Clostridium perfringens type C (C. perfringens type C) is one of the main microbial pathogens responsible for piglet diarrhea worldwide, causing substantial economic losses for pig-rearing industries. The mitogen-activated protein kinase (MAPK) signaling pathway is a key regulator of inflammatory bowel disease, especially necrotic enteritis. However, whether and how the MAPK signaling pathway is involved in regulating the process of piglet diarrhea when challenged by C. perfringens type C are still...
Thu Aug 13, 2020 10:20
Objective. We aimed at investigating the effects of uniaxial static strain on osteoblasts in distraction osteogenesis (DO). Methods. To simulate the mechanical stimulation of osteoblasts during DO, 10% uniaxial static strain was applied to osteoblasts using a homemade multiunit cell stretching and compressing device. Before and after applying strain stimulation, the morphological changes of osteoblasts were observed by inverted phase-contrast microscopy, Coomassie blue staining, and immunofluorescence....
Thu Aug 13, 2020 10:20
MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants that exist as complex mixtures in vivo. When humans are simultaneously exposed to these compounds, the development of atherosclerosis is known to be enhanced. However, the roles of miRNA in TCDD- and PCB-induced atherosclerosis are largely unknown. Therefore, the present study is aimed at elucidating the possible...
Thu Aug 13, 2020 10:20
Abstract Purpose Pararenal abdominal aortic aneurysms (PRAAAs) is a life‐threatening disease, and hemodynamic analysis may provide greater insight into the effectiveness and long‐term outcomes of endovascular aneurysm repair (EVAR). However, the lack of patient‐specific boundary conditions on the periphery compromises the accuracy. Windkessel (WK) boundary conditions coupled to hemodynamic follow‐up models of a PRAAA patient, aims to provide insights into the link between hemodynamics and poor...
Thu Aug 13, 2020 17:14
With the COVID-19 pandemic, critical illnesses, such as Acute Respiratory Distress Syndrome and sepsis are coming into the spotlight. Despite their severity and risk for patients, critical illnesses remain understudied and lack the number of treatment options of many other diseases with a similar level of mortality and morbidity. Part of the challenge lies in the time sensitivity of such conditions, whereby clinicians have little time to make treatment decisions and typically can’t...
Thu Aug 13, 2020 23:40
The details of what goes on within the GI tract are still largely unknown to medical science. Bacteria come in a huge variety and the microbiome within the gut can be radically different from place to place. To better understand the bacterial composition of the human GI tract, researchers at Purdue University have developed a 3D printed ingestable capsule that can capture samples throughout the gut and safely transport these outside the body for testing. The technology consists...
Thu Aug 13, 2020 19:25
Stem cell research has come into prominence because of its applications in assisted reproductive technology and the treatment of deadly diseases. In teleost fishes, spermatogonial stem cells have been effectively used to produce surrogate gametes and progeny through germ cell transplantation technique. The present study is the first report of an innovative application of stem cell therapy in fish species for revitalising the reproductive competence of senescent individuals. Senescent male goldfish,...
Thu Aug 13, 2020 03:00
Modern microbial and ecosystem sciences require diverse interdisciplinary teams that are often challenged in “speaking” to one another due to different languages and data product types. Here we introduce the IsoGenie Database (IsoGenieDB; https://isogenie-db.asc.ohio-state.edu/), a de novo developed data management and exploration platform, as a solution to this challenge of accurately representing and integrating heterogenous environmental and microbial data across ecosystem scales. The IsoGenieDB...
Thu Aug 13, 2020 03:00
Bacterial gene transformation used with Escherichia coli as a desired microorganism is one of the important techniques in genetic engineering. In this study, the preparation of E. coli DH5α competent cells treated with SrCl2 and transformation by heat-shock with pUC19 plasmid was optimized by Response Surface Methodology (RSM). Other five E. coli strains including BL21 (DE3), HB-101, JM109, TOP10 and TG1, three different sizes plasmids (pUC19, pET32a, pPIC9k) were used to verify the protocol, respectively....
Thu Aug 13, 2020 03:00
Riparian soils and vegetation are important factors influencing the biodiversity and biogeochemical processes of river ecosystems. Riparian soils and vegetation form the foundation for multiple ecosystem services provided by river ecosystems. However, it remains poorly understood how riparian soils and vegetation interact with one another to maintain these services. In this study, we sampled four common types of riparian vegetation associated with the Beijiang River in South China. These included...
Thu Aug 13, 2020 03:00
When the evolution of Euarthropoda is discussed, often the lineage of Chelicerata s. str. is assumed to be the more ‘primitive’ or ‘basal’ part of the tree, especially when compared to the other major lineage, Mandibulata. This claimed primitiveness is (at least partly) based on the assumption that different morphological structures are still in an ancestral state and did not evolve any further. One of these sets of structures is the feeding apparatus, which has been stated to be highly advanced...
Thu Aug 13, 2020 03:00
Background Salinity is one of the most lethal abiotic stresses which affect multiple aspects of plant physiology. Natural variations in plant germplasm are a great resource that could be exploited for improvement in salt tolerance. Eruca sativa (E. sativa) exhibits tolerance to abiotic stresses. However, thorough evaluation of its salt stress tolerance and screening for traits that could be reliably applied for salt tolerance needs to be studied. The current study was designed to characterize 25...
Thu Aug 13, 2020 03:00
The study of the reproductive aspects of chondrichthyans through the analysis of steroid hormones has been carried out for more than five decades in several species around the world. This scientific knowledge constitutes the basis of the reproductive endocrinology of chondrichthyans, which has provided information regarding their sexual maturation, gametogenesis, mating seasons, gestation periods, and parturition. The present review summarises the existing literature on steroid hormones in chondrichthyan...
Thu Aug 13, 2020 03:00
Publication date: Available online 13 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Yvonne M. Mowery, Irina Vergalasova, Christel N. Rushing, Kingshuk Roy Choudhury, Donna Niedzwiecki, Qiuwen J. Wu, David S. Yoo, Shiva Das, Terence Z. Wong, David M. Brizel
Thu Aug 13, 2020 14:14
Publication date: Available online 13 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Bismarck Odei, Emma Brey Holliday, Reshma Jagsi, Fumiko Chino, Cole Schulmire, Mahesh Kudrimoti, Allen Chen, Raju Raval, Denise Fabian
Thu Aug 13, 2020 14:14
Publication date: Available online 12 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Encouse B. Golden, Ariel E. Marciscano, Silvia C. Formenti
Thu Aug 13, 2020 14:14
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