(Florida Atlantic University) Daily tasks are difficult for some people with autism because they often involve sequential steps. Since people with autism are strong visual learners, a study examined if parents could help their teens learn using portable, mainstream devices like an iPad. Similar studies have primarily targeted parents of young children with autism. Results show that video prompting interventions produced both immediate and lasting effects for teens with autism and that parents can...
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Brain Sciences, Vol. 9, Pages 296: Clinical Role of Aspirin in Mood Disorders: A Systematic Review Brain Sciences doi: 10.3390/brainsci9110296 Authors: Qin Xiang Ng Krishnapriya Ramamoorthy Wayren Loke Matthew Wei Liang Lee Wee Song Yeo Donovan Yutong Lim Vivekanandan Sivalingam Worldwide, depression and bipolar disorder affect a large and growing number of people. However, current pharmacotherapy options remain limited. Despite adequate treatment, many patients continue...
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Abstract Background Colorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association between diagnosis of CRC, obesity and diabetes was investigated. Methods Demographic characteristics, colonoscopy reports,...
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Abstract Background Cytologically indeterminate thyroid nodules currently present a challenge for clinical decision-making. The main aim of our study was to determine whether the classifications, American College of Radiology (ACR) TI-RADS and 2015 American Thyroid Association (ATA) guidelines, in association with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), could be used to stratify the malignancy risk of indeterminate...
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Publication date: Available online 28 October 2019Source: Auris Nasus LarynxAuthor(s): Dong-Hyun Kim, Kyungil Jang, Seulah Lee, Hyun Jin LeeAbstractPain after tonsil surgery is troublesome because it causes discomfort. In addition, handling patients with postoperative pain is challenging to otolaryngologists. Many laboratory studies have assessed the use of analgesics and surgical techniques to discover methods for effective control of postoperative pain associated with tonsil surgery. In this review...
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Introduction: Although highly pertinent for children, outbreaks of human parainfluenza virus (HPIV) may cause up to 15% of all respiratory illnesses in adults and predispose them to serious adverse outcomes, with HPIV serotype 3 (HPIV3) being the most common. This study represents the first report of an HPIV3 outbreak among adults at a long-term health-care facility in Croatia. Methods: A retrospective study was conducted to investigate an outbreak of acute respiratory infection (ARI) at a single...
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Abstract Background Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Methods...
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Publication date: Available online 28 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): M T Rodriguez-Estrada, V Cardenia, M Poirot, L Iuliano, G Lizard
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Publication date: Available online 29 October 2019Source: Journal of Controlled ReleaseAuthor(s): S. Roovers, J. Deprez, D. Priwitaningrum, G. Lajoinie, N. Rivron, H. Declercq, O. De Wever, E. Stride, S. Le Gac, M. Versluis, J. Prakash, S.C. De Smedt, I. LentackerAbstractUltrasound-triggered drug-loaded microbubbles have great potential for drug delivery due to their ability to locally release drugs and simultaneously enhance their delivery into the target tissue. We have recently shown that upon...
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Publication date: Available online 28 October 2019Source: Journal of Controlled ReleaseAuthor(s): Zhiying Zeng, Dongmei Qi, Lan Yang, Jin Liu, Yaqin Tang, Hui Chen, Xuli FengAbstractOral delivery of protein is very challenging for therapeutic applications due to protein instability and degradability. Herein we synthesized benzoboroxole-containing multi-armed poly(ethylene glycol) amphiphilic dendrimers sensitive to both pH and glucose. The multi-branched structure of dendrimer facilitated its self-assembly...
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Publication date: Available online 28 October 2019Source: Journal of Controlled ReleaseAuthor(s): Yue Wu, Yong Zhang, LiLi Dai, QianQian Wang, LingJing Xue, Zhigui Su, Can ZhangAbstractThe macrophages mediated inflammation participates in every stage of atherosclerosis. Attenuation of macrophages inflammatory responses by active ingredients in atherosclerotic plaques is benefit to atherosclerotic stabilization and regression, but meanwhile, it is highly desired to develop accurate therapeutics for...
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Publication date: Available online 28 October 2019Source: Journal of Controlled ReleaseAuthor(s): Cao Dai Phung, Hanh Thuy Nguyen, Ju Yeon Choi, Thanh Tung Pham, Suman Acharya, Maheshwor Timilshina, Jae-Hoon Chang, Ju-Hyun Kim, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh KimAbstractIn this study, dual drug-loaded nanoparticles were constructed to co-deliver low-dose doxorubicin (DOX) and miR-200c (DOX/miR-NPs) to inhibit programmed death-1 receptor (PD-L1) expression and trigger...
