New England Journal of Medicine, Ahead of Print.
Wed Aug 12, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Wed Aug 12, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Wed Aug 12, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Wed Aug 12, 2020 12:00
New England Journal of Medicine, Volume 383, Issue 7, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 611-613, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 617-629, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 664-664, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 684-686, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 689-691, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 608-611, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 687-689, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 650-663, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 640-649, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 605-608, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 677-679, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 630-639, August 2020.
Wed Aug 12, 2020 11:55
New England Journal of Medicine, Volume 383, Issue 7, Page 693-695, August 2020.
Wed Aug 12, 2020 11:55
A 24-year-old woman presented to her primary care doctor with a 1-month history of worsening fatigue, diffuse arthralgias, a rash on her face and arms, and swelling in her legs. She also reported frequent urination. . . .
Thu Aug 13, 2020 03:00
Chromatin is one of the earliest identified targets for cancer therapeutics. Drug development aimed at altering chromatin can be traced to the differentiating agents of the 1970s and their link to DNA methylation. A more precise understanding of the complexity of chromatin and its role in…
Thu Aug 13, 2020 03:00
Cellulitis is a common bacterial infection of the skin and subcutaneous tissue that occurs mostly in the legs and is associated with health care costs and adverse health outcomes. Recurrence of cellulitis is common: up to 47% of patients have a recurrent episode within 3 years. Penicillin…
Thu Aug 13, 2020 03:00
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Aug 13, 2020 03:00
Stillbirth, or fetal loss after 20 weeks of gestation, remains a major public health challenge that occurs in approximately 6 per 1000 pregnancies in the United States. Unfortunately, many of these losses remain unexplained, even after standard postmortem evaluation. The use of karyotype and…
Wed Aug 12, 2020 03:00
Stillbirth (defined as fetal death in utero at ≥20 weeks of gestation) accounts for 60% of all perinatal deaths and is unexplained in 25 to 60% of cases. Data are limited regarding the contribution of known mendelian diseases to stillbirth. In many clinical disciplines, it is now standard practice…
Wed Aug 12, 2020 03:00
There is no question that the United States spends a great deal on health care, both in absolute dollars and relative to other high-income countries: in 2018, U.S. health care spending totaled $3.6 trillion, which amounted to 17.7% of the gross domestic product (GDP) and $11,200 per capita — almost…
Thu Aug 13, 2020 03:00
The development of highly curative direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection has transformed clinical management of HCV and provided the impetus for the World Health Organization’s ambitious HCV-related targets for 2030. These targets include marked improvements in…
Thu Aug 13, 2020 03:00
Direct-acting antiviral (DAA) drugs have transformed the treatment of hepatitis C virus (HCV) infection. With cure rates above 95% and minimal side effects, DAAs are far more efficacious and safer than previously used therapies and have quickly become the standard of care for HCV. Public and…
Thu Aug 13, 2020 03:00
Lung cancer is made up of a group of molecularly and histologically heterogeneous subtypes. Two major histologic subtypes are non–small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC), which account for 76% and 13%, respectively, of all cases of lung cancer in the United States. Although…
Thu Aug 13, 2020 03:00
Acute myeloid leukemia (AML) is a molecularly heterogeneous disorder characterized by symptoms related to pancytopenia and by an accumulation of immature myeloid precursors that is a consequence of a blockage in normal cellular differentiation. Although the therapeutic approach to AML has remained…
Thu Aug 13, 2020 03:00
Acute myeloid leukemia (AML) is primarily a disease of older adults, with a median age of 68 years at diagnosis. Standard curative treatment for AML consists of intensive induction chemotherapy followed by consolidation chemotherapy, allogeneic stem-cell transplantation, or both. However, because…
Thu Aug 13, 2020 03:00
In a recent report, Lee et al. showed a new therapeutic approach: the use of hyaluronic acid–bilirubin nanoparticles to treat acute colitis in a mouse model of inflammatory bowel disease. They used hyaluronate, a potent activator of innate immunity and inducer of type 1 helper T-cell responses, as…
Thu Aug 13, 2020 03:00
A 36-year-old woman (gravida 2, para 1) with a monochorionic, monoamniotic twin pregnancy was admitted to the hospital at 32 weeks of gestation for a planned cesarean section. The antenatal course had been unremarkable. Routine cardiotocography before the procedure showed severe variable…
Thu Aug 13, 2020 03:00
To the Editor: From September 4, 2018, to March 12, 2019, Zimbabwe experienced a large cholera outbreak, with 10,730 suspected cases of cholera and 69 deaths (Fig. S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). Antimicrobial-susceptibility data that were…
Thu Aug 13, 2020 03:00
As the U.S. health care system defines the new normal for ambulatory care in the Covid-19 era, it needs a new approach to providing routine preventive care for adults. Concerns about contagion, competing demands, and shortages of personal protective equipment may limit preventive care visits — most…
Wed Aug 12, 2020 03:00
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