IJMS, Vol. 21, Pages 5747: In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?
IJMS, Vol. 21, Pages 5747: In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go? International Journal of Molecular Sciences doi: 10.3390/ijms21165747 Authors: Sandra Clara-Trujillo Gloria Gallego Ferrer José Luis Gómez Ribelles In hematological malignancies, leukemias or myelomas, malignant cells present bone marrow (BM) homing, in which the niche contributes to tumor development and drug resistance. BM architecture, cellular and molecular composition and interactions...
Tue Aug 11, 2020 03:00
IJMS, Vol. 21, Pages 5748: Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications International Journal of Molecular Sciences doi: 10.3390/ijms21165748 Authors: Zsófia Bognár Róbert E. Gyurcsányi Nucleic acid aptamers show clear promise as diagnostic reagents, as highly specific strands were reported against a large variety of biomarkers. They have appealing benefits in terms of reproducible generation by chemical synthesis, controlled modification with...
Tue Aug 11, 2020 03:00
IJMS, Vol. 21, Pages 5749: Comparing Gene Expression in the Parabrachial and Amygdala of Diestrus and Proestrus Female Rats after Orofacial Varicella Zoster Injection International Journal of Molecular Sciences doi: 10.3390/ijms21165749 Authors: Rebecca Hornung Addison Pritchard Paul R. Kinchington Phillip R. Kramer The orofacial pain pathway projects to the parabrachial and amygdala, and sex steroids have been shown to affect neuronal activity in these regions. GABA positive...
Tue Aug 11, 2020 03:00
IJMS, Vol. 21, Pages 5746: Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease International Journal of Molecular Sciences doi: 10.3390/ijms21165746 Authors: Laura van der Schoor Emma J. van Hattum Sophie M. de Wilde Netanja I. Harlianto Aart-Jan van Weert Meye Bloothooft Marcel A. G. van der Heyden Inward rectifier potassium ion channels (IK1-channels) of the Kir2.x family are responsible for maintaining...
Tue Aug 11, 2020 03:00
IJMS, Vol. 21, Pages 5745: Integrated Framework of the Immune-Defense Transcriptional Signatures in the Arabidopsis Shoot Apical Meristem International Journal of Molecular Sciences doi: 10.3390/ijms21165745 Authors: Muhammad Naseem Özge Osmanoğlu Martin Kaltdorf Afnan Ali M. A. Alblooshi Jibran Iqbal Fares M. Howari Mugdha Srivastava Thomas Dandekar The growing tips of plants grow sterile; therefore, disease-free plants can be generated from them. How plants safeguard...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2609: Metabolic Activity of Human Embryos after Thawing Differs in Atmosphere with Different Oxygen Concentrations Journal of Clinical Medicine doi: 10.3390/jcm9082609 Authors: Michal Ješeta Andrea Celá Jana Žáková Aleš Mádr Igor Crha Zdeněk Glatz Bartosz Kempisty Pavel Ventruba The vitrification of human embryos is more and more frequently being utilized as a method of assisted reproduction. For this technique, gentle treatment of the embryos...
