Abstract Background Armed conflicts can have severe adverse effects on population health, both directly and indirectly, through the destruction of health care systems. This paper evaluates the causal effect of the Boko Haram insurgency in northeastern Nigeria on the vaccination rate. Methods By matching children’s birth months and the months...
1m
Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women ’s cervical health. Th... (Source: Infectious Agents and Cancer)
34m
Spin transfer nano-oscillators (STNOs) are a new type of radio frequency (RF) oscillators that utilize the current-induced magnetization precession in a magnetic tunnel junction device to generate high frequency microwave signal. Since both the frequency and the amplitude of STNOs can be tuned by changing the current, they are potentially used for amplitude shift keying and frequency shift keying modulation without the need for an RF mixer, which leads to compact RF components. In this...
36m
A high-performance supercapacitor electrode NiCo 2 S 4 (NCS) nanosheet on SiO 2 @C core-shell nanospheres (SiO 2 @C-NCS nanocomposite) is prepared via simple an effective solution-based method. Benefiting from compositional and structural advantages, the as-prepared SiO 2 @C-NCS nanocomposite exhibits a high specific capacitance (625 F g −1 at 1 mA cm −2 ) and a stable cycling performance. An asymmetric supercapacitor (ASC) assembled with SiO 2 @C-NCS nanocomposite as a positive electrode ...
36m
We reveal the comparative relationship between small changes in quantum conductivity behavior for molecular junctions. We clarify the mechanisms of acquiring and losing additional thermal activation energy during average current flow in a gold-1,4 benzenediamine (BDA)-gold molecular junction and explain the quantum conductance modulation process. Small changes in working temperature lead to a change in quantum conductivity, which is reflected in random telegraph signal behavior. We demonstrate...
36m
Prussian blue (PB) modified nanoporous gold (NPG) electrodes exhibit great potential for improving the detection sensitivity and stability for hydrogen peroxide monitoring. The NPG provides large surface-to-volume ratio as well as diffusion ‘highways’ to assist the transfer of the ions. In the present work, we optimized the deposition time for NPG fabrication and examine the electrochemical performance of the electrodes. A critical deposition time on the electrochemical performances including...
36m
Elizabeth Warren’s education plan, released this month, features copious new spending, new plans for Washington to dictate student discipline and collective bargaining policy, and an attack on charter schools. The anti-charter piece is more than a little ironic, given that Warren once wrote a book arguing that “fully funded vouchers would relieve parents” from choosing between “lousy schools” or “bankrupting themselves.” And, it’s hardly necessary to observe that Warren has plenty of company in...
37m
(Source: Journal of Allergy and Clinical Immunology)
38m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Wenhui Wang, Hongliu Wu, Yu Sun, Jun Yan, Lei Zhang, Shaoxiang Zhang, Jiahua Ni, Yang Song, Xiaonong ZhangAbstractMg-based implants are used in biomedical applications predominantly because of their degradable property. In this paper, the effect of local misorientations (intragranular misorientation) on the corrosion behavior of high-purity Mg (HPM) was systematically investigated according to microstructure characterization...
41m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Zhuqing Wan, Ping Zhang, Yunsong Liu, Longwei Lv, Yongsheng ZhouAbstractFour-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as the fourth dimension, is widely proposed as the next-generation of tissue engineering technology as it presents the possibility of constructing complex, functional structures. 4D bioprinting can be used to fabricate dynamic...
41m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): D. Cristea, S. Krishtul, P. Kuppusamy, L. Baruch, M. Machluf, A. BlankAbstractCell microencapsulation within biocompatible polymers is an established technology for immobilizing living cells that secrete therapeutic products. These can be transplanted into a desired site in the body for the controlled and continuous delivery of the therapeutic molecules. One of the most important properties of the material that...
41m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Tien-Chun Yang, Chia-Yu Chang, Aliaksandr A. Yarmishyn, Yen-Shiang Mao, Yi-Ping Yang, Mong-Lien Wang, Chih-Chien Hsu, Hsin- Yu Yang, De-Kuang Hwang, Shih-Jen Chen, Ming-Long Tsai, Yun-Hsien Lai, Yonhua Tzeng, Chia-Ching Chang, Shih-Hwa ChiouAbstractNanodiamonds (NDs) are considered to be relatively safe carbon nanomaterials used for the transmission of DNA, proteins and drugs. The feasibility of utilizing the NDs...
41m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Ying Li, Yu Cao, Lai Wei, Jinjie Wang, Min Zhang, Xuexia Yang, Wenshuo Wang, Guang YangAbstractProtein-templated gold nanoclusters have attracted attention in fluorescence imaging due to their simple synthesis and good biocompatibility. However, limitations still exist such as poor colloid stability and undesirable fluorescence intensity. Here we describe the self-assembly of keratin-templated gold nanoclusters...
