Abstract Sotalol is a class III anti-arrhythmic agent with beta receptor blocking properties. Intravenous (IV) sotalol may be useful to treat refractory atrial and ventricular arrhythmias. A report on the efficacy and safety of IV sotalol in an infant on extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT), who developed refractory ventricular arrhythmias following surgery for congenital heart disease. A 10-day old infant with severe pulmonary...
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ObjectiveTo compare perinatal and maternal outcomes for Australian women with uncomplicated pregnancies according to planned place of birth, that is, in hospital labour wards, birth centres or at home. DesignA population-based retrospective design, linking and analysing routinely collected electronic data. Analysis comprised 2 tests and binary logistic regression for categorical data, yielding adjusted ORs. Continuous data were analysed using analysis of variance. SettingAll eight Australian states...
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Networking has evolved, but there are still certain situations—like when making an ask to a senior manager—where formality prevails. Networking is a delicate art. While it’s certainly evolved in the past decade, there are still certain situations (and certain industries) where you must abide by a particular set of strict, unspoken rules. Mess one of these up, and you risk missing out on a critical opportunity to advance your career.Read Full Story
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When you see the deaths pile up, suddenly that puff seems way less appealing. Whether it’s flavored like strawberries or not, the sensation of vaping fills your lungs so smoothly it feels there could be nothing wrong with it. Heck, the plumes almost feel therapeutic as you exhale them through your mouth. Like Vicks VapoRub in a pen.Read Full Story
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As a result of the disappointing Q3 revenue and Q4 forecasts, the stock received five downgrades, causing GrubHub’s share price to plummet. Food delivery company GrubHub has seen its stock price slashed by over a third after it posted disappointing third-quarter earnings today, reports CNBC. The company disappointed investors in a one-two punch. First, GrubHub reported Q3 revenue of $322 million when the Street was expecting $330.5 million.Read Full Story
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Customers kept asking the Detroit startup which mattress to buy for its ultra-popular bed frame, so it designed one. Back in 2015, the fledgling Detroit-based furniture brand Floyd launched a minimal, low-slung platform bed. The design was simple—just a few slabs of wood which you would connect with a few metal components, no tools required—but it quickly developed a cult following. You’ve likely seen pictures of it, covered in rumpled sheets dappled with sunshine from a nearby window, while...
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Within each of the 10 metro areas with the most solar panels, there are big differences in where people have started embracing solar. There’s now 40 times as much solar power generation in the U.S. as there was a decade ago—enough, by last year, to power more than 9 million homes. Most of this is on large solar farms, but nearly a third is on rooftops. A new report takes a look at where solar panels are most common on roofs, using AI to analyze aerial photos of cities.Read Full Story
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Burnout has gotten a lot of attention this year. But these four symptoms can actually indicate something else. Ask around, and it may seem like everyone is experiencing burnout. A survey from staffing firm Accountemps earlier this year found that 96% of senior managers say their team members are experiencing some degree of burnout. In a separate survey, 91% of workers said they are at least somewhat burned out.Read Full Story
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A “foreign substance” in the medication could cause infections if ingested. Pharmaceutical company Mylan has announced a voluntary recall of Alprazolam Tablets, its generic Xanax medication. In the company’s announcement, posted on the U.S. Food and Drug Administration’s website, Mylan says its Alprazolam Tablets could have a “foreign substance” in it that could harm patients if ingested.Read Full Story
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We taste tested black currant, “Zombie,” and yogurt-coated Skittles to learn how Mars Wrigley adapts its candy for regional palates. Jealous? Time machines don’t exist, no, but mankind has successfully developed artificial grape flavoring. So as I bite into this purple Skittle, my mouth rewinds back to my childhood. I recall the sensation of chewing a big wad of grape Bubblicious while riding my bike, and cracking open a grape pop during a sleepover. All the while, I’m ignoring the dental hygiene...
