Antibiotics, Vol. 8, Pages 203: Nursing Students’ Knowledge and Awareness of Antibiotic Use, Resistance and Stewardship: A Descriptive Cross-Sectional Study Antibiotics doi: 10.3390/antibiotics8040203 Authors: Andrea Rábano-Blanco Eva María Domínguez-Martís Diego Gabriel Mosteiro-Miguéns Manuel Freire-Garabal Silvia Novío Antibiotic resistance is an emerging worldwide concern with serious repercussions in terms of morbi-mortality. Bearing in mind that the inadequate use of...
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Antibiotics, Vol. 8, Pages 202: Novel spa and Multi-Locus Sequence Types (MLST) of Staphylococcus Aureus Samples Isolated from Clinical Specimens in Korean Antibiotics doi: 10.3390/antibiotics8040202 Authors: Mun Hwang Staphylococcus aureus bacteremia is one of the most frequent and severe bacterial infections worldwide. The increased incidence of S. aureus infections with a diverse pattern of S. aureus protein A (spa) types across different geographic regions is a global challenge....
Tue Oct 29, 2019 02:00
Antibiotics, Vol. 8, Pages 201: Combating Antimicrobial Resistance in Singapore: A Qualitative Study Exploring the Policy Context, Challenges, Facilitators, and Proposed Strategies Antibiotics doi: 10.3390/antibiotics8040201 Authors: Shweta Rajkumar Singh Alvin Qijia Chua Sok Teng Tan Clarence C. Tam Li Yang Hsu Helena Legido-Quigley Antimicrobial resistance (AMR) is a global public health threat that warrants urgent attention. However, the multifaceted nature of AMR often...
Tue Oct 29, 2019 02:00
Antioxidants, Vol. 8, Pages 518: A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells Antioxidants doi: 10.3390/antiox8110518 Authors: Carsten Theo Hack Theresa Buck Konstantin Bagnjuk Katja Eubler Lars Kunz Doris Mayr Artur Mayerhofer Recent studies showed that KGN cells, derived from a human granulosa cell tumor (GCT), express NADPH oxidase 4 (NOX4), an important source of H2O2. Transient receptor potential melastatin 2 (TRPM2) channel is...
Tue Oct 29, 2019 02:00
Antioxidants, Vol. 8, Pages 519: Vitamin C in Plants: From Functions to Biofortification Antioxidants doi: 10.3390/antiox8110519 Authors: Costantino Paciolla Stefania Fortunato Nunzio Dipierro Annalisa Paradiso Silvana De Leonardis Linda Mastropasqua Maria Concetta de Pinto Vitamin C (l-ascorbic acid) is an excellent free radical scavenger, not only for its capability to donate reducing equivalents but also for the relative stability of the derived monodehydroascorbate...
Tue Oct 29, 2019 02:00
Antioxidants, Vol. 8, Pages 517: Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products Antioxidants doi: 10.3390/antiox8110517 Authors: María Elena Alañón Iván Palomo Lyanne Rodríguez Eduardo Fuentes David Arráez-Román Antonio Segura-Carretero The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them,...
Tue Oct 29, 2019 02:00
Atmosphere, Vol. 10, Pages 660: Investigating the Influence of the Implementation of an Energy Development Plan on Air Quality Using WRF-CAMx Modeling Tools: A Case Study of Shandong Province in China Atmosphere doi: 10.3390/atmos10110660 Authors: Luo He Yu He Zhang Ma In this paper, the Weather Research Forecast (WRF) Comprehensive Air Quality Model with Extensions (CAMx) modeling system with the particulate source apportionment technology (PSAT) module was used...
Tue Oct 29, 2019 02:00
Atmosphere, Vol. 10, Pages 659: Comparing Annoyance Potency Assessments for Odors from Different Livestock Animals Atmosphere doi: 10.3390/atmos10110659 Authors: Hanns Moshammer Dietmar Oettl Michael Mandl Michael Kropsch Lisbeth Weitensfelder (1) Background: When it comes to estimating the annoyance potency of odors, European countries relate to different guidelines. In a previous study we compared complaint rates for different agricultural odors, but due to different guidelines,...
