Authors: Chen Q, Chen K, Qian S, Wu S, Xu L, Huang X, Shi P, Wang K, Wang M, Wang X Abstract Mucormycosis is an angioinvasive fungal infection with a high mortality rate. Patients with hematological malignancies following voriconazole therapy are at high risk from mucormycosis. Here, the present study reports on a 68-year-old man diagnosed with multiple myeloma and secondary myelodysplastic syndrome, who was infected with disseminated mucormycosis with cerebellum involvement confirmed by...
Tue Oct 29, 2019 22:45
In conclusion, these results suggest that miR-552 has an oncogenic function in HCC and is a potential biomarker for detecting HCC. PMID: 31656538 [PubMed] (Source: Experimental and Therapeutic Medicine)
Tue Oct 29, 2019 22:45
Salidroside prevents tumor necrosis factor-α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation. Exp Ther Med. 2019 Nov;18(5):4137-4143 Authors: Li R, Dong Z, Zhuang X, Liu R, Yan F, Chen Y, Gao X, Shi H Abstract Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. Salidroside is an important active ingredient extracted from the root of the Rhodiola rosea plant, which has been reported to have...
Tue Oct 29, 2019 22:45
Authors: Andriescu EC, Giuşcă SE, Ciobanu Apostol DG, Lozneanu L, Căruntu ID Abstract EpCAM is a cell-adhesion molecule, located at the basolateral membrane of the normal epithelial cells. Changes in EpCAM expression are reported in several malignancies, as an early indicator for carcinogenesis. Our study aimed to evaluate the EpCAM expression in different subtypes of papillary thyroid carcinoma (PTC), focusing on its role in the risk stratification of the histological variants and its...
Tue Oct 29, 2019 22:37
Authors: Aluaş M, Todea DA, Gherman CD Abstract Medicine is an ever-changing science. Stem cell research is nowadays part of the medicine. After developments and trials for decades, in 1988 it was announced that a variety of diseases and injuries would be cured with new stem cell therapy, such as: cancer, diabetes, Parkinson's, spinal cord injuries and many others. After almost 10 years of research in the field, in 2007 other good news and hopes were announced: the possibility to create...
Tue Oct 29, 2019 22:37
In this study, we analyzed the immunoexpression of these transcription factors in 50 cases of ccRCC, in relation to histopathological aggressiveness parameters of the lesions. The results indicated the association of Snail and Twist1 expression with high Fuhrman grade, as well as the association of Slug expression with low Fuhrman grade. The immunoexpression of Snail and Twist1 was significantly superior for advanced stages and Slug was overexpressed in early stages of ccRCC. Our study supports the...
Tue Oct 29, 2019 22:37
Authors: Ertoy Baydar D, Akkaya H, Dusmez Apa D, Bal N, Demirsam A, Gucluer B, Nese N, Akder Sari A, Kirdar S, Akdogan B, Karabulut E Abstract Squamous cell carcinoma (SCC) of the penis has been subject to only a few studies in populations where late childhood circumcision is performed. To asses clinicopathological features and human papillomavirus (HPV) status of penile SCC in men with late circumcision, eight institutions in the country volunteered to collaborate and 15 cases of penile...
Tue Oct 29, 2019 22:37
Authors: Coroi MC, Bakraoui A, Sala C, Ţica O, Ţica OA, Jurcă MC, Jurcă AD, Holhoş LB, Bălăşoiu AT, Todor L Abstract Uveal melanoma is the most common intraocular tumor characterized by increased metastatic potential. The tumor develops from uveal melanocytes that, from an embryological point of view, derive from the cells of the anterior neural crest. The risk factors associated with melanoma development are close related to patient phenotype: light-colored hair and iris, fair skin. Recent...
Tue Oct 29, 2019 22:37
CONCLUSIONS: Laryngeal cancer evolution is linked to inherited risk factors found within the genetic code. Most studied were the genes belonging to NER pathways, DNA repair and xenobiotic metabolism, which all favored mutant homozygote and heterozygote variants, as high risk factors. Only five articles focused on overall survival rates with insufficient results to undisputedly predict the risk variants. The consumption of external toxins has a positive effect on the overall cancer risk in consumers....