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Millennials are the most diverse generation in history—and they’ll be the largest voting bloc in the 2020 elections. Here’s what politicians need to be doing to include them in the election conversation. Too often, large swaths of the nation—including those in southern and rural areas, people of color, and young people—are left out of the get-out-the-vote conversation. However, members of these communities deserve to receive the same degree of information, marketing, and engagement that “high propensity...
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Apple touts its latest earbuds’ noise cancelling features and sound quality, but it didn’t bother to make the AirPods Pro easier to repair when the battery starts to fail. Apple’s new AirPods Pro seem like a major step forward in terms of audio quality and ease of use. The $250 wireless earbuds are Apple’s first with active noise cancellation, and their silicone tips come in three sizes for better comfort. They even have a new “transparency mode” that lets outside sound in while the earbuds are...
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More than 93% of part-time workers said they would work longer hours if they had flexible work arrangements. In 2019, the case for flexible work is clear, and companies are scrambling to keep up with employee demand for it. Many companies have already implemented more flexible working practices: More than a quarter of companies surveyed in a recent study offered the option of full-time telecommuting, while over two-thirds of them allowed it as needed; about 57% of companies even encouraged employees...
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The displaced have both immediate and longterm needs. These local and national organizations get will get the right relief to them. Fed by powerful winds and cloudless skies, fires continue to rage across California. The Kincade fire in the Sonoma County wine country has swelled to over 70,000 acres–twice the size of San Francisco–and has forced about 200,000 people from their homes. Los Angeles County was just getting a handle on the Tick and Saddle Ridge fires when the new Getty inferno flared...
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Amazon and a host of startups offer a walled garden for kids from the internet’s Wild West. Do they get the job done? It’s complicated. The summer sun is beating down on lower Manhattan in late July as I turn into the shaded courtyard entrance of the NoMo SoHo hotel for a media breakfast organized by Amazon FreeTime, the company’s family-friendly alternative to YouTube that it says has been used by over 10 million children.Read Full Story
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Short answer: not really. Its popularity may have more to do with the “bigger minimalism trend” than usability, says one expert. Design types are notorious for wearing black (guilty as charged) and they aren’t alone: Black was the most popular color in womenswear in 2017, taking up 36% of the market according to the retail technology company Edited. The popularity of dark hues has even crossed the boundaries of fashion and made its way into UX and UI design, with a slew of popular apps and programs...
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Using the material in a large HVAC system on a commercial building could produce thousands of gallons of water an hour. In cities hit by drought—including Harare, Zimbabwe, where the city turned off taps in some neighborhoods for weeks this summer—a new material could make it possible to pull clean drinking water directly from the air. The sponge-like nanomaterial, from Ireland’s University of Limerick and a think tank and incubator fund called Molecule, is designed to be used in existing dehumidifiers,...
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Marjorie Kelly and the Democracy Collaborative are working to foster a more democratic economy—starting with employee ownership. Marjorie Kelly has a problem with the word “capitalism.” As the senior fellow and EVP of The Democracy Collaborative, a nonprofit research organization, says, “People like that word and if they want to hold onto it, I suppose they can. But to me, I think of ‘capital-hyphen-ism’—a system designed to benefit capital holders and maximize financial capital. Until we come to...
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The company is also working on a Bluetooth device that could stem teenage use of its products. Leading e-cigarette maker Juul will lay off up to 500 of its employees by year’s end, reports the Wall Street Journal. Currently, Juul employs a little over 4,000 people, making the planned layoffs amount to up to 15% of its workforce. The WSJ cites sources familiar with the matter, but those same sources note that the exact amount of people Juul is planning on laying off isn’t set in stone and could be...
