British Journal of Cancer, Published online: 12 August 2020; doi:10.1038/s41416-020-1024-2Plasma-based early screening and monitoring of EGFR mutations in NSCLC patients by a 3-color digital PCR assay
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Abstract Ex‐vivo evaluation of personalized models can facilitate individualized treatment selection for patients, and advance discovery of novel therapeutic options. However, for embryonal malignancies, representative primary cultures have been difficult to establish. We developed patient‐derived cell cultures (PDCs) from chemo‐naïve and post‐treatment neuroblastoma tumors in a consistent and efficient manner, and characterized their in‐vitro growth dynamics, histomorphology, gene expression and...
Mon Aug 10, 2020 21:49
Publication date: Available online 10 August 2020Source: Cancer/RadiothérapieAuthor(s): N. Ponsard, L. Heddadi, O. Pradier
Tue Aug 11, 2020 19:10
Publication date: Available online 10 August 2020Source: Cancer/RadiothérapieAuthor(s): R. Jumeau, É. Pruvot, J. Thariat, I. Latorzeff, P.-U. Milliez, L. Champ-Rigot, R. De Crevoisier, V. Ferchaud
Tue Aug 11, 2020 19:10
Purpose: Immunotherapy is remarkably effective, yet tumor escape is common. It remains unclear how brain tumors escape immunotherapy and how to overcome this immune escape. Experimental Design: We studied KR158B-luc glioma-bearing mice during treatment with adoptive cellular therapy (ACT) with polyclonal tumor-specific T cells. We tested the immunogenicity of primary and escaped tumors using T cell restimulation assays. We used flow cytometry and RNA profiling of whole tumors to further define escape...
Tue Aug 11, 2020 15:13
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Valesca P. Retèl, Danalyn Byng, Sabine C. Linn, Katarzyna Jóźwiak, Hendrik Koffijberg, Emiel J. Rutgers, Fatima Cardoso, Martine J. Piccart, Coralie Poncet, Laura J. van't Veer, Wim H. van Harten
Tue Aug 11, 2020 16:01
Publication date: Available online 10 August 2020Source: European Journal of CancerAuthor(s): Peter A. van Dam, Manon Huizing, Kostantinos Papadimitriou, Hans Prenen, Marc Peeters
Tue Aug 11, 2020 16:01
Publication date: Available online 11 August 2020Source: European Journal of Surgical OncologyAuthor(s): Marie-Mélanie Gac, Cécile Loaec, Johanna Silve, Edouard Vaucel, Paule Augereau, Romuald Wernert, Charlotte Bourgin, Xavier Aireau, Alain Lortholary, Philippe Descamps, Frank Priou, Pascaline Deblaye, Hugues Bourgeois, Valérie Delecroix, Fabienne Empereur, Loïc Campion, Jean-Marc Classe
Tue Aug 11, 2020 19:12
Publication date: Available online 11 August 2020Source: European Journal of Surgical OncologyAuthor(s): Vincent T. Hoek, Pim P. Edomskis, Anand G. Menon, Gert-Jan Kleinrensink, Sjoerd M. Lagarde, Johan F. Lange, Bas P.L. Wijnhoven
Tue Aug 11, 2020 19:12
Publication date: Available online 10 August 2020Source: European Journal of Surgical OncologyAuthor(s): Ru-Hong Tu, Jian-Xian Lin, Wei Wang, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin, Zhi-wei Zhou, Chao-Hui Zheng, Chang-Ming Huang
Tue Aug 11, 2020 19:12
Determinants of choice in offering drug holidays during first-line therapy for metastatic colorectal cancer. Future Oncol. 2020 Aug 10;: Authors: Garattini SK, Bonotto M, Porcu L, Ongaro E, Gerratana L, Basile D, Parnofiello A, Pelizzari G, Cortiula F, Corvaja C, Casagrande M, Cardellino GG, Buonadonna A, Aprile G, Puglisi F, Fasola G, Pella N Abstract Background: "Drug holidays" (DH) for metastatic colorectal cancer (mCRC) were introduced...
Tue Aug 11, 2020 13:52
Recapitulating intracavitary brachytherapy in cervical cancer patients during the COVID-19 pandemic: a viewpoint. Future Oncol. 2020 Aug 10;: Authors: Kumar D, Dey T PMID: 32776790 [PubMed - as supplied by publisher]
Tue Aug 11, 2020 13:52
Developing a growing cancer profile database based on quantitative analysis of protein biomarkers in formalin-fixed paraffin-embedded specimens. Future Oncol. 2020 Aug 08;: Authors: Zhang J, Yang M Abstract Over a century of clinical practice has led to the accumulation of millions of archived formalin fixed paraffin embedded (FFPE) cancer specimens with detailed medical records worldwide. Absolute quantitation of clinical protein biomarkers...