Tue Oct 29, 2019 22:37
Conclusions: The synchronous approach of both the primary tumor and liver metastases in colorectal cancer is a possible therapeutic method, even in the case of major hepatectomies. PMID: 31658344 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Oct 29, 2019 22:37
Authors: Al Khatib AM, Mărgăritescu C, Taisescu O, Andreiana BC, Florescu MM, Ciurea RN Abstract Epithelial-mesenchymal transition (EMT) is an important mechanism in tumor progression. Snail is a transcription factor, expressed in cells which have undergone almost complete EMT and have left the tumor, and Twist is considered important in the process of metastasis, both playing a major role in EMT by indirect inhibition of E-cadherin. The study analyzed the immunoexpression of E-cadherin,...
Tue Oct 29, 2019 22:37
Authors: Gofiţă CE, Ciurea ME, Dinescu ŞC, Vreju AF, Stoica LE, Ciurea RN, Boldeanu MV, Rogoveanu OC, Trăistaru MR, Bumbea AM, Ciurea PL, Muşetescu AE Abstract Metatypical basal cell carcinoma (MTBCC) is a rare form of tumor, which associates the clinical and histopathological (HP) characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), with a 5% chance for the development of metastases. The reference diagnosis remains the HP confirmation from the lesional...
Tue Oct 29, 2019 22:37
This study concerns atypical squamous of undetermined significance (ASC-US) results, the grey zone of cytology that hides up to 15% high-grade lesions, to see how dual immunocytochemistry (ICC) staining for p16INK4a∕Ki67 help to better identify and manage high-risk (HR) ASC-US patients. We included and reviewed 183 cases with ASC-US results and p16INK4a∕Ki67 double staining (DS) performed in MICOMI Clinic (Bucharest) during 2014-2016. All patients were referred for colposcopy and biopsy if appreciated...
Tue Oct 29, 2019 22:37
In this study, we analyzed the immunoexpression of E-cadherin, P-cadherin and fibronectin in 50 gastric carcinomas, in relation with the tumoral type, differentiation grade and lesions stage. The reactions presented variable patterns related to lesions stage. Membrane and cytoplasmic reactions were present in 62% of cases for E-cadherin and in 56% of cases for P-cadherin, being present only cytoplasmic in 34% of cases for fibronectin. The immunoexpression for E-cadherin and P-cadherin was superior...
Tue Oct 29, 2019 22:37
Authors: Ştefănescu-Dima AŞ, Mănescu MR, Bălăşoiu AT, Bălăşoiu M, Mocanu CL, Stanca HT, Mercuţ Nicolcescu MF Abstract Ocular surface squamous neoplasia (OSSN) is a malignant or dysplastic lesion that has its origins in the epithelial cells at the ocular surface. The structures from which these lesions can arise are the conjunctiva, the limbus, and the cornea. Our study was conducted on a group of seven patients with ocular surface squamous cell carcinoma (SCC). Histopathologically diagnosed...
Tue Oct 29, 2019 22:37
We present the case of a 68-year-old woman, who complained of abdominal enlargement and abdominal pain in the left part of the abdomen. Imagistic investigations (native and contrast abdominal computed tomography) revealed an inhomogeneous retroperitoneal mass of 210∕182∕200 mm, containing calcifications. Laboratory findings were not relevant, just a slight and non-significant elevation of carcinoembryonic antigen and a slight elevation of C-reactive protein. Diagnosis of cancer of undetermined origin...
Tue Oct 29, 2019 22:37
We present the case of a 42-year-old male patient, with intestinal and lung TB presenting as intestinal obstruction to emphasize the importance of clinical suspicion and histopathology for final diagnosis. Chest and abdomen computed tomography (CT) evidenced a few left-sided pulmonary nodules and wall thickening of some parts of the small and large bowel. Also, CT evidenced nearby mesenteric lymphadenopathy. He was admitted in the Department of Surgery and later confirmed with intestinal TB. Because...