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Meati Foods, the newest entrance to the fake-meat market, is building uncannily real looking steaks and chicken breasts from fungus. Inside a brewery-like space in Boulder, Colorado, fermentation tanks are growing mycelium—the root-like part of mushrooms—instead of brewing beer. Meati Foods, a new alternative meat brand, is making the fungi into steak and chicken breasts that look remarkably similar to the real thing.Read Full Story
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Publication date: Available online 28 October 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): L. Carrion-Martin, J. Orcajo Rincón, A. Rotger, M. Gonzalez-Leyte, L. Márquez Pérez, M. Echenagusia, A. MatillaAbstractThe detection of malignant liver tumours is recently increasing. These lesions have frequently arterial vascularization which differs from healthy parenchyma with main portal flow making them especially susceptible to transarterial therapies.Transarterial...
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Authors: Newsom KJ, Starostik P PMID: 31655711 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
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CONCLUSIONS: Many patients with IDA, with or without GI tract lesions thought to be responsible for their IDA, remain anemic despite adequate therapy during long-term follow-up. In this study, after appropriate initial GI evaluation, even in those patients with persistent IDA, new GI malignancies were not identified. PMID: 31655715 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
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This study is registered with PROSPERO (CRD42017059372, CRD42017059373, CRD42017059376, CRD42017064996, and CRD42018102977).Findings83 eligible studies (40 randomised controlled trials, n=3067) were included: 42 for depression (23 randomised controlled trials; n=2551), 31 for anxiety (17 randomised controlled trials; n=605), eight for Tourette syndrome (two randomised controlled trials; n=36), three for ADHD (one randomised controlled trial; n=30), 12 for post-traumatic stress disorder (one randomised...
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DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The original version of this article unfortunately contained a mistake in Fig. 6. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
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CONCLUSIONS: EpCAM detection in colon cancer using anti-human CD326/EpCAM clone VU-1D9 does not allow the correlation between its expression and the clinico-pathological characteristics of the patients and it should only be used for EpCAM identification in colon cancer tissues. KEY WORDS: Cancer, Colon, EpCAM, Immunohistochemistry. PMID: 31657353 [PubMed - in process] (Source: Annali Italiani di Chirurgia)
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CONCLUSIONS: It is probably that early cholecystectomy in all the patients with PLG of diameter <1cm, isolated or associated with lithiasis, symptomatic and asymptomatic, can contribute to the reduction of the incidence of GBC. KEY WORDS: Cholecystectomy, Gallbladder polyps, Gallbladder cancer, Ultrasound scan. PMID: 31657359 [PubMed - in process] (Source: Annali Italiani di Chirurgia)
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CONCLUSION: Hepatopancreatobiliary surgery is a difficult intervention and is associated with serious morbidities. Synchronisation of hepatopancreatobiliary surgery with CRS/HIPEC may be challenging for the surgeon and clinician. Here we emphasise that this combination can be performed safely by an experienced team with a multidisciplinary approach and good patient preparation. KEY WORDS: Cytoreductive surgery, HIPEC, Hepatopancreatobiliary surgery, Peritoneal carcinomatosis. PMID: 31657354...
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CONCLUSIONS: The possibility to detect patients with a lower risk of nodal disease before surgery may reduce the rate of false negative results of sentinel lymph node biopsy in patients receiving a neoadjuvant therapy. KEY WORDS: Axilla, Breast cancer, Lymphnodes, Lymphonodes sentinel. PMID: 31657352 [PubMed - in process] (Source: Annali Italiani di Chirurgia)
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CONCLUSION: We believe that the LNR, especially in cases of adequate lymph node sampling, is a useful gauge to better sub-stratify "node-positive" patients. KEY WORDS: Colorectal cancer, Liver metastases, Lymph node ratio. PMID: 31657350 [PubMed - in process] (Source: Annali Italiani di Chirurgia)
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Conclusion Low ER-β expression is associated with improved pCR rates in univariate analyses. However multivariate analyses and survival analyses do not indicate an impact of ER-β on survival in patients undergoing neoadjuvant chemotherapy. Further examination of ER-β as predictor for endocrine therapy might be of value. PMID: 31656321 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
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Authors: Welslau M, Hartkopf AD, Müller V, Wöckel A, Lux MP, Janni W, Ettl J, Lüftner D, Belleville E, Schütz F, Fasching PA, Kolberg HC, Nabieva N, Overkamp F, Taran FA, Brucker SY, Wallwiener M, Tesch H, Schneeweiss A, Fehm TN Abstract Significant advancements have been made in recent years in advanced breast cancer and nearly all of them have been in the field of targeted therapy. Pertuzumab and trastuzumab-emtansine (T-DM1) have been able to be introduced in HER2-positive breast cancer....
