Abstract Individuals with diabetes are more susceptible to cerebral vascular aging. However, the underlying mechanisms are not well elucidated. The present study examined whether the myogenic response of the middle cerebral artery (MCA) is impaired in diabetic rats due to high glucose (HG)–induced cerebral vascular smooth muscle cell (CVSMC) dysfunction, and whether this is associated with ATP depletion and changes in mitochondrial dynamics and membrane potential. The diameters...
Thu Mar 12, 2020 02:00
The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown yeast. The hormetic effect was also TOR-dependent. The mutation in genes encoding either TOR1 or TOR2 protein makes yeast highly sensitive to both α-dicarbonyls studied. Simultaneous disruption of TOR1...
Thu Mar 12, 2020 09:50
Abstract Purpose of Review Although differentiating neonatal-onset epilepsies from acute symptomatic neonatal seizures has been increasingly recognized as crucial, existing guidelines, and recommendations on EEG monitoring are mainly based on acute symptomatic seizures, especially secondary to hypoxic-ischemic encephalopathy. We aimed to narratively review current knowledge on neonatal-onset epilepsies of genetic, metabolic, and...
Thu Mar 12, 2020 02:00
Abstract Purpose of Review Recent evidence indicates that chronic, low-level neuroinflammation underlies epileptogenesis. Targeted imaging of key neuroinflammatory cells, receptors, and tissues may enable localizing epileptogenic onset zone, especially in those patients who are treatment-resistant and considered MRI-negative. Finding a specific, sensitive neuroimaging-based biomarker could aid surgical planning and improve overall...
Thu Mar 12, 2020 02:00
Publication date: Available online 12 March 2020Source: American Journal of Infection ControlAuthor(s): Mohammad Ammad Ud Din, Leela Krishna Teja Boppana
Thu Mar 12, 2020 15:59
Publication date: Available online 12 March 2020Source: American Journal of Infection ControlAuthor(s): Shamsuddin Anwar, Allison Glaser, Sudeep Acharya, Fahad Yousaf
Thu Mar 12, 2020 15:59
Human insulin was the first major product of the modern biotech industry and has been available in the U.S. market since 1982. Yet as insulin patents have expired in the early 21st century, the prices of human insulins have been rising sharply rather than falling. Draft guidance recently released…
Thu Mar 12, 2020 02:00
Before she arrived, it was as if she had already left. Her chart was riddled with indicators. This past February, when she had her first stroke, she had left the hospital against medical advice. Two months later, when she had her second, she left the emergency department against medical advice. The…
Thu Mar 12, 2020 02:00
Americans love freedom, but our freedom is not unlimited. It ends, as the Supreme Court has repeatedly ruled, when it is exercised in such a way that we harm or threaten to harm other people. New York’s measles epidemic of 2018–2019 is a good example of such harm. Whatever one believes about the…
Thu Mar 12, 2020 02:00
When abortion is legally restricted or otherwise inaccessible, girls, women, and those who care about them look outside formal medical care to end pregnancies. Worldwide, people increasingly choose misoprostol or a combination of mifepristone and misoprostol to end pregnancies on their own…
Thu Mar 12, 2020 02:00
Under the U.S. Health Information Technology for Economic and Clinical Health (HITECH) Act, $48 billion in federal funds were invested to promote adoption of electronic health records (EHRs). Now, in an effort to realize returns on this outlay — and the vastly larger private investment that…
Wed Mar 11, 2020 02:00
Smartphones and electronic transparency have transformed our lives and the U.S. economy. Yet health care remains a stark exception. When health information is available, it tends to be accessible only in ways that bind patients to their current health care providers and insurance plans. Medical and…
Wed Mar 11, 2020 02:00
Thu Mar 12, 2020 02:00
Abstract Due to the increased usage of high throughput sequencing for the diagnosis of genetically inherited disorders, it is vital to evaluate the risk of new variants and novel genes before accepting them in clinical practice. However, discordant in‐silico and in‐vitro results, challenge estimations of the effect of an identified genetic variant. We aimed to comprehensively evaluate pathogenic and polymorphic variants using the activation‐induced‐cytidine‐deaminase (AICDA) gene as a model....
Thu Mar 12, 2020 15:54
Predominant mode of inheritance of genetic diagnoses in “consanguineous” families is influenced by degree of relatedness and number of affected individuals. ABSTRACT Exome sequencing (ES) is an effective diagnostic tool with a high yield in consanguineous families. However, how diagnostic yield and mode of inheritance relate to family structure has not been well delineated. We reviewed ES results from families enrolled in the Care4Rare Canada research consortium with various degrees of...
Thu Mar 12, 2020 15:54
Abstract Objective To find a better screening test by correlating between history and video-laryngoscopy in patients with laryngopharyngeal reflux disease. To compare the Reflux Symptom Index (RSI) and the Reflux Finding Score (RFS). Method Patients with the signs and symptoms of LPRD were scored based on RSI. Those with RSI above 13 were included...
Thu Mar 12, 2020 02:00
Abstract The complaint of nasal obstruction or difficulty in nasal breathing is highly subjective. The benefits of surgery vary depending upon patient perception and satisfaction. Along with objective methods like nasal endoscopy improvement in subjective score of patients symptoms is definitely an important outcome parameter of management. Assessing the disease specific quality of life outcomes of patients undergoing septoplasty by means of a questionnaire using nose scale and...