Tue Oct 29, 2019 22:37
Authors: Buzdugă CM, Costea CF, Cărăuleanu A, Lozneanu L, Turliuc MD, Cucu AI, Ciocoiu M, Floria M, Tănase DM, Dragomir RA, Haba RM, Dumitrescu AM, Bogdănici CM, Ciobanu Apostol DG Abstract Medullary thyroid carcinoma (MTC) accounts for only 0.5-3% of all malignant diseases, but is responsible for more deaths every year than all the other endocrine malignancies taken together. Approximately 75-80% of MTCs occur sporadically, while the inherited forms of MTC are responsible for the rest...
Tue Oct 29, 2019 22:37
Authors: Sava A, Nemţoi A, Stan CI, Dumitrescu GF, Haba D, Budacu CC, Covrig V, Costan VV, Eva L Abstract Warthin tumor is described using various terms, such as papillary cystadenoma lymphomatosum, adenolymphoma or monomorphic adenoma. It is a medical condition related to the salivary glands, namely a benign cystic tumor which contains an epithelial component and an abundant lymphoid stroma. It is also named Warthin tumor after Aldred Scott Warthin, the pathologist who described this entity...
Tue Oct 29, 2019 22:37
Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism. J. Med. Invest. 66 : 241-247, August, 2019. PMID: 31656282 [PubMed - in process] (Source: Journal of Medical Investigation)
Tue Oct 29, 2019 22:35
Conclusions Preoperative 3D imaging might contribute to successful and safe LG by trainee surgeons. J. Med. Invest. 66 : 280-284, August, 2019. PMID: 31656289 [PubMed - in process] (Source: Journal of Medical Investigation)
Tue Oct 29, 2019 22:35
Authors: Ochi S, Nishiyama Y, Morita A Abstract Radiation damage to normal tissues is a serious concern in radiation therapy. Advances in radiotherapeutic technology have improved the dose distribution of the target volumes and risk organs, but damage to risk organs that are located within the irradiation field still limits the allowable prescription dose. To overcome this dose-limiting toxicity, and to further improve the efficacy of radiotherapy, the development of drugs that protect...
Tue Oct 29, 2019 22:35
CONCLUSIONS: Newly devised criteria CLS could be an independent prognostic indicator in colorectal carcinoma and would be utilized as a helpful information. J. Med. Invest. 66 : 264-268, August, 2019. PMID: 31656286 [PubMed - in process] (Source: Journal of Medical Investigation)
Tue Oct 29, 2019 22:35
Conclusions : High serum CRP level on POD1 can predict the occurrence of POPF. J. Med. Invest. 66 : 285-288, August, 2019. PMID: 31656290 [PubMed - in process] (Source: Journal of Medical Investigation)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Oct 29, 2019 22:35
In conclusion, this report describes a rare case of a metastatic tumor at the orbital apex derived from the cervix of the uterus. J. Med. Invest. 66 : 355-357, August, 2019. PMID: 31656305 [PubMed - in process] (Source: Journal of Medical Investigation)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Oct 29, 2019 22:35
Authors: Liu H, Cheng Y, Xu Y, Xu H, Lin Z, Fan J, Lang J Abstract A close relation between microRNA-151a-3p (miR-151a-3p) and nasopharyngeal carcinoma (NPC) has been reported, however, the molecular mechanism is still unclear. The aim of the present study was to explore the mechanism in the promotion of miR-151a-3p to NPC progression. The levels of miR-151-3p in several NPC cell lines were detected in order to screen an experimental cell line. MiR-151a-3p mimic and inhibitor were constructed...
Tue Oct 29, 2019 21:44
Authors: Chen C, Shu L, Zou W Abstract Cancer incidence rate has increased so much that it is the second leading cause of deaths worldwide after cardiovascular diseases. Sensitive and specific biomarkers are needed for an early diagnosis of cancer and in-time treatment. Recent studies have found that long non-coding RNAs (lncRNAs) participate in cancer tumorigenesis. LncRNA P73 antisense RNA 1T (TP73-AS1), also known as KIAA0495 and p53-dependent apoptosis modulator (PDAM), is located in...
Tue Oct 29, 2019 21:44
Authors: Xiao L, Zeng F, Deng G Abstract Some doubts were generated during the reading of nomograms based on inflammatory biomarkers for preoperatively predicting tumor grade and microvascular invasion in stage I/II hepatocellular carcinoma (HCC). We would like to highlight and discuss with authors. First, neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR) should not be entered into multivariate analysis simultaneously. Second, authors should clarify how the cutoffs of these variables...