Tue Oct 29, 2019 02:00
Atmosphere, Vol. 10, Pages 658: Temporal Analysis of OMI-Observed Tropospheric NO2 Columns over East Asia during 2006–2015 Atmosphere doi: 10.3390/atmos10110658 Authors: Kyung M. Han The study analyzed temporal variations of Ozone Monitoring Instrument (OMI)-observed NO2 columns, interregional correlation, and comparison between NO2 columns and NOx emissions during the period from 2006 to 2015. Regarding the trend of the NO2 columns, the linear lines were classified into four groups:...
Tue Oct 29, 2019 02:00
Atmosphere, Vol. 10, Pages 657: Measurement of SO2 and NO2 in Ship Plumes Using Rotary Unmanned Aerial System Atmosphere doi: 10.3390/atmos10110657 Authors: Fan Zhou Jing Gu Wei Chen Xunpeng Ni A key research problem in the field of ship emissions is how to perform efficient, accurate, and timely measurements of pollutant gases in a ship’s plume. To address this, we have designed and implemented an unmanned aerial system (UAS) that consists of a rotary unmanned aerial...
Tue Oct 29, 2019 02:00
Bioengineering, Vol. 6, Pages 100: Effect of Residual and Transformation Choice on Computational Aspects of Biomechanical Parameter Estimation of Soft Tissues Bioengineering doi: 10.3390/bioengineering6040100 Authors: Ankush Aggarwal Several nonlinear and anisotropic constitutive models have been proposed to describe the biomechanical properties of soft tissues, and reliably estimating the unknown parameters in these models using experimental data is an important step towards developing...
Tue Oct 29, 2019 02:00
Biology, Vol. 8, Pages 82: Autophagy in Cancer Cell Death Biology doi: 10.3390/biology8040082 Authors: Linder Kögel Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of autophagy in cell survival and cell death decisions is highly dependent...
Tue Oct 29, 2019 02:00
Biomolecules, Vol. 9, Pages 666: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Biomolecules doi: 10.3390/biom9110666 Authors: Lipps Northe Figueiredo Rohde Brahmer Krämer-Albers Liebetrau Wiedenroth Mayer Kriechbaum Dörr Nef Hamm Keller Troidl Extracellular vesicles are released by numerous cell types of the human body under physiological but also under...
Tue Oct 29, 2019 02:00
Biomolecules, Vol. 9, Pages 665: Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control Biomolecules doi: 10.3390/biom9110665 Authors: Kim Translation of mRNA is an important process that controls cell behavior and gene regulation because proteins are the functional molecules that determine cell types and function. Cancer develops as a result of genetic mutations, which lead to the production of abnormal...
Tue Oct 29, 2019 02:00
Biosensors, Vol. 9, Pages 128: A Sustainable Biomineralization Approach for the Synthesis of Highly Fluorescent Ultra-Small Pt Nanoclusters Biosensors doi: 10.3390/bios9040128 Authors: Rajkamal Balu Robert Knott Christopher M. Elvin Anita J. Hill Namita R. Choudhury Naba K. Dutta Herein we report the first example of a facile biomineralization process to produce ultra-small-sized highly fluorescent aqueous dispersions of platinum noble metal quantum clusters (Pt-NMQCs)...
Tue Oct 29, 2019 02:00
Biosensors, Vol. 9, Pages 127: What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications Biosensors doi: 10.3390/bios9040127 Authors: Paloma Yáñez-Sedeño Lourdes Agüí Susana Campuzano José Manuel Pingarrón This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods...
