Contributor : Wang shouhuaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe hypothesized that the circRNA will play an important role in the progresion of gallbladder cancer. To test this hypothesis, we collect the gallbladder cancer and matched normal tissue from 4 different patients and examined the circRNA expression in these 8 sampels through next generation sequencing.
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Contributors : Antoinette F van Ouwerkerk ; Vincent M ChristoffelsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExpression analysis of whole tissue and cardiomyocytes of fetal and adult atrial free wall
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Contributors : Ji Wu ; Jian Wang ; Zhuxia ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculuswe employed RNA-Seq to examine transcriptome profiles of male and female mouse gonads at 12.5dpc, 13.5dpc, 16.5dpc and 6dpp.Methods: Gonadal mRNA profiles of 12.5dpc,13.5dpc, 16.5dpc and 6dpp mice were generated by deep sequencing, in triplicate, using Illumina Hiseq 2500. The cDNA library was constructed with a SMARTer® Ultra Low Input RNA for lllumina® Sequencing...
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Contributors : Reka Toth ; Heiko Schiffmann ; Claudia Hube-Magg ; Franziska Büscheck ; Doris Höflmayer ; Sören Weidemann ; Patrick Lebok ; Christoph Fraune ; Sarah Minner ; Guido Sauter ; Christoph Plass ; Yassen Assenov ; Ronald Simon ; Jan Meiners ; Clarissa GerhäuserSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy and robust prognostic...
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Contributor : S H YuebenSeries Type : OtherOrganism : Homo sapiensTo investigate the role of METTL3-mediated m6A modification, we performed m6A-sequencing to map the m6A modification in control or METTL3 knockdown BGC823 cells.
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Osram, a German company best known for manufacturing LED lights, recently unveiled CHRONOGY Eyewear, a pair of glasses that can regulate and supplement the light that falls onto the photoreceptors in the eyes, helping to regulate our body clocks. The CHRONOGY Eyewear comes with a smartphone app that can be used to program the glasses. Intensity and timing can be set to achieve a variety of goals, whether it be to recover from jet lag faster, to get better sleep, or maybe even to improve...
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Recent fluorescence imaging technology applications of indocyanine green in general thoracic surgery
Abstract Thoracic surgeons perform a wide variety of cancer operations, which are often associated with high morbidity and mortality. Thus, thoracic surgery involves many special challenges that require innovative solutions. The increased utilization of minimally invasive practices, poor overall cancer survival, and significant morbidity of critical operations remain key obstacles to overcome. Fluorescence imaging technology (FIT), involving the implementation of fluorescent dyes...
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Abstract Low-stakes assessments are theorised to stimulate and support self-regulated learning. They are feedback-, not decision-oriented, and should hold little consequences to a learner based on their performance. The use of low-stakes assessment as a learning opportunity requires an environment in which continuous improvement is encouraged. This may be hindered by learners’ perceptions of assessment as high-stakes. Teachers play a key role in learners’ assessment perceptions....
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Pathogens, Vol. 8, Pages 210: Rotavirus Burden, Genetic Diversity and Impact of Vaccine in Children under Five in Tanzania Pathogens doi: 10.3390/pathogens8040210 Authors: Joseph J. Malakalinga Gerald Misinzo George M. Msalya Rudovick R. Kazwala In Tanzania, rotavirus infections are responsible for 72% of diarrhea deaths in children under five. The Rotarix vaccine was introduced in early 2013 to mitigate rotavirus infections. Understanding the disease burden and virus genotype...
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Pathogens, Vol. 8, Pages 209: Advances in Legionella Control by a New Formulation of Hydrogen Peroxide and Silver Salts in a Hospital Hot Water Network Pathogens doi: 10.3390/pathogens8040209 Authors: Luna Girolamini Ada Dormi Tiziana Pellati Paolo Somaroli Davide Montanari Andrea Costa Francesca Savelli Andrea Martelli Antonella Grottola Giulia Fregni Serpini Sandra Cristino Legionella surveillance is an important issue in public health, linked to the severity...
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Cells, Vol. 8, Pages 1338: The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins Cells doi: 10.3390/cells8111338 Authors: Jonathan Turpin Etienne Frumence Philippe Desprès Wildriss Viranaicken Pascale Krejbich-Trotot Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction...
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Cells, Vol. 8, Pages 1337: Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease Cells doi: 10.3390/cells8111337 Authors: Karina Reyes-Gordillo Ruchi Shah Jaime Arellanes-Robledo Ying Cheng Joseph Ibrahim Pamela L. Tuma Akt kinase isoforms (Akt1, Akt2, and Akt3) have generally been thought to play overlapping roles in phosphoinositide 3-kinase (PI3K)-mediated-signaling. However, recent...
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Cells, Vol. 8, Pages 1336: Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain Cells doi: 10.3390/cells8111336 Authors: Diana Grajales Vitor Ferreira Ángela M. Valverde Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes...