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JCM, Vol. 9, Pages 2608: Biologic Therapy in Refractory Non-Multiple Sclerosis Optic Neuritis Isolated or Associated to Immune-Mediated Inflammatory Diseases. A Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9082608 Authors: Alba Herrero-Morant Carmen Álvarez-Reguera José L. Martín-Varillas Vanesa Calvo-Río Alfonso Casado Diana Prieto-Peña Belén Atienza-Mateo Olga Maiz-Alonso Ana Blanco Esther Vicente Íñigo Rúa-Figueroa Laura Cáceres-Martin...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2607: The American Society of Anesthesiologists Physical Status (ASA-PS) Risk Group Classification Can Be Used to Anticipate Functional Recovery Outcomes after the Surgical Treatment of Female Urinary Incontinence with Transobturator Suburethral Tape Journal of Clinical Medicine doi: 10.3390/jcm9082607 Authors: Cisneros-Pérez Yusta-Martín Sánchez-Conde Padilla-Fernandez Valverde-Martínez Martin-Hernandez Nogal Flores-Fraile Esteban-Fuertes...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2605: A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9082605 Authors: Alexander Steinke Florian Lange Caroline Seer Susanne Petri Bruno Kopp Executive dysfunction is a well-documented, yet nonspecific corollary of various neurological diseases and psychiatric disorders. Here, we applied computational modeling of latent cognition for executive control in amyotrophic lateral sclerosis...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2604: Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs Journal of Clinical Medicine doi: 10.3390/jcm9082604 Authors: Simone Johanna Pecher Arne Björn Potthast Frauke von Versen-Höynck Anibh Martin Das Background: Sirtuins (SIRT) are NAD+-dependent deacetylases that are involved in stress response, antioxidative defense, and longevity via posttranslational modifications. SIRT1 directly activates nitric oxide synthase (NOS). Aging is...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2606: Low PCSK-9 levels Are Associated with Favorable Neurologic Function after Resuscitation from out of Hospital Cardiac Arrest Journal of Clinical Medicine doi: 10.3390/jcm9082606 Authors: Merrelaar Buchtele Schriefl Clodi Poppe Ettl Herkner Jilma Schwameis Schoergenhofer Endotoxemia after cardiopulmonary resuscitation (CPR) is associated with unfavorable outcome. Proprotein convertase subtilisin/kexin type-9 (PCSK–9)...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2603: Prediction of Adverse Events in Stable Non-Variceal Gastrointestinal Bleeding Using Machine Learning Journal of Clinical Medicine doi: 10.3390/jcm9082603 Authors: Dong-Woo Seo Hahn Yi Beomhee Park Youn-Jung Kim Dae Ho Jung Ilsang Woo Chang Hwan Sohn Byuk Sung Ko Namkug Kim Won Young Kim Clinical risk-scoring systems are important for identifying patients with upper gastrointestinal bleeding (UGIB) who are at a high risk of hemodynamic...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2602: Should We Report 15q11.2 BP1-BP2 Deletions and Duplications in the Prenatal Setting? Journal of Clinical Medicine doi: 10.3390/jcm9082602 Authors: Idit Maya Sharon Perlman Mordechai Shohat Sarit Kahana Shiri Yacobson Tamar Tenne Ifaat Agmon-Fishman Reut Tomashov Matar Lina Basel-Salmon Rivka Sukenik-Halevy Copy number variations of the 15q11.2 region at breakpoints 1-2 (BP1-BP2) have been associated with variable phenotypes and low...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2601: Effects of 12-Week Methylphenidate Treatment on Neurometabolism in Adult Patients with ADHD: The First Double-Blind Placebo-Controlled MR Spectroscopy Study Journal of Clinical Medicine doi: 10.3390/jcm9082601 Authors: Simon Maier Ludger Tebartz van Elst Alexandra Philipsen Thomas Lange Bernd Feige Volkmar Glauche Kathrin Nickel Swantje Matthies Barbara Alm Esther Sobanski Katharina Domschke Evgeniy Perlov Dominique Endres Attention...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2600: Sodium-Glucose Cotransporter-2 Inhibitors at Discharge from Cardiology Hospitalization Department: Decoding A New Clinical Scenario Journal of Clinical Medicine doi: 10.3390/jcm9082600 Authors: José Rozado Daniel García Iglesias Miguel Soroa Alejandro Junco-Vicente Noemí Barja Antonio Adeba María Vigil-Escalera Rut Alvarez Francisco Torres Saura Esmeralda Capín Laura García María Luisa Rodriguez David Calvo Cesar Moris Elías...