Tue Oct 29, 2019 02:00
Brain Sciences, Vol. 9, Pages 296: Clinical Role of Aspirin in Mood Disorders: A Systematic Review Brain Sciences doi: 10.3390/brainsci9110296 Authors: Qin Xiang Ng Krishnapriya Ramamoorthy Wayren Loke Matthew Wei Liang Lee Wee Song Yeo Donovan Yutong Lim Vivekanandan Sivalingam Worldwide, depression and bipolar disorder affect a large and growing number of people. However, current pharmacotherapy options remain limited. Despite adequate treatment, many patients continue...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1684: NEDD9 Inhibition by miR-25-5p Activation Is Critically Involved in Co-Treatment of Melatonin- and Pterostilbene-Induced Apoptosis in Colorectal Cancer Cells Cancers doi: 10.3390/cancers11111684 Authors: Ji Hoon Jung Eun Ah Shin Ju-Ha Kim Deok Yong Sim Hyemin Lee Ji Eon Park Hyo-Jung Lee Sung-Hoon Kim The underlying interaction between melatonin (MLT) and daily fruit intake still remains unclear to date, despite multibiological effects...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1685: Intra-Patient Heterogeneity of Circulating Tumor Cells and Circulating Tumor DNA in Blood of Melanoma Patients Cancers doi: 10.3390/cancers11111685 Authors: Katharina Gorges Lisa Wiltfang Tobias M. Gorges Alexander Sartori Lina Hildebrandt Laura Keller Beate Volkmer Sven Peine Anna Babayan Ingrid Moll Stefan W. Schneider Sören Twarock Peter Mohr Jens W. Fischer Klaus Pantel Despite remarkable progress in melanoma...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1686: Protein Kinase A Distribution in Meningioma Cancers doi: 10.3390/cancers11111686 Authors: Caretta Denaro D’Avella Mucignat-Caretta Deregulation of intracellular signal transduction pathways is a hallmark of cancer cells, clearly differentiating them from healthy cells. Differential intracellular distribution of the cAMP-dependent protein kinases (PKA) was previously detected in cell cultures and in vivo in glioblastoma and medulloblastoma. Our...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1678: The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells Cancers doi: 10.3390/cancers11111678 Authors: Chiara Bellio Celeste DiGloria David R. Spriggs Rosemary Foster Whitfield B. Growdon Bo R. Rueda One of the most significant therapeutic challenges in the treatment of ovarian cancer is the development of recurrent platinum-resistant disease. Cancer stem cells (CSCs) are postulated to contribute to recurrent...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1681: Targeting STAT3 in Cancer with Nucleotide Therapeutics Cancers doi: 10.3390/cancers11111681 Authors: Yue-Ting K. Lau Malini Ramaiyer Daniel E. Johnson Jennifer R. Grandis Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an “undruggable” target for therapy;...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1679: Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors Cancers doi: 10.3390/cancers11111679 Authors: Celia Nieto Milena A. Vega Jesús Enrique Gema Marcelo Eva M. Martín del Valle Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1682: SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment Cancers doi: 10.3390/cancers11111682 Authors: Xiang Deng Shaoli Das Kristin Valdez Kevin Camphausen Uma Shankavaram Synthetic lethality exploits the phenomenon that a mutation in a cancer gene is often associated with new vulnerability which can be uniquely targeted therapeutically, leading to a significant increase in favorable outcome....
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1680: Radiomics Model Based on Non-Contrast CT Shows No Predictive Power for Complete Pathological Response in Locally Advanced Rectal Cancer Cancers doi: 10.3390/cancers11111680 Authors: Gordian Hamerla Hans-Jonas Meyer Peter Hambsch Ulrich Wolf Thomas Kuhnt Karl-Titus Hoffmann Alexey Surov (1) Background: About 15% of the patients undergoing neoadjuvant chemoradiation for locally advanced rectal cancer exhibit pathological complete response...
