Πέμπτη 20 Αυγούστου 2020

 


Association of Nuclear Receptor Coactivators with Hypoxia-Inducible Factor-1α in the Serum of Patients with Chronic Kidney Disease
Nuclear receptor coactivators (NCOAs), consisting of coactivators and corepressors, dramatically enhance the transcriptional activity of nuclear receptors. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that plays a major role under hypoxic conditions. This study was performed with the focus on the association of NCOAs with HIF-1α in the serum of chronic kidney disease (CKD) patients. Sixty patients with stage 5 CKD and 30 healthy controls from The Second Affiliated Hospital of Shantou...
BioMed Research International
Thu Aug 20, 2020 16:20
Hepatitis B Infection and Mother-to-Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions
Background. There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam. Objective. This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods. A transversal survey of 1721 pregnant women followed by an observational prospective cohort study of 183 HBV-infected women was conducted at Haiphong Gyneco-Obstetric Hospital. Women were followed up up to 12-month postpartum; use of prevention measures...
BioMed Research International
Thu Aug 20, 2020 16:20
Uncovering PD-L1 and CD8+ TILS Expression and Clinical Implication in Cervical Squamous Cell Carcinoma
Objective. To investigate the association between programmed death-ligand 1 (PD-L1) coupled with CD8+ tumor-infiltrating lymphocytes (TILS) and the clinicopathological features, along with prognosis of cervical squamous cell carcinoma (CSCC). Methods. 95 patients of CSCC received tumor resection at the Department of Pathology of the First Affiliated Hospital of University of Science and Technology of China (USTC) from 2015 to 2020. Full-automatic immunohistochemistry was applied to measure PD-L1...
BioMed Research International
Thu Aug 20, 2020 11:20
Characteristics and Unexpected COVID-19 Diagnoses in Resuscitation Room Patients during the COVID-19 Outbreak—A Retrospective Case Series
Introduction. Emergency department (ED) triage regarding infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging. During the coronavirus disease 2019 (COVID-19) outbreak in Germany, the diagnostic outcomes of critically ill patients admitted to the resuscitation room in the ED of our academic 754-bed hospital should be analyzed. Methods. All resuscitation room patients between March 1st and April 15th 2020 were included in this retrospective study. Every patient...
BioMed Research International
Thu Aug 20, 2020 11:05
Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis
Background. The association between the lymphotoxin-α (LTA) A252G polymorphism and sepsis risk has been extensively studied, but the results have been controversial. This study is aimed at investigating the overall association between the LTA A252G polymorphism and the risk of sepsis/septic shock and sepsis-related mortality. Methods. We searched the PubMed and EMBASE databases to identify studies that investigated the association between the LTA A252G polymorphism and risks of sepsis, septic shock,...
BioMed Research International
Thu Aug 20, 2020 10:50
Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis
ALKBH5 (alkylation repair homolog protein 5), FTO (fat mass and obesity-associated protein), and RNA N6-methyladenosine (m6A) demethylase, are essential for the m6A mRNA modification. YTHDF2 (YT521-B homology domains 2) called m6A “readers” can recognize m6A modification. As the key enzymes of m6A methylation modification, ALKBH5, FTO, and YTHDF2 have been implicated in many diseases. However, little is known about the role of ALKBH5, FTO, and YTHDF2 in rheumatoid arthritis (RA). We measured the...
BioMed Research International
Thu Aug 20, 2020 10:50
Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma
With recent advances in immunooncology and tumor microenvironment, the treatment landscape of bladder urothelial carcinoma has been changing dramatically. We aim to construct an immune gene-related signature which can predict BLCA patients’ overall survival. Transcriptomic data of BLCA patients was downloaded from The Cancer Genome Atlas database, and immune-related genes were downloaded from the Immunology Database and Analysis Portal database. Prognostic immune-related genes were identified. We...
BioMed Research International
Thu Aug 20, 2020 10:35
Schisandra Inhibit Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats via Suppressing M2 Macrophage Polarization
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause and limited to the lungs. Schisandrae chinensis fructus (Wuweizi, Schisandra) is commonly used traditional Chinese medicines (TCM) for the treatment of pulmonary fibrosis, bronchitis, and other lung diseases in China. In this study, we investigated the therapeutic effect of Schisandra on IPF which is induced by bleomycin (BLM) in rats and the inhibition of alternatively...
BioMed Research International
Thu Aug 20, 2020 10:20
Hope of Recovery in Patients in the Terminal Phase of Cancer under Palliative and Hospice Care in Poland
Introduction. The objective of the presented research is to characterize hope in the situational dimension, i.e., health, in the patients with cancer in the terminal phase of the disease, being treated in hospices and palliative care centers. Hope is very important for all the patients, especially for patients with cancer in various phases of the disease. Giving up on oncologic therapy and causal treatment is often associated with a transition into palliative care. When death and a loss of values...
