Objectives: Survival of patients with locally advanced pancreatic cancer (LAPC) is improved when neoadjuvant chemoradiation enables subsequent surgical resection. Here, the authors assess changes in vessel involvement as a possible indicator of resectability. Methods: Pancreatic gross tumor and all major abdominal vessels were contoured for 49 patients with unresectable LAPC before and after neoadjuvant chemoradiation. Changes were compared by paired t tests. Tumor-vessel relationships...
Wed Aug 19, 2020 03:00
Background: Mesothelioma is a rare and deadly form of cancer, linked to asbestos exposure. Although the United Kingdom has banned asbestos, the incidence rate remains high. Previous research has indicated that female individuals have better survival than male individuals, but this has never been examined in the United Kingdom. Materials and Methods: Pleural mesothelioma cases from 2005 to 2014 were extracted from the United Kingdom Lung Cancer Dataset. Multivariable logistic regression...
Wed Aug 19, 2020 03:00
Objectives: The objective of this study was to compare the clinical effectiveness of uncovered stent and covered stent as percutaneous endoprosthesis for malignant biliary obstruction of the extrahepatic bile duct. Materials and Methods: After completion of percutaneous internal and external tube placement for unresectable malignant biliary obstruction, 60 patients were registered and randomly assigned in a 1:1 ratio to an uncovered or covered stent group. Metallic stent placement was...
Wed Aug 19, 2020 03:00
Background The early integration of palliative care significantly improves quality of life for children with cancer. However, cultural, structural, and socioeconomic barriers can delay the integration of palliative care into cancer care, particularly in low‐income and middle‐income countries. To date, little is known regarding the timing of and barriers to palliative care integration in Eurasia. Methods The Assessing Doctors' Attitudes on Palliative Treatment (ADAPT) survey evaluates physician...
Wed Aug 19, 2020 21:38
British Journal of Cancer, Published online: 20 August 2020; doi:10.1038/s41416-020-1027-zCorrection: MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer
Thu Aug 20, 2020 03:00
Thu Aug 20, 2020 03:00
Publication date: Available online 20 August 2020Source: Cancer/RadiothérapieAuthor(s): P. Blanchard, D. Peiffert, G. Truc
Thu Aug 20, 2020 18:24
Publication date: Available online 20 August 2020Source: Cancer/RadiothérapieAuthor(s): G. Noël, J. Thariat, D. Antoni
Thu Aug 20, 2020 18:24
Publication date: Available online 20 August 2020Source: Cancer/RadiothérapieAuthor(s): F. Dhermain, G. Noël, D. Antoni, A. Tallet
Thu Aug 20, 2020 18:24
Publication date: Available online 20 August 2020Source: Cancer/RadiothérapieAuthor(s): P.-A. Laurent, E. Martin, J. Thariat, J. Doyen
Thu Aug 20, 2020 18:24
Place et modalités de l’irradiation postopératoire dans la prise en charge des métastases cérébrales
Publication date: Available online 20 August 2020Source: Cancer/RadiothérapieAuthor(s): D. Pasquier, R. Mouttet Audouard, G. Martinage, T. Lacornerie, X. Mirabel, E. Lartigau
Thu Aug 20, 2020 18:24
Purpose: Intrapatient heterogeneity of programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB) in gastroesophageal adenocarcinoma (GEA) could influence their roles as predictive biomarkers for response to immune checkpoint inhibitors (ICIs). In this retrospective analysis, we evaluated the spatiotemporal heterogeneity and prognostic relevance of PD-L1 expression and TMB in GEA. Patients and methods: A cohort of 211 patients with stage II-IV GEA was retrospectively reviewed...
Thu Aug 20, 2020 15:55
Purpose: Spleen tyrosine kinase (SYK) signaling is a proposed target in acute myeloid leukemia (AML). Sensitivity to SYK inhibition has been linked to HOXA9 and MEIS1 overexpression in preclinical studies. This trial evaluated the safety and efficacy of entospletinib, a selective inhibitor of SYK, in combination with chemotherapy in untreated AML. Methods: This was an international multicenter phase 1b/2 study: entospletinib dose escalation (standard 3+3 design between 200 mg and 400 mg BID) + 7+3...
Thu Aug 20, 2020 15:55
Purpose:The extracellular matrix (ECM) is an intriguing yet understudied component of therapy resistance. Here we investigated the role of ECM remodeling by the collagenase MT1-MMP in conferring resistance of BRAF-mutant melanoma to BRAF inhibitor therapy. Experimental Design: Publicly available RNA sequencing (RNAseq) data and reverse-phase-protein-array (RPPA) were used to determine the relevance of MT1-MMP up-regulation in BRAFi-resistant melanoma in patients, PDX and cell line derived tumors....
