Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-17700-9The main site of cytokinin perception in plant cells is thought to be the endoplasmic reticulum where most cytokinin receptors localise. Here via the use of bioactive probes that cannot enter plant cells and super-resolution microscopy, Antoniadi et al. show that cytokinin can also be perceived at the plasma membrane.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-18061-z“Life in a seasonal environment requires appropriate timing of physiological changes to survive, but how the circadian clockwork times these changes remains unclear. Here the authors show that the circadian clock genes BMAL2 and DEC1, in concert with epigenetic pathways in the pituitary, have a central role in seasonal timekeeping in mammals.”
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-18054-yEpigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-17969-wHow murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowledge to generate tracheal cartilage and smooth muscle on dish from mouse and human embryonic stem cells.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-18158-5Single cell transcriptomics technologies have vast potential in advancing our understanding of biology and disease. Here, Sarah Aldridge and Sarah Teichmann review the last decade of technological advancements in single-cell transcriptomics and highlight some of the recent discoveries enabled by this technology.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-18066-8WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-17948-1Supercooled liquids near the glass transition show remarkable non-Arrhenius transport phenomena, whose origin is yet to be clarified. Here, the authors use GPU molecular dynamics simulations for various binary mixtures in the supercooled regime to show the validity of a quasiuniversal excess-entropy scaling relation for viscosity and diffusion.
Thu Aug 27, 2020 03:00
Nature Communications, Published online: 27 August 2020; doi:10.1038/s41467-020-18088-2Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.
Thu Aug 27, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου