Y. Haigh
Fri Aug 28, 2020 15:42
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