Background Optimal chemotherapy for treating mixed‐phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World Health Organization 2016 (WHO2016) classification. Methods To assess the relative efficacy of chemotherapy types for treating pediatric MPAL, the Children's Oncology Group (COG)...
Tue Oct 29, 2019 14:38
Background Colorectal cancer screening uptake is low, particularly among individuals enrolled in Medicaid. To the authors' knowledge, little is known regarding the effectiveness of direct‐to‐member outreach by Medicaid health insurance plans to raise colorectal cancer screening use, nor how best to deliver such outreach. Methods BeneFIT is a hybrid implementation‐effectiveness study of 2 program models that health plans developed for a mailed fecal immunochemical test (FIT) intervention. The...
Mon Oct 28, 2019 18:39
Background Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatments are limited. Methods A multicenter, retrospective case series investigation of consecutive BRAF‐mutant patients with melanoma brain metastases (MBMs) treated with a combination...
Mon Oct 28, 2019 18:39
Background News of cancer progression is critical to setting accurate prognostic understanding, which guides patients' treatment decision making. This study examines whether religious belief in miracles modifies the effect of receiving news of cancer progression on change in prognostic understanding. Methods In a multisite, prospective cohort study, 158 patients with advanced cancer, whom oncologists expected to die within 6 months, were assessed before and after the visit at which scan results...
Mon Oct 28, 2019 18:38
Abstract Rationale Cocaine is a psychostimulant drug that facilitates monoaminergic neurotransmission. The endocannabinoid system, comprising the cannabinoid receptors (CB1R and CB2R), the endocannabinoids, and their metabolizing-enzymes, modulates the mesolimbic dopaminergic pathway and represents a potential target for the treatment of addiction. Objectives ...
02:00
Abstract Rationale Gambling and alcohol use are recreational behaviours that share substantial commonalities at a phenomenological, clinical and neurobiological level. Past studies have shown that alcohol can have a disinhibiting effect on gambling behaviour, in terms of bet size and persistence. Objectives This study was conducted in order to characterise...
Tue Oct 29, 2019 02:00
Abstract Rationale Sleep difficulties are one of the problems associated with adolescent binge drinking. However, the mechanisms underlying adolescent alcohol-associated sleep disturbances and potential targets for therapy remain under investigated. Orexin receptor antagonists may have therapeutic value in the treatment of insomnia, yet the use of this class of drugs in the treatment of sleep disturbances following adolescent alcohol exposure...
Mon Oct 28, 2019 02:00
Somatic PTEN mutation occurs in a proportion of ovarian endometrioid carcinomas. However, these cancers have seldom been reported in diseases associated with germline PTEN variants, such as Cowden syndrome (CS).
Tue Oct 29, 2019 02:00
Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adeq...
Tue Oct 29, 2019 02:00
The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using i...
Tue Oct 29, 2019 02:00
Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) assoc...
Tue Oct 29, 2019 02:00
The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verify...
Tue Oct 29, 2019 02:00
Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available...
Mon Oct 28, 2019 02:00
Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that ...
Mon Oct 28, 2019 02:00
We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium.
Mon Oct 28, 2019 02:00
Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical p...
Mon Oct 28, 2019 02:00
The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to in...
Mon Oct 28, 2019 02:00
Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine kinase inhibitors (TKIs) has shown the effec...
Sat Oct 26, 2019 03:00
Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity ...
Sat Oct 26, 2019 03:00
The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical an...
Sat Oct 26, 2019 03:00
Background and Purpose. The thrombin-activatable fibrinolysis inhibitor (TAFI) is an important inhibitor of fibrinolysis and plays a critical role in the pathogenesis of arterial thrombosis; genetic polymorphisms of the TAFI gene affect its activity and increase the risk of thrombosis. Moreover, studies in young patients are still scarce. The aim was to examine the contribution of the Thr325Ile and Ala147Thr polymorphisms with ST acute myocardial infarction (STEMI) or idiopathic ischemic stroke (IIS)...
07:05
Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent kidney malignancies. The tumor microenvironment (TME) is highly related to the oncogenesis, progress, and prognosis of ccRCC. The aim of this study was to infer the level of infiltrating stromal and immune cells and assess the prognostic value of them. The gene expression profile was obtained from TCGA and used for calculating the stromal and immune scores. Based on a cut-off value, patients were divided into low- and high-stromal/immune...
04:05
This study is aimed at exploring the levels of peripheral blood circular RNAs (circRNAs) as biomarker candidates for the diagnosis of new-onset rheumatoid arthritis (RA). The selected twenty-two circRNAs in peripheral blood from new-onset RA patients and healthy controls (HC) were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The levels of hsa_circ_0002715, hsa_circ_0001947, hsa_circ_0000367, and hsa_circ_0035197 were significantly increased in the peripheral...
