Antioxidants, Vol. 9, Pages 217: Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts Antioxidants doi: 10.3390/antiox9030217 Authors: Armando Alcazar Magana Ralph L. Reed Rony Koluda Cristobal L. Miranda Claudia S. Maier Jan F. Stevens Vitamin C (L-ascorbic acid, AA) is an essential cellular antioxidant and cofactor for several α-ketoglutarate-dependent dioxygenases. As an antioxidant, AA interacts with vitamin E to control oxidative stress....
Thu Mar 05, 2020 02:00
Antioxidants, Vol. 9, Pages 213: Phytochemicals and Antioxidant Activity of Korean Black Soybean (Glycine max L.) Landraces Antioxidants doi: 10.3390/antiox9030213 Authors: Lee Baek Lee Cho So Lee Ma Chung Hyun Black soybean (Glycine max L.) has been used as a traditional medicine because its seed coat contains various natural phenolic compounds such as anthocyanins. The objective of this study was to reveal the genetic variation in the agricultural traits,...
Thu Mar 05, 2020 02:00
Antioxidants, Vol. 9, Pages 215: Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes Antioxidants doi: 10.3390/antiox9030215 Authors: Cobley Noble Bessell Guille Husi Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive...
Thu Mar 05, 2020 02:00
Antioxidants, Vol. 9, Pages 214: Oxyresveratrol Induces Autophagy via the ER Stress Signaling Pathway, and Oxyresveratrol-Induced Autophagy Stimulates MUC2 Synthesis in Human Goblet Cells Antioxidants doi: 10.3390/antiox9030214 Authors: Yeom Ma Lim Background: Autophagy is a cell protection system invoked to eliminate the damaged organelles and misfolded proteins that induce various stresses, including endoplasmic reticulum (ER) stress. Autophagy can control mucin secretion...
Thu Mar 05, 2020 02:00
Antioxidants, Vol. 9, Pages 212: Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage Antioxidants doi: 10.3390/antiox9030212 Authors: Balazs Sonkodi Istvan Berkes Erika Koltai According to our hypothesis, delayed onset muscle soreness (DOMS) is an acute compression axonopathy of the nerve endings in the muscle spindle. It is caused by the superposition of compression when repetitive...
Thu Mar 05, 2020 02:00
Antioxidants, Vol. 9, Pages 216: An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events Antioxidants doi: 10.3390/antiox9030216 Authors: Marika Cordaro Salvatore Cuzzocrea Rosalia Crupi The inflammation process represents of a dynamic series of phenomena that manifest themselves with an intense vascular reaction. Neuroinflammation is a reply from the central nervous system (CNS) and the peripheral nervous system (PNS)...
Thu Mar 05, 2020 02:00
Arts, Vol. 9, Pages 35: Books, Scrolls and Ripples: In Search of an Audience through the Printed Works of Helen Douglas Arts doi: 10.3390/arts9010035 Authors: Chris Taylor In this interview, artist and small press publisher Dr. Helen Douglas appraises the development of the artist’s book from its emergence in the 1950s and 1960s to seeking public recognition as a bone fide art form in the mid-1970s, through to the current global attention that it now attracts. Notions of the...
Thu Mar 05, 2020 02:00
Arts, Vol. 9, Pages 34: Fence-Sitting and an Opportunity to Unsettle the Settled: Placing Critical Pressure on Creative Holography Arts doi: 10.3390/arts9010034 Authors: Andrew Pepper The field of creative holography is not known for its critical introspection [...]
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 262: The Long-Term Change of Latent Heat Flux over the Western Tibetan Plateau Atmosphere doi: 10.3390/atmos11030262 Authors: Li Zhao Wang Deng The Tibetan Plateau (TP) has been experiencing warming and wetting since the 1980s. Under such circumstances, we estimated the summer latent heat flux (LE) using the maximum entropy production model driven by the net radiation, surface temperature, and soil moisture of three reanalysis datasets (ERA5, JRA-55,...
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 261: Characterization of Total OH Reactivity in a Rapeseed Field: Results from the COV3ER Experiment in April 2017 Atmosphere doi: 10.3390/atmos11030261 Authors: Bsaibes Gros Truong Boissard Baisnée Sarda-Esteve Zannoni Lafouge Ciuraru Buysse Kammer Gonzaga Gomez Loubet Croplands remain poorly studied ecosystems in terms of total hydroxyl radical (OH) reactivity, especially when compared to forests. As part of...
