Abstract Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CIRI and its mechanism were studied. Transient middle cerebral artery occlusion (tMCAO) model was established in SD rats with KCNQ1OT1 intervention. PC12 cells...
03:00
Abstract Periodontitis and rheumatoid arthritis (RA) are inflammatory diseases characterized by chronic inflammation and bone erosion. Electroacupuncture (EA) shows anti-inflammatory and anti-resorptive effects in experimental periodontitis (EP) and in RA. It is important to investigate whether EA shows these effects in periodontal tissues in the presence of these two inflammatory diseases or not. For this, Wistar rats were divided into six groups: control (C); experimental rheumatoid...
Thu Aug 13, 2020 03:00
Abstract Many studies using N2pc as a marker of attentional capture have demonstrated top‐down contingent capture for salient color singletons: Among all salient cues that are not predictive of the target location, only cues similar to searched‐for target features, and thus, matching to the top‐down attentional control settings capture attention. This is reflected in matching cue's elicitation of an N2pc and a cueing effect in behavior, and the absence of the corresponding effects for non‐matching...
Thu Aug 13, 2020 20:14
Abstract The human frontal cortex is asymmetrically involved in motivational and affective processing. Several studies have shown that the left‐frontal hemisphere is related to positive and approach‐related affect, whereas the right‐frontal hemisphere is related to negative and withdrawal‐related affect. The present study aimed to investigate whether evolutionarily threatening stimuli modulate asymmetrical frontal activity. We examined hemispheric differences in frontal late positive potentials...
Thu Aug 13, 2020 20:03
Abstract Situations involving increased closeness or exceptional kindness are often labeled as moving or touching and individuals often report bodily symptoms, including tears, goosebumps, and warmth in the body. Recently, the kama muta framework has been proposed as a cross‐cultural conceptualization of these experiences. Prior research on kama muta has mostly relied on subjective reports. Thus, our main goal of the present project was to examine the pattern of physiological responses to kama muta...
Wed Aug 12, 2020 17:24
Key points Tetraspanin (TSPAN) proteins regulate many biological processes including intracellular calcium (Ca2+) handling. TSPAN‐7 is enriched in pancreatic islet cells; however, the function of islet TSPAN‐7 has not been identified. Here we characterize how β‐cell TSPAN‐7 regulates Ca2+ handling and hormone secretion. We find that TSPAN‐7 reduces β‐cell glucose‐stimulated Ca2+ entry, slows Ca2+ oscillation frequency, and decreases glucose‐stimulated insulin secretion. TSPAN‐7 controls β‐cell...
Thu Aug 13, 2020 17:48
Abstract Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that are widespread in the living kingdom. Their critical role in excitatory neurotransmission and brain function of arthropods and vertebrates made them a compelling subject of interest for neurophysiologists and pharmacologists. This is particularly true for NMDA receptor (NMDARs), a subclass of iGluRs that act as central drivers of synaptic plasticity in the CNS. How and when the unique properties...
Wed Aug 12, 2020 17:55
Key points Pre‐clinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to humans We conducted two separate protocols utilizing intravenous infusion of a nitric oxide synthase inhibitor and isovolumic hemodilution to assess the influence of nitric oxide in humans Isovolumic hemodilution did not alter neurovascular coupling Intravenous infusion of a nitric oxide synthase inhibitor reduced the neurovascular coupling response...
Wed Aug 12, 2020 14:19
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