Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but to the authors' knowledge, limited data exist regarding the safety and efficacy of these agents in transplant recipients. Herein, the authors have reported their experience with 17 patients who were treated with ICIs for metastatic malignancies after undergoing solid organ transplantation. Methods Data were abstracted for solid organ transplant recipients who received ICIs for the treatment of malignancy...
Wed Aug 12, 2020 16:57
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Aug 12, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Aug 12, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Aug 12, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Aug 12, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Aug 12, 2020 10:00
Abstract Multiple myeloma (MM) is an incurable hematopoietic neoplasm derived from plasma cells and existing in bone marrow region. Recent developments in the field of myeloma onco‐biology enabled to use proteasome inhibitors (PIs) as key drugs for MM. PIs can increase cell sensitivity to endoplasmic reticulum stress, leading to apoptosis against myeloma cells. However, PI cannot kill all of myeloma cells. One reason of this might be activation of autophagy via hypoxic stress under bone marrow microenvironment....
Thu Aug 13, 2020 11:53
Cover of this issue. An image of scanning electron microscopy of cervical adenocarcinoma cells overexpressing aldolase A. See also Saito et al. (pp. https://doi.org/10.1111/cas.145243071–3081 of this issue).
Tue Aug 11, 2020 20:49
Opinion statement As the world becomes more connected through online and offline social networking, there has been much discussion of how the rapid rise of social media could be used in ways that can be productive and instructive in various healthcare specialties, such as Cardiology and its subspecialty areas. In this review, the role of social media in the field of Cardio-Oncology is discussed. With an estimated 17 million cancer survivors in the USA in 2019 and 22 million...
Thu Aug 13, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source...
Thu Aug 13, 2020 03:00
Thu Aug 13, 2020 03:00
We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European...
Thu Aug 13, 2020 03:00
Background Human cases of West Nile virus (WNV) infection are recorded since 2010 in Greece, with seasonal outbreaks occurring almost annually. Enhanced surveillance has been implemented since 2010, to promptly characterise cases’ temporal and geographical distribution and inform authorities for implementation of appropriate measures (mosquito control, health education, blood safety). Aim We describe the epidemiology of WNV human infections in Greece focusing on the 2018 season....
Thu Aug 13, 2020 03:00
Future Oncology, Ahead of Print.
Thu Aug 13, 2020 11:34
Related Articles Abemaciclib, a CDK4 and CDK6 inhibitor for the treatment of metastatic breast cancer. Future Oncol. 2020 Aug 12;: Authors: Martin M, Garcia-Saenz JA, Manso L, Llombart A, Cassinello A, Atienza M, Ringeisen F, Ciruelos E Abstract The addition of CDK4 and 6 inhibitors (abemaciclib, palbociclib or ribociclib) to endocrine therapy, as first-line treatment or following progression after initial endocrine therapy, significantly increased...
Thu Aug 13, 2020 13:05
Abstract The aryl hydrocarbon receptor (AHR) is a ligand binding transcription factor of the basic helix‐loop‐helix family regulating multiple cellular functions such as differentiation, cell cycle, apoptosis and inflammatory reactions. In neoplastic diseases, the AHR has been described to modulate proliferation and differentiation in dichotomous ways, either inhibiting or augmenting the growth of tumors. The precise role of AHR in melanoma is mostly unknown. Here we report a functional effect of...
Thu Aug 13, 2020 11:20
Abstract CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by immune cells but is often overexpressed in human tumors. In cancer, CD24 is a regulator of cell migration, invasion, and proliferation. Its expression is associated with poor prognosis and it is used as cancer stemness marker. Recently, CD24 on tumor cells was identified as a phagocytic inhibitor (“don't eat me“...
Thu Aug 13, 2020 11:18
Abstract Chemotherapy is a commonly used cancer treatment. However, it causes physical side effects and psychological side effects such as distress. Providing prechemotherapy education using audiovisual methods can reduce distress, but not all research about the use of educational videos have the same conclusions. This study aimed to evaluate the effect of prechemotherapy education using audio visual methods on distress of patients with cancer. This study was a quasi-experiment...
Thu Aug 13, 2020 03:00
Abstract The purpose of this study was to investigate the effect of IL‐1RN polymorphisms on thyroid cancer (TC) risk in Han population. Genotypes of four single nucleotide polymorphisms (SNPs) (rs17042888, rs928940, rs3181052, and rs452204) were analyzed by Agena MassARRAY. Meanwhile, we used the logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and significant differences were evaluated by t test and χ 2 test. Findings found that allele “G” of rs452204...
Thu Aug 13, 2020 13:34
Abstract Objective Cognitive‐behavioural models suggest that vicarious illness experiences precipitate health anxiety; however, this assumption is largely untested. This study aimed to (a) compare the severity of health anxiety and rates of clinical health anxiety, Illness Anxiety Disorder (IAD), and Somatic Symptom Disorder (SSD) in participants with and without a loved one with cancer, and (b) determine the predictors of health anxiety severity in participants with vicarious cancer experiences....
Wed Aug 12, 2020 18:04
The incidence of oropharynx squamous cell carcinoma (SCC) in North America is increasing despite a decline in cigarette smoking, likely due to an increase in human papilloma virus (HPV) related cancers. [1 2] HPV-related oropharynx SCC, often identified based on p16 positivity, has excellent long term outcomes with three year overall survival rates of over 80%. [1 3] = Impaired host immunity may reduce the probability of mounting an adequate cell-mediated immune response to HPV and subsequent viral...
Thu Aug 13, 2020 03:00
Significant technological advancement in the field of brachytherapy over the last decade has led to rapid implementation of trans-rectal ultrasound (TRUS) based high dose rate (HDR) prostate brachytherapy (pBT) treatments around the world [1–4]. The advantage of this TRUS based technique as compared to traditional CT based planning is the improved visualisation of the prostate gland on TRUS images, the ability to perform the entire procedure in the operating theatre, without having to move the patient...
Thu Aug 13, 2020 03:00
We have read with great interest the GEC-ESTRO ACROP recommendations for head and neck cancer brachytherapy [1]. In their article, the authors defined magnetic resonance imaging (MRI) as feasible for treatment planning. MRI is commonly used for diagnosis and staging of many diseases, and for target delineation. Benefit is well-known for brachytherapy and MRI guided brachytherapy (MRgBT), is recommended by gyn-GEC ESTRO for cervical cancer and more particularly in EMBRACE II protocol [2]. Some teams...
Thu Aug 13, 2020 03:00
Prior to the introduction of [18F]-Fluorodeoxyglucose (FDG) positron emission tomography (PET), the historical approach to head and neck cancer patients with bulky cervical nodal metastases or a residual neck mass following radiation therapy (RT) was mandatory post-treatment neck dissection (PTND) [1,2]. Whilst this was undoubtedly effective in reducing the risk of recurrence in the neck, it exposed those patients with a residual (but non-viable) neck mass to unnecessary surgery. PET records patterns...
Thu Aug 13, 2020 03:00
Publication date: Available online 12 August 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Tomasz Kolenda, Kacper Guglas, Magda Kopczyńska, Joanna Sobocińska, Anna Teresiak, Renata Bliźniak, Katarzyna Lamperska
Thu Aug 13, 2020 13:26
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