Osram, a German company best known for manufacturing LED lights, recently unveiled CHRONOGY Eyewear, a pair of glasses that can regulate and supplement the light that falls onto the photoreceptors in the eyes, helping to regulate our body clocks. The CHRONOGY Eyewear comes with a smartphone app that can be used to program the glasses. Intensity and timing can be set to achieve a variety of goals, whether it be to recover from jet lag faster, to get better sleep, or maybe even to improve...
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Abstract Low-stakes assessments are theorised to stimulate and support self-regulated learning. They are feedback-, not decision-oriented, and should hold little consequences to a learner based on their performance. The use of low-stakes assessment as a learning opportunity requires an environment in which continuous improvement is encouraged. This may be hindered by learners’ perceptions of assessment as high-stakes. Teachers play a key role in learners’ assessment perceptions....
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美國加州福斯特城與中國上海--(BUSINESS WIRE)--(美國商業資訊)--Terns Pharmaceuticals 拓臻生物是一家專注於非酒精性脂肪性肝炎（NASH）和癌症創新療法研發的全球生物製藥公司，今天宣布其候選藥物farnesoid X受體（FXR）激動劑TERN-101已獲得美國食品和藥物管理局（FDA）針對治療NASH適應症的快速審查認證。 拓臻生物醫學長Erin Quirk博士表示：「我們非常高興看到美國FDA對TERN-101在用於目前尚無有效治療選擇，存在未滿足臨床需求的NASH患者中治療潛力的認可。獲得快速審查認證是儘快將這種有潛力的治療方法應用於NASH患者的一個重要步驟，我們希望在推動TERN-101的臨床開發過程中與FDA緊密合作以加速其進度。」 到目前為止，在Ⅰ期臨床研究中，TERN-101顯示了與每日一次給藥一致的臨床藥代動力學特性。在維也納舉行的2019年國際肝病大會(International Liver Congress™)上，拓臻生物發表了TERN-101的臨床前研究資料，證明TERN-101在NASH臨床前動物模型中降低了肝臟脂肪變
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INGELHEIM, Germany--(BUSINESS WIRE)--Boehringer Ingelheim today presented promising preclinical data from its pan-KRAS program including the novel, oral inhibitor BI 1701963 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, USA1. Based on these results the compound has been advanced to Phase I clinical testing alone and in combination with trametinib in patients with different types of advanced solid tumors with KRAS mutations. KRAS mutations
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Research suggests that we may have only begun to scratch the surface on the number of variations present in the genetic codes of all living organisms.
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In work that could someday improve treatments for epilepsy, scientists have the first three-dimensional structure of a member of a large family of human proteins that carry charged particles -- ions -- across the cell membrane.
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Οὐδέποτε μπόρεσα νὰ καταλάβω γιατί όλοι αὐτοί, ποὺ μᾶς κουβαλῶνται ἐδῶ πέρα, δὲν στρώνουν τὸν κῶλο τοὺς κάτω νὰ φτιάξουν τὶς χῶρες τους. Ἡ Εὐρώπη εἶναι ἡ μονὴ Ἤπειρος ἡ ὁποία ὑπέστη δύο παγκοσμίους πολέμους. Τὸ «παγκοσμίους», βέβαια, τὸ θεωρῶ ὑπερβολικό, ἀφοῦ στὴν οὐσία τὸ κύριο θέατρο ἦταν ἡ Ἤπειρός μας. Τόσες καταστροφές, τόσες ἑκατόμβες … Συνέχεια →
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Survey shows over half of patients with low-risk thyroid cancer in Japan chose active surveillance over immediate surgery. A similar US program reports over 70% of similar patients also opted for watchful waiting. Medscape Medical News
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A shift towards the use of long-acting reversible contraceptives, particularly by young women, is associated with declining abortion rates in New Zealand, new research has found.
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Introduction: The vestibular implant could become a clinically useful device in the near future. This study investigated the feasibility of restoring the high-frequency dynamic visual acuity (DVA) with a vestibular implant, using the functional Head Impulse Test (fHIT). Methods: A 72-year-old female, with bilateral vestibulopathy and fitted with a modified cochlear implant incorporating three vestibular electrodes (MED-EL, Innsbruck, Austria), was available for this study. Electrical stimulation...
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Background and Objectives: Hereditary hearing loss (HL) can originate from mutations in one of many genes involved in the complex process of hearing. CABP2 mutations have been reported to cause moderate HL. Here, we report the whole exome sequencing (WES) of a proband presenting with prelingual, severe HL in an Iranian family. Methods: A comprehensive family history was obtained, and clinical evaluations and pedigree analysis were performed in the family with 2 affected members. After excluding mutations...
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Background: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. Objective: The aim of this study was to determine whether cisplatin is associated with hearing loss...
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Objective: Our aim was to determine the effect of acute changes in cochlear place of stimulation on cochlear implant (CI) sound quality. Design: In Experiment 1, 5 single-sided deaf (SSD) listeners fitted with a long (28-mm) electrode array were tested. Basal shifts in place of stimulation were implemented by turning off the most apical electrodes and reassigning the filters to more basal electrodes. In Experiment 2, 2 SSD patients fitted with a shorter (16.5-mm) electrode array were tested. Both...
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Abstract Background Armed conflicts can have severe adverse effects on population health, both directly and indirectly, through the destruction of health care systems. This paper evaluates the causal effect of the Boko Haram insurgency in northeastern Nigeria on the vaccination rate. Methods By matching children’s birth months and the months...
