Abstract Tricuspid annuloplasty is a surgical procedure that cinches the valve’s annulus in order to reduce regurgitant blood flow. One of its critical parameters is the degree of downsizing. To provide insight into the effect of downsizing, we studied the annulus of healthy sheep during suture annuloplasty. To this end, we implanted fiduciary markers along the annulus of sheep and subsequently performed a DeVega suture annuloplasty. We performed five downsizing steps in each animal...
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Abstract Introduction Since Hirschsprung’s disease (HSCR) already proved to benefit from robotic surgery, we aimed at describing a wider series of patients with this rare disease who were operated on with a robotic approach. Patients and methods All consecutive HSCR patients who underwent totally robotic soave pull-through (TRSPT), between October 2015 and...
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Demyelinating central nervous system diseases include several disorders that multiple sclerosis (MS) is identified as the most common among them. Ocular movement disturbances are a typical presentation in MS p...
Spastic paraplegia, optic atrophy and neuropathy (Spoan syndrome) is an autosomal recessive disease with approximately 70 cases recorded in Brazil and Egypt.
A persistent trigeminal artery (PTA) is a non-involuted embryonic vessel that connects the cavernous part of the internal carotid artery with the posterior circulation. In the adult it is associated with multi...
Many patients with chronic illness have sexual dysfunction that may be related to the condition itself, drug side effects, emotional sequel, or a combination of those factors. Patients with epilepsy are no exc...
We encountered two unrelated individuals suffering from neurological disorders, including epilepsy and scoliosis.
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Abstract This study aimed to evaluate the effect of low-level laser therapy (LLLT) on immediate postpartum pain relief during cesarean section. A randomized, parallel controlled trial was carried out. In total, 88 women with immediate postpartum were divided into 4 groups: control group (n = 22), placebo group (n = 22), experimental group I (n = 22, dose of 4 J/cm2), and experimental group II (n = 22, dose of 2 J/cm2). The pain measured by Numeric Rating Scale (NRS), algometry,...
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Following publication of the original article (Machowska et al. 2019), the authors provided new footnotes for Table 1 and Table 2. The complete tables and updated footnotes are supplied below.
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Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2060-9MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2064-5ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2059-2Correction: TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2056-5Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2057-4Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2055-6Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2045-8Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells
Cell Death & Disease, Published online: 28 October 2019; doi:10.1038/s41419-019-2031-1MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer
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Abstract Background Despite recent advances in the diagnosis and understanding of many autoinflammatory diseases, there are still a great number of patients with phenotypes that do not fit any clinically- and/or genetically-defined disorders. Case presentation We describe a fourteen-year-old boy who presented at two and a half years of age with...
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16h
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“There is an emerging focus on the importance of assessing motor performance as well as cognitive performance to predict cognitive function loss,” explained guest editor Manuel Montero-Odasso, MD, PhD, Departments of Medicine (Geriatric Medicine), and Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, and Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, ON, Canada. “In the past two decades, large epidemiological...
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Abstract Rhipicephalus microplus is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytoplasmic degradation called autophagy. In order to deepen our understanding of this process during R. microplus non-parasitic stages, we determined the expression dynamics of...
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Abstract The present study aims to characterize nodule endophytic bacteria of spontaneous lupine plants regarding their diversity and their plant growth promoting (PGP) traits. The potential of PGPR inoculation was investigated to improve white lupine growth across controlled, semi-natural and field conditions. Lupinus luteus and Lupinus angustifolius nodules were shown inhabited by a large diversity of endophytes. Several endophytes harbor numerous plant growth promotion traits...
Abstract Strain 6021061333T was isolated from the sputum of 16-year-old girl with cystic fibrosis following a pulmonary exacerbation. This bacterial strain could not be identified by our systematic MALDI-TOF mass spectrometry screening on a MicroFlex. This led to the sequencing of the 16S rRNA gene, which shows 97.83% sequence identity with Chryseobacterium kwangjuense strain KJ1R5T, the phylogenetic closely related type strain of a species with standing in nomenclature, which...
Abstract A new taxon is created for the thermophilic purple nonsulfur bacterium previously designated as Rhodopseudomonas strain GI. Strain GI was isolated from a New Mexico (USA) hot spring microbial mat and grows optimally above 40 °C and to a maximum of 47 °C. Strain GI is a bacteriochlorophyll b-containing species of purple nonsulfur bacteria and displays a budding morphology, typical of species of the genus Blastochloris. Although resembling the species Blc. viridis in many...
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Abstract In this work, a novel magnetic nanocomposite combining selenium nanoparticles (SeNPs) with iron oxide nanoparticles (IONPs) was synthesized for the first time, in which the size of the iron oxide nanoparticles was 7–12 nm, and nearly spherical or rod-like selenium nanoparticles were obtained according to the different pH values of the reaction mixtures. Selenium incorporation into iron oxide nanoparticles was improved by using a chitosan coating with pentasodium triphosphate...
Abstract Polylactic acid (PLA) is a biodegradable thermoplastic polymer that is presented as a good alternative to petroleum-derived plastics. Some of the major drawbacks of this material are its lack of thermal stability and rapid degradation in large-scale production; thus, special care must be taken during processing. To improve their properties, a reactive extrusion with a multi-epoxy chain extender (SAmfE) has been performed at pilot plant scale. The induced topological...
Abstract Transition metal phosphides have been regarded as reliable supercapacitor electrode materials and extensively researched. In this work, a facile three-step way has been taken to synthesize NiCoP@NiCoP core–shell nanoarrays directly grown on carbon cloth, which was used as a high-performance supercapacitor electrode. Compared with the NiCo-LDH precursor and NiCoP nanowire and NiCoP nanosheet, NiCoP@NiCoP core–shell composite shows higher electrochemical performance owing...
