Abstract Parkinson's disease (PD), best characterized by its classic motor symptoms, also manifests non‐motor symptoms including perceptual impairments. Normal motor and perceptual brain functions interact continuously in an action‐perception loop, hence perceptual and motor dysfunction in PD are likely also intertwined. A vital skill in order to maintain balance, and to move around in the environment is the ability to perceive one's own motion in space (self‐motion perception). Self‐motion perception...
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Related ArticlesNeglected Odontoid Fracture During Growth. Ann Rehabil Med. 2020 Feb;44(1):99-100 Authors: Kim JS, Hong BY, Lim SH PMID: 32130845 [PubMed - as supplied by publisher]
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Related ArticlesIncidental Diagnosis of Pediatric Arytenoid Cartilage Dislocation During Videofluoroscopic Swallowing Study: A Case Report. Ann Rehabil Med. 2020 Feb;44(1):94-98 Authors: Lee Y, Park H, Park JE, Kim SK, Park ES, Rha DW Abstract Arytenoid cartilage dislocation is one of the most common mechanical causes of vocal fold immobility. The most common etiologies are intubation and external trauma, but its incidence is lower than 0.1%. Its symptoms...
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Related ArticlesTwo Pediatric Cases of Successful Management of Postictal Transient Urinary Retention. Ann Rehabil Med. 2020 Feb;44(1):90-93 Authors: Park HE, Lee JS, Kim DM, Shin YB Abstract We report two cases of postictal urinary retention in pediatric patients with cognitive impairment. Two girls with intellectual disabilities, concomitant cerebral palsy (case 1) and Rett syndrome (case 2), developed urinary retention following seizures. Their caregivers...
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Related ArticlesThoracolumbar Junction Syndrome Accompanying Renal Artery Stenosis: A Case Repor. Ann Rehabil Med. 2020 Feb;44(1):85-89 Authors: Noh K, Jung JB, Seong JW, Kim DE, Kwon D, Kim Y Abstract Flank pain is a common reason for visits to the emergency room. The most common reason warranting hospital visits are urology-related problems. However, there are many other causes, such as musculoskeletal lesions, that difficult to achieve a correct diagnosis....
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Related ArticlesChanges in Aerobic Capacity Over Time in Elderly Patients With Acute Myocardial Infarction During Cardiac Rehabilitation. Ann Rehabil Med. 2020 Feb;44(1):77-84 Authors: Kim KH, Jang YC, Song MK, Park HK, Choi IS, Han JY Abstract OBJECTIVE: To test the hypothesis that a longer duration of phase II cardiac rehabilitation is required to recover the exercise capacity of elderly patients compared to younger patients. METHODS: We retrospectively...
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Related ArticlesFactors Affecting the Discharge Destination of Patients With Spinal Bone Metastases. Ann Rehabil Med. 2020 Feb;44(1):69-76 Authors: Akezaki Y, Nakata E, Kikuuchi M, Sugihara S Abstract OBJECTIVE: To investigate the factors affecting the discharge destination of patients with spinal bone metastases. METHODS: We reviewed the medical records of patients admitted to our institute with a diagnosis of skeletalrelated events secondary...
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Related ArticlesDifferences of Spinal Curvature, Thoracic Mobility, and Respiratory Strength Between Chronic Neck Pain Patients and People Without Cervical Pain. Ann Rehabil Med. 2020 Feb;44(1):58-68 Authors: Cheon JH, Lim NN, Lee GS, Won KH, Lee SH, Kang EY, Lee HK, Cho Y Abstract OBJECTIVE: To investigate the differences of spinal curvature, thoracic sagittal mobility, and respiratory strength between patients with chronic neck pain (CNP) and people...
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Related ArticlesDetermining the Most Appropriate Assistive Walking Device Using the Inertial Measurement Unit-Based Gait Analysis System in Disabled Patients. Ann Rehabil Med. 2020 Feb;44(1):48-57 Authors: Lee J, Bae CH, Jang A, Yang S, Bae H Abstract OBJECTIVE: To evaluate the gait pattern of patients with gait disturbances without consideration of defilades due to assistive devices. This study focuses on gait analysis using the inertial measurement...
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Related ArticlesCharacteristics of Patients With Esophageal Dysphagia Assessed by Chest X-Ray Imaging After Videofluoroscopic Swallowing Study. Ann Rehabil Med. 2020 Feb;44(1):38-47 Authors: Min YK, Baek S, Kang EK, Nam SJ Abstract OBJECTIVE: To evaluate the prevalence rate, types, characteristics, and associated factors of esophageal dysphagia detected on chest X-ray images after videofluoroscopic swallowing study (VFSS). METHODS: The medical...