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Cells, Vol. 8, Pages 1334: P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells Cells doi: 10.3390/cells8111334 Authors: Xiaolong Yuan Zhonghui Li Yaru Kong Yuyi Zhong Yingting He Ailing Zhang Xiaofeng Zhou Yao Jiang Zhe Zhang Hao Zhang Jiaqi Li In female mammals, the abnormal apoptosis of ovarian granulosa cells (GCs) impairs follicular development and causes reproductive dysfunction. Many studies have indicated that the FGFR1 gene of the...
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Cells, Vol. 8, Pages 1335: SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis Cells doi: 10.3390/cells8111335 Authors: Pengtao Wang Jianhong Xia Leilei Zhang Shaoyang Zhao Shengbiao Li Haiyun Wang Shan Cheng Heying Li Wenguang Yin Duanqing Pei Xiaodong Shu Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis...
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Abstract Purpose To assess atrophy differences among brain regions and time-dependent changes after whole-brain radiation therapy (WBRT). Materials and methods Twenty patients with lung cancer who underwent both WBRT and chemotherapy (WBRT group) and 18 patients with lung cancer who underwent only chemotherapy (control group) were recruited. Three-dimensional...
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Abstract Background Oral follow‐up therapy is problematic in moulds with reduced azole‐susceptibility, such as azole‐resistant A. fumigatus infection. Currently only intravenous liposomal amphotericin B (L‐AmB) is advocated by guidelines for the treatment of azole‐resistant aspergillosis infections. Preclinical research indicates that high‐dose posaconazole (HD‐POS) might be a feasible option provided that high drug exposure (i.e. POS serum through levels >3 mg/L) can be achieved and is safe....
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Publication date: Available online 28 October 2019Source: Journal of the American Academy of DermatologyAuthor(s): Rebecca S. Kimyon, Jamie P. Schlarbaum, Yujie Linda Liou, Brandon L. Adler, Alyssa Breneman, Jeanette R. Comstock, Chelsea Handfield, Dawson Kimyon, Hannah Kopelman, Ross Kopelman, Vidhi Patel, Jodie Raffi, Fernanda Salgado, Sara A. Hylwa, Erin M. Warshaw
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Abstract Background Somatic PTEN mutation occurs in a proportion of ovarian endometrioid carcinomas. However, these cancers have seldom been reported in diseases associated with germline PTEN variants, such as Cowden syndrome (CS). Case presentation The present case was a 39-year-old woman with a left ovarian carcinoma who demonstrated a germline...
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Abstract Background Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. Method Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow cytometry and fluorescence...
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Abstract Background Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tumor cell survival and chemoresistance. The aim of our study was to demonstrate therapeutic efficiency of GX 15–070, a pan-Bcl-2 family inhibitor, used alone and in combination with conventional...
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Abstract Background Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemotherapy-induced AM. While the DPP-4 enzyme degrades this GLP-1, the DPP-4 inhibitor blocks the degradation process and raises the concentration of GLP-1. This study aimed to assess the role of DPP-4 inhibitor,...
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Abstract Background Pre-clinical studies have shown that furosemide slows cancer cell growth by acting on the Na-K-2Cl transporter, particularly for gastric cancer cells. However, epidemiological studies have not investigated furosemide use and mortality in gastroesophageal cancer patients. Consequently, we conducted a population-based study to investigate whether furosemide use is associated with reduced cancer-specific mortality...
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Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. ...
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Abstract Background The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verifying NER efficiency. Previously we have shown that DDB2, a protein involved in the Global Genome Repair, interacts directly with PCNA and, in human cells, the loss of this interaction affects DNA repair machinery....
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Publication date: Available online 28 October 2019Source: Health PolicyAuthor(s): Thomas Karlsson, Pia Mäkelä, Christoffer Tigerstedt, Ilmo KeskimäkiAbstractFinnish alcohol policy has aimed for many years to mitigate alcohol-related harm by using high taxation and restrictions on the physical availability of alcohol. The state monopoly on the retail of alcohol has played a central role in reducing the availability of alcohol. In 2011, preparations began for a comprehensive reform of the 1994 Alcohol...
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Publication date: Available online 29 October 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Ygor Marinho, Camila Marques-da-Silva, Patricia Teixeira Santana, Mariana Martins Chaves, Augusto Shuiti Tamura, Thuany Prado Rangel, Isabel Virgínia Gomes-e-Silva, Marília Zaluar Passos Guimarães, Robson Coutinho-SilvaAbstractBackgroudThe mechanism by which monosodium urate (MSU) crystals induce inflammation is not completely understood. Few studies have shown that MSU is capable...