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 259: WRF Sensitivity Analysis in Wind and Temperature Fields Simulation for the Northern Sahara and the Mediterranean Basin Atmosphere doi: 10.3390/atmos11030259 Authors: Rizza Mancinelli Canepa Piazzola Missamou Yohia Morichetti Virgili Passerini Miglietta Different configurations for the Weather Research and Forecasting (WRF) model were evaluated to improve wind and temperature fields predictions in the Northern Sahara...
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 260: Diurnal and Seasonal Variations of Surface Energy and CO2 Fluxes over a Site in Western Tibetan Plateau Atmosphere doi: 10.3390/atmos11030260 Authors: Zhao Liu Yang Li Land surface process observations in the western Tibet Plateau (TP) are limited because of the abominable natural conditions. During the field campaign of the Third Tibetan Plateau Atmospheric Scientific Experiment (TIPEX III), continuous measurements on the four radiation...
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 258: Fog Droplet Size Distribution and the Interaction between Fog Droplets and Fine Particles during Dense Fog in Tianjin, China Atmosphere doi: 10.3390/atmos11030258 Authors: Liu Wu Wang Hao From November 2016 to January 2017, there were large-scale dense fog processes in Tianjin area on the west coast of Bohai Bay, China, even strong dense fog with visibility less than 50 m occurred. Based on the observation data of fog droplet spectrum monitor,...
Thu Mar 05, 2020 02:00
Atmosphere, Vol. 11, Pages 257: Effect of a New Manure Amendment on Ammonia Emissions from Poultry Litter Atmosphere doi: 10.3390/atmos11030257 Authors: Kelsey Anderson Philip A. Moore Jerry Martin Amanda J. Ashworth Treating manure with aluminum sulfate (alum) is a best management practice (BMP) which reduces ammonia (NH3) emissions and phosphorus (P) runoff from poultry litter. However, the price of alum has increased markedly in recent years, creating a need for less expensive...
Thu Mar 05, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 63: Empathy Mediates the Relations between Working Memory and Perpetration of Intimate Partner Violence and Aggression Behavioral Sciences doi: 10.3390/bs10030063 Authors: Donald A. Godfrey Caitlin M. Kehoe Adriana Bastardas-Albero Julia C. Babcock Deficits in executive functioning have been associated with aggressive and violent behavior toward intimate partners. However, it is unclear what specific mechanisms are being affected by cognitive...
Thu Mar 05, 2020 02:00
Biology, Vol. 9, Pages 47: A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs Biology doi: 10.3390/biology9030047 Authors: Takanori Eguchi Eman Ahmed Taha Stuart K. Calderwood Kisho Ono Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted...
Thu Mar 05, 2020 02:00
Biomolecules, Vol. 10, Pages 405: PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease Biomolecules doi: 10.3390/biom10030405 Authors: Giaccone Moda Prion diseases are neurodegenerative and invariably fatal conditions that affect humans and animals. In particular, Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE) are paradigmatic forms of human and animal prion diseases, respectively. Human exposure...
Thu Mar 05, 2020 02:00
Biomolecules, Vol. 10, Pages 404: Epicardial TGFβ and BMP Signaling in Cardiac Regeneration: What Lesson Can We Learn from the Developing Heart? Biomolecules doi: 10.3390/biom10030404 Authors: Dronkers Wauters Goumans Smits The epicardium, the outer layer of the heart, has been of interest in cardiac research due to its vital role in the developing and diseased heart. During development, epicardial cells are active and supply cells and paracrine cues to the myocardium. In...
Thu Mar 05, 2020 02:00
Biomolecules, Vol. 10, Pages 403: New Insights into ADAMTS Metalloproteases in the Central Nervous System Biomolecules doi: 10.3390/biom10030403 Authors: Mohamedi Fontanil Cobo Cal Obaya Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance, proliferation, and migration,...