41m
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Y. Li, P. Pavanram, J. Zhou, K. Lietaert, P. Taheri, W. Li, H. San, M.A. Leeflang, J.M.C. Mol, H. Jahr, A.A. ZadpoorAbstractAdditively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability....
41m
Publication date: Available online 28 October 2019Source: Materials & DesignAuthor(s): Yaofeng Luo, Yunlai Deng, Liqun Guan, Lingying Ye, Xiaobin GuoAbstractIn this study, the microstructure and corrosion resistance of Mg-6Gd-2Y-χNd-0.2Zr (χ = 0, 0.5, 1 and 1.5 wt%) alloys in extrusion condition are investigated using the correlative microscopic observations, immersion tests and electrochemical measurements. Results show that the addition of Nd can affect the grain size, crystal orientation and...
43m
Publication date: Available online 28 October 2019Source: Materials & DesignAuthor(s): Jianglong Gu, Shouliang Yang, Minjie Gao, Jing Bai, Yuchun Zhai, Jialuo DingAbstractThe application of wire + arc additively manufactured (WAAM) aluminum alloys has been restricted by the porosity defect, which is generally detrimental to the mechanical properties. Suppressing of micropores in the WAAM components has attracted considerable attention in recent years. Inter-layer rolling was introduced to eliminate...
43m
Abstract Oral dapagliflozin (Edistride®, Forxiga®) is approved in the EU at a dosage of 5 mg/day as an adjunct to insulin in adults with type 1 diabetes (T1D) and a body mass index (BMI) of ≥ 27 kg/m2, when insulin alone does not provide adequate glycaemic control despite optimal insulin therapy. As a highly selective SGLT2 inhibitor, dapagliflozin decreases plasma glucose levels independently of insulin action and enables glycaemic control improvement without increasing the risks...
44m
Publication date: Available online 29 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): C. Paterson, M.C. Thomson, B. Caldwell, R. Young, A. McLean, S. Porteous, S. Clark, C.M. Messow, S. Kean, D. Grose, C. Lamb, M. Rizwannullah, A. James, S. Schipani, C. Wilson, R. Rulach, R. JonesAbstractRadiotherapy-induced xerostomia (RIX) is a common and untreatable side effect of radiotherapy to the head and neck. Visco-ease™ mouth spray (Lamellar Biomedical Ltd), a new product...
44m
Publication date: Available online 29 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Y. Jinno, K. Johansson, M. Stocchero, M. Toia, S. Galli, A. Stavropoulos, J.P. BecktorAbstractOur aim was to investigate the possible impact of contamination with saliva on osseointegration during placement of implants with simultaneous bone augmentation. Six hemispheric shape bone defects (8 mm in diameter × 4 mm deep) were prepared in each iliac bone of six sheep. A dental implant...
45m
Abstract Purpose To search the pattern of diagnoses in nonagenarians undergoing emergency abdominal surgery between January 2009 and December 2013 in two hospitals. To test the hypothesis that pre-hospital functional status is an effective criterion for predicting postoperative mortality in nonagenarians after emergency abdominal surgery. Methods The study...
46m
Abstract Background To compare the mechanical strength of antegrade versus retrograde lag screw fixation of anterior column acetabular fractures. Methods Standardised anterior column fractures were created in synthetic pelvis models and stabilised by either antegrade (ANTE, n = 4) or retrograde (RETRO, n = 4) anterior column screw fixation. In a validated...
5h
(Source: Journal of Clinical Immunology)
47m
(Source: Journal of Clinical Immunology)
47m
We’ve discovered brain cells help us judge the distance to an object, and they remain active even if we can no longer see the object suggesting a role in memory
51m
Once thought too abstract, category theory has become remarkably pervasive in science, says mathematician and pianist Eugenia Cheng
51m
A new vaccine is the first that prevents people with a dormant tuberculosis infection from developing active disease
1h
AbstractMultivesicular bodies (MVBs) are membrane-bound organelles that belong to the endosomal pathway. They participate in the transport, sorting, storage, recycling, degradation, and release of multiple substances. They interchange cargo with other organelles and participate in their renovation and degradation. We have used focused ion beam milling and scanning electron microscopy (FIB-SEM) to obtain stacks of serial sections from the neuropil of the somatosensory cortex of the juvenile rat. Using...
52m
Abstract Background In order to further identify the needed interventions for continued poverty reduction in our study area Cuatro Santos, northern Nicaragua, we aimed to elucidate what predicts poverty, measured by the Unsatisfied Basic Need index. This analysis was done by using decision tree methodology applied to the Cuatro Santos health and demographic surveillance databases. ...
