IJMS, Vol. 21, Pages 5820: Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH International Journal of Molecular Sciences doi: 10.3390/ijms21165820 Authors: Gianluca Svegliati-Baroni Bárbara Patrício Gessica Lioci Maria Paula Macedo Amalia Gastaldelli Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease worldwide. Due to its association with obesity and diabetes and the fall in hepatitis C virus morbidity, cirrhosis...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5815: N6-(2-hydroxyethyl)-Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21165815 Authors: Hongqing Xie Xiaotong Li Weiwei Yang Liping Yu Xiasen Jiang Yajie Chen Zhangfei Shen Conghui Li Meier Gu Liangen Shi Gastric cancer is the most common malignant tumor of the digestive tract and is great challenge in clinical treatment....
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5817: Reduction of Allergenic Potential in Bread Wheat RNAi Transgenic Lines Silenced for CM3, CM16 and 0.28 ATI Genes International Journal of Molecular Sciences doi: 10.3390/ijms21165817 Authors: Raviraj M. Kalunke Silvio Tundo Francesco Sestili Francesco Camerlengo Domenico Lafiandra Roberta Lupi Colette Larré Sandra Denery-Papini Shahidul Islam Wujun Ma Stefano D’Amico Stefania Masci Although wheat is used worldwide as a staple...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5813: E2F8 Induces Cell Proliferation and Invasion through the Epithelial–Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21165813 Authors: Kyung Jin Eoh Hee Jung Kim Jong Woo Lee Lee Kyung Kim Sun-Ae Park Hyun-Soo Kim Young Tae Kim Peter J. Koo Background: Despite the recent research implicating E2F8 (E2F Transcription Factor 8) in cancer, the role of E2F8 in...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5811: EphrinA1-Fc Attenuates Ventricular Remodeling and Dysfunction in Chronically Nonreperfused WT but not EphA2-R-M mice International Journal of Molecular Sciences doi: 10.3390/ijms21165811 Authors: K’Shylah S. Whitehurst Victoria A. Chan Heather K. Estes Smrithi Valsaraj Susan Kent Uma M. Sharma R. Christopher Chase Maliha Bhuiyan Jitka A. I. Virag Background: EphrinA1-Fc abolishes acute I/R injury and attenuates nonreperfused cardiac...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5812: Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis International Journal of Molecular Sciences doi: 10.3390/ijms21165812 Authors: Chien-Wei Wu Shyang-Guang Wang Ching-Hsiao Lee Wen-Ling Chan Meng-Liang Lin Shih-Shun Chen Pharmacologic intervention to affect the membrane lipid homeostasis of lipid...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5810: The Effect of Different Immunization Cycles of a Recombinant Mucin1-Maltose-Binding Protein Vaccine on T Cell Responses to B16-MUC1 Melanoma in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21165810 Authors: Hongyue Zhou Zenan Zhang Guomu Liu Mengyu Jiang Jingjing Wang Yu Liu Guixiang Tai We explored the effect of a recombinant mucin1-maltose-binding protein vaccine, including immunization cycles of recombinant mucin1-maltose-binding...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5814: DispHred: A Server to Predict pH-Dependent Order–Disorder Transitions in Intrinsically Disordered Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21165814 Authors: Jaime Santos Valentín Iglesias Carlos Pintado Juan Santos-Suárez Salvador Ventura The natively unfolded nature of intrinsically disordered proteins (IDPs) relies on several physicochemical principles, of which the balance between a low sequence hydrophobicity and...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5807: Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications International Journal of Molecular Sciences doi: 10.3390/ijms21165807 Authors: Konstantinos Farsalinos Elias Eliopoulos Demetres D. Leonidas Georgios E. Papadopoulos Socrates Tzartos Konstantinos Poulas While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5809: Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance? International Journal of Molecular Sciences doi: 10.3390/ijms21165809 Authors: Paulo Linhares Bruno Carvalho Rui Vaz Bruno M. Costa Glioblastoma (GBM) is the most frequent malignant primary brain tumor in adults, characterized by a highly aggressive, inflammatory and angiogenic phenotype. It is a remarkably heterogeneous tumor at several levels, including histopathologically,...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5808: Adenovirus Reveals New Pathway for Cholesterol Egress from the Endolysosomal System International Journal of Molecular Sciences doi: 10.3390/ijms21165808 Authors: Cathleen Carlin Danny Manor In addition to providing invaluable insights to the host response to viral infection, adenovirus continues to be an important model system for discovering basic aspects of cell biology. This is especially true for products of early region three (E3), which have provided...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5806: IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21165806 Authors: Felipe Silva Rodrigues Vanessa Silva Miranda Tatiana Correa Carneiro-Lobo Luiza Coimbra Scalabrini Björn Kruspig Elena Levantini Daniel J. Murphy Daniela Sanchez Bassères KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of KRAS has...