Thu Mar 05, 2020 02:00
Biomolecules, Vol. 10, Pages 402: Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis Biomolecules doi: 10.3390/biom10030402 Authors: Wójcik Žarković Gęgotek Skrzydlewska Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous and exogenous factors, including stress and metabolic alterations. Reactive oxygen species (ROS), as well as ROS-dependent lipid peroxidation products (including isoprostanes and reactive aldehydes...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 604: The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis Cancers doi: 10.3390/cancers12030604 Authors: Feijs Cooper Žaja : Post-translational modifications (PTM) of proteins are crucial for fine-tuning a cell’s response to both intracellular and extracellular cues. ADP-ribosylation is a PTM, which occurs in two flavours: modification of a target with multiple ADP-ribose moieties (poly(ADP-ribosyl)ation...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 603: The Application of Deep Learning in Cancer Prognosis Prediction Cancers doi: 10.3390/cancers12030603 Authors: Zhu Xie Han Guo Deep learning has been applied to many areas in health care, including imaging diagnosis, digital pathology, prediction of hospital admission, drug design, classification of cancer and stromal cells, doctor assistance, etc. Cancer prognosis is to estimate the fate of cancer, probabilities of cancer recurrence and progression,...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 605: Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway Cancers doi: 10.3390/cancers12030605 Authors: Yun Lee Lee Shim Kim Novel strategies for overcoming multidrug resistance are urgently needed to improve chemotherapy success and reduce side effects. Ginsenosides, the main active components of Panax ginseng, display anti-cancer properties and reverse drug resistance;...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 596: VE1 Immunohistochemistry Improves the Limit of Genotyping for Detecting BRAFV600E Mutation in Papillary Thyroid Cancer Cancers doi: 10.3390/cancers12030596 Authors: Choden Keelawat Jung Bychkov Detection of BRAFV600E is useful for making diagnosis and risk stratification of papillary thyroid carcinoma (PTC). Molecular testing, however, is not always available for routine clinical use. To assess the clinical utility and reliability of VE1 immunohistochemistry...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 598: Heading Towards a Possible Rebirth of the Induced Renal Cell Carcinoma Models? Cancers doi: 10.3390/cancers12030598 Authors: Mazzola Ribatti : Introduction: Animal models are interesting tools to improve our knowledge of the pathophysiological processes underlying kidney cancer development. Recent advances have been made in the understanding of the genetic founding events underlying clear cell renal carcinoma. The aim of this paper was to review and...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 601: FDG-PET Imaging for Hodgkin and Diffuse Large B-Cell Lymphoma—An Updated Overview Cancers doi: 10.3390/cancers12030601 Authors: Voltin Mettler Grosse Dietlein Baues Schmitz Borchmann Kobe Hellwig Since the mid-1990s, 18F-fluorodeoxglucose (FDG)-positron emission tomography (PET) in combination with computed tomography has come to play a prominent role in the management of malignant lymphomas. One of the first PET applications...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 599: Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas Cancers doi: 10.3390/cancers12030599 Authors: Sarkadi Meszaros Krencz Canu Krokker Zakarias Barna Sebestyen Papay Hujber Butz Darvasi Igaz Doczi Luconi Chinopoulos Patocs Pheochromocytoma/paragangliomas (Pheo/PGL) are rare endocrine cancers with strong genetic background. Mutations in the SDHB subunit of succinate...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 600: Thromboprophylaxis in the End-of-Life Cancer Care: The Update Cancers doi: 10.3390/cancers12030600 Authors: Zabrocka Sierko Cancer patients are at increased risk for venous thromboembolism (VTE), which further increases with advanced stages of malignancy, prolonged immobilization, or prior history of thrombosis. To reduce VTE-related mortality, many official guidelines encourage the use of thromboprophylaxis (TPX) in cancer patients in certain situations,...