Tue Oct 29, 2019 08:05
Background. Radical gastrectomy with D2 lymphadenectomy is recognized as the standard treatment for resectable advanced gastric cancer. Preoperative fibrinogen and albumin measurements may bring clinical benefits in terms of providing advanced notice of a poor prognosis or recurrence in patients undergoing radical resection. The aim of this study was to identify markers that are predictive of a poor prognosis prior to surgery. Methods. Eight hundred forty-two consecutive patients who underwent curative...
Tue Oct 29, 2019 06:05
Background. The difference of macrophage-specific interleukin-1 beta (IL-1b) response between latent tuberculosis infection (LTBI) and active tuberculosis (TB) remains less studied. Method. We performed this prospective study and recruited active TB patients, contacts with LTBI, and uninfected contacts. The gene and protein expression of human monocyte-derived macrophage (hMDM) after ex vivo stimulation by early secretory antigenic target-6KD (ESAT-6) and tuberculin purified protein derivatives (PPD)...
Tue Oct 29, 2019 04:05
The purpose of this retrospective study was to evaluate risk factors for external root resorption (ERR) on maxillary second molars (MxM2) in association with impacted third molars (MxM3) using cone beam computed tomography (CBCT) scans. The angles between the axes of MxM2/MxM3 (inclination) were measured. Further, ERR on MxM2 was classified as absent, slight, moderate, or severe. Contact location between MxM3 and MxM2, the size of the dental follicle, type of impaction, root formation, and patient...
Tue Oct 29, 2019 00:00
Background and Objectives Post inflammatory hyperpigmentation (PIH) can be difficult to treat especially in patients with darker skin types as darker skin carries increased epidermal melanin content. Various treatments available to improve the appearance of PIH may incite further pigmentation thus making treatment extremely difficult and frustrating. The purpose of this study was to perform a retrospective chart and photographic review to evaluate the efficacy and safety profile of a low energy...
Tue Oct 29, 2019 18:19
Εφόσον πήρατε την απόφαση να ξεκινήσετε ψυχοθεραπεία, κι αφού έχετε επιλέξει τον θεραπευτή που σας ταιριάζει, σίγουρα θα επιθυμείτε να αξιοποιηθούν στο έπακρο τα χρήματα και ο χρόνος που θα επενδύσετε. Για να επωφεληθείτε από την διαδικασία της ψυχοθεραπείας χρειάζεται πρωτίστως να είστε σίγουροι ότι είστε έτοιμοι για σημαντικές αλλαγές στην ζωή σας. Μην περιμένετε από τον θεραπευτή σας να σας αλλάξει και μην αρκείστε μόνο στα 50 λεπτά ψυχοθεραπείας κάθε εβδομάδα. Παρακάτω, δίνονται κάποιες...
07:41
«Ο φόβος σκοτώνει πολύ περισσότερους ανθρώπους από ότι ο θάνατος.» – George Patton Πραγματικά παίρνοντας αυτή τη φράση ως αφορμή σκεφτήκαμε πόσες φορές ένας άνθρωπος πεθαίνει πριν τελικά πεθάνει; Πόσες φορές ο φόβος σκότωσε τη ζωή και τα όνειρα του; Τι ζωή ζει ο άνθρωπος, με κλεμμένα ή σκοτωμένα τα όνειρα του; Πόσες φορές ο φόβος του έκλεψε τη ζωή, τη χαρά, την ευτυχία; Πόσοι άνθρωποι επιβιώνουν χωρίς να ζουν; Πίσω από όλα αυτά και πολλά άλλα, αυτός. Ο μεγαλύτερος και πιο ύπουλος εχθρός...
Tue Oct 29, 2019 08:00
Absolute Obstetric Anesthesia Review: The Complete Study Guide for Certification and Recertification
No abstract available
Mon Oct 28, 2019 02:00
BACKGROUND: Enhanced recovery after surgery (ERAS) expedites return to patient baseline and functional status by reducing surgical trauma, stress, and organ dysfunction. Despite the potential benefits of enhanced recovery protocols, limited research has been done in low-resource settings, where 95% of cesarean deliveries are emergent and could possibly benefit from the application of ERAS protocols. METHODS: In a prospective, randomized, single-blind, controlled trial, mothers delivering...
Mon Oct 28, 2019 02:00
No abstract available
Mon Oct 28, 2019 02:00
BACKGROUND: Many believe obesity is associated with higher rates of mortality in the critically ill. The purpose of this retrospective observational study is to evaluate the association between body mass index (BMI) and survival in patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) for acute hypoxic or hypercarbic respiratory failure. METHODS: All of the patients admitted to a dedicated VV ECMO unit were included. Patients
Mon Oct 28, 2019 02:00
Επικίνδυνη άγνοια έχουν οι ασθενείς για τους κινδύνους που κρύβουν τα αντιπηκτικά όταν συνδυάζονται με παυσίπονα και άλλα σκευάσματα. The post Παίρνετε αντιπηκτικά; Προσοχή στα παυσίπονα και τα συμπληρώματα appeared first on Iatropedia.