Tue Oct 29, 2019 21:44
Authors: PMID: 31652458 [PubMed - in process] (Source: Bioscience Reports)
Tue Oct 29, 2019 21:44
CONCLUSION: We provided some novel data suggesting MAML2 polymorphisms might contribute to glioma risk and prognosis. Future studies are warranted to validate these findings and characterize mechanisms underlying these associations. PMID: 31652449 [PubMed - in process] (Source: Bioscience Reports)
Tue Oct 29, 2019 21:44
Authors: Warrier VU, Makandar AI, Garg M, Sethi G, Kant R, Pal JK, Yuba E, Gupta RK Abstract Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell microenvironment, antigen internalization routes and adjuvants regulate the process...
Tue Oct 29, 2019 21:44
In conclusion, we introduced and implemented a VAE model to represent large-scale epigenomics data. The model could be used to explore classifications of histone modifications and tissue/cell specificity and to classify new data with unknown sources. (Source: Methods)
Tue Oct 29, 2019 21:14
In this study, we first found that FoxG1 expression and autophagy both increased gradually in the low concentration lipopolysaccharide (LPS)-induced inflammation model, while after high concentration of LPS treatment both FoxG1 expression and autophagy levels decreased as the concentration of LPS increased. We then used siRNA to downregulate Foxg1 expression in hair cell-like OC-1 cells and found that cell death and apoptosis were significantly increased after LPS injury. Furthermore, we used d-galactose...
Tue Oct 29, 2019 20:41
Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which transmembrane channel-like 1 (TMC1) and transmembrane channel-like 2 (TMC2) have been proposed to be the pore-forming subunits in mammals. TMCs were also found to regulate other biological processes than MET in invertebrates ranging from sensations to motor function. However, whether TMCs have a non-MET role remains elusive in mammals. Here, we report that in mouse hair cells, TMC1, but not...
Tue Oct 29, 2019 01:00
Authors: Shaw M, Winczewska-Wiktor A, Badura-Stronka M, Koirala S, Gardner A, Kuszel Ł, Kowal P, Steinborn B, Starczewska M, Garry S, Scheffer I, Berkovic SF, Gecz J Abstract Mutations in ATP6V1B2, which encodes the B2 subunit of the vacuolar H + ATPase have previously been associated with Zimmermann-Laband syndrome 2 (ZLS2) and deafness-onychodystrophy (DDOD) syndrome. Recently epilepsy has also been described as a potentially associated phenotype. Here we further uncover the role of ATP61VB2...
Wed Oct 23, 2019 00:00
This study examined native and second-language speaking rates in a speeded sentence production task; speaking rate was expected to reflect the speed with which processes underlying speech production can be executed. Sixty Spanish-English bilingual adults participated. They differed according to AOL (2–38), years of English Experience (1–45), and percent English Use (10–100). The purpose was to determine the influence of the three just-mentioned factors and their interactions using linear mixed-effects...
Tue Oct 29, 2019 19:35
Publication date: Available online 29 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jyoti Sharma, Vivek Kumar, Smita S. Kumar, Sandeep K. Malyan, Thangavel Mathimani, Narsi R. Bishnoi, Arivalagan PugazhendhiAbstractThe present study investigates the phycoremediation potentials of two microalgal consortia (MAC1 and MAC2) for treating sewage water and producing biomass with high lipid, protein and chlorophyll contents. During the study, the microalgal strains were...
Tue Oct 29, 2019 19:35
In conclusion, AuNPs ease PD symptoms by the inhibition of TLR/NF-κB signaling pathway and recommend promise approach in the treatment of neurodegenerative diseases such as PD. (Source: Journal of Photochemistry and Photobiology B: Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Oct 29, 2019 19:35
Publication date: Available online 29 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jia Wang, He Zhu, Huizhu Gan, Qin Meng, Guangguang Du, Yang An, Jihua LiuAbstractAs a molecular chaperone, β-casein is difficult to form amyloid fibrils under physiological conditions due to its chaperone activity. Heparan sulfate (HS) has drawn attention of technologists all over the word because of its relation to amyloid deposits in some amyloidosis diseases. For better understanding...
Tue Oct 29, 2019 19:35
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