New England Journal of Medicine, Volume 382, Issue 10, Page 888-889, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, Page 893-902, March 2020.
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New England Journal of Medicine, Volume 382, Issue 10, Page 885-887, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, Page 974-976, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, Page 937-950, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, Page 952-957, March 2020.
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New England Journal of Medicine, Ahead of Print.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 10, Page 959-960, March 2020.
Wed Mar 04, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 04, 2020 12:00
Abstract Biparametric MRI (bpMRI), which uses only T2-weighted imaging and diffusion-weighted imaging, continues to gain support for the detection of prostate cancer, as this imaging technique offers many benefits over traditional mpMRI. However, the Prostate Imaging Reporting and Data System (PI-RADS) v2.1 document released in 2019 emphasized that mpMRI is still preferred over bpMRI in most clinical scenarios. As one article in a series of four providing arguments for and against...
Thu Mar 05, 2020 02:00
First report of childhood progressive cerebellar atrophy due to compound heterozygous MTFMT variants
Thu Mar 05, 2020 11:12
Thu Mar 05, 2020 11:08
Abstract Mastitis is one of the most common diseases that both affects human and animals. Morin is derived from the member of Moraceae family, which has been used in the treatment of many inflammatory diseases. The purpose of this study was to test the protective effect of morin on LPS-induced mastitis and to clarify the possible mechanism. In vivo, the mastitis model was established by lipopolysaccharide (LPS), and morin was treated...
Thu Mar 05, 2020 02:00
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 64-year-old man…
Thu Mar 05, 2020 02:00
Mr. J. was 35 years old when he died. He had loved the ocean, playing music, and joking with family and hospital staff alike. As an inpatient palliative care consultant, I took care of him during his last week. Mr. J. had all the makings of a "difficult case": he was young with an invasive pelvic…
Thu Mar 05, 2020 02:00
Malignancies have demonstrated the ability to metastasize to cardiac tissue. However, an optimal diagnostic algorithm for cardiac tumors has not yet been established, due at least in part to the scarcity of symptomatic cases. Several case reports describe how the usage of 18F-labeled fluorodeoxyglucose positron emission tomography (18F-FDG PET) incidentally revealed cardiac neoplasia. This modality, which indicates uptake sites of the radioisotope 18F-FDG, allows for whole-body imaging and is often...
Thu Mar 05, 2020 09:50
Papillary thyroid carcinoma is the most common primary thyroid cancer. Most frequently treated with surgical resection, some cases require radioactive iodine (RAI) therapy. Studies have suggested that there is an increase in second primary malignancy after RAI therapy amongst thyroid cancer survivors including acute myeloid leukemia (AML) as an infrequent cancer related to RAI therapy; it has a higher relative risk ratio in patients on higher doses of radiation exposure. We would like to report a...
Thu Mar 05, 2020 09:49
Pembrolizumab (Keytruda®) is an anti-programmed cell death 1-specific monoclonal antibody that has become the standard second-line chemotherapy for unresectable advanced microsatellite instability-high colorectal cancer. Several immune-related adverse events (irAEs), particularly endocrinopathy, are linked to the administration of pembrolizumab. We report here a case of pembrolizumab-induced isolated adrenocorticotropic hormone deficiency in a patient with metastatic colon cancer. A 65-year-old woman...
Thu Mar 05, 2020 09:46
If average Americans or a representative sample of health professionals were asked what the most important clinical problems are today, there would probably be a fair amount of agreement. Mental health conditions and addiction topped the list in recent community needs assessments conducted in the…
Thu Mar 05, 2020 02:00
On average, Americans have worse health outcomes than their counterparts in other high-income countries, even though the United States spends far more on health care than those countries do. This disparity is often attributed to social factors that influence health, such as housing, nutrition, and…
Thu Mar 05, 2020 02:00
On April 1, 2020, the Trump administration plans to implement the first in a series of three proposed changes to the Supplemental Nutrition Assistance Program (SNAP), the federal safety-net program formerly known as "food stamps." More than 36 million Americans, the majority of whom are extremely…
Wed Mar 04, 2020 02:00
The aggressiveness of prostate cancers ranges from indolent to highly lethal. Low-grade prostate cancer (i.e. grade group 1) has been shown in large trials to be associated with a very low risk of cancer-specific death. In contrast, cancers of grade groups 3 through 5 have significantly higher…
Thu Mar 05, 2020 02:00
Abstract Background Immune-related adverse events (irAEs) comprise a distinct spectrum of auto-inflammatory manifestations triggered due to immune checkpoint inhibitors (ICI). Current data on the association of irAEs with outcomes in NSCLC treated with nivolumab are limited. Methods and objectives We pooled data from 531 metastatic NSCLC patients from...
Thu Mar 05, 2020 02:00
Abstract Background Reports of oral manifestations of granulomatosis with polyangiitis usually refer to single‐case reports; “strawberry gingivitis” has been increasingly reported. Objective To study the clinicopathological findings of four patients in which the diagnosis of granulomatosis with polyangiitis was suspected from the observation of their oral lesions and compare these to existent data. Methods Retrospective study of a case series. Results One patient...
Thu Mar 05, 2020 09:24
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