Tue Aug 11, 2020 13:52
Adjuvant systemic treatment in hepatocellular carcinoma: tempted to do something, rather than nothing. Future Oncol. 2020 Aug 08;: Authors: Rizzo A, Ricci AD, Brandi G PMID: 32772560 [PubMed - as supplied by publisher]
Tue Aug 11, 2020 13:52
Plain Language Summary of Publication articles: helping disseminate published scientific articles to patients. Future Oncol. 2020 Aug 10;: Authors: Dormer L, Walker J PMID: 32772553 [PubMed - as supplied by publisher]
Tue Aug 11, 2020 13:52
Abstract Integrative oncology is a burgeoning field and typically provided by a multiprofessional team. To ensure cancer patients receive effective, appropriate, and safe care, health professionals providing integrative cancer care should have a certain set of competencies. The aim of this project was to define core competencies for different health professions involved in integrative oncology. The project consisted of two phases. A systematic literature review on published competencies...
Tue Aug 11, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Tue Aug 11, 2020 03:00
Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute...
Mon Aug 10, 2020 03:00
Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting g...
Mon Aug 10, 2020 03:00
Abstract Musashi 2 (MSI2), a member of the Musashi RNA-binding family, is reported to be an oncoprotein in pancreatic ductal adenocarcinoma (PDAC), but the mechanisms of MSI2 in the development and progression of PDAC have not been fully demonstrated. In this research, we studied the clinical significance, biologic effects and the underlying mechanism of MSI2 in the progression of PDAC. The expression of MSI2, Mps-binding protein 1 (MOB1) and Salvador family WW domain-containing...
Tue Aug 11, 2020 03:00
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. USP7 inhibition may thus decrease oncogene function, increase tumor suppressor function and sensitize tumors to DNA-damaging agents. We have discovered a novel chemical series that potently and selectively inhibits USP7 in biochemical and cellular assays. Our inhibitors reduce the viability of multiple TP53 wild-type cell lines, including several hematologic cancer and MYCN-amplified...
Tue Aug 11, 2020 13:54
TAS-119 is a novel orally active, selective inhibitor of Aurora kinase A identified as a clinical candidate for efficacy testing in combination with taxanes. In vitro, TAS-119 enhanced cell growth inhibition of paclitaxel in multiple human cancer cell lines derived from various tissues, including paclitaxel-resistant cell lines. Interestingly, TAS-119 did not enhance paclitaxel antitumor activity in normal lung diploid fibroblast cell lines WI-38 and MRC5. In vivo, TAS-119 enhanced the antitumor...
Tue Aug 11, 2020 13:54
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is aberrant. In the present study, we sought to evaluate the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated via a peptide linker to the highly cytotoxic DNA alkylator,...
Tue Aug 11, 2020 13:54
Abstract Purpose Pediatric low-grade gliomas (pLGGs) are the most common CNS tumor of childhood and comprise a heterogenous group of tumors. Children with progressive pLGG often require numerous treatment modalities including surgery, chemotherapy, rarely radiation therapy and, more recently, molecularly targeted therapy. We describe our institutional experience using the MEK inhibitor, trametinib, for recurrent/progressive pLGGs. ...
Tue Aug 11, 2020 03:00
Publication date: Available online 11 August 2020Source: Practical Radiation OncologyAuthor(s): Peter G.F. Watson, Marija Popovic, Liheng Liang, Nada Tomic, Slobodan Devic, Jan Seuntjens
Tue Aug 11, 2020 13:37
Publication date: Available online 10 August 2020Source: Practical Radiation OncologyAuthor(s): Takahisa Eriguchi, Nobuhiro Tsukamoto, Nobuko Kuroiwa, Takafumi Nemoto, Takeru Ogata, Yusuke Okubo, Shigeru Nakano, Akitomo Sugawara
Tue Aug 11, 2020 13:37
Abstract Objective Long term information on lifestyle changes among prostate survivors is lacking. In this nation‐wide, population‐based study we investigated the prevalence of lifestyle changes, factors associated with lifestyle changes and associations between lifestyle changes and general quality of life. Methods All men registered in the National Prostate Cancer Register of Sweden diagnosed in 2008 with low‐risk prostate cancer at age 70 years or younger were sent a questionnaire. Logistic...