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5805: New Perspectives on Polycythemia Vera: From Diagnosis to Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21165805 Authors: Alessandra Iurlo Daniele Cattaneo Cristina Bucelli Luca Baldini Polycythemia vera (PV) is mainly characterized by elevated blood cell counts, thrombotic as well as hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic progression and/or leukemic evolution over time. Major changes...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5804: Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D International Journal of Molecular Sciences doi: 10.3390/ijms21165804 Authors: Jarosław Nuszkiewicz Alina Woźniak Karolina Szewczyk-Golec Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients and healthcare professionals are exposed to various IR doses. To minimize...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5800: The LL-100 Cell Lines Panel: Tool for Molecular Leukemia–Lymphoma Research International Journal of Molecular Sciences doi: 10.3390/ijms21165800 Authors: Hans G. Drexler Hilmar Quentmeier Certified cell line models provide ideal experimental platforms to answer countless scientific questions. The LL-100 panel is a cohort of cell lines that are broadly representative of all leukemia–lymphoma entities (including multiple myeloma and related diseases),...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5802: KCND3-Related Neurological Disorders: From Old to Emerging Clinical Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms21165802 Authors: Luca Pollini Serena Galosi Manuela Tolve Caterina Caputi Carla Carducci Antonio Angeloni Vincenzo Leuzzi KCND3 encodes the voltage-gated potassium ion channel subfamily D member 3, a six trans-membrane protein (Kv4.3), involved in the transient outward K+ current. KCND3 defect causes...
Thu Aug 13, 2020 03:00
IJMS, Vol. 21, Pages 5803: Psoriasis and Connective Tissue Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21165803 Authors: Toshiyuki Yamamoto Psoriasis is a chronic systemic inflammatory disease with various co-morbidities, having been recently considered as a comprehensive disease named psoriatic disease or psoriatic syndrome. Autoimmune diseases are one form of its co-morbidities. In addition to the genetic background, shared pathogenesis including innate immunity,...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2637: Long-Term Outcomes of Switching from Fixed-Dose to As-Needed Regimen for Treating Submacular Hemorrhage Secondary to Polypoidal Choroidal Vasculopathy Journal of Clinical Medicine doi: 10.3390/jcm9082637 Authors: Jae Hui Kim Jong Woo Kim Chul Gu Kim Dong Won Lee Background: The aim of this study was to evaluate outcomes in patients with submacular hemorrhage secondary to polypoidal choroidal vasculopathy (PCV) after switching treatment from a fixed-dose...
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JCM, Vol. 9, Pages 2635: Mobile-Based Lifestyle Intervention in Women with Glucose Intolerance after Gestational Diabetes Mellitus (MELINDA), a Multicenter Randomized Controlled Trial: Methodology and Design Journal of Clinical Medicine doi: 10.3390/jcm9082635 Authors: Caro Minschart Toon Maes Christophe De Block Inge Van Pottelbergh Nele Myngheer Pascale Abrams Wouter Vinck Liesbeth Leuridan Chantal Mathieu Jaak Billen Christophe Matthys Babs Weyn Annouschka...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2634: Expression of Pinopodes in the Endometrium from Recurrent Pregnancy Loss Women. Role of Thrombomodulin and Ezrin Journal of Clinical Medicine doi: 10.3390/jcm9082634 Authors: D’Ippolito Di Nicuolo Papi Castellani Palmieri Masciullo Arena Tersigni Bernabei Pontecorvi Scambia Di Simone Background: Pinopode expression has been suggested as a marker of endometrial receptivity. Methods: We set up an experimental study comparing...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2636: Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond Journal of Clinical Medicine doi: 10.3390/jcm9082636 Authors: Le Blanc Mullier Vayne Lordkipanidzé Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2632: Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes? Journal of Clinical Medicine doi: 10.3390/jcm9082632 Authors: López-Cano Gutiérrez-Carrasquilla Barbé Sánchez Hernández Martí Ceperuelo-Mallafre Dalmases Fernández-Veledo Vendrell Hernández Simó Lecube Limited reports exist on the relationships between regulation of oxygen homeostasis...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2633: Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts Journal of Clinical Medicine doi: 10.3390/jcm9082633 Authors: Alain Calender Thomas Weichhart Dominique Valeyre Yves Pacheco Sarcoidosis is a complex disease that belongs to the vast group of autoinflammatory disorders, but the etiological mechanisms of which are not known. At the crosstalk of environmental, infectious, and genetic factors, sarcoidosis is a multifactorial disease...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2630: Erratum: Mina, R.; et al. Minimal Residual Disease in Multiple Myeloma: State of the Art and Future Perspectives. J. Clin. Med. 2020, 9, 2142 Journal of Clinical Medicine doi: 10.3390/jcm9082630 Authors: Roberto Mina Stefania Oliva Mario Boccadoro The authors sincerely apologize for the inaccuracies made during the revision that a product line has been associated with the wrong company [...]