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Publication date: Available online 28 October 2019Source: Journal of Controlled ReleaseAuthor(s): Neda Kordalivand, Elena Tondini, Chun Yin Lau, Tina Vermonden, Enrico Mastrobattista, Wim E. Hennink, Ferry Ossendorp, Cornelus F. van NostrumAbstractRecent studies have shown a high potency of protein-based vaccines for cell-mediated cancer immunotherapy. However, due to their poor cellular uptake, efficient immune responses with soluble protein antigens are often not observed. As a result of superior...
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Abstract Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs signatures and their role in tumor microenvironment. Methods Here we analyzed...
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Objective: To explore the diversity and clinical features of anti-glutamate decarboxylase (GAD) antibody-associated neurological diseases. Methods: Clinical data of a series of 5 patients positive for anti-GAD antibodies were retrospectively analyzed. Results: All 5 patients were female, with a median age of 41.5 years (range 19–60 years). Their neurological symptoms included stiff-person syndrome (SPS), encephalitis, myelitis, cramp, visual loss, and paresthesia. Three patients (60%) were diagnosed...
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Antibiotics, Vol. 8, Pages 201: Combating Antimicrobial Resistance in Singapore: A Qualitative Study Exploring the Policy Context, Challenges, Facilitators, and Proposed Strategies Antibiotics doi: 10.3390/antibiotics8040201 Authors: Shweta Rajkumar Singh Alvin Qijia Chua Sok Teng Tan Clarence C. Tam Li Yang Hsu Helena Legido-Quigley Antimicrobial resistance (AMR) is a global public health threat that warrants urgent attention. However, the multifaceted nature of AMR often...
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Abstract Background Knowledge of the effect of marine protein hydrolysate (MPH) supplementation to promote recovery after high intensity performance training is scarce. The aim of this study was to examine the effect of MPH supplementation to whey protein (WP) and carbohydrate (CHO): (CHO-WP-MPH), on short-term recovery following high intensity performance, compared to an isoenergetic and isonitrogenous supplement of WP and CHO:...
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Publication date: Available online 28 October 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): Z. Hasbek, H. Ozer, S.A. Erturk, E. Erdiş, B. Yucel, E. Çiftçi, A. ÇakmakcilarResumenObjetivoEl factor inducible para hipoxia (HIF-1) tiene un papel crítico en la homeostasis del oxígeno y es un activador transcripcional de angiogénesis, eritropoyesis, hierro y metabolismo de glucosa. La tasa de metabolismo de glucosa aumenta en algunos tumores a través de HIF-1α. Nuestro objetivo...
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Abstract Professor Hugh A. Sampson, MD is a Canadian‐ born American clinician and translational researcher, whose evidence‐based approach validated food allergy as a legitimate allergic disorder. He single‐handedly transformed the management of patients with food allergies and initiated investigations that led to novel diagnostic tests and therapies giving hope to millions of individuals and their families worldwide. Hugh Sampson's immense impact on the rapidly developing field of food allergy makes...
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Scott wants DeVos to testify on stalled ‘borrower defense’ claims — GAO finds increase in religious-based hate crimes on campus
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Pink Week has raised hundreds of thousands of pounds from younger people. Its success should be a lesson to other charitiesWhen I was 16 I founded my charity, Pink Week, to raise awareness of breast cancer among young people.It’s a cause close to my heart. My mother, Dina Rabinovitch, the former Guardian columnist, was diagnosed with breast cancer when I was just 10. As I grew up I realised that young women were not being targeted by breast cancer charities, despite it being the most commonly diagnosed...
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Toxins, Vol. 11, Pages 627: Phytotoxic Metabolites Produced by Legume-Associated Ascochyta and Its Related Genera in the Dothideomycetes Toxins doi: 10.3390/toxins11110627 Authors: Wonyong Kim Weidong Chen Phytotoxins, secondary metabolites toxic to plants and produced by fungi, are believed to play an important role in disease development by targeting host cellular machineries and/or interfering with host immune responses. The Ascochyta blight diseases on different legume plants...
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Toxins, Vol. 11, Pages 626: Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways Toxins doi: 10.3390/toxins11110626 Authors: Yashad Dongol Fernanda Caldas Cardoso Richard J Lewis Voltage-gated sodium channels (NaVs) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit NaV channels have helped unravel the role of NaV channels in diseases, including chronic pain. Spider...
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Publication date: Available online 29 October 2019Source: CortexAuthor(s): Patrice Revol, Nathalie Toutounji, Laurence Havé, Gilles Rode, Sophie Jacquin-Courtois, Yves RossettiAbstractNeglect manifestations are typically explored in the visual modality. Although they are less commonly investigated tactile deficits also exist, and the aim of this study was to explore neglect in this modality. A haptic object discrimination task was designed to assess whether or not shape perception is impaired in...