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Related ArticlesSuggested Assessments for Sarcopenia in Patients With Stroke Who Can Walk Independently. Ann Rehabil Med. 2020 Feb;44(1):20-37 Authors: Jung HJ, Lee YM, Kim M, Uhm KE, Lee J Abstract OBJECTIVE: To investigate variables for assessment of stroke-related sarcopenia that are alternative options to the current assessment for sarcopenia, which focuses on age-related sarcopenia and also has limitations in addressing sarcopenia due to weakness...
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Related ArticlesKorean Version of the Stroke Rehabilitation Motivation Scale: Reliability and Validity Evaluation. Ann Rehabil Med. 2020 Feb;44(1):11-19 Authors: Park M, Lee JY, Ham Y, Oh SW, Shin JH Abstract OBJECTIVE: To translate the Stroke Rehabilitation Motivation Scale (SRMS), developed to evaluate the motivation level of stroke patients during rehabilitation, into the Korean language and to verify the reliability and validity of the Korean version...
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Related ArticlesEpiglottic Retroflexion is a Key Indicator of Functional Recovery of Post-stroke Dysphagia. Ann Rehabil Med. 2020 Feb;44(1):1-10 Authors: Choi JS, Bang H, Lee GJ, Seo HG, Oh BM, Han TR Abstract OBJECTIVE: To evaluate the longitudinal changes of swallowing kinematics based on videofluoroscopic swallowing studies (VFSSs) in subacute stroke patients grouped according to the method of dietary intake. METHODS: Sixty-nine subacute...
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Researchers found that unlike immunodeficiency viruses (IVs) that infect other primates, the IV that infects the greater spot-nosed monkey is able to antagonize human BST-2 to survive and proliferate. These findings may help explain the evolution of other IVs.
Tue Mar 03, 2020 18:33
Scientists have proposed an addition to the theory of evolution that can explain how and why genes move on chromosomes. The hypothesis is called the SNAP Hypothesis.
Wed Mar 04, 2020 21:16
Honeybees use their waggle dance to tell their conspecifics where to find food. Depending on the honeybee species, there are different dance dialects.
Wed Mar 04, 2020 21:15
Whether it's coronavirus or misinformation, scientists can use mathematical models to predict how something will spread across populations. But what happens if a pathogen mutates, or information becomes modified, changing the speed at which it spreads? Researchers now show for the first time how important these considerations are.
Mon Mar 02, 2020 22:35
Studying the inner ear of apes and humans could uncover new information on our species' evolutionary relationships, suggests a new study.
Tue Mar 03, 2020 18:33
Purpose:Between 30%–40% of patients with prostate cancer experience disease recurrence following radical prostatectomy. Existing clinical models for recurrence risk prediction do not account for population-based variation in the tumor phenotype, despite recent evidence suggesting the presence of a unique, more aggressive prostate cancer phenotype in African American (AA) patients. We investigated the capacity of digitally measured, population-specific phenotypes of the intratumoral stroma to create...
Thu Mar 05, 2020 16:58
Purpose: To examine effect of oncolytic herpes simplex virus (oHSV) on NOTCH signaling in CNS tumors. Experimental design: Bioluminescence imaging, RPPA proteomics, fluorescence microscopy, reporter assays, and molecular biology approaches were used to evaluate NOTCH signaling. Orthotopic glioma- mouse models were utilized to evaluate effects in vivo. Results: We have identified that HSV-1 (oncolytic and wild type) infected glioma cells induce NOTCH signaling from inside of infected cells into...
Thu Mar 05, 2020 16:58
Obtaining blood and cerebrospinal fluid (CSF) is generally less invasive than standard tumor biopsy, and are increasingly used to develop surrogate biomarkers. Leptomeningeal disease (LMD), a devastating complication of cancer, represents a unique opportunity for using liquid biopsies for diagnosis, treatment and to elucidate underlying mechanisms of resistance to therapy.
Thu Mar 05, 2020 16:58
Purpose: SMAD4 loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study if SMAD4 loss sensitizes HNSCCs to olaparib (PARP inhibitor) in combination with radiotherapy (RT). Experimental Design: We analyzed HNSCC TCGA data for SMAD4 expression in association with FANC/BRCA family gene expression. Human HNSCC cell lines were screened for sensitivity to olaparib. Isogenic HNSCC cell lines were generated to restore or reduce SMAD4...