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2599: Clusterin as a New Marker of Kidney Injury in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9082599 Authors: Kinga Musiał Monika Augustynowicz Izabella Miśkiewicz-Migoń Krzysztof Kałwak Marek Ussowicz Danuta Zwolińska Background and aims: The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2597: Reliability and Validity of the Dyskinesia Impairment Scale in Children and Young Adults with Inherited or Idiopathic Dystonia Journal of Clinical Medicine doi: 10.3390/jcm9082597 Authors: Annika Danielsson Inti Vanmechelen Cecilia Lidbeck Lena Krumlinde-Sundholm Els Ortibus Elegast Monbaliu Kristina Tedroff Background: The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and choreoathetosis in children and youth with...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2596: Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review Journal of Clinical Medicine doi: 10.3390/jcm9082596 Authors: Karolina M. Stepien Federico Roncaroli Nadia Turton Christian J. Hendriksz Mark Roberts Robert A. Heaton Iain Hargreaves Mitochondrial dysfunction is emerging as an important contributory factor to the pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial dysfunction in LSDs...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2598: Adverse Pregnancy Outcomes after Multi-Professional Follow-Up of Women with Systemic Lupus Erythematosus: An Observational Study from a Single Centre in Sweden Journal of Clinical Medicine doi: 10.3390/jcm9082598 Authors: Muna Saleh Christopher Sjöwall Helena Strevens Andreas Jönsen Anders A. Bengtsson Michele Compagno While the management of pregnant patients with systemic lupus erythematosus (SLE) has improved over the last decades, the risk...
Tue Aug 11, 2020 03:00
JCM, Vol. 9, Pages 2595: The Effects of Physical Exercise on Balance and Prevention of Falls in Older People: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9082595 Authors: Giuseppe Francesco Papalia Rocco Papalia Lorenzo Alirio Diaz Balzani Guglielmo Torre Biagio Zampogna Sebastiano Vasta Chiara Fossati Anna Maria Alifano Vincenzo Denaro The aims of this systematic review and meta-analysis were to evaluate the effects of physical...
Tue Aug 11, 2020 03:00
JoF, Vol. 6, Pages 132: Phylogenetic Species of Paracoccidioides spp. Isolated from Clinical and Environmental Samples in a Hyperendemic Area of Paracoccidioidomycosis in Southeastern Brazil Journal of Fungi doi: 10.3390/jof6030132 Authors: Tiago A. Cocio Erika Nascimento Marcia R. von Zeska Kress Eduardo Bagagli Roberto Martinez Paracoccidioides brasiliensis complex and P. lutzii are the etiological agents of paracoccidioidomycosis. The geographic distribution of these species...
Tue Aug 11, 2020 03:00
J. Imaging, Vol. 6, Pages 80: Full 3D Microwave Breast Imaging Using a Deep-Learning Technique Journal of Imaging doi: 10.3390/jimaging6080080 Authors: Vahab Khoshdel Mohammad Asefi Ahmed Ashraf Joe LoVetri A deep learning technique to enhance 3D images of the complex-valued permittivity of the breast obtained via microwave imaging is investigated. The developed technique is an extension of one created to enhance 2D images. We employ a 3D Convolutional Neural Network, based...
Tue Aug 11, 2020 03:00
Life, Vol. 10, Pages 147: Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum Life doi: 10.3390/life10080147 Authors: Fabiana Miraglia Verdiana Valvano Lucia Rota Cristina Di Primio Valentina Quercioli Laura Betti Gino Giannaccini Antonino Cattaneo Emanuela Colla Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient...
Tue Aug 11, 2020 03:00
Medicina, Vol. 56, Pages 403: Osimertinib-Associated Toxic Epidermal Necrolysis in a Lung Cancer Patient Harboring an EGFR Mutation—A Case Report and a Review of the Literature Medicina doi: 10.3390/medicina56080403 Authors: Izumi Sato Hiroki Mizuno Nobutaka Kataoka Yusuke Kunimatsu Yusuke Tachibana Takumi Sugimoto Nozomi Tani Yuri Ogura Kazuki Hirose Takayuki Takeda Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening dermatologic...