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Authors: Schütz F, Fasching PA, Welslau M, Hartkopf AD, Wöckel A, Lux MP, Janni W, Ettl J, Lüftner D, Belleville E, Kolberg HC, Overkamp F, Taran FA, Brucker SY, Wallwiener M, Tesch H, Fehm TN, Schneeweiss A, Müller V Abstract The further development of therapies for women with early breast cancer is progressing far more slowly than in the case of patients with advanced breast cancer and is additionally delayed compared to developments in metastatic breast cancer. Nonetheless, significant...
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Conclusion In this patient collective, surgeries represent an independent risk factor for venous thromboses. In addition, a correlation was seen between inpatient thrombosis prophylaxis, leukocytosis as well as port systems and an increased risk of thrombosis. Neither the Khorana nor the Protecht score were independent risk factors for venous thromboses. Significantly more thrombosis patients died during the observation period. PMID: 31656320 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
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Authors: Fox E, Cheng V, Rawlins M, Dyer J, De Keulenaer B, Page MM, Hoad K, Roberts JA Abstract Prolonged intermittent renal replacement therapy (PIRRT) use has been increasing in critically ill patients with kidney dysfunction. PIRRT can affect the pharmacokinetics of many drugs, although no data is available to guide flucloxacillin dosing in this clinical scenario. Herein, we describe the pharmacokinetics of flucloxacillin, given at 1 g every 4 h during PIRRT, in a 76-year-old, critically...
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Authors: Eljaaly K, Botaish A, Bahobail F, Almehmadi M, Assabban Z, Thabit AK, Alraddadi B, Aljabri A, Alqahtani N, Aseeri MA, Hashim A, Torres A Abstract Macrolides are recommended for the treatment of community-acquired pneumonia (CAP). It is debatable whether erythromycin is associated with more adverse drug reactions (ADRs) compared to clarithromycin, and both are recommended in clinical practice guidelines. This meta-analysis aim is to compare ADRs in CAP patients treated with erythromycin...
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CONCLUSION: The upregulation of MCM genes expressions in cervical carcinogenesis reaffirms MCM as a proliferative marker in DNA replication pathway, whereby proliferation of dysplastic and cancer cells become increasingly dysregulated and uncontrolled. A strong expression of MCM2 protein in HSIL may aid as a concatenated screening tool in detecting pre-cancerous cervical lesions. PMID: 31653153 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: MM patients with bone metastases have poor HRQoL, with pain as the most frequently reported challenge, which is associated with an advanced stage of MM and SRE event. PMID: 31653168 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Based on the results, it can be concluded that there was an association between good family support and effective coping strategies and lower anxiety levels in cancer patients undergoing chemotherapy. These results can be an input for health services to increase family support for cancer patients undergoing chemotherapy in combination with effective coping strategies to decrease anxiety levels. PMID: 31653149 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSIONS: Both oral function and muscle mass-related measurements significantly affected QOL in HNC patients. PMID: 31653164 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: A concentration of 25(OH)D below 16 ng/ml was found to be independently associated with poor survival in breast cancer patients, regardless of age, lymph node status, stage or breast cancer subtype. An investigation of potential benefit of 25(OH)D supplements appears warranted. PMID: 31653160 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media...