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Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common genetic neuromuscular disease in children, resulting from a defect in the DMD gene located on Xp21.2. The new emerging treatment using exon skipping...
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To evaluate the availability of information regarding patient access to investigational treatments through clinical trials and non-trial pre-approval access pathways from a sample of patient advocacy organizat...
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Publication date: November 2019Source: Journal of Phonetics, Volume 77Author(s): Anders HøjenAbstractSecond-language acquisition has been shown to be influenced by age of learning (AOL), years of second-language experience and degree of second-language use. This study examined native and second-language speaking rates in a speeded sentence production task; speaking rate was expected to reflect the speed with which processes underlying speech production can be executed. Sixty Spanish-English bilingual...
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Condition: Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene FusionIntervention: Drug: larotrectinib(Vitrakvi, BAY2757556)Sponsor: BayerNot yet recruiting
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Condition: Squamous Cell CarcinomasIntervention: Other: solar irradiation and biopsiesSponsor: Centre Hospitalier Universitaire de NiceNot yet recruiting
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Publication date: Available online 29 October 2019Source: Medical HypothesesAuthor(s): Leslie M. KlevayAbstractSecondary analyses of data from the Age-Related Eye Disease Study (AREDS) revealed that higher calcium intakes were associated with slower progression to age-related macular degeneration (AMD). Earlier, primary analyses had revealed that a supplement containing copper reduced the odds of developing AMD while lengthening life. Because ocular lesions are being reported increasingly in neuropathy...
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Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Merve Açikoğlu, Seda Arslan TuncerAbstractThe present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification performance of the model by removing the irrelevant features....
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Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Jeremy D.W. Clifton, Eric S. KimAbstractAaron Beck’s insight—that beliefs about one’s self, future, and environment shape behavior—had major implications for health psychology research and practice. Yet, beliefs about one’s environment have remained relatively understudied. A recent comprehensive empirically-driven effort has led to the identification of 26 primal world beliefs, or primals, (e.g., the world is:...
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Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Qiang Zi, Weiping Ding, Chunli Sun, Shibo Li, Dayong Gao, Liqun He, Jing Liu, Lei Xu, Bensheng QiuAbstractCell survival rate (CSR) is a very important parameter in biological and medical fields. Today, the routine method to determine this parameter is time-consuming; it also makes the labeled cells no longer usable for subsequent experiments. Here, we developed an on-chip label-free method for determining...
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Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Pengfei Qiao, Xiu-Hong Wang, Shoufei Gao, Xiaoyan Yin, Yingying Wang, Pu WangAbstractHollow core anti-resonant fiber (HARF) has found a handful applications in optical communications, nonlinear optics and high power delivery. The intrinsic property of the fiber also renders it an ideal candidate for biosensing, which has not been explored intensively. Herein, we demonstrate an optical fiber sensing platform,...
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Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Wanying Li, Zhichao Liu, Bingqing Fang, Ming Jin, Yang TianAbstractAs an essential transition-metal ion in organism, zinc ion (Zn2+) plays a significant role in cellular metabolism, apoptosis and neurotransmission. Herein, we reported a new intramolecular charge transfer-based two-photon probe, (E)-1-(6-(4-(2-(2-(2-methoxyethoxy)ethoxy)eth-oxy)-3,5-dimethylstyryl)quinolin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine...
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12683-8Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibrils.
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-13016-5Author Correction: Unifying scrambling, thermalization and entanglement through measurement of fidelity out-of-time-order correlators in the Dicke model
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12895-yImpulsive behaviour is common in various neuropsychiatric disorders. Here, the authors identify a pathway from the lateral hypothalamus to the ventral hippocampus and the role of melanin-concentrating hormone signaling in these neurons in specifically regulating impulsivity.
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12883-2The loss of anomalous sulfur isotope compositions from sedimentary rocks has been considered a symptom of permanent atmospheric oxygenation. Here the authors show sulfur and oxygen isotope evidence from
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12902-2Recombinant MHC class II molecules are instrumental in antigen-specific T-cell identification assays and showed efficacy as experimental medicines. Here, the authors engineer MHC class II molecules with species-specific knob-into-hole heteromerization domains, enabling a translatable purification process with improved stability, yields, and biological potency.
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12763-9Familial cortical myoclonic tremor with epilepsy (FAME) is a slowly progressing cortical tremor mapping to various genomic loci, including intronic expansions in SAMD12 for FAME1. Here, Florian et al. describe mixed intronic TTTTA/TTTCA expansions of various lengths in the first intron of MARCH6 as a cause of FAME3.