07:30
Ελληνική πατέντα και παγκόσμια πρωτοτυπία, η οποία θέτει σε κίνδυνο την Δημόσια Υγεία και υποβαθμίζει την τριτοβάθμια εκπαίδευση, χαρακτηρίζει ο Πανελλήνιος Σύλλογος των Φυσικοθεραπευτών (ΠΣΦ), την απόφαση του υπουργείου Παιδείας να προχωρήσει σε αναγνώριση όλων των πτυχιούχων από Κέντρα Μεταλυκειακής Εκπαίδευσης. The post Κίνδυνος για τη Δημόσια Υγεία η αναγνώριση «πτυχίων» Κολλεγίων, λένε οι Φυσικοθεραπευτές appeared first on Iatropedia.
07:02
Διευκρινιστική ανακοίνωση για τη μη ανανέωση συμβάσεων επτά επικουρικών γιατρών στο αντικαρκινικό νοσοκομείο "Άγιος Σάββας", εξέδωσε η Διοίκηση του Νοσοκομείου. The post «Άγιος Σάββας» : Τι απαντά η Διοίκηση για τις απολύσεις επικουρικών γιατρών appeared first on Iatropedia.
Tue Oct 29, 2019 19:59
Ψωρίαση και Ατοπική Δερματίτιδα. Δύο κοινά, χρόνια φλεγμονώδη νοσήματα που ταλαιπωρούν εκατομμύρια ανθρώπους παγκοσμίως. The post Ψωρίαση και Ατοπική Δερματίτιδα (έκζεμα): Ανυπολόγιστες επιπτώσεις στη ζωή των ασθενών και τα Συστήματα Υγείας appeared first on Iatropedia.
Tue Oct 29, 2019 19:26
Η πολυφαρμαρκία και η αντίσταση των μικροβίων στα αντιβιοτικά αποτελεί ζήτημα αιχμής για την παγκόσμια ιατρική κοινότητα, αλλά και την Ελλάδα. Ο Πανελλήνιος Ιατρικός Σύλλογος (ΠΙΣ) συμμετείχε σε σχετική συνάντηση του World Medical Association (Παγκόσμιου Ιατρικού Συλλόγου), κατά τη διάρκεια της οποίας τέθηκαν οι νέες προτεραιότητες για την προάσπιση της Δημόσιας Υγείας των λαών. The post WMA: Η αντίσταση των μικροβίων στα αντιβιοτικά, πρώτη αιτία θανάτου το 2050 appeared first on Iatropedia.
Tue Oct 29, 2019 17:24
Most prostate cancers are adenocarcinomas, cancers that arise in glandular cells of the prostate’s epithelial tissue. Prostate cancers usually progress slowly and produce no symptoms in the initial stages. Eventually, the tumor may enlarge like mine too, the prostate gland, pressing on the urethra and causing painful or frequent urination and blood in the urine. So I was so uncomfortable with this prostate cancer diseases then I decided to do online search on how to cure cancer because I well have read a lot about herbal medicine, I came across a lot of testimony how Dr Itua cure HIV/herpes then Cancer was listed below the comment.with courage I contacted Dr Itua and he sent me his herbal medicine through Courier service then I was asked to pick it up at my post office which i quickly did. I contacted Dr Itua that I have received my herbal medicine so he instructed me on how to drink it for three weeks and that is how Dr Itua Herbal Medicine cures my prostate Cancer, The treatment takes three weeks and I was cured completely. Dr Itua is a god sent and I thank him every day of my life. Contact him now On: Email:drituaherbalcenter@gmail.com/ Whatsapp:+2348149277967. He listed that he can as well cure the following diseases below.... Cerebral Amides. Lung Cancer,Brain cancer,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Hodgkin lymphoma Intestinal cancer,Kidney cancer,Leukemia,Liver cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors,Hodgkin lymphoma,Oral cancer,Ovarian cancer,Sinus cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Meniere's disease , Testicular cancer,Throat cancer,Thyroid Cancer,Uterine cancer,Vaginal cancer,Vulvar cancer. Alzheimer's disease,Autism,measles, tetanus, whooping cough, tuberculosis, polio and diphtheria Adrenocortical carcinoma. Alma, Uterine Cancer, Breast Cancer, Allergic diseases. Kidney cancer, Love Spell, Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Generalized dermatitis,Alzheimer's disease,Brain Tumor,Lupus,Endometrial Cancer, cerebrovascular diseases
ΑπάντησηΔιαγραφήDementia.Colo rectal cancer, Lottery Spell, Bladder Cancer, Skin Cancer,Ovarian Cancer,Pancreatic Cancer, HIV /Aids,Brain Tumor, Herpes, Non-Hodgkin lymphoma, Inflammatory bowel disease, Copd, Diabetes, Hepatitis