Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17783-4Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3.
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-18036-0Author Correction: Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17931-wColumns are the functional and morphological unit of the brain, but how neurons assemble into this structure was unclear. Here, the authors show that Dscam gene rewires neurons that derive from the same stem cell to establish columns through the process of lineage-dependent repulsion.
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17903-0Phosphorus ligands have been extensively used in metal complexes for homogeneous catalysis. Here, the authors broaden this scope to heterogeneous catalysis by preparing a P-coordinated Fe single atom catalyst with excellent catalytic performance in hydrogenative transformations.
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17837-7The ability to reversibly control monobody binding affinity would find use in biotechnology and research applications. Here the authors fuse the light-sensitive AsLOV2 domain to a monobody against the Abl SH2 domain to obtain a light dependent monobody and apply it in vitro and in mammalian cells.
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17882-2How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML.
Thu Aug 13, 2020 03:00
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17889-9Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.
Thu Aug 13, 2020 03:00
Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic
Nature Communications, Published online: 13 August 2020; doi:10.1038/s41467-020-17922-xRecommendations regarding the use of face masks as a preventive measure for COVID-19 are inconsistent. Here, the authors show that optimal distribution of surgical-standard face masks in the population, or universal coverage of homemade face coverings, could reduce total infections and deaths.
Thu Aug 13, 2020 03:00
Thu Aug 13, 2020 03:00
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