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Authors: Shekhar S, L J PMID: 31653172 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: We found increased VEGF and PDGF serum levels in CNS patient's tumor. A different role for PDGF was found in the pathogenesis of neovascularization of meningioma, as well as oligodendroglioma. No significant result was found for FGF. TNF-α and IL-1β can serve as key prognostic biomarker in high-grade glioma and meningioma patients. PMID: 31653130 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: Have you tried our new medical search engine?...
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CONCLUSION: Parental use of Tobacco influences the uptake of Tobacco habits in their children, with the father's parenting (low paternal warmth) being a strong risk factor. PMID: 31653151 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: First-line triplet chemotherapy may overcome the difference in prognosis between right sided and left sided primaries in metastatic colorectal cancer. A larger analysis is warranted. PMID: 31653131 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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Authors: El-Kady DS, Ali NA, Sayed AH, Abdelhaliem MM, Elmegeed GA, Ahmed HH Abstract Cancer is recognized as one of the most prevalent contributors to mortality in several nations and it remains one of the common health issues globally. In particular, hepatocellular carcinoma (HCC) has become a public health problem along with the increase of hepatitis B (HBV) and hepatitis C (HCV) virus infections. Based on this fact, our study goaled to synthesize newly hybrid drugs containing heterocyclic...
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CONCLUSION: The results of our study showed for the first time that HP1-1 genotype is the dominant genotype in patients with esophageal cancer in Golestan province. As well, modification of nutritional pattern and consumption of high level of antioxidant compounds can be effective in reducing the prevalence of esophageal cancer in this region. PMID: 31653132 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: The results can predispose family-centered nursing care to support more the parents of children with cancer in the face of the stress of illness. Developing programs for training muscle relaxation techniques will improve family functioning and mental health. PMID: 31653133 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: QoL of Egyptian females with BC was influenced by several factors like age, marital status, occupation, smoking, residence, comorbidities, symptoms, grade, chemotherapy, radiation, and recurrence. PMID: 31653162 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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This study was using descriptive epidemiological incidence and prevalence-based research design to estimate the burden of 14 types of cancer attributable to tobacco smoking in member countries of ASEAN, in term of incidence and mortality. The cancer incidence and mortality data gained from GLOBOCAN 2018. According to the estimation, tobacco smoking was responsible for 121,849 new cancer cases in 2018 (106,858 male and 14,991 female cases) in ASEAN 2018. Our findings are mostly lower than previous...
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CONCLUSION: Overall, this study showed a positive correlation between cytology and tissue samples and ploidy and grade of dysplasia and cytology proved to be a simple and efficient with a reasonable diagnostic value. PMID: 31653166 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: On combining all possible immunoprofile combinations, p63+ve/p40-ve immunoprofile appears to be the most sensitive profile for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. PMID: 31653135 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links...
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CONCLUSIONS: Cancer registration workers and cancer experts generally agreed on the need to expand the essential items for cancer registration. The findings of this study will be useful for devising plans to expand cancer registration items. PMID: 31653170 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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CONCLUSION: In short HRM based DNA methylation can serve as a robust and sensitive diagnostic method for promoter methylation detection and as a biomarker for early epithelial ovarian cancer detection. PMID: 31653136 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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This study could open new avenues for the improvement of therapeutic efficacy of Sorafenib treated HCC patients by using Tau in combination. PMID: 31653148 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Microarray methods showed promise as potential biomarkers for CRC screening; however, these methods had to be optimized to improve accuracy and applicability by clinical routine. PMID: 31653137 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: The performance of the colposcopic score that replaces iodine staining with the size and location of the lesion is good and practical. High cut-off level can be used in see and treat approach for high-grade squamous intraepithelial lesions. Low cut-off level may be used for omitting biopsy in case of low grade impression. This scoring system seems to have greater performance in womens with type 3 T- zone. PMID: 31653150 [PubMed - in process] (Source: Asian Pacific Journal of Cancer...