Abstract Flexible unidirectional (UD) composite laminates are commonly being used for ballistic-resistant body armor. These laminates comprise UD layers, each constructed by laminating thin layers of high-performance fibers held in place using very low modulus binder resins, with the fibers in each layer oriented parallel to each other. As these materials are used in body armor, it is important to investigate their long-term reliability, particularly with regard to exposure to...
Abstract Magnesium-based alloys presented great potential for biodegradable implant materials. However, the poor mechanical properties and high corrosion rate blocked its extensive application. In this study, a new biodegradable Mg–Zn–Y–Gd–Zr alloy was fabricated and extruded. The microstructure, corrosion morphologies and corrosion products film of the as-cast, homogenized and as-extruded alloys were characterized by optical micrographs, scanning electron microscopy, X-ray diffraction...
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Toxins, Vol. 11, Pages 625: The Sequence and a Three-Dimensional Structural Analysis Reveal Substrate Specificity Among Snake Venom Phosphodiesterases Toxins doi: 10.3390/toxins11110625 Authors: Ullah Ullah Ali Betzel ur Rehman (1) Background. Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes. In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysis....
Toxins, Vol. 11, Pages 624: Analysis of the Use of Cylindrospermopsin and/or Microcystin-Contaminated Water in the Growth, Mineral Content, and Contamination of Spinacia oleracea and Lactuca sativa Toxins doi: 10.3390/toxins11110624 Authors: Maria Llana-Ruiz-Cabello Angeles Jos Ana Cameán Flavio Oliveira Aldo Barreiro Joana Machado Joana Azevedo Edgar Pinto Agostinho Almeida Alexandre Campos Vitor Vasconcelos Marisa Freitas Cyanobacteria and cyanotoxins...
Toxins, Vol. 11, Pages 623: Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus Toxins doi: 10.3390/toxins11110623 Authors: Giulia Fassio Maria Vittoria Modica Lou Mary Paul Zaharias Alexander E. Fedosov Juliette Gorson Yuri I. Kantor Mandё Holford Nicolas Puillandre Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining...
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OBJECTIVE: The incidence and disability rate of spinal tuberculosis is high. The role of the expression of lncRNA SNHG15 in spinal tuberculosis and related mechanisms remains unclear.PATIENTS AND METHODS: Spinal tuberculosis and normal control tissues were collected, and lncRNA SNHG15 level was analyzed by real-time PCR. Mouse RAW264.7 cells were cultured and divided into control group, tuberculin (PPD) group, si-SNHG15, and PPD+ si-SNHG15 group followed by analysis of lncRNA SNHG15 level, cell proliferation...
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OBJECTIVE: The aim of this study was to elucidate whether the knockdown of microRNA-106-3p (miR-106-3p) could mediate the nerve regeneration and functional recovery after the spinal cord injury (SCI) and its potential mechanism.MATERIALS AND METHODS: Microglia were extracted from the cerebral cortex of the neonatal rats and cultured in vitro. Subsequently, biomarkers of M1-type and M2-type in microglia transfected with miR-106-3p inhibitor were measured. Furthermore, in vivo SCI model in rats was...
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SurgRob
A relevant article was published at the IEEE SACI2019 conference from Nagy et al., "Recent Advances in Robot-Assisted Surgery: Soft Tissue Contact Identification":"Robot-Assisted Minimally Invasive Surgery (RAMIS) is becoming standard-of-care in western medicine. RAMIS offers better patient outcome compared to traditional open surgery, however, the surgeons’ ability to identify the tissues with the sense of touch is missing from most robotic systems. ...
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OBJECTIVE: This study aims to ascertain the effect of miR-100 on inflammation, apoptosis and functional rehabilitation after spinal cord injury (SCI) and the potential mechanism. MATERIALS AND METHODS: Firstly, microglia were extracted from 3-day-old neonatal rats and cultured for the purpose of inflammatory activation. Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was conducted to detect the levels of miR-100, toll-like receptors 4 (TLR4) and nuclear factor-κB (NF-κB). Moreover, proteins...
OBJECTIVE: Anterior cruciate ligament (ACL) injuries which cause knee disabilities remain a clinical challenge due to the compromised tendon-bone repair. Multiple strategies have been proposed to treat the tendon-bone injuries, and the combination of these therapies hold great potential to achieve synergistic effects. MATERIALS AND METHODS: We built PLGA-BMP-2 (bone morphogenetic protein 2) system and confirmed the sustained release of BMP-2 both in vitro and in vivo. We then applied different therapies...
OBJECTIVE: To uncover the role of XIXT in influencing the osteogenesis of hBMSCs by adsorbing microRNA-30a-5p (miRNA-30a-5p) to upregulate RUNX2. PATIENTS AND METHODS: The serum samples were collected from osteoporosis patients and normal people. hBMSCs were isolated from femoral head tissues. The serum levels of XIXT and miRNA-30a-5p were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The expression levels and activities of the osteogenic differentiation-related genes...
OBJECTIVE: The functions of lncRNAs have been verified to be important biomarkers and regulators for diagnosis and treatment of human diseases. In osteosarcoma (OS), emerging evidence determined that lncRNA was associated with cell progression. However, due to the high incidence and recurrence rate of osteosarcoma, it is important to find an effective treatment for osteosarcoma. PATIENTS AND METHODS: QRT-PCR was used to detect the expression of ADPGK-AS1 and miR-542-3p in tissues and cells. Western...
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