Mon Aug 10, 2020 21:01
Abstract Objective Patients with cancer are at high risk of depression. However, the risk of major depressive disorder (MDD) after cancer diagnosis has not been studied in a population setting in Japan. This cohort study used a Japanese medical claims database to examine time to MDD in cancer patients and the risk of MDD (hazard ratio; HR) compared with matched cancer‐free controls. Methods Primary endpoint was time to MDD (starting 6 months before cancer diagnosis) in adult (18–74 years)...
Mon Aug 10, 2020 21:01
Abstract Objective This investigation explores how using different e‐health interventions facilitates positive psychosocial changes and how these changes reduce cancer concerns and improve quality of life in breast cancer patients over time. Methods A total of 326 breast cancer patients were randomly assigned to one of three e‐health interventions: (1) Internet only, (2) the Comprehensive Health Enhancement Support System information and support services (CHESS‐IS), or (3) CHESS with mentor....
Mon Aug 10, 2020 21:00
Abstract Objective Gestational cancer is defined as any type of cancer diagnosed during pregnancy or within 12 months of delivery. To date, existing studies on the psychological aspects of this type of cancer have not been evaluated for methodological quality. The aim of this systematic review was to identify the psychological aspects of gestational cancer. Method Five journal databases were searched to identify peer‐reviewed articles reporting upon the psychological aspects of women with...
Mon Aug 10, 2020 21:00
Abstract Objective Cancer survivors commonly experience long‐term anxiety and depression. Anxiety and depression might result from problems emerging during survivorship rather than illness and treatment. This study tested three potential causal paths: 1) concerns about physical symptoms and functional problems and fear of cancer recurrence (FCR) arising during survivorship directly cause anxiety and depression, 2) an indirect path whereby FCR mediates effects of concerns about physical symptoms...
Mon Aug 10, 2020 20:59
Abstract Objectives The purpose of this study was to examine the association between physicians’ exercise counseling and post‐diagnosis physical activity (PA) in patients with cancer by investigating the mediating role of patients’ satisfaction with exercise counseling as well as the moderating role of patients’ previous PA. Methods The study sample consisted of 1002 people with cancer (503 breast, 265 prostate, 234 colorectal cancer). Participants reported their pre‐ and post‐diagnosis...
Mon Aug 10, 2020 20:59
Abstract Objective Receiving a diagnosis of head and neck cancer is devastating for patients and family carers and causes high levels of distress. Previous studies report that carer distress levels exceed that of patients, but go largely unnoticed by health professionals. To date, there is a paucity of studies that have described carers’ perspectives of the lived experience of caring for a loved one diagnosed with head and neck cancer. The aim of this study was to explore the lived experiences...
Mon Aug 10, 2020 20:59
Abstract Objective This paper describes the development of an assessment tool capturing competencies of healthcare professionals (HCPs) in caring for cancer patients with minor children. Methods We combined the methods of clinical case vignettes and situational judgement tests (SJTs). Scenarios were created based on literature and interviews with patients, HCPs, and experts. We pre‐tested the instrument by conducting cognitive interviews with n = 6 HCPs, who gave feedback on realism, clarity,...
Mon Aug 10, 2020 20:59
Abstract Objective Fear of progression (FoP), also referred to as fear of cancer recurrence, is gaining increasing interest in survivorship research as it constitutes a great burden for patients and relatives. However, only little is known about FoP in parents of childhood cancer survivors. The objective of this study was to investigate the impact of FoP on quality of life (QoL) in parental couples. Methods We analyzed dyadic data of 197 couples parenting childhood cancer survivors (aged...
Mon Aug 10, 2020 20:57
Coronavirus Disease 2019 (COVID-19) pandemic had an overwhelming impact on healthcare worldwide. Outstandingly, the aftermath on neoplastic patients is still largely unknown, and only isolated cases of COVID-1...
Mon Aug 10, 2020 03:00
The fission yeast Schizosaccharomyces pombe is an excellent model organism for the study of eukaryotic cellular physiology. The organism is genetically tractable and several tools to study the functions of individual genes are available. One such tool is regulatable gene expression and overproduction of proteins. Limitations of currently available overexpression systems include: delay in expression after induction; narrow dynamic range; and system-wide changes due to induction conditions. Here I...
Tue Aug 11, 2020 22:52
Publication date: Available online 10 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Timothy M. Pawlik
Tue Aug 11, 2020 13:29
Publication date: Available online 10 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Andrea S. Wolf, Raja M. Flores
Tue Aug 11, 2020 13:29
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