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CONCLUSION: The findings of the present study revealed that using filial therapy could reduce the depression of children with cancer and their parent's depression, anxiety, and stress. Accordingly, we suggest filial therapy programs as a routine for addressing psychosocial problems of children with cancer and their families. PMID: 31653138 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Our results showed that the MDM2 -309T>G polymorphism was significantly associated with increased risk of AML in the Iranian population. Thus, the MDM2 -309T>G polymorphism might be useful genetic susceptibility factors in the pathogenesis of AML. PMID: 31653152 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: These preliminary results suggest the promising anticancer potential of petroleum ether, ethyl acetate, chloroform, and ethanol extracts of L. coronopifolia against MDA-MB-321 cells. Further studies are required to know the mechanism(s) involved in the cell death. PMID: 31653139 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSIONS: The dissimilarities in the results of our study and published literature could be attributed to the genetic or ethnic differences that exist between the Indian population and other global populations. The results of our study warrant a need to conduct studies of GIST in a much larger population of India. Such large scale studies may also help in better treatment and/or prevention of GIST in developing countries like India. PMID: 31653154 [PubMed - in process] (Source: Asian Pacific...
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CONCLUSION: According to the results, currently, electronic documentation is less frequently used for cancer patients. Therefore, an extensive effort is needed to identify users' requirements before designing and implementing an oncology information system. As multidisciplinary teams are involved in cancer care, all potential users and their requirements should be taken into account. Such a system can help to collect and use cancer data effectively. PMID: 31653158 [PubMed - in process] (Source:...
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CONCLUSION: We noted morphological changes in liver and other rats' organs due to a chemical carcinogen and their protection by NDV AF2240 and NDV V4-UPM seems to be most protective. PMID: 31653156 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Our study suggests that blocking PD1/PDL1 pathway may become an effective mode of treatment in cancer immunotherapy especially for Renal Cell Carcinomas. Our findings confirmed the significant association between expression of PDL1 and the high graded tumors which proves it to be an important prognostic factor. PMID: 31653140 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: Have you tried our new medical search engine? More powerful than...
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CONCLUSION: It is important to consider a program which will provide accurate information about the HPV vaccination to the community, especially adolescents. Financial management, such as insurance or vaccination savings schemes, may be one way to overcome the problem of the HPV vaccination's cost. PMID: 31653141 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: A significant association was observed between DPYD*9A polymorphism and CAPOX induced dose-limiting toxicities strengthening its role as a predictive biomarker. PMID: 31653159 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Saudi women in the Qassim region have moderate awareness of cervical cancer but negative attitudes toward screening. Awareness campaigns are needed to promote knowledge and improve pap smear attendance to eliminate negative perceptions and beliefs. PMID: 31653142 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: To the best of our knowledge, this is the first study to reveal the HRQOL scores for Jordanian adolescents with cancer. Addressing the special needs in such a unique age group is essential when planning a comprehensive care plan for a better quality of life. PMID: 31653161 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: It is important to provide exposure to education related to shisha hazards and increase the awareness of students and the public about the health effects of shisha smoking. PMID: 31653143 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: In AML, SALL4 is one of few genes that bridge the self-renewal properties of ESCs, normal HSCs and LSCs. Their expression is easily determined by real time PCR. They may be useful markers to predict prognosis and help to stratify patients into risk adapted groups. Further studies including increasing patient numbers are essential to understand the relations between SALL4 gene expression and its prognostic impact. PMID: 31653163 [PubMed - in process] (Source: Asian Pacific Journal...
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CONCLUSION: CEA mRNA evaluation is diagnostically valuable as a breast cancer marker. Additionally, CEA can significantly improve the sensitivity of diagnosis. PMID: 31653144 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: In our results, prevalent prostate cancer increased significantly with socioeconomic status and the increase in prevalent prostate cancer may be attributable to earlier detection rather than to a real increase in prevalence. PMID: 31653165 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained...