Thu Mar 12, 2020 02:00
Related ArticlesInfant hydrocephalus in sub-Saharan Africa: Impact of perioperative care in the Zanzibar archipelago. Neurocirugia (Astur). 2020 Mar 07;: Authors: Moreno Oliveras L, Llácer Ortega JL, Leidinger A, Ali Haji M, Chisbert Genovés MP, Piquer Belloch J Abstract INTRODUCTION: Child hydrocephalus in low- and middle-income countries represents one of the most sensitive ethical and health problems facing international health development. The most...
Thu Mar 12, 2020 15:42
Publication date: March–April 2020Source: Allergologia et Immunopathologia, Volume 48, Issue 2Author(s): Belén García Avilés, Nuria Marco Lozano, Francisco Javier Contreras-Porta
Thu Mar 12, 2020 15:37
Abstract Purpose Mounting studies have investigated the clinicopathological and prognostic value of hypoxia-inducible factor-1α (HIF-1α) in breast cancer (BC), yet conclusions remain controversial. Therefore, we conducted this meta-analysis to clarify this issue. Methods All relevant studies were searched using Cochrane Library, Web of Science, PubMed,...
Thu Mar 12, 2020 02:00
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Pascaline Boudou-Rouquette, Eric Grignano, Jennifer Arrondeau, Barbara Burroni, Laurent Chouchana
Thu Mar 12, 2020 15:16
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Yanan Zheng, Xiao Yang, Chao Yan, Runhua Feng, Birendra Kumar Sah, Zhongyin Yang, Zhenglun Zhu, Wentao Liu, Wei Xu, Zhentian Ni, Maneesh Kumarsing Beeharry, Zichen Hua, Min Yan, Zhenggang Zhu, Chen Li
Thu Mar 12, 2020 15:16
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Rosa T. van der Kaaij, Willem J. Koemans, Margreet van Putten, Petur Snaebjornsson, Josianne C.H.B.M. Luijten, Jolanda M. van Dieren, Annemieke Cats, Valery E.P.P. Lemmens, Rob H.A. Verhoeven, Johanna W. van Sandick
Thu Mar 12, 2020 15:16
Publication date: Available online 11 March 2020Source: European Journal of CancerAuthor(s): Sarah Atallah, Odile Casiraghi, Nicolas Fakhry, Michel Wassef, Emmanuelle Uro-Coste, Florent Espitalier, Anne Sudaka, Marie Christine Kaminsky, Stéphanie Dakpe, Laurence Digue, Olivier Bouchain, Sylvain Morinière, Muriel Hourseau, Chloé Bertolus, Franck Jegoux, Juliette Thariat, Valentin Calugaru, Philippe Schultz, Pierre Philouze, Olivier Mauvais
Thu Mar 12, 2020 15:16
Publication date: Available online 12 March 2020Source: NeuroImageAuthor(s): Fuqiang Zhao, Xiangjun Meng, Sherry Lu, Lynn A. Hyde, Matthew E. Kennedy, Andrea K. Houghton, Jeffrey L. Evelhoch, Catherine D.G. Hines
Thu Mar 12, 2020 15:11
Reduced hippocampal recruitment during response conflict resolution in mesial temporal lobe epilepsy
Publication date: Available online 12 March 2020Source: NeuroImageAuthor(s): Markus Ramm, Benedikt Sundermann, Carlos Assuncao Dias Gomes, Gabriel Möddel, Lisa Langenbruch, Nina Nagelmann, Mahboobeh Dehghan Nayyeri, Peter Young, Bettina Pfleiderer, Nikolai Axmacher
Thu Mar 12, 2020 15:11
Publication date: Available online 12 March 2020Source: NeuroImageAuthor(s): Benjamin Gagl, Jona Sassenhagen, Sophia Haan, Klara Gregorova, Fabio Richlan, Christian J. Fiebach
Thu Mar 12, 2020 15:11
Abstract Clear cell renal cell carcinoma (ccRCC) constitutes the most common renal cell carcinoma subtype and has long been recognized as an immunogenic cancer. As such, significant attention has been directed toward optimizing immune-checkpoints (IC)-based therapies. Despite proven benefits, a substantial number of patients remain unresponsive to treatment, suggesting that yet unreported, immunosuppressive mechanisms coexist within tumors and their microenvironment. Here, we...
Thu Mar 12, 2020 02:00
Publication date: Available online 12 March 2020Source: Human PathologyAuthor(s): Ming-Tseh Lin, Gang Zheng, Li-Hui Tseng, Peng Zhang, Hua Ling, Nilo Azad, Christopher D. Gocke, Elizabeth Montgomery, James R. Eshleman
Thu Mar 12, 2020 14:48
Publication date: Available online 12 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Javier Fábrega, José Vicente Ríos-Santos, Carlos Falcão, Mariano Herrero-Climent
Thu Mar 12, 2020 14:45
Publication date: Available online 11 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Walaa Magdy Ahmed, Tyler V. Verhaeghe, Anthony P.G. McCullagh
Thu Mar 12, 2020 14:45
Publication date: October 2020Source: Current Opinion in Neurobiology, Volume 64Author(s): David M Schneider
Thu Mar 12, 2020 14:35
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/03/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Mar 12, 2020 14:27
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/03/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Mar 12, 2020 12:26
102 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/03/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Mar 12, 2020 14:22
102 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/03/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Mar 12, 2020 12:27
Introduction: Cowden syndrome patients are at an increased risk of developing differentiated thyroid carcinoma (DTC). There are limited studies of thyroid cancer biology within this population. We aimed to describe the frequency and progression of DTC in this population. Method: We reviewed all patients with clinically or genetically confirmed Cowden syndrome treated at our institution between 1979 and 2017. Presentation, operative details, pathology, and adjuvant treatment for all thyroid diseases...
Thu Mar 12, 2020 11:51
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2020/03/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Mar 12, 2020 14:17
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