54m
Publication date: Available online 28 October 2019Source: Neuroscience ResearchAuthor(s): Yoshikazu Ugawa, John C Rothwell, Walter PaulusAbstractA single pulse of TMS or direct electric stimulation over M1 causes repetitive synchronized firing of corticospinal tract (CST) neurons. Two mechanisms for the repetitive firing have been proposed: a cascade of synaptic inputs to the pyramidal neurons and a single reverberating circuit of interneurons. Here, we propose another possibility in which bursting...
54m
Cancers, Vol. 11, Pages 1685: Intra-Patient Heterogeneity of Circulating Tumor Cells and Circulating Tumor DNA in Blood of Melanoma Patients Cancers doi: 10.3390/cancers11111685 Authors: Katharina Gorges Lisa Wiltfang Tobias M. Gorges Alexander Sartori Lina Hildebrandt Laura Keller Beate Volkmer Sven Peine Anna Babayan Ingrid Moll Stefan W. Schneider Sören Twarock Peter Mohr Jens W. Fischer Klaus Pantel Despite remarkable progress in melanoma...
54m
Cancers, Vol. 11, Pages 1678: The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells Cancers doi: 10.3390/cancers11111678 Authors: Chiara Bellio Celeste DiGloria David R. Spriggs Rosemary Foster Whitfield B. Growdon Bo R. Rueda One of the most significant therapeutic challenges in the treatment of ovarian cancer is the development of recurrent platinum-resistant disease. Cancer stem cells (CSCs) are postulated to contribute to recurrent...
4h
Cancers, Vol. 11, Pages 1683: Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11111683 Authors: Frank Aboubakar Nana Marie Vanderputten Sebahat Ocak Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most aggressive type, being characterized by a tendency for early metastasis, with two-thirds of the patients diagnosed with an extensive stage (ES) disease and a five-year...
4h
Cancers, Vol. 11, Pages 1681: Targeting STAT3 in Cancer with Nucleotide Therapeutics Cancers doi: 10.3390/cancers11111681 Authors: Yue-Ting K. Lau Malini Ramaiyer Daniel E. Johnson Jennifer R. Grandis Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an “undruggable” target for therapy;...
4h
Cancers, Vol. 11, Pages 1682: SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment Cancers doi: 10.3390/cancers11111682 Authors: Xiang Deng Shaoli Das Kristin Valdez Kevin Camphausen Uma Shankavaram Synthetic lethality exploits the phenomenon that a mutation in a cancer gene is often associated with new vulnerability which can be uniquely targeted therapeutically, leading to a significant increase in favorable outcome....
4h
Cancers, Vol. 11, Pages 1680: Radiomics Model Based on Non-Contrast CT Shows No Predictive Power for Complete Pathological Response in Locally Advanced Rectal Cancer Cancers doi: 10.3390/cancers11111680 Authors: Gordian Hamerla Hans-Jonas Meyer Peter Hambsch Ulrich Wolf Thomas Kuhnt Karl-Titus Hoffmann Alexey Surov (1) Background: About 15% of the patients undergoing neoadjuvant chemoradiation for locally advanced rectal cancer exhibit pathological complete response...
5h
Cancers, Vol. 11, Pages 1679: Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors Cancers doi: 10.3390/cancers11111679 Authors: Celia Nieto Milena A. Vega Jesús Enrique Gema Marcelo Eva M. Martín del Valle Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of...
5h
Publication date: December 2019Source: Data in Brief, Volume 27Author(s): Marena Molano-Mendoza, Dayana Donneys-Victoria, Nilson Marriaga-Cabrales, Miguel Angel Mueses, Gianluca Li Puma, Fiderman Machuca-MartínezAbstractThe XRD profiles and FTIR analysis of sludge aggregates, Mg–Al layered double hydroxides, produced during electrocoagulation processes are presented. The data describes the composition of materials (LDH) produced at different operations conditions (atmospheric conditions and Mg2+/Al3+...
55m
Abstract In the August issue of JEADV, Piaserico et al. report the results of a study of “Zoon Balanitis in men” (ZB). It is gratifying to encounter in the literature publications concerning the oft‐neglected domain of male genital dermatoses and it is laudable of colleagues to take a clinical and investigative interest. However, in my opinion, this paper is significantly flawed and sadly therefore fails usefully to advance our understanding of the topic.
56m
Abstract Immune checkpoint inhibitor (ICI) therapy has demonstrated impressive antitumor activity. However, it causes adverse effects, including lichenoid reactions. Cases of ICI‐triggered bullous pemphigoid (BP) and anecdotally mucous membrane pemphigoid (MMP) have also been reported. We describe two new cases of pembrolizumab‐triggered MMP, one of which was associated with cutaneous lichenoid lesions.