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CONCLUSION: HAART had cytoprotective effect against cervical dysplasia in HIV+ve females, by reducing progression of ASCUS to LSIL, HSIL and cervical cancer. Progression from normal to ASCUS increased which could be due to latency or/and prolonged persistent high risk HPV and HIV infections, of the most sexually active age group before diagnosed of HIV. PMID: 31653145 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: If you are looking to buy something...
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CONCLUSION: Mammography screening in Kazakhstan was found to be highly cost-effective, associated with treatment cost savings, and can be an efficient use of limited resources in Kazakhstan. PMID: 31653167 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: Higher values of SMI inclination, indicating a faster rate of skeletal muscle mass reduction, may serve as a useful predictive marker for OS in mUC patients undergoing second-line GD chemotherapy. PMID: 31653146 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: In spite of suffering from all the challenges and traumas, husbands of women with breast cancer have not left their wives alone and have done their best to improve their lives; so, we can raise ""Scarifying your life to save your wife's life"" as an extract from the experience of spouses of women with breast cancer. Knowing and understanding this point by clinical staffs and policy makers can provide pave the way for planning to provide comprehensive support to these men. PMID: 31653169...
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CONCLUSION: The results of the current study hold significance since the hypermethylation patterns can be identified in the cell-free circulating tumor DNA from a small volume of blood plasma and is a simple and minimally-invasive method. Assessment of hypermethylation patterns of a panel of TSG along with the existing screening markers could aid in better diagnosis and management of the disease. It could also aid in designing specifically tailored treatment strategies to fight the disease. ...
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CONCLUSIONS: Physician gender, residency program and level of knowledge play a role in HPV vaccine barriers and recommendation in Lebanon. Future improvements in cost and awareness about HPV might improve vaccination rates. Creating uniform practices towards HPV vaccine is warranted to improve patient care. PMID: 31653171 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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CONCLUSION: The early execution of preventive measures of lymphedema prevents the lymphedema occurrence and promotes the quality of life among patients undergone mastectomy. PMID: 31653157 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
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Authors: Zhang C, Wan J, Long F, Liu Q, He H Abstract Osteosarcoma (OS) is the most common type of bone cancer in children and adolescents, and has a poor prognosis. Previous studies have demonstrated that a number of microRNAs (miRNAs) were deregulated in OS, and that the expression of certain miRNAs was correlated with the stage of OS. Therefore, miRNAs may serve a role as a diagnostic and prognostic biomarker of OS. miRNA and mRNA integrated analysis of public expression profiles in...
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Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
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ConclusionSaprochaete clavata infection represents a life-threatening mycosis in severely immunocompromised patients. The successful outcome of treatment seems to be critically dependent on the early diagnosis and the recovery of underlying conditions associated with immune dysfunction or deficiency. (Source: Frontiers in Microbiology)
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Conclusions. Medicare-insured patients undergoing kidney transplant became increasingly medically complex between 1998 and 2014. Despite this, both patient and graft survival improved during this period. A marked decrease in serious cardiovascular events likely contributed to this positive trend. (Source: Transplantation)
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Conclusions. This initial patient demonstrated the feasibility of performing combined histocompatibility leukocyte antigen-matched, sibling donor bone marrow and kidney transplantation for ESRD due to multiple myeloma. This experience paved the way for extending the initial trial to 9 additional patients with multiple myeloma and ESRD and, more recently, to tolerance induction strategies involving combined bone marrow and kidney transplantation for patients with and without an underlying malignancy....