Tue Aug 11, 2020 03:00
Medicina, Vol. 56, Pages 402: Quality of Life Indicators in Patients Operated on for Breast Cancer in Relation to the Type of Surgery—A Retrospective Cohort Study of Women in Serbia Medicina doi: 10.3390/medicina56080402 Authors: Predrag Kovačević Snežana Miljković Aleksandar Višnjić Jefta Kozarski Radmilo Janković Background and objectives: Quality of life (QoL) after breast cancer surgery is an important public health issue. The aim of this study was to determine the relationship...
Tue Aug 11, 2020 03:00
Metabolites, Vol. 10, Pages 328: Metabolomics in Radiation Biodosimetry: Current Approaches and Advances Metabolites doi: 10.3390/metabo10080328 Authors: Merriline M. Satyamitra David R. Cassatt Brynn A. Hollingsworth Paul W. Price Carmen I. Rios Lanyn P. Taliaferro Thomas A. Winters Andrea L. DiCarlo Triage and medical intervention strategies for unanticipated exposure during a radiation incident benefit from the early, rapid and accurate assessment of dose level....
Tue Aug 11, 2020 03:00
Metabolites, Vol. 10, Pages 327: VenoMS—A Website for the Low Molecular Mass Compounds in Spider Venoms Metabolites doi: 10.3390/metabo10080327 Authors: Yvonne M. Forster Silvan Reusser Florian Forster Stefan Bienz Laurent Bigler Spider venoms are highly complex mixtures. Numerous spider venom metabolites are uniquely found in spider venoms and are of interest concerning their potential use in pharmacology, agriculture, and cosmetics. A nontargeted ultra-high performance...
Tue Aug 11, 2020 03:00
Metabolites, Vol. 10, Pages 326: Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling Metabolites doi: 10.3390/metabo10080326 Authors: Joselyn N. Allen Adwitia Dey Jingwei Cai Jingtao Zhang Yuan Tian Mary Kennett Yanling Ma T. Jake Liang Andrew D. Patterson Pamela A. Hankey-Giblin Non-alcoholic steatohepatitis (NASH) represents the progressive...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1224: Effects of Weather and Environmental Factors on the Seasonal Prevalence of Foodborne Viruses in Irrigation Waters in Gyeonggi Province, Korea Microorganisms doi: 10.3390/microorganisms8081224 Authors: Zhaoqi Wang Hansaem Shin Soontag Jung Daseul Yeo Hyunkyung Park Sangah Shin Dong Joo Seo Ki Hwan Park Changsun Choi This study aimed to investigate the prevalence of foodborne viruses in reservoirs (an important resource of irrigation...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1219: Ultrasound-Attenuated Microorganisms Inoculated in Vegetable Beverages: Effect of Strains, Temperature, Ultrasound and Storage Conditions on the Performances of the Treatment Microorganisms doi: 10.3390/microorganisms8081219 Authors: Daniela Campaniello Maria Rosaria Corbo Barbara Speranza Milena Sinigaglia Antonio Bevilacqua Four microorganisms (Lactobacillus acidophilus LA5, Bifidobacterium animalis subsp. lactis DSM 10140 and Lactiplantibacillus...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1222: Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles Microorganisms doi: 10.3390/microorganisms8081222 Authors: Yu Jiang Mengxin Geng Liping Bai Biofilms are aggregate of microorganisms in which cells are frequently embedded within a self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other and/or to a surface. The development of biofilm affords pathogens significantly increased tolerances...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1220: Surviving Reactive Chlorine Stress: Responses of Gram-Negative Bacteria to Hypochlorous Acid Microorganisms doi: 10.3390/microorganisms8081220 Authors: Waleska Stephanie da Cruz Nizer Vasily Inkovskiy Joerg Overhage Sodium hypochlorite (NaOCl) and its active ingredient, hypochlorous acid (HOCl), are the most commonly used chlorine-based disinfectants. HOCl is a fast-acting and potent antimicrobial agent that interacts with several biomolecules,...