Thu Mar 05, 2020 16:58
Related ArticlesModified Littler Flap Reconstruction of the Small Finger. Eplasty. 2020;20:ic1 Authors: O'Neill RC, Bogdasarian RN, Datiashvili RO PMID: 32128021 [PubMed]
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Abstract Purpose Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer’s disease. [18F]PF-06684511 is a positron emission tomography (PET) radioligand for imaging BACE1. Despite favorable brain kinetic properties, the effective dose (ED) of [18F]PF-06684511 estimated in non-human primates was relatively high. This study was therefore designed to evaluate the whole-body distribution, dosimetry, quantification,...
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Abstract Purpose We analysed quantitative biomarkers derived from both baseline whole-body imaging and blood serum to identify prognostic markers in patients treated within the lutetium-177 prostate-specific membrane antigen (LuPSMA) phase 2 trial. Methods PET image analysis was carried out using whole-body segmentation quantifying molecular tumour...
Thu Mar 05, 2020 02:00
Abstract Objective To determine the rate and risk factors for osteoradionecrosis (ORN) in osseous free flaps after postoperative radiation therapy (PORT). To describe the treatment of free flap ORN. Methods Seventy‐four patients undergoing osseous free flap reconstruction were analyzed. Thirty‐eight completed PORT. Patients were followed for ≥6 months. Results The rate of ORN was 34% overall; 0% with 50 to 59.9 Gy; 8% with 60 Gy; 40% with 66 Gy; 56% with 70 to 74.4 Gy....
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Background Transgender individuals' cancer prevalence and transgender cancer survivors' health needs have received scarce attention. The current study compared transgender and cisgender individuals' cancer prevalence and described the health needs of transgender cancer survivors. Methods The authors used Behavioral Risk Factor Surveillance System data on 95,800 cisgender and transgender individuals who self‐reported a cancer diagnosis. Using multiple logistic regression, they estimated...
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Circulating adipokines and C‐reactive protein have been linked to breast cancer risk in observational epidemiological studies. The causal nature of these associations is unclear because of the susceptibility of conventional observational designs to residual confounding, reverse causation, and other forms of bias. Mendelian randomization uses genetic variants as proxies for risk factors to strengthen causal inference in observational settings. We performed a Mendelian randomization analysis to evaluate...
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Nature Communications, Published online: 06 March 2020; doi:10.1038/s41467-020-14929-2High throughput imaging flow cytometry suffers from trade-offs between throughput, sensitivity and spatial resolution. Here the authors introduce a method to virtually freeze cells in the image acquisition window to enable 1000 times longer signal integration time and improve signal-to-noise ratio.
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Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-14956-zTumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own production of angiogenic ligands to deplete adjacent endothelial cells of the capacity to respond to these signals.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-15039-9The electronic structure of benzene has been a test bed for competing theories along the years. Here the authors show via quantum chemistry calculations that the wavefunction of benzene can be partitioned into tiles which show that the two electron spins exhibit staggered Kekulé structures.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-14989-4A concentration gradient of HAM transcription factors specifies apical-basal patterning in the Arabidopsis shoot apical meristem. Here, the authors show that epidermal expression of the ATML1 transcription factor defines this concentration gradient via activation of mobile micro RNA.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-14699-xThere lacks research to figure out the variations in sources, magnitude, and spatiotemporal patterns of Nr flows in urban system. Here the authors develop a coupled human-natural urban nitrogen flow analysis model and show that anthropogenic perturbations not only intensify Nr input to sustain increasing demands for production and consumption of cities, but also greatly change the Nr distribution pattern in the...
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-15046-wIn breast cancer, genome-wide associations studies (GWAS) have highlighted loci associated with disease risk. Here, the authors perform a meta-analysis of GWAS data from Asian populations, discovering 31 potential new risk loci, 10 of which are validated in an independent disease cohort.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-15096-0FinFETs are an evolution of metal-oxide-semiconductor field effect transistors (MOSFETs) featuring a semiconducting channel vertically wrapped by conformal gate electrodes. Here, the authors use a two-dimensional semiconductor to push the FinFET width to sub-nm whilst achieving a 107 ON/OFF ratio.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-14869-xMechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promoting metastatic cancer growth.
Thu Mar 05, 2020 02:00
Nature Communications, Published online: 05 March 2020; doi:10.1038/s41467-020-15117-yHere, the authors present a gate-controlled valley-polarizer based on bilayer graphene, and through optimized device geometry and stacking method they obtain two orders of magnitude difference in conductance between the valley-polarized state and gapped states without the application of external magnetic fields.
Thu Mar 05, 2020 02:00
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