Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-17965-0The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immune-checkpoint blockade.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-17908-9Here, the authors show that the resolution and speed limitations in broadband photo-acoustic spectroscopy can be overcome by combining dual-comb spectroscopy with photo-acoustic detection. This enables broadband detection and allows for rapid and sensitive multi-species molecular analysis across all wavelengths of light.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-17780-7Spiralians have ciliary bands, used for locomotion and feeding, but defining molecular features of these structures are unknown. Here, the authors report a gene, Lophotrochin, that contains a protein domain only found in spiralians, and specifically expressed in diverse ciliary bands across the group, which provides a molecular signature for these structures.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-18026-2The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive. Here authors use in solution NMR on the isolated human TRPV1 S1-S4 domain and show that this domain undergoes a non-denaturing temperature-dependent transition with a high thermosensitivity.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-17943-6Blue light-emitting diodes (LEDs) are critical for displays. Employing a large organic cation into a quasi-two dimensional perovskite with green emission, Chu et al. achieve LEDs exhibiting a high external quantum efficiency of 12.1% and stable spectra in the sky-blue region.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-18029-zThe functionalization of a sulfur-sulfur motif is synthetically challenging but highly desired for the production of bioactive compounds. Here, the authors report a disulfurating reagent for sequential and modular assembly of polysulfides where the S-S motif is functionalized with different C-, N- and S-nucleophiles.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-17620-8Chronic inflammation is a feature of age-related regenerative decline in skeletal muscles, but how it directly affects resident muscle stem cell fate and function is unclear. Here, the authors show that Ccr2 signaling in muscle stem cell derived progenitors represses terminal myogenic differentiation, and that targeting Ccr2 on aged myogenic progenitors rejuvenates aged skeletal muscle healing and function.
Thu Aug 20, 2020 03:00
Nature Communications, Published online: 20 August 2020; doi:10.1038/s41467-020-18062-yIron phthalocyanine with a 2D structure and symmetric electron distribution around Fe-N4 active sites is not optimal for O2 adsorption and activation. Here, the authors report an axial Fe–O coordination induced electronic localization strategy to enhance oxygen reduction reaction performance.
Thu Aug 20, 2020 03:00
Thu Aug 20, 2020 03:00
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