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We’ve discovered brain cells help us judge the distance to an object, and they remain active even if we can no longer see the object suggesting a role in memory
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Once thought too abstract, category theory has become remarkably pervasive in science, says mathematician and pianist Eugenia Cheng
Wed Oct 23, 2019 20:00
ConclusionWhile radiation therapy might increase long-term toxicity in cHL, in our large data cohort, radiotherapy consolidation as part of the initial therapy for early stage disease provides superior survival at 10 years, especially in favorable risk cHL. (Source: Hematology Oncology and Stem Cell Therapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links...
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CONCLUSIONS This new nomogram could be conveniently used to predict the selection preference of robotic surgery for patients with pancreatic head cancer. PMID: 31654999 [PubMed - in process] (Source: Medical Science Monitor)
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CONCLUSIONS Our study showed that the lncRNAs C2orf48 and LINC00261 might be key regulators of uterine corpus endometrial carcinoma and might serve as prognostic indicators. Our study contributes to the understanding of the molecular mechanisms of uterine corpus endometrial carcinoma, and it identifies lncRNAs that might serve as prognostic markers and therapeutic targets. PMID: 31650984 [PubMed - in process] (Source: Medical Science Monitor)
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CONCLUSIONS Xanthoxyletin inhibited the proliferation of human oral squamous carcinoma cells and induced apoptosis, autophagy, and cell cycle arrest by modulation of the MEK/ERK signaling pathway. PMID: 31654522 [PubMed - in process] (Source: Medical Science Monitor)
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A strong association between Epstein-Barr virus (EBV) infection and nasopharyngeal carcinoma (NPC) has been widely recognized in recent decades. The aim of the present study was to investigate latent membrane ... (Source: Infectious Agents and Cancer)
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(Source: OncoTargets and Therapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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In the published article [1], an error was noticed in Fig. 6B. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is ... (Source: Molecular Cancer)
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(Source: Cancer Management and Research)
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IJERPH, Vol. 16, Pages 4177: Social Media, Thin-Ideal, Body Dissatisfaction and Disordered Eating Attitudes: An Exploratory Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214177 Authors: Aparicio-Martinez Perea-Moreno Martinez-Jimenez Redel-Macías Pagliari Vaquero-Abellan Disordered eating attitudes are rapidly increasing, especially among young women in their twenties. These disordered behaviours result from the interaction...
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IJERPH, Vol. 16, Pages 4181: Protective Effect of Breastfeeding on the Adverse Health Effects Induced by Air Pollution: Current Evidence and Possible Mechanisms International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214181 Authors: Zielinska Hamulka Air pollution is a major social, economic, and health problem around the world. Children are particularly susceptible to the negative effects of air pollution due to their immaturity and excessive growth...
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Cells, Vol. 8, Pages 1341: MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy? Cells doi: 10.3390/cells8111341 Authors: Britten Ragusa Tosi Kamel The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases. These translocations...
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Cells, Vol. 8, Pages 1342: Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor Cells doi: 10.3390/cells8111342 Authors: Morbiato Frigato Dinarello Maradonna Facchinello Argenton Carnevali Dalla Valle Bertolucci Glucocorticoids (GCs) are steroid hormones mainly acting as key regulators of body homeostasis and stress responses. Their activities are primarily based on the binding to the GC receptor (GR), a member...
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IJERPH, Vol. 16, Pages 4182: Food Safety Incident, Public Health Concern, and Risk Spillover Heterogeneity: Avian Influenza Shocks as Natural Experiments in China’s Consumer Markets International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214182 Authors: Yi Tao Zhu Tan Qi Background: Food safety incidents have aroused widespread public health concern, causing food price risk. However, the causal paths remain largely unexplored in previous...
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IJERPH, Vol. 16, Pages 4180: Conveying Safety Messages on Agricultural Machinery: The Comprehension of Safety Pictorials in a Group of Migrant Farmworkers in Italy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214180 Authors: Bagagiolo Vigoroso Caffaro Cremasco Cavallo The comprehension of safety signs affixed to agricultural machinery is fundamental to warning users about the residual risks which cannot be eliminated with machinery...
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IJERPH, Vol. 16, Pages 4179: Interaction Among Influenza Viruses A/H1N1, A/H3N2, and B in Japan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214179 Authors: Ayako Suzuki Kenji Mizumoto Andrei R. Akhmetzhanov Hiroshi Nishiura Seasonal influenza epidemics occur each winter season in temperate zones, involving up to 650,000 deaths each year globally. A published study demonstrated that the circulation of one influenza virus type during...
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Applied Sciences, Vol. 9, Pages 4600: Analysis of Guided Wave Propagation in a Multi-Layered Structure in View of Structural Health Monitoring Applied Sciences doi: 10.3390/app9214600 Authors: Yevgeniya Lugovtsova Jannis Bulling Christian Boller Jens Prager Guided waves (GW) are of great interest for non-destructive testing (NDT) and structural health monitoring (SHM) of engineering structures such as for oil and gas pipelines, rails, aircraft components, adhesive bonds and...
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Cancers, Vol. 11, Pages 1686: Protein Kinase A Distribution in Meningioma Cancers doi: 10.3390/cancers11111686 Authors: Caretta Denaro D’Avella Mucignat-Caretta Deregulation of intracellular signal transduction pathways is a hallmark of cancer cells, clearly differentiating them from healthy cells. Differential intracellular distribution of the cAMP-dependent protein kinases (PKA) was previously detected in cell cultures and in vivo in glioblastoma and medulloblastoma. Our...
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IJERPH, Vol. 16, Pages 4178: Associations between the Home Physical Environment and Children’s Home-Based Physical Activity and Sitting International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214178 Authors: Sheldrick Maitland Mackintosh Rosenberg Griffiths Fry Stratton It is important to understand the correlates of children’s physical activity (PA) and sitting at home, where children spend significant time. The home...
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