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Publication date: Available online 29 October 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Manuela Leri, Paola Rebuzzini, Anna Caselli, Simone Luti, Antonino Natalello, Sofia Giorgetti, Loredana Marchese, Silvia Garagna, Massimo Stefani, Paolo Paoli, Monica BucciantiniAbstractBackgroundL-Homocysteine (Hcy) is a non-proteinogenic α-amino acid synthesized from dietary methionine. In healthy humans, high Hcy levels are a risk factor for cardiovascular diseases, stroke...
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Publication date: Available online 28 October 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yi He, Ling Xiong, Xuejuan Gao, Miaomiao Hai, Yanping Liu, Gao Wang, Guo Chen, Jianwei Shuai, Yang Jiao, Xixiang Zhang, Ruchuan Liu, Liyu LiuAbstractBackgroundMetastasis determines the lethality of cancer. In most clinical cases, patients are able to live with tumor proliferation before metastasis. Thus, the transition from tumor proliferation to metastasis/invasion is essential....
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Publication date: Available online 29 October 2019Source: Pathology - Research and PracticeAuthor(s): Alena Kalfusova, Zdenek Linke, Marketa Kalinova, Lenka Krskova, Irena Hilska, Jana Szabova, Ales Vicha, Roman KodetABSTRACTThe most important findings revealing pathogenesis, molecular characteristics, genotyping and targeted therapy of gastrointestinal stromal tumors (GISTs) are activated oncogenic mutations in KIT and PDGFRA genes. Imatinib mesylate (IM), which inhibits both KIT and PDGFRA receptors,...
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Abstract The development of drug resistance affecting the prognosis of patients with hepatocellular carcinoma (HCC) leads to low survival rate of HCC patients. Caffeine is reported to have a function of protecting the liver and anti-tumor activity. Therefore, caffeine may be an ideal enhancer for HCC chemotherapy regimens. Our study showed that the combination of caffeine and 5-FU significantly inhibited the proliferation of HCC cells in vivo and in vitro comparing with caffeine...
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As a parent who has paid $60 per session for math tutoring, I thought this was a resource worth sharing. There are free demonstration lessons available on the site to let you see if you think the... [Please click on the post title to continue reading the full post. Thanks (and thanks for subscribing)!]
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Abstract Patient-ventilator asynchrony is associated with intolerance to noninvasive ventilation (NIV) and worsened outcomes. Our goal was to develop a tool to determine a patient needs for intervention by a practitioner due to the presence of patient-ventilator asynchrony. We postulated that a clinician can determine when a patient needs corrective intervention due to the perceived severity of patient-ventilator asynchrony. We hypothesized a new measure, patient breathing variability,...
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Atmosphere, Vol. 10, Pages 659: Comparing Annoyance Potency Assessments for Odors from Different Livestock Animals Atmosphere doi: 10.3390/atmos10110659 Authors: Hanns Moshammer Dietmar Oettl Michael Mandl Michael Kropsch Lisbeth Weitensfelder (1) Background: When it comes to estimating the annoyance potency of odors, European countries relate to different guidelines. In a previous study we compared complaint rates for different agricultural odors, but due to different guidelines,...
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Atmosphere, Vol. 10, Pages 657: Measurement of SO2 and NO2 in Ship Plumes Using Rotary Unmanned Aerial System Atmosphere doi: 10.3390/atmos10110657 Authors: Fan Zhou Jing Gu Wei Chen Xunpeng Ni A key research problem in the field of ship emissions is how to perform efficient, accurate, and timely measurements of pollutant gases in a ship’s plume. To address this, we have designed and implemented an unmanned aerial system (UAS) that consists of a rotary unmanned aerial...
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Atmosphere, Vol. 10, Pages 658: Temporal Analysis of OMI-Observed Tropospheric NO2 Columns over East Asia during 2006–2015 Atmosphere doi: 10.3390/atmos10110658 Authors: Kyung M. Han The study analyzed temporal variations of Ozone Monitoring Instrument (OMI)-observed NO2 columns, interregional correlation, and comparison between NO2 columns and NOx emissions during the period from 2006 to 2015. Regarding the trend of the NO2 columns, the linear lines were classified into four groups:...
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Abstract Background Natural extracts with beneficial biological activities are nowadays of high interest, in various treatment or prophylaxis. Hypericum capitatum has been known for its curative effects for centuries and its extracts have become of interest due to their distinct activity among other Hypericaceae members. In this study, further light is aimed to be shed on the secondary-metabolites composition of H. capitatum extracts,...
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Cell Research, Published online: 29 October 2019; doi:10.1038/s41422-019-0247-3Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans
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Abstract Background Aesthetic porcelain veneers proved to be a long-term reliable prosthetic solution, ensuring minimal invasiveness. The use of veneers requires an adhesive cementation technique, so maintaining as much enamel as possible is to ensure lasting success. A diagnostic mock-up is a key tool that allows a preview of the outcome of the aesthetic restoration: it is obtainable both in an analog and digital way. With the recent...
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