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 597: mTOR and STAT3 Pathway Hyper-Activation is Associated with Elevated Interleukin-6 Levels in Patients with Shwachman-Diamond Syndrome: Further Evidence of Lymphoid Lineage Impairment Cancers doi: 10.3390/cancers12030597 Authors: Vella D’Aversa Api Breveglieri Allegri Giacomazzi Busilacchi Fabrizzi Cestari Sorio Bedini D’Amico Bronte Poloni Benedetti Bovo Corey Borgatti Cipolli Bezzerri...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 595: Muscle Loss after Chemoradiotherapy as a Biomarker of Distant Failures in Locally Advanced Cervical Cancer Cancers doi: 10.3390/cancers12030595 Authors: Lee Lin Wu Chang Jan Chen This study aimed to evaluate whether computed tomography (CT)-based muscle measurement predicts distant failure in patients with locally advanced cervical cancer (LACC). Data from 278 patients with LACC who underwent chemoradiation therapy (CCRT) between 2004...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 602: Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes Cancers doi: 10.3390/cancers12030602 Authors: Kim Joo Lee Cho Park Cho In recent years, renal epithelial tumors have been among the fastest reclassifying tumors, requiring updates to the tumor classification system. Nonetheless, immunohistochemistry (IHC) remains the most widely used tool for renal epithelial tumors. In this proposal, we aimed to create the most efficient IHC...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 593: Studies on the Drug Loading and Release Profiles of Degradable Chitosan-Based Multilayer Films for Anticancer Treatment Cancers doi: 10.3390/cancers12030593 Authors: Hyeongdeok Sun Daheui Choi Jiwoong Heo Se Yong Jung Jinkee Hong This study demonstrates the possibility of developing a rapidly degradable chitosan-based multilayer film for controlled drug release. The chitosan (CHI)-based multilayer nanofilms were prepared with three different types...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 594: Long Leukocyte Telomere Length Is Associated with Increased Risks of Soft Tissue Sarcoma: A Mendelian Randomization Study Cancers doi: 10.3390/cancers12030594 Authors: Yifan Xu Junfeng Xu Haidee Chancoco Maosheng Huang Keila E. Torres Jian Gu Background: Leukocyte telomere length (LTL) has been associated with the risks of several cancers in observational studies. Mendelian randomization (MR) studies, using genetic variants as instrumental...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 591: Karyotypic Flexibility of the Complex Cancer Genome and the Role of Polyploidization in Maintenance of Structural Integrity of Cancer Chromosomes Cancers doi: 10.3390/cancers12030591 Authors: Christina Raftopoulou Fani-Marlen Roumelioti Eleni Dragona Stefanie Gimelli Frédérique Sloan-Béna Vasilis Gorgoulis Stylianos E. Antonarakis Sarantis Gagos Ongoing chromosomal instability in neoplasia (CIN) generates intratumor genomic heterogeneity...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 592: Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches Cancers doi: 10.3390/cancers12030592 Authors: Aravind Sanjeevaiah Haeseong Park Benjamin Fangman Matthew Porembka Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide...
Thu Mar 05, 2020 02:00
Cancers, Vol. 12, Pages 590: Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting Cancers doi: 10.3390/cancers12030590 Authors: Alexey V. Baldin Lyudmila V. Savvateeva Alexandr V. Bazhin Andrey A. Zamyatnin Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of DC vaccine generation with different outcomes have been proposed. Numerous...
Thu Mar 05, 2020 02:00
Cells, Vol. 9, Pages 627: Regulation of Necroptosis by Phospholipids and Sphingolipids Cells doi: 10.3390/cells9030627 Authors: Xuewei Zhang Masaya Matsuda Nobuo Yaegashi Takeshi Nabe Kazuyuki Kitatani Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein....
Thu Mar 05, 2020 02:00
Cells, Vol. 9, Pages 629: Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies Cells doi: 10.3390/cells9030629 Authors: Arnaud Gilles Léo Frechin Kundhavai Natchiar Giulia Biondani Ottilie von Loeffelholz Samuel Holvec Julie-Lisa Malaval Jean-Yves Winum Bruno P. Klaholz Jean-François Peyron The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis...
Thu Mar 05, 2020 02:00
Cells, Vol. 9, Pages 632: MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1 Cells doi: 10.3390/cells9030632 Authors: Daozhi Xu Peixin Dong Ying Xiong Junming Yue Yosuke Konno Kei Ihira Noriko Kobayashi Yukiharu Todo Hidemichi Watari Epithelial-mesenchymal transition (EMT) is a key process contributing to cervical cancer (CC) metastasis, and microRNAs (miRNAs) modulate the expression of genes...
Thu Mar 05, 2020 02:00
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