Tue Oct 29, 2019 02:00
Cancers, Vol. 11, Pages 1683: Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11111683 Authors: Frank Aboubakar Nana Marie Vanderputten Sebahat Ocak Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most aggressive type, being characterized by a tendency for early metastasis, with two-thirds of the patients diagnosed with an extensive stage (ES) disease and a five-year...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1346: Isolation, Characterization, Differentiation and Immunomodulatory Capacity of Mesenchymal Stromal/Stem Cells from Human Perirenal Adipose Tissue Cells doi: 10.3390/cells8111346 Authors: Baer Koch Hickmann Schubert Cinatl Hauser Geiger Mesenchymal stromal/stem cells (MSCs) are immature multipotent cells, which represent a rare population in the perivascular niche within nearly all tissues. The most abundant source to isolate MSCs is...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1347: Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges Cells doi: 10.3390/cells8111347 Authors: Sicari Igbaria Chevet : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows efficiency and fidelity in protein production. Among...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1344: MicroRNAs in Uteroplacental Vascular Dysfunction Cells doi: 10.3390/cells8111344 Authors: Hu Zhang Pregnancy complications of preeclampsia and intrauterine growth restriction (IUGR) are major causes of maternal and perinatal/neonatal morbidity and mortality. Although their etiologies remain elusive, it is generally accepted that they are secondary to placental insufficiency conferred by both failure in spiral artery remodeling and uteroplacental vascular...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1342: Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor Cells doi: 10.3390/cells8111342 Authors: Morbiato Frigato Dinarello Maradonna Facchinello Argenton Carnevali Dalla Valle Bertolucci Glucocorticoids (GCs) are steroid hormones mainly acting as key regulators of body homeostasis and stress responses. Their activities are primarily based on the binding to the GC receptor (GR), a member...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1343: Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells Cells doi: 10.3390/cells8111343 Authors: Szeder Tárnoki-Zách Lakatos Vas Kudlik Merő Koprivanacz Bányai Hámori Róna Czirók Füredi Buday Epithelial to mesenchymal transition (EMT) is a multipurpose process involved in wound healing, development, and certain pathological processes, such as metastasis...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1341: MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy? Cells doi: 10.3390/cells8111341 Authors: Britten Ragusa Tosi Kamel The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases. These translocations...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1340: A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells Cells doi: 10.3390/cells8111340 Authors: Kurgan Whitley Maddalena Moradi Stoikos Hamstra Rubie Kumar Roy Woodgett Stuart Fajardo : Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1345: Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations Cells doi: 10.3390/cells8111345 Authors: Azarnia Tehran López-Hernández Maritzen Cells need to exchange material and information with their environment. This is largely achieved via cell-surface receptors which mediate processes ranging from nutrient uptake to signaling responses. Consequently, their surface levels have to be dynamically controlled. Endocytosis...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1338: The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins Cells doi: 10.3390/cells8111338 Authors: Jonathan Turpin Etienne Frumence Philippe Desprès Wildriss Viranaicken Pascale Krejbich-Trotot Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1337: Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease Cells doi: 10.3390/cells8111337 Authors: Karina Reyes-Gordillo Ruchi Shah Jaime Arellanes-Robledo Ying Cheng Joseph Ibrahim Pamela L. Tuma Akt kinase isoforms (Akt1, Akt2, and Akt3) have generally been thought to play overlapping roles in phosphoinositide 3-kinase (PI3K)-mediated-signaling. However, recent...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1339: Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview Cells doi: 10.3390/cells8111339 Authors: Daphne Pinheiro Isabelle Dias Karina Ribeiro Silva Ana Carolina Stumbo Alessandra Thole Erika Cortez Lais de Carvalho Ralf Weiskirchen Simone Carvalho Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates...
Tue Oct 29, 2019 02:00
Cells, Vol. 8, Pages 1336: Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain Cells doi: 10.3390/cells8111336 Authors: Diana Grajales Vitor Ferreira Ángela M. Valverde Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes...
Tue Oct 29, 2019 02:00
Chemosensors, Vol. 7, Pages 51: Optical Sensing of Nitrogen, Phosphorus and Potassium: A Spectrophotometrical Approach Toward Smart Nutrient Deployment Chemosensors doi: 10.3390/chemosensors7040051 Authors: Monteiro-Silva Jorge Martins The feasibility of a compact, modular sensing system able to quantify the presence of nitrogen, phosphorus and potassium (NPK) in nutrient-containing fertilizer water was investigated. Direct UV-Vis spectroscopy combined with optical fibers were...
Tue Oct 29, 2019 02:00
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