56m
Abstract Hailey–Hailey disease (HHD; MIM 16960), also known as familial benign pemphigus, is a rare autosomal dominant acantholytic genodermatosis, with a prevalence estimated at 1/40000. HHD is characterized by recurrent grouped vesicles, blisters and erosions restricted almost entirely to the neck and symmetrical intertriginous areas. HHD is caused by mutations in ATP2C1, which encodes an intracellular calcium ATPase pump. ATP2C1 mutations lead to haploinsufficiency, which results in abnormal...
56m
Abstract Zoon Balanitis: misdiagnosis or missed diagnosis? Zoon balanitis (ZB) is a chronic inflammatory benign mucositis showing well‐circumscribed orange red glazed areas on the glans (and sometimes the inside of the foreskin), with ‘cayenne pepper spots’ and a symmetrical distribution. Male genital dermatoses represent an oft‐neglected domain. ZB deserves more attention, as its impact on quality of life of the affected patients might be considerable.
56m
Abstract Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops at a previously irradiated site and is triggered by administration of various drugs following radiotherapy. Although RRD is typically confined to the irradiated area, the lesion may occasionally spread or become generalized. The most common causative drugs are the conventional anticancer agents, including anthracycline (doxorubicin), taxanes (docetaxel and paclitaxel), and antimetabolites (gemcitabine and capecitabine)....
56m
Abstract We read with great interest the original article by Tsai et al.1 Several studies have been previously showed that patients with acne receiving isotretinoin treatment revealed changes in the serum level of homocysteine, folate and vitamin B12: nevertheless, data still remain sparse. Tsai checked that isotretinoin may cause hyperhomocysteinemia and folate deficiency in acne patients and potentially increase cardiovascular and neuropsychiatric risks. Plasmatic homocysteine may contribute...
56m
Abstract The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations...
56m
Abstract Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common types of cancer in the Caucasian population, with an increasing incidence. cSCC is mostly a local invasive disease that can be treated surgically in the majority of the cases. However, in the case of advanced cSCC (acSCC), a multimodality approach also involving systemic therapies needs to be considered. Methods One hundred and ninety‐five patients diagnosed with acSCC (stages III and IV) treated in our...
56m
Abstract Background During recent years, Quality of Life (QoL) is a significant assessment factor in clinical trials and epidemiological researches due to the advent of Antiretroviral Therapy (ART), Human Immunodeficiency Virus (HIV) has become a manageable,chronic disease. With regards, more attention must be paid to the QoL of infected patients. Limited evidence exists on the impact of ART on QoL among HIV infected patients. Due...
1h
Abstract Background In Finland, the reimbursement rate for antidiabetic medicines other than insulins was lowered from 100 to 65% at the beginning of 2017. The objective of this study was to examine the effects of this reform experienced by patients with type 2 diabetes. The objective was also to explore if socio-economic status affects this experience. Methods ...
1h
Abstract Background Strong and effective workforce models are essential for improving comprehensive Indigenous primary healthcare service (PHC) provision to Indigenous peoples in Canada, Australia, New Zealand and the USA (CANZUS nations). This review systematically scoped the literature for studies that described or evaluated models and systems that support the sustainability, capacity or growth of the Indigenous PHC workforce to...
1h
Abstract Background To address deficits in the delivery of acute services in Ireland, the National Acute Medicine Programme (NAMP) was established in 2010 to optimise the management of acutely ill medical patients in the hospital setting, and to ensure their supported discharge to primary and community-based care. NAMP aims to reduce inappropriate hospital admissions, reduce length of hospital stay and ensure patients receive timely...
3h
The slur isn’t appropriate for school personnel or students of any race to ever use, writes Tyrone C. Howard.
1h
Chicago schools have canceled classes for a ninth day as talks to end a teachers' strike appeared stalled Monday.
1h
The slur isn’t appropriate for school personnel or students of any race to ever use, writes Tyrone C. Howard.
1h
Oncogene, Published online: 28 October 2019; doi:10.1038/s41388-019-1078-xThe reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis
1h
Oncogene, Published online: 28 October 2019; doi:10.1038/s41388-019-1073-2Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor
1h
Oncogene, Published online: 28 October 2019; doi:10.1038/s41388-019-1072-3Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization
1h
Oncogene, Published online: 28 October 2019; doi:10.1038/s41388-019-1074-1Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
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Oncogene, Published online: 28 October 2019; doi:10.1038/s41388-019-1079-9Comparison of the different mechanisms of cytotoxicity induced by checkpoint kinase I inhibitors when used as single agents or in combination with DNA damage
1h
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