Thu Aug 20, 2020 15:55
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Yung-Jue Bang, Talia Golan, Laetitia Dahan, Siqing Fu, Victor Moreno, Keunchil Park, Ravit Geva, Filippo De Braud, Zev A. Wainberg, Martin Reck, Laura Goff, Naomi Laing, Gu Mi, Joana M. Oliveira, Heather Wasserstrom, Chia-Chi Lin
Thu Aug 20, 2020 16:27
Future Oncology, Ahead of Print.
Thu Aug 20, 2020 13:16
Future Oncology, Ahead of Print.
Thu Aug 20, 2020 12:57
Related Articles Uncommon cytogenetic abnormalities identifying high-risk acute myeloid leukemia in children. Future Oncol. 2020 Aug 19;: Authors: Masetti R, Bertuccio SN, Guidi V, Cerasi S, Lonetti A, Pession A Abstract Pediatric acute myeloid leukemia (AML) represents an aggressive disease and is the leading cause of childhood leukemic mortality. The genomic landscape of pediatric AML has been recently mapped and redefined thanks to large-scale...
Thu Aug 20, 2020 15:09
Related Articles Dysregulated microRNAs in laryngeal cancer: a comprehensive meta-analysis using a robust rank aggregation approach. Future Oncol. 2020 Aug 19;: Authors: Cao Z, Guo Y, Ao Y, Zhou S Abstract We need a reasonable method of compiling data from different studies regarding the expression of microRNA (miRNA) in laryngeal squamous cell carcinoma (LSCC). The robust rank aggregation method was used to integrate the rank lists of miRNAs...
Thu Aug 20, 2020 15:09
Related Articles Excellent diagnostic performance of FNA-Tg in detecting lymph nodes metastases from papillary thyroid cancer. Future Oncol. 2020 Aug 19;: Authors: Wang J, Jiang X, Xiao G, Zhou W, Hu Y Abstract Background: Thyroglobulin washout of fine needle aspiration (FNA-Tg) has proved to be useful in detecting lymph node metastases from papillary thyroid cancer; however, the influences of thyroid gland, Hashimoto thyroiditis, serum thyroglobulin...
Thu Aug 20, 2020 15:09
Abstract Introduction In the last decade, a number of genomic and pharmacological studies have demonstrated the importance of epigenetic dysregulation in medulloblastoma initiation and progression. High throughput approaches including gene expression array, next-generation sequencing (NGS), and methylation profiling have now clearly identified at least four molecular subgroups within medulloblastoma, each with distinct clinical and...
Thu Aug 20, 2020 03:00
Stereotactic ablative radiotherapy (SABR) has recently shown promising potential for the treatment of prostate cancer [1–5] with support for the use of SABR for low and intermediate risk patients [6], and the number of clinics opting to use SABR to treat patients is increasing [7]. However, due to the escalated biological effect and requirement for stricter treatment margins, techniques to manage intrafraction tumour motion must be implemented to achieve safe and accurate SABR [8,9].
Thu Aug 20, 2020 03:00
Drawing statistical conclusions from experiments with multiple quantitative measurements per subject
In experiments with multiple quantitative measurements per subject, for example measurements on multiple lesions per patient, the additional measurements on the same patient provide limited additional information. Treating these measurements as independent observations will produce biased estimators for standard deviations and confidence intervals, and increases the risk of false positives in statistical tests.The problem can be remedied in a simple way by first taking the average of all observations...
Thu Aug 20, 2020 03:00
Publication date: Available online 19 August 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Nelson Ferreira, Eduardo Netto, Leonor Fonseca, João Fonseca, Susana Esteves, Miguel Labareda, António Mota, Rute Pocinho, Miguel Magalhães, Filomena Santos
Thu Aug 20, 2020 16:35
Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5’,3’-phosphodiester bonds in the mRNA body and polyA tail influence the biological properties of eukaryotic mRNA. To obtain modified and unmodified in vitro transcribed mRNAs, we used ATP and ATP analogues modified at the α-phosphate (containing either O-to-S or O-to-BH3 substitutions) and three different RNA polymerases—SP6, T7 and polyA...
Thu Aug 20, 2020 19:56
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Jenil Patel, Jeremy M. Schraw, Philip J. Lupo, Amir Mian, Wendy N. Nembhard
Thu Aug 20, 2020 17:10
Publication date: Available online 20 August 2020Source: Seminars in OncologyAuthor(s):
Thu Aug 20, 2020 20:42
Publication date: Available online 20 August 2020Source: Seminars in OncologyAuthor(s): Lauren Chiec, Ami N. Shah
Thu Aug 20, 2020 20:42
Abstract Background The COVID-19 pandemic outbreak has set the emergency services in developing countries on major alert, as the installed response capacities are easily overwhelmed by the constantly increasing high demand. The deficit of intensive care unit beds and ventilators in countries like Peru is forcing practitioners to seek preventive or early interventional strategies to prevent saturating these chronically neglected facilities....
Thu Aug 20, 2020 03:00
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