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1221: Organic Carbon and Nitrogen Isoscapes of Reef Corals and Algal Symbionts: Relative Influences of Environmental Gradients and Heterotrophy Microorganisms doi: 10.3390/microorganisms8081221 Authors: Takanori Fujii Yasuaki Tanaka Koh Maki Nobue Saotome Naoko Morimoto Atsushi Watanabe Toshihiro Miyajima The elemental (C/N) and stable isotopic (δ13C, δ15N) compositions and compound-specific δ15N values of...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1218: Adaptation of Coccomyxa sp. to Extremely Low Light Conditions Causes Deep Chlorophyll and Oxygen Maxima in Acidic Pit Lakes Microorganisms doi: 10.3390/microorganisms8081218 Authors: Javier Sánchez-España Carmen Falagán Diana Ayala Katrin Wendt-Potthoff Deep chlorophyll maxima (DCM) and metalimnetic oxygen maxima (MOM) are outstanding biogeochemical features of acidic pit lakes (APL). However, knowledge of the eukaryotic phototrophs responsible...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1223: Human Skin Bacterial Community Response to Probiotic (Lactobacillus reuteri DSM 17938) Introduction Microorganisms doi: 10.3390/microorganisms8081223 Authors: Marie Frerejacques Camille Rousselle Loüen Gauthier Salomé Cottet-Emard Léa Derobert Anne Roynette Thomas Z. Lerch Changey The introduction of a strain or consortium has often been considered as a potential solution to restore microbial ecosystems. Extensive research on...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1216: Biological Processes Highlighted in Saccharomyces cerevisiae during the Sparkling Wines Elaboration Microorganisms doi: 10.3390/microorganisms8081216 Authors: María del Carmen González-Jiménez Teresa García-Martínez Anna Puig-Pujol Fina Capdevila Jaime Moreno-García Juan Moreno Juan Carlos Mauricio Sparkling wines elaboration has been studied by several research groups, but this is the first report on analysis of biological processes...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1217: Decreased Expression of the High Mobility Group Box 1 (HMGB1) Gene in Peripheral Blood in Patients with Mild or Moderate Clostridioides difficile Infection Microorganisms doi: 10.3390/microorganisms8081217 Authors: Jacek Czepiel Grażyna Biesiada Ewelina Pitera Paweł P. Wołkow Mateusz Michalak Aleksander Garlicki Cytokines are mediators of inflammation induced in the course of Clostridioides difficile infection (CDI). High Mobility Group...
Tue Aug 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1215: Differences in Viral RNA Synthesis but Not Budding or Entry Contribute to the In Vitro Attenuation of Reston Virus Compared to Ebola Virus Microorganisms doi: 10.3390/microorganisms8081215 Authors: Bianca S. Bodmer Josephin Greßler Marie L. Schmidt Julia Holzerland Janine Brandt Stefanie Braun Allison Groseth Thomas Hoenen Most filoviruses cause severe disease in humans. For example, Ebola virus (EBOV) is responsible for the two...
Tue Aug 11, 2020 03:00
Molbank, Vol. 2020, Article M1152: 3,5-Dimethoxy-2-[(4-methoxyphenyl)diazenyl]phenol Molbank doi: 10.3390/M1152 Authors: Gabriele Micheletti Dario Telese Carla Boga 3,5-Dimethoxy-2-[(4-methoxyphenyl)diazenyl]phenol was synthesized by an azo-coupling reaction between 3,5-dimethoxyphenol and 4-methoxy benzenediazonium tetrafluoroborate. The structure of newly synthesized compound was elucidated based on 1H NMR, 13C NMR, ESI-MS, UV-Vis and FT-IR.
Tue Aug 11, 2020 03:00
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