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12671-yFamilial cortical myoclonic tremor (FAME) has so far been mapped to regions on chromosome 2, 3, 5 and 8 and pentameric repeat expansions in SAMD12 were identified as cause of FAME1. Here, Corbett et al. identify ATTTT/ATTTC repeat expansions in intron 1 of STARD7 in individuals with FAME2.”
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Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12735-zAML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.
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Publication date: Available online 28 October 2019Source: Allergology InternationalAuthor(s): Michihiro Hide, Atsushi Fukunaga, Junichi Maehara, Kazunori Eto, James Hao, Moshe Vardi, Yuji NomotoAbstractBackgroundHereditary angioedema (HAE) is a genetic disease characterized by recurrent swelling episodes affecting the skin, gastrointestinal mucosa, and upper respiratory tract.MethodsA phase 3, single-arm, open-label study was performed to evaluate a selective bradykinin B2 receptor antagonist, icatibant,...
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Burnout, a syndrome of emotional exhaustion, cynicism, and reduced effectiveness at work, has been linked to poor health, alcoholism, depression, and suicide in physicians. Burnout has adverse effects on patient care and the physician workforce, since burned-out physicians are more likely to report…
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Publication date: Available online 29 October 2019Source: Acta HistochemicaAuthor(s): A. Aizic, V. Raiser, I. Solar, Z. Aharon, B. Shlomi, I. KaplanAbstractIntroductionTraumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE) is a rare oral ulcerated lesion of uncertain etiology, showing eosinophil-rich granulation tissue, with occasional large atypical CD30 positive mononuclear cells. It had been suggested that it may represent an oral counterpart of cutaneous lymphomatoid papulosis, with...
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Publication date: Available online 28 October 2019Source: Free Radical Biology and MedicineAuthor(s): Sarit Anavi, Oren TiroshAbstractNitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different biochemical processes. NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS). iNOS-derived NO has been associated with the...
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Microorganisms, Vol. 7, Pages 504: Comparative Study on A Novel Pathogen of European Seabass. Diversity of Aeromonas veronii in the Aegean Sea Microorganisms doi: 10.3390/microorganisms7110504 Authors: Maria Smyrli Adriana Triga Nancy Dourala Panos Varvarigos Michael Pavlidis Viet Ha Quoc Pantelis Katharios Aeromonas veronii is an emerging pathogen causing severe pathology and mortalities in European seabass aquaculture in the Aegean Sea, Mediterranean. More than 50...
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Microorganisms, Vol. 7, Pages 506: Profiling Bacterial Diversity and Potential Pathogens in Wastewater Treatment Plants Using High-Throughput Sequencing Analysis Microorganisms doi: 10.3390/microorganisms7110506 Authors: Cecilia Oluseyi Osunmakinde Ramganesh Selvarajan Bhekie B. Mamba Titus A.M. Msagati Next-generation sequencing provides new insights into the diversity and structure of bacterial communities, as well as the fate of pathogens in wastewater treatment systems....
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Microorganisms, Vol. 7, Pages 505: Responses of Rhizosphere Fungal Communities to the Sewage Sludge Application into the Soil Microorganisms doi: 10.3390/microorganisms7110505 Authors: Katarína Ondreičková Marcela Gubišová Michaela Piliarová Miroslav Horník Pavel Matušinský Jozef Gubiš Lenka Klčová Martina Hudcovicová Ján Kraic Due to the increasing sewage sludge production in the world and problems with its disposal, an application of sludge to the soil appears...
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Microorganisms, Vol. 7, Pages 507: Defective RNA of a Novel Mycovirus with High Transmissibility Detrimental to Biocontrol Properties of Trichoderma spp. Microorganisms doi: 10.3390/microorganisms7110507 Authors: Jiaqi You Kang Zhou Xiaolin Liu Mingde Wu Long Yang Jing Zhang Weidong Chen Guoqing Li Trichoderma species are a group of fungi which is widely distributed in major terrestrial ecosystems; they are also commonly used as biocontrol agents for many plant diseases....
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Microorganisms, Vol. 7, Pages 503: The Reduction of Pathogen Load on Ross 708 Broilers when Using Different Sources of Commercial Peracetic Acid Sanitizers in a Pilot Processing Plant Microorganisms doi: 10.3390/microorganisms7110503 Authors: Kristina M. Feye Dana K. Dittoe Zhaohao Shi Jessica Woitte Casey M. Owens Mike H. Kogut Steven C. Ricke Peracetic acid (PAA) in poultry processing is not necessarily the same from company to company. Anecdotal evidence suggests...
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