Severe cutaneous adverse drug reactions: Incidence, Clinical Patterns, Causative Drugs and Modalities of Treatment in Assiut University Hospital, Upper Egypt

Abstract Background Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and overlap SJS/TEN are life‐threatening diseases that are most frequently caused by drugs. Much debate remains about the role of systemic corticosteroids (SCs) in their treatment. Our aim to determine the incidence, causative drugs, the role and side effects of SCs in severe cutaneous adverse reactions (SCARs), in Assiut University Hospital (AUH). Patients This study was conducted in Department of Dermatology...

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 21:31

Intralesional steroid treatment for the intermediate stage of retronychia: a pilot study

Abstract Introduction Retronychia describes the proximal ingrowing of the nail plate. In the early stage, topical steroids are the gold standard therapy, while in the late stage surgical treatment is mandatory. We identified an intermediate severity stage of retronychia, where the topical treatment alone is ineffective and surgery is avoidable. Intralesional steroids turn the best treatment in these patients. Materials and Method A pilot study consisting of a 3‐month treatment period and...

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 21:16

Erythema Dyschromicum Perstans in an Infant with positive Darier Sign: A case report successfully treated with Tacrolimus

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 21:11

Letter to the Editor: “Iatrogenic Vision Loss following Aesthetic Treatment with Hyaluronic Acid‐containing Filler: Every injector should be prepared.”

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 20:44

Dupilumab in atopic dermatitis, a protocol for SARS‐COV 2 infected patients

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 20:38

Maculopapular eruptions associated to COVID‐19: a subanalysis of the COVID‐Piel study

Abstract Background A previous study has defined the maculopapular subtype of manifestations of COVID‐19. Objectives To describe and classify maculopapular eruptions associated with COVI‐19. Methods We carried out a subanalysis of the maculopapular cases found in the previous cross‐sectional study. Using a consensus, we defined 7 clinical patterns. We described patient demographics, the therapy received by the patient and the characteristics of each pattern. Results Consensus...

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 20:18

Psoriasis onset under dupilumab treatment in two patients affected by Atopic Dermatitis and one patient affected by Alopecia Areata: clinical and dermoscopic patterns

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 20:11

Comorbidities burden and previous exposure to biological agents may predict drug survival of apremilast for psoriasis in a real‐world setting

Abstract Background Apremilast is the first small molecule approved for the treatment of moderate to severe psoriasis and psoriatic arthritis in adult patients. Objectives To evaluate survival, efficacy and safety of apremilast in patients with moderate to severe psoriasis and investigate possible associations between apremilast survival and clinical parameters in a real‐world setting. Methods In this retrospective study, a total of 71 patients who started on Apremilast treatment...

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 20:10

Use of dupilumab in a patient with atopic dermatitis, severe asthma, and HIV infection

Abstract Dupilumab is a monoclonal antibody against interleukin 4 (IL‐4) receptor α that blocks signaling from IL‐4 and IL‐13, essential mediators of T helper 2 (Th2) pathway. To date, all clinical trials investigating the use of dupilumab excluded patients with human immunodeficiency virus. Herein, we describe the safe and successful use of dupilumab in a patient with atopic dermatitis, severe therapy resistant asthma, and HIV infection. This article is protected by copyright. All rights reserved.

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 15:05

Alopecia Areata Treated With Dimethyl Fumarate: A Case Series

Abstract Alopecia areata is an autoimmune condition leading to non‐scarring hair loss. Clinically, several presentations ranging from single or few small patches to complete hair loss are documented. The management of alopecia areata is challenging and all available treatments do not ensure a long‐term remission. to assess the safety and efficacy of systemic dimethyl fumarate in alopecia areata patients not responding to other systemic treatments. After obtaining informed consent, we administered...

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 11:35

Refractory leg ulcers in prolidase deficiency with antiphospholipid antibody positivity responding to aspirin‐hydroxychloroquine‐vitamin C combination therapy

Wiley: Dermatologic Therapy: Table of Contents

Mon Aug 10, 2020 11:25