BioMed Research International
Thu Aug 20, 2020 10:20
Establishment and Analysis of a Combined Diagnostic Model of Polycystic Ovary Syndrome with Random Forest and Artificial Neural Network
Polycystic ovary syndrome (PCOS) is one of the most common metabolic and reproductive endocrinopathies. However, few studies have tried to develop a diagnostic model based on gene biomarkers. In this study, we applied a computational method by combining two machine learning algorithms, including random forest (RF) and artificial neural network (ANN), to identify gene biomarkers and construct diagnostic model. We collected gene expression data from Gene Expression Omnibus (GEO) database containing...
BioMed Research International
Thu Aug 20, 2020 10:20
A Nomogram Predicting Overall and Cancer-Specific Survival of Patients with Primary Bone Lymphoma: A Large Population-Based Study
We aimed to develop a nomogram for evaluating the overall survival (OS) and cancer-specific survival (CSS) in patients with primary bone lymphoma (PBL). Patients diagnosed with PBL between 2007 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. All patients were randomly allocated to the training cohort and validation cohort (2 : 1). The nomogram was developed by the training cohort and validated by the validation cohort using the concordance index (C-index),...
BioMed Research International
Thu Aug 20, 2020 10:05
Remote Control of Ventilators for COVID Patients Protects Clinicians from Infection
When dealing with patients infected by a contagious disease and that are suffering from acute respiratory distress, protecting clinicians is critically important. However, much of the bedside equipment that interfaces with patients in the intensive care unit has to be directly controlled, putting staff in close proximity with those infected. Now, a team at Johns Hopkins has developed a system that allows just about any device with a touch screen to be remotely operated. The...
Medgadget
Thu Aug 20, 2020 20:14
A Unified Framework for Multimodal Structure–function Mapping Based on Eigenmodes
Publication date: Available online 20 August 2020Source: Medical Image AnalysisAuthor(s): Samuel Deslauriers-Gauthier, Mauro Zucchelli, Matteo Frigo, Rachid Deriche
Medical Image Analysis
Thu Aug 20, 2020 15:13
Position paper on COVID-19 imaging and AI: from the clinical needs and technological challenges to initial AI solutions at the lab and national level towards a new era for AI in healthcare
Publication date: Available online 19 August 2020Source: Medical Image AnalysisAuthor(s): Hayit Greenspan, Raúl San José Estépar, Wiro J. Niessen, Eliot Siegel, Mads Nielsen
Medical Image Analysis
Thu Aug 20, 2020 15:13
Lake water volume fluctuations in response to climate change in Xinjiang, China from 2002 to 2018
Climate change has a global impact on the water cycle and its spatial patterns, and these impacts are more pronounced in eco-fragile regions. Arid regions are significantly affected by human activities like farming, and climate change, which influences lake water volumes, especially in different latitudes. This study integrates radar altimetry data from 2002 to 2018 with optical remote sensing images to analyze changes in the lake areas, levels, and volumes at different altitudes in Xinjiang, China....
PeerJ Computer Science
Thu Aug 20, 2020 03:00
Projection range of eDNA analysis in marshes: a suggestion from the Siberian salamander (Salamandrella keyserlingii) inhabiting the Kushiro marsh, Japan
Background Freshwater ecosystems are rapidly declining. The Siberian salamander (Salamandrella keyserlingii) which inhabits the Kushiro marsh in Hokkaido, Japan has lost some habitat due to human activity. There are many challenges associated with conventional monitoring methods, including cost, the need for specialist personnel, environmental impact, and ability to detect the presence of this species; thus, we investigated the feasibility of using environmental DNA (eDNA) analysis to detect its...
PeerJ Computer Science
Thu Aug 20, 2020 03:00
Improving the physical, mechanical and energetic properties of Quercus spp. wood pellets by adding pine sawdust
Background Biomass usage for energy purposes has emerged in response to global energy demands and environmental problems. The large amounts of by-products generated during logging are rarely utilized. In addition, some species (e.g., Quercus spp.) are considered less valuable and are left in the cutting areas. Production of pellets from this alternative source of biomass may be possible for power generation. Although the pellets may be of lower quality than other types of wood pellets, because...
PeerJ Computer Science
Thu Aug 20, 2020 03:00
Further evaluation of differential expression of keratoconus candidate genes in human corneas
Background Keratoconus (KTCN) is a progressive eye disease, characterized by changes in the shape and thickness of the cornea that results in loss of visual acuity. While numerous KTCN candidate genes have been identified, the genetic etiology of the disease remains undetermined. To further investigate and verify the contribution of particular genetic factors to KTCN, we assessed 45 candidate genes previously indicated as involved in KTCN etiology based on transcriptomic and genomic data. ...
PeerJ Computer Science
Thu Aug 20, 2020 03:00

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