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2631: Systemic Inflammation during and after Bronchiectasis Exacerbations: Impact of Pseudomonas aeruginosa Journal of Clinical Medicine doi: 10.3390/jcm9082631 Authors: Rosario Menéndez Raúl Méndez Isabel Amara-Elori Soledad Reyes Beatriz Montull Laura Feced Ricardo Alonso Rosanel Amaro Victoria Alcaraz Laia Fernandez-Barat Antoni Torres Bronchiectasis is a chronic structural disease associated with exacerbations that provoke systemic...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2629: Nafamostat Mesylate Improved Survival Outcomes of Sepsis Patients Who Underwent Blood Purification: A Nationwide Registry Study in Japan Journal of Clinical Medicine doi: 10.3390/jcm9082629 Authors: Hiroshi Kamijo Katsunori Mochizuki Yuta Nakamura Kotaro Mori Michitaro Ichikawa Kenichi Nitta Hiroshi Imamura Nafamostat mesylate (NM) is a synthetic serine protease inhibitor that can be used as an anticoagulant during blood purification in critically...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2627: Effect of Calcium Chloride Hydrothermal Treatment of Titanium on Protein, Cellular, and Bacterial Adhesion Properties Journal of Clinical Medicine doi: 10.3390/jcm9082627 Authors: Takuya Haraguchi Yasunori Ayukawa Yukie Shibata Toru Takeshita Ikiru Atsuta Yoichiro Ogino Noriyuki Yasunami Yoshihisa Yamashita Kiyoshi Koyano Topographical modification of the dental implant surface is one of the main topics for the improvement of the material,...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2628: High Endothelial Venule with Concomitant High CD8+ Tumor-Infiltrating Lymphocytes Is Associated with a Favorable Prognosis in Resected Gastric Cancer Journal of Clinical Medicine doi: 10.3390/jcm9082628 Authors: Soon Auck Hong Hye Won Hwang Min Kyoon Kim Tae Jin Lee Kwangil Yim Hye Sung Won Der Sheng Sun Eun Young Kim Yoon Ho Ko CD8+ tumor-infiltrating lymphocytes (TILs) play a major role in antitumor immunity. High endothelial venules...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2626: Trends in the Prevalence of Non-Alcoholic Fatty Liver Disease and Its Future Predictions in Korean Men, 1998–2035 Journal of Clinical Medicine doi: 10.3390/jcm9082626 Authors: Seo Young Kang Ye-Jee Kim Hye Soon Park Non-alcoholic fatty liver disease (NAFLD) is a serious health concern as it can progress to liver cirrhosis and hepatoma. We investigated past trends in the prevalence of NAFLD and related factors among Korean men and women from 1998 to 2017...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2625: Correction: Faria, A.V.S. et al., Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. J. Clin. Med. 2019, 8, 936 Journal of Clinical Medicine doi: 10.3390/jcm9082625 Authors: Alessandra V. S. Faria Sheila S. Andrade Agnes N. Reijm Manon C. W. Spaander Moniek P. M. de Maat Maikel P. Peppelenbosch Carmen V. Ferreira-Halder Gwenny M. Fuhler The authors wish to make...
Thu Aug 13, 2020 03:00
JCM, Vol. 9, Pages 2624: The Interrelation of Neurological and Psychological Symptoms of COVID-19: Risks and Remedies Journal of Clinical Medicine doi: 10.3390/jcm9082624 Authors: Mohammad Nami Bharathi S. Gadad Li Chong Usman Ghumman Amogh Misra Shrikanth S. Gadad Dharmendra Kumar George Perry Samuel J. K. Abraham K. S. Rao COVID-19 has catastrophically affected the world’s panoramic view of human well-being in terms of healthcare and management....