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Conclusion: In our study, it was found that the most common second primary malignancy in patients with thyroid cancer was breast cancer. However, other cancers (skin cancer, renal cell cancer, lymphoma, and colon, lung, or endometrial cancer) may occur in patients with thyroid cancer. PMID: 31651125 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
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Conclusion: The SIB-VMAT technique is effective and safe for irradiating locally advanced rectal cancer. Its effectiveness is expressed in higher clinical and pathological complete response rates and safety with the same rates of acute toxicity. PMID: 31651118 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
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CONCLUSION: It is suggested that inflammation has limited effect on cisplatin nephrotoxicity in this experimental design and as reflected by decreased BUN and creatinine levels NAC can be used as an additional therapeutic agent to standard cisplatin treatment protocols. PMID: 31655538 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
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Conclusion: SE and SWE are both feasible imaging modalities in the differentiation of malignant and benign breast lesions with similar diagnostic performances. PMID: 31651122 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
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Conclusion: Interventional bronchoscopy is an invasive but considerably safe and efficient procedure for selected cases and effective treatment modality for airway obstructions, massive hemoptysis, and foreign body aspiration. Interventional pulmonology is a field of pulmonary medicine that needs effort to progress and provide an opportunity to witness relevant developments, and increase the number of competent physicians and centers. PMID: 31651113 [PubMed - in process] (Source: Turkish Journal...
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CONCLUSION We detected no CTCs in the peripheral circulation following biopsy. Prostate needle biopsy seems to be a safe method in terms of spillage of tumor cells into blood circulation as a sign of possible further metastasis. PMID: 31655516 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
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CONCLUSION: Our study provided strong evidence for snuff and paan/betel leaf to be independent risk factor for oral cavity cancer. PMID: 31655504 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
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Conclusion: Tumor size was not a risk factor predicting recurrence in patients with stage I or II endometrioid-type endometrial cancer who had lymphadenectomy. PMID: 31650820 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
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Conclusion: It was therefore concluded that there is a significant association between rs8176318 and BC risk in a case-control study in a Pakistani population. Furthermore, an association study using a large sample size is required to further verify these findings. PMID: 31651107 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
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Conclusion: This study suggests that NNMT may promote cancer progression and that NNMT overexpression is associated with aberrant p53 expression, pAkt, and poor survival. NNMT’s role in cancer progression could make it a target of EC therapy. PMID: 31652035 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained...
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CONCLUSION: We firstly report bilateral renal involvement of ES/PNET in the English medical literature. Physicians dealing with pediatric renal mass should be alert about the high mortality rate in children with MRT, MBN and ES/PNET; and should plan a substantial management plan for NWRT. PMID: 31655501 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
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by Boyang Zhao, Justin R. Pritchard The somatic co-evolution of tumors and the cellular immune responses that combat them drives the diversity of immune-tumor interactions. This includes tumor mutations that generate neo-antigenic epitopes that elicit cytotoxic T-cell activity and subsequent pressure to select for genetic loss of an tigen presentation. Most studies have focused on how tumor missense mutations can drive tumor immunity, but frameshift mutations have the potential to create far greater...
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Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte function could lead to improved treatment strategies. RND3 (RhoE/Rho8), a Rho-related GTP-binding protein that inhibits Rho kinase (ROCK) signaling, has been linked to diverse diseases such as apoptotic cardiomyopathy, heart failure, cancer and type 2 diabetes, in part by regulating cytoskeleton...
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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western societies and a major cause of hepatic disease worldwide. Its more severe type, namely nonalcoholic steatohepatitis (NASH), may result in the development of cirrhosis and hepatocellular carcinoma. NAFLD, and especially NASH, are also associated with increased cardiovascular morbidity and mortality. Type 2 diabetes mellitus (T2DM) predisposes to NAFLD development and progression via insulin resistance and...
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(Source: Journal of General Internal Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionsSubregional radiomics analysis of PET/CT imaging has the potential to predict PFS in patients with NPC, which also provides complementary prognostic information for traditional predictors. (Source: Molecular Imaging and Biology)
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(Source: Journal of General Internal Medicine)
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This study aimed to describe breast and ovarian cancer screening recommendations that primary care physicians would consider advisable for young trueBRCA1/2 non-carriers. One hundred thirty-four family physicians and 123 gynecologists (response rate 45%) completed a cross-sectional mailed survey administered in the Province of Quebec, Canada. The survey included questions about basic genetic knowledge and screening recommendations for two fictitious cases (< 40 years), one carrier and one non-carrier,...
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