Thu Aug 13, 2020 03:00
JoF, Vol. 6, Pages 134: Congruence Amidst Discordance between Sequence and Protein-Content Based Phylogenies of Fungi Journal of Fungi doi: 10.3390/jof6030134 Authors: Guohua Xiao Guirong Tang Chengshu Wang Amid the genomic data explosion, phylogenomic analysis has resolved the tree of life of different organisms, including fungi. Genome-wide clustering has also been conducted based on gene content data that can lighten the issue of the unequal evolutionary rate of genes. In this...
Thu Aug 13, 2020 03:00
J. Imaging, Vol. 6, Pages 81: On Computational Aspects of Krawtchouk Polynomials for High Orders Journal of Imaging doi: 10.3390/jimaging6080081 Authors: Basheera M. Mahmmod Alaa M. Abdul-Hadi Sadiq H. Abdulhussain Aseel Hussien Discrete Krawtchouk polynomials are widely utilized in different fields for their remarkable characteristics, specifically, the localization property. Discrete orthogonal moments are utilized as a feature descriptor for images and video frames in computer...
Thu Aug 13, 2020 03:00
JPM, Vol. 10, Pages 88: Immunotherapy in Corticotroph and Lactotroph Aggressive Tumors and Carcinomas: Two Case Reports and a Review of the Literature Journal of Personalized Medicine doi: 10.3390/jpm10030088 Authors: Camille Duhamel Mirela Diana Ilie Henri Salle Adjoa Sika Nassouri Stephan Gaillard Elise Deluche Richard Assaker Laurent Mortier Christine Cortet Gérald Raverot Once temozolomide has failed, no other treatment is recommended for pituitary carcinomas...
Thu Aug 13, 2020 03:00
JPM, Vol. 10, Pages 87: The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity Journal of Personalized Medicine doi: 10.3390/jpm10030087 Authors: Yulia I. Ragino Veronika I. Oblaukhova Yana V. Polonskaya Natalya A. Kuzminykh Liliya V. Shcherbakova Elena V. Kashtanova Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid...
Thu Aug 13, 2020 03:00
JPM, Vol. 10, Pages 86: Precision Telemedicine through Crowdsourced Machine Learning: Testing Variability of Crowd Workers for Video-Based Autism Feature Recognition Journal of Personalized Medicine doi: 10.3390/jpm10030086 Authors: Peter Washington Emilie Leblanc Kaitlyn Dunlap Yordan Penev Aaron Kline Kelley Paskov Min Woo Sun Brianna Chrisman Nathaniel Stockham Maya Varma Catalin Voss Nick Haber Dennis P. Wall Mobilized telemedicine is becoming...
Thu Aug 13, 2020 03:00
Medical Sciences, Vol. 8, Pages 32: Antimicrobial Susceptibilities and Laboratory Profiles of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates as Agents of Urinary Tract Infection in Lebanon: Paving the Way for Better Diagnostics Medical Sciences doi: 10.3390/medsci8030032 Authors: Elie S. Sokhn Ali Salami Ali El Roz Lamis Salloum Hisham F. Bahmad Ghassan Ghssein Background: Urinary tract infections (UTIs) are major healthcare problems that are usually...
Thu Aug 13, 2020 03:00
Medicina, Vol. 56, Pages 408: UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers Medicina doi: 10.3390/medicina56080408 Authors: Manuela Pellegrini Emilia Marchei Esther Papaseit Magí Farré Simona Zaami Background and Objectives: The use of synthetic cannabinoids has increased around the world. As a result, the implementation of accurate analysis in human biological matrices is relevant and fundamental. Two different...
Thu Aug 13, 2020 03:00
Medicina, Vol. 56, Pages 410: Bayés’ Syndrome—A Comprehensive Short Review Medicina doi: 10.3390/medicina56080410 Authors: Emma Murariu Attila Frigy Prediction and early detection of atrial fibrillation (AF) remain a permanent challenge in everyday practice. Timely identification of an increased risk for AF episodes (which are frequently asymptomatic) is essential in the primary and secondary prevention of cardioembolic events. One of the noninvasive modalities of AF prediction is